Multivalent fusion protein vaccine for lymphatic filariasis.
Identifieur interne : 001F25 ( PubMed/Curation ); précédent : 001F24; suivant : 001F26Multivalent fusion protein vaccine for lymphatic filariasis.
Auteurs : Gajalakshmi Dakshinamoorthy [États-Unis] ; Abhilash Kumble Samykutty ; Gnanasekar Munirathinam ; Maryada Venkatarami Reddy ; Ramaswamy KalyanasundaramSource :
- Vaccine [ 1873-2518 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (immunologie), Brugia malayi, Filariose lymphatique (), Humains, Immunité cellulaire, Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th2 (immunologie), Production d'anticorps, Protéines de fusion recombinantes (immunologie), Protéines du choc thermique (immunologie), Protéines recombinantes (immunologie), Souris, Souris de lignée BALB C, Tétraspanines (immunologie), Vaccins (immunologie), Vaccins à ADN (immunologie).
- MESH :
- immunologie : Antigènes d'helminthe, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Protéines de fusion recombinantes, Protéines du choc thermique, Protéines recombinantes, Tétraspanines, Vaccins, Vaccins à ADN.
- sang : Anticorps antihelminthe.
- Animaux, Brugia malayi, Filariose lymphatique, Humains, Immunité cellulaire, Production d'anticorps, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (blood), Antibody Formation, Antigens, Helminth (immunology), Brugia malayi, Elephantiasis, Filarial (prevention & control), Heat-Shock Proteins (immunology), Humans, Immunity, Cellular, Mice, Mice, Inbred BALB C, Recombinant Fusion Proteins (immunology), Recombinant Proteins (immunology), Tetraspanins (immunology), Th1 Cells (immunology), Th2 Cells (immunology), Vaccines (immunology), Vaccines, DNA (immunology).
- MESH :
- chemical , blood : Antibodies, Helminth.
- chemical , immunology : Antigens, Helminth, Heat-Shock Proteins, Recombinant Fusion Proteins, Recombinant Proteins, Tetraspanins, Vaccines, Vaccines, DNA.
- immunology : Th1 Cells, Th2 Cells.
- prevention & control : Elephantiasis, Filarial.
- Animals, Antibody Formation, Brugia malayi, Humans, Immunity, Cellular, Mice, Mice, Inbred BALB C.
Abstract
Lymphatic filariasis affects approximately 3% of the whole world population. Mass drug administration is currently the major control strategy to eradicate this infection from endemic regions by year 2020. Combination drug treatments are highly efficient in controlling the infection. However, there are no effective vaccines available for human or animal lymphatic filariasis despite the identification of several subunit vaccines. Lymphatic filariasis parasites are multicellular organisms and potentially use multiple mechanisms to survive in the host. Therefore, there is a need to combine two or more vaccine candidate antigens to achieve the desired effect. In this study we combined three well characterized vaccine antigens of Brugia malayi, heat shock protein 12.6 (HSP12.6), Abundant Larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL) as a multivalent fusion vaccine. Putative immune individuals carry circulating antibodies against all three antigens. Depletion of these antigen specific antibodies from the sera samples removed the ability of the sera to participate in the killing of B. malayi L3 in an antibody dependent cellular cytotoxicity (ADCC) mechanism. Vaccination trials in mice with a bivalent [HSP12.6+ALT-2 (HA), HSP12.6+TSP-LEL (HT) or TSP-LEL+ALT-2 (TA)] or trivalent [HSP12.6+ALT-2+TSP-LEL (HAT)] vaccines using DNA, protein or heterologous prime boost regimen showed that trivalent HAT vaccine either as protein alone or as heterologous prime boost vaccine could confer significant protection (95%) against B. malayi L3 challenge. Immune correlates of protection suggest a Th1/Th2 bias. These finding suggests that the trivalent HAT fusion protein is a promising prophylactic vaccine against lymphatic filariasis infection in human.
DOI: 10.1016/j.vaccine.2012.09.055
PubMed: 23036503
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001F25
Links to Exploration step
pubmed:23036503Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multivalent fusion protein vaccine for lymphatic filariasis.</title>
<author><name sortKey="Dakshinamoorthy, Gajalakshmi" sort="Dakshinamoorthy, Gajalakshmi" uniqKey="Dakshinamoorthy G" first="Gajalakshmi" last="Dakshinamoorthy">Gajalakshmi Dakshinamoorthy</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, IL 61107, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, IL 61107</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Samykutty, Abhilash Kumble" sort="Samykutty, Abhilash Kumble" uniqKey="Samykutty A" first="Abhilash Kumble" last="Samykutty">Abhilash Kumble Samykutty</name>
</author>
<author><name sortKey="Munirathinam, Gnanasekar" sort="Munirathinam, Gnanasekar" uniqKey="Munirathinam G" first="Gnanasekar" last="Munirathinam">Gnanasekar Munirathinam</name>
</author>
<author><name sortKey="Reddy, Maryada Venkatarami" sort="Reddy, Maryada Venkatarami" uniqKey="Reddy M" first="Maryada Venkatarami" last="Reddy">Maryada Venkatarami Reddy</name>
</author>
<author><name sortKey="Kalyanasundaram, Ramaswamy" sort="Kalyanasundaram, Ramaswamy" uniqKey="Kalyanasundaram R" first="Ramaswamy" last="Kalyanasundaram">Ramaswamy Kalyanasundaram</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23036503</idno>
<idno type="pmid">23036503</idno>
<idno type="doi">10.1016/j.vaccine.2012.09.055</idno>
<idno type="wicri:Area/PubMed/Corpus">001F25</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F25</idno>
<idno type="wicri:Area/PubMed/Curation">001F25</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F25</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Multivalent fusion protein vaccine for lymphatic filariasis.</title>
<author><name sortKey="Dakshinamoorthy, Gajalakshmi" sort="Dakshinamoorthy, Gajalakshmi" uniqKey="Dakshinamoorthy G" first="Gajalakshmi" last="Dakshinamoorthy">Gajalakshmi Dakshinamoorthy</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, IL 61107, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, IL 61107</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Samykutty, Abhilash Kumble" sort="Samykutty, Abhilash Kumble" uniqKey="Samykutty A" first="Abhilash Kumble" last="Samykutty">Abhilash Kumble Samykutty</name>
</author>
<author><name sortKey="Munirathinam, Gnanasekar" sort="Munirathinam, Gnanasekar" uniqKey="Munirathinam G" first="Gnanasekar" last="Munirathinam">Gnanasekar Munirathinam</name>
</author>
<author><name sortKey="Reddy, Maryada Venkatarami" sort="Reddy, Maryada Venkatarami" uniqKey="Reddy M" first="Maryada Venkatarami" last="Reddy">Maryada Venkatarami Reddy</name>
</author>
<author><name sortKey="Kalyanasundaram, Ramaswamy" sort="Kalyanasundaram, Ramaswamy" uniqKey="Kalyanasundaram R" first="Ramaswamy" last="Kalyanasundaram">Ramaswamy Kalyanasundaram</name>
</author>
</analytic>
<series><title level="j">Vaccine</title>
<idno type="eISSN">1873-2518</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Helminth (blood)</term>
<term>Antibody Formation</term>
<term>Antigens, Helminth (immunology)</term>
<term>Brugia malayi</term>
<term>Elephantiasis, Filarial (prevention & control)</term>
<term>Heat-Shock Proteins (immunology)</term>
<term>Humans</term>
<term>Immunity, Cellular</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Recombinant Fusion Proteins (immunology)</term>
<term>Recombinant Proteins (immunology)</term>
<term>Tetraspanins (immunology)</term>
<term>Th1 Cells (immunology)</term>
<term>Th2 Cells (immunology)</term>
<term>Vaccines (immunology)</term>
<term>Vaccines, DNA (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antihelminthe (sang)</term>
<term>Antigènes d'helminthe (immunologie)</term>
<term>Brugia malayi</term>
<term>Filariose lymphatique ()</term>
<term>Humains</term>
<term>Immunité cellulaire</term>
<term>Lymphocytes auxiliaires Th1 (immunologie)</term>
<term>Lymphocytes auxiliaires Th2 (immunologie)</term>
<term>Production d'anticorps</term>
<term>Protéines de fusion recombinantes (immunologie)</term>
<term>Protéines du choc thermique (immunologie)</term>
<term>Protéines recombinantes (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Tétraspanines (immunologie)</term>
<term>Vaccins (immunologie)</term>
<term>Vaccins à ADN (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term>
<term>Heat-Shock Proteins</term>
<term>Recombinant Fusion Proteins</term>
<term>Recombinant Proteins</term>
<term>Tetraspanins</term>
<term>Vaccines</term>
<term>Vaccines, DNA</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term>
<term>Lymphocytes auxiliaires Th1</term>
<term>Lymphocytes auxiliaires Th2</term>
<term>Protéines de fusion recombinantes</term>
<term>Protéines du choc thermique</term>
<term>Protéines recombinantes</term>
<term>Tétraspanines</term>
<term>Vaccins</term>
<term>Vaccins à ADN</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Th1 Cells</term>
<term>Th2 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Antibody Formation</term>
<term>Brugia malayi</term>
<term>Humans</term>
<term>Immunity, Cellular</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Brugia malayi</term>
<term>Filariose lymphatique</term>
<term>Humains</term>
<term>Immunité cellulaire</term>
<term>Production d'anticorps</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Lymphatic filariasis affects approximately 3% of the whole world population. Mass drug administration is currently the major control strategy to eradicate this infection from endemic regions by year 2020. Combination drug treatments are highly efficient in controlling the infection. However, there are no effective vaccines available for human or animal lymphatic filariasis despite the identification of several subunit vaccines. Lymphatic filariasis parasites are multicellular organisms and potentially use multiple mechanisms to survive in the host. Therefore, there is a need to combine two or more vaccine candidate antigens to achieve the desired effect. In this study we combined three well characterized vaccine antigens of Brugia malayi, heat shock protein 12.6 (HSP12.6), Abundant Larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL) as a multivalent fusion vaccine. Putative immune individuals carry circulating antibodies against all three antigens. Depletion of these antigen specific antibodies from the sera samples removed the ability of the sera to participate in the killing of B. malayi L3 in an antibody dependent cellular cytotoxicity (ADCC) mechanism. Vaccination trials in mice with a bivalent [HSP12.6+ALT-2 (HA), HSP12.6+TSP-LEL (HT) or TSP-LEL+ALT-2 (TA)] or trivalent [HSP12.6+ALT-2+TSP-LEL (HAT)] vaccines using DNA, protein or heterologous prime boost regimen showed that trivalent HAT vaccine either as protein alone or as heterologous prime boost vaccine could confer significant protection (95%) against B. malayi L3 challenge. Immune correlates of protection suggest a Th1/Th2 bias. These finding suggests that the trivalent HAT fusion protein is a promising prophylactic vaccine against lymphatic filariasis infection in human.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23036503</PMID>
<DateCreated><Year>2013</Year>
<Month>03</Month>
<Day>04</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>08</Month>
<Day>05</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>31</Volume>
<Issue>12</Issue>
<PubDate><Year>2013</Year>
<Month>Mar</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Vaccine</Title>
<ISOAbbreviation>Vaccine</ISOAbbreviation>
</Journal>
<ArticleTitle>Multivalent fusion protein vaccine for lymphatic filariasis.</ArticleTitle>
<Pagination><MedlinePgn>1616-22</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2012.09.055</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0264-410X(12)01375-8</ELocationID>
<Abstract><AbstractText>Lymphatic filariasis affects approximately 3% of the whole world population. Mass drug administration is currently the major control strategy to eradicate this infection from endemic regions by year 2020. Combination drug treatments are highly efficient in controlling the infection. However, there are no effective vaccines available for human or animal lymphatic filariasis despite the identification of several subunit vaccines. Lymphatic filariasis parasites are multicellular organisms and potentially use multiple mechanisms to survive in the host. Therefore, there is a need to combine two or more vaccine candidate antigens to achieve the desired effect. In this study we combined three well characterized vaccine antigens of Brugia malayi, heat shock protein 12.6 (HSP12.6), Abundant Larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL) as a multivalent fusion vaccine. Putative immune individuals carry circulating antibodies against all three antigens. Depletion of these antigen specific antibodies from the sera samples removed the ability of the sera to participate in the killing of B. malayi L3 in an antibody dependent cellular cytotoxicity (ADCC) mechanism. Vaccination trials in mice with a bivalent [HSP12.6+ALT-2 (HA), HSP12.6+TSP-LEL (HT) or TSP-LEL+ALT-2 (TA)] or trivalent [HSP12.6+ALT-2+TSP-LEL (HAT)] vaccines using DNA, protein or heterologous prime boost regimen showed that trivalent HAT vaccine either as protein alone or as heterologous prime boost vaccine could confer significant protection (95%) against B. malayi L3 challenge. Immune correlates of protection suggest a Th1/Th2 bias. These finding suggests that the trivalent HAT fusion protein is a promising prophylactic vaccine against lymphatic filariasis infection in human.</AbstractText>
<CopyrightInformation>Copyright © 2012 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dakshinamoorthy</LastName>
<ForeName>Gajalakshmi</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, IL 61107, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Samykutty</LastName>
<ForeName>Abhilash Kumble</ForeName>
<Initials>AK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Munirathinam</LastName>
<ForeName>Gnanasekar</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Reddy</LastName>
<ForeName>Maryada Venkatarami</ForeName>
<Initials>MV</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kalyanasundaram</LastName>
<ForeName>Ramaswamy</ForeName>
<Initials>R</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 AI064745</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R56 AI064745</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>AI064745</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>10</Month>
<Day>02</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Vaccine</MedlineTA>
<NlmUniqueID>8406899</NlmUniqueID>
<ISSNLinking>0264-410X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C521555">ALT-2 protein, Brugia malayi</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006360">Heat-Shock Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011993">Recombinant Fusion Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D059470">Tetraspanins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014612">Vaccines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019444">Vaccines, DNA</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2010 Jul 12;28(31):5038-48</RefSource>
<PMID Version="1">20653106</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasitol Today. 1991 Dec;7(12):341-3</RefSource>
<PMID Version="1">15463411</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasitol Today. 1997 Dec;13(12):472-6</RefSource>
<PMID Version="1">15275135</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Malar J. 2007;6:135</RefSource>
<PMID Version="1">17925026</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2006 Jan 16;24(3):335-44</RefSource>
<PMID Version="1">16125280</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Microbes Infect. 2000 Sep;2(11):1363-71</RefSource>
<PMID Version="1">11018453</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasit Vectors. 2010 Nov 19;3:109</RefSource>
<PMID Version="1">21087526</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2008 Nov 5;26(47):5997-6005</RefSource>
<PMID Version="1">18817835</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 1989 Jun;40(6):598-604</RefSource>
<PMID Version="1">2662785</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>DNA Seq. 2008 Apr;19(2):151-6</RefSource>
<PMID Version="1">17852334</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2000 Jul;68(7):4174-9</RefSource>
<PMID Version="1">10858234</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2009;3(6):e457</RefSource>
<PMID Version="1">19513102</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Biochem Parasitol. 2008 Jun;159(2):98-103</RefSource>
<PMID Version="1">18395809</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2009 Jul 9;27(32):4263-71</RefSource>
<PMID Version="1">19450648</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13146-51</RefSource>
<PMID Version="1">9371814</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Procedia Vaccinol. 2010;3:12-18</RefSource>
<PMID Version="1">21709765</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1982;76(3):362-70</RefSource>
<PMID Version="1">7112659</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2005 Oct-Nov;27(10-11):417-29</RefSource>
<PMID Version="1">16179035</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(3):e18141</RefSource>
<PMID Version="1">21448458</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Parasitol. 1990 Oct;20(6):725-30</RefSource>
<PMID Version="1">2242956</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2005 Apr;73(4):2298-305</RefSource>
<PMID Version="1">15784574</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Folia Microbiol (Praha). 1997;42(2):105-12</RefSource>
<PMID Version="1">9306653</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2004 Aug;72(8):4707-15</RefSource>
<PMID Version="1">15271932</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Biochem Parasitol. 2001 Nov;118(1):89-96</RefSource>
<PMID Version="1">11704277</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Struct Mol Biol. 2005 Oct;12(10):842-6</RefSource>
<PMID Version="1">16205709</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Res Rep Trop Med. 2011 Mar;2011(2):45-56</RefSource>
<PMID Version="1">21760754</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2006 Sep 11;24(37-39):6208-15</RefSource>
<PMID Version="1">16870314</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2012;6(3):e1564</RefSource>
<PMID Version="1">22428079</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Expert Rev Mol Med. 2003 Feb;5(7):1-17</RefSource>
<PMID Version="1">14987410</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(4):e34077</RefSource>
<PMID Version="1">22496777</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Parasitol. 2007 Aug;116(4):483-91</RefSource>
<PMID Version="1">17442307</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2000 May;68(5):3034-5</RefSource>
<PMID Version="1">10769010</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Parasitol. 2011 Nov;129(3):247-53</RefSource>
<PMID Version="1">21864531</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2000 Feb;22(2):89-96</RefSource>
<PMID Version="1">10652121</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000917" MajorTopicYN="N">Antibody Formation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017178" MajorTopicYN="N">Brugia malayi</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006360" MajorTopicYN="N">Heat-Shock Proteins</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007111" MajorTopicYN="N">Immunity, Cellular</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011993" MajorTopicYN="N">Recombinant Fusion Proteins</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059470" MajorTopicYN="N">Tetraspanins</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018417" MajorTopicYN="N">Th1 Cells</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018418" MajorTopicYN="N">Th2 Cells</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014612" MajorTopicYN="N">Vaccines</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019444" MajorTopicYN="N">Vaccines, DNA</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">NIHMS410997</OtherID>
<OtherID Source="NLM">PMC3554871</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year>
<Month>06</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2012</Year>
<Month>09</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2012</Year>
<Month>09</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2012</Year>
<Month>10</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2012</Year>
<Month>10</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2013</Year>
<Month>8</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">23036503</ArticleId>
<ArticleId IdType="pii">S0264-410X(12)01375-8</ArticleId>
<ArticleId IdType="doi">10.1016/j.vaccine.2012.09.055</ArticleId>
<ArticleId IdType="pmc">PMC3554871</ArticleId>
<ArticleId IdType="mid">NIHMS410997</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F25 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001F25 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:23036503 |texte= Multivalent fusion protein vaccine for lymphatic filariasis. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:23036503" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |