Successful treatment of an angiosarcoma of the nose with radiation therapy.
Identifieur interne : 001E49 ( PubMed/Curation ); précédent : 001E48; suivant : 001E50Successful treatment of an angiosarcoma of the nose with radiation therapy.
Auteurs : Vatsal B. Patel [États-Unis] ; Tod W. SpeerSource :
- Case reports in oncology [ 1662-6575 ] ; 2012.
Abstract
Angiosarcoma is a rare, aggressive malignancy of endothelial cells lining blood vessels. It poses therapeutic challenges since there is no standard established treatment. It is typically treated with resection and wide-field postoperative radiation therapy. Chemotherapy and radiation therapy have also been reported as initial therapies. Regardless of the treatment rendered, the risk of local regional failure and distant relapse remains high for this disease. We present the case of a patient who developed a well-differentiated angiosarcoma of the nose with bilateral malar extension. No commonly associated risk factors such as lymphedema, prior radiotherapy or chronic venous ulceration were present. Given her age, pre-existing renal condition and preference not to receive chemotherapy, systemic therapy was not utilized. Surgery was also refused by the patient due to the projected cosmetic deficit. The patient was ultimately treated with definitive radiotherapy, utilizing electrons to the central face, differential thickness bolus, an intraoral stent, eye shields, an aquaplast mask for immobilization and a wax-coated lead shield over the face in order to limit penumbra of the radiation beam. Right and left anterior 6-MV photons were used to tangentially treat the bilateral malar region in order to extend the field edges. At the time of this report, the patient remains disease free at nearly 2.0 years after radiotherapy. To the best of our knowledge, this represents only the second case in the literature reporting radiotherapy as a single modality treatment that resulted in complete remission of an angiosarcoma of the face.
DOI: 10.1159/000343675
PubMed: 23185161
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Patel</name><affiliation wicri:level="1"><nlm:affiliation>University of Connecticut, Farmington, Conn., Madison, Wisc., USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Connecticut, Farmington, Conn., Madison, Wisc.</wicri:regionArea></affiliation></author><author><name sortKey="Speer, Tod W" sort="Speer, Tod W" uniqKey="Speer T" first="Tod W" last="Speer">Tod W. Speer</name></author></analytic><series><title level="j">Case reports in oncology</title><idno type="eISSN">1662-6575</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Angiosarcoma is a rare, aggressive malignancy of endothelial cells lining blood vessels. It poses therapeutic challenges since there is no standard established treatment. It is typically treated with resection and wide-field postoperative radiation therapy. Chemotherapy and radiation therapy have also been reported as initial therapies. Regardless of the treatment rendered, the risk of local regional failure and distant relapse remains high for this disease. We present the case of a patient who developed a well-differentiated angiosarcoma of the nose with bilateral malar extension. No commonly associated risk factors such as lymphedema, prior radiotherapy or chronic venous ulceration were present. Given her age, pre-existing renal condition and preference not to receive chemotherapy, systemic therapy was not utilized. Surgery was also refused by the patient due to the projected cosmetic deficit. The patient was ultimately treated with definitive radiotherapy, utilizing electrons to the central face, differential thickness bolus, an intraoral stent, eye shields, an aquaplast mask for immobilization and a wax-coated lead shield over the face in order to limit penumbra of the radiation beam. Right and left anterior 6-MV photons were used to tangentially treat the bilateral malar region in order to extend the field edges. At the time of this report, the patient remains disease free at nearly 2.0 years after radiotherapy. To the best of our knowledge, this represents only the second case in the literature reporting radiotherapy as a single modality treatment that resulted in complete remission of an angiosarcoma of the face.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">23185161</PMID><DateCreated><Year>2012</Year><Month>11</Month><Day>27</Day></DateCreated><DateCompleted><Year>2012</Year><Month>11</Month><Day>28</Day></DateCompleted><DateRevised><Year>2013</Year><Month>05</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1662-6575</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>3</Issue><PubDate><Year>2012</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Case reports in oncology</Title><ISOAbbreviation>Case Rep Oncol</ISOAbbreviation></Journal><ArticleTitle>Successful treatment of an angiosarcoma of the nose with radiation therapy.</ArticleTitle><Pagination><MedlinePgn>570-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1159/000343675</ELocationID><Abstract><AbstractText>Angiosarcoma is a rare, aggressive malignancy of endothelial cells lining blood vessels. It poses therapeutic challenges since there is no standard established treatment. It is typically treated with resection and wide-field postoperative radiation therapy. Chemotherapy and radiation therapy have also been reported as initial therapies. Regardless of the treatment rendered, the risk of local regional failure and distant relapse remains high for this disease. We present the case of a patient who developed a well-differentiated angiosarcoma of the nose with bilateral malar extension. No commonly associated risk factors such as lymphedema, prior radiotherapy or chronic venous ulceration were present. Given her age, pre-existing renal condition and preference not to receive chemotherapy, systemic therapy was not utilized. Surgery was also refused by the patient due to the projected cosmetic deficit. The patient was ultimately treated with definitive radiotherapy, utilizing electrons to the central face, differential thickness bolus, an intraoral stent, eye shields, an aquaplast mask for immobilization and a wax-coated lead shield over the face in order to limit penumbra of the radiation beam. Right and left anterior 6-MV photons were used to tangentially treat the bilateral malar region in order to extend the field edges. At the time of this report, the patient remains disease free at nearly 2.0 years after radiotherapy. To the best of our knowledge, this represents only the second case in the literature reporting radiotherapy as a single modality treatment that resulted in complete remission of an angiosarcoma of the face.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Vatsal B</ForeName><Initials>VB</Initials><AffiliationInfo><Affiliation>University of Connecticut, Farmington, Conn., Madison, Wisc., USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Speer</LastName><ForeName>Tod W</ForeName><Initials>TW</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>10</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Case Rep Oncol</MedlineTA><NlmUniqueID>101517601</NlmUniqueID><ISSNLinking>1662-6575</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Eur J Cancer. 2008 Nov;44(16):2433-6</RefSource><PMID Version="1">18771914</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Dermatol. 2008 Nov;47(11):1190-2</RefSource><PMID Version="1">18986458</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Dermatol Case Rep. 2009 Apr 5;3(1):8-10</RefSource><PMID Version="1">21886720</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Indian J Dermatol Venereol Leprol. 2012 Jul-Aug;78(4):496-7</RefSource><PMID Version="1">22772626</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Radiol. 2012 Nov;85(1019):e1127-33</RefSource><PMID Version="1">22806620</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer. 1987 Mar 1;59(5):1046-57</RefSource><PMID Version="1">3815265</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Head Neck. 2008 Feb;30(2):262-6</RefSource><PMID Version="1">17685450</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Oncol (R Coll Radiol). 1999;11(3):208-10</RefSource><PMID Version="1">10465481</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Dermatol. 2002 Jul;147(1):150-3</RefSource><PMID Version="1">12100199</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer. 2003 Oct 15;98(8):1716-26</RefSource><PMID Version="1">14534889</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Clin Oncol. 2006 Oct;29(5):524-8</RefSource><PMID Version="1">17023791</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer. 2007 Aug 1;110(3):648-51</RefSource><PMID Version="1">17582627</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Radiat Oncol Biol Phys. 1981 Dec;7(12):1655-9</RefSource><PMID Version="1">7199518</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">PMC3506051</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Angiosarcoma</Keyword><Keyword MajorTopicYN="N">Endothelial cells</Keyword><Keyword MajorTopicYN="N">Radiation therapy</Keyword><Keyword MajorTopicYN="N">Single modality treatment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23185161</ArticleId><ArticleId IdType="doi">10.1159/000343675</ArticleId><ArticleId IdType="pii">cro-0005-0570</ArticleId><ArticleId IdType="pmc">PMC3506051</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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