c-myc and cutaneous vascular neoplasms.
Identifieur interne : 001E17 ( PubMed/Curation ); précédent : 001E16; suivant : 001E18c-myc and cutaneous vascular neoplasms.
Auteurs : John K. Feller [États-Unis] ; Meera MahalingamSource :
- The American Journal of dermatopathology [ 1533-0311 ] ; 2013.
Descripteurs français
- KwdFr :
- Biopsie, Conformation des protéines, Humains, Immunohistochimie, Néovascularisation pathologique, Pronostic, Protéines proto-oncogènes c-myc (), Protéines proto-oncogènes c-myc (génétique), Protéines proto-oncogènes c-myc (métabolisme), Relation structure-activité, Technique FISH, Transduction du signal, Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (génétique), Tumeurs cutanées (métabolisme), Tumeurs du tissu vasculaire (anatomopathologie), Tumeurs du tissu vasculaire (génétique), Tumeurs du tissu vasculaire (métabolisme), Valeur prédictive des tests.
- MESH :
- anatomopathologie : Tumeurs cutanées, Tumeurs du tissu vasculaire.
- génétique : Protéines proto-oncogènes c-myc, Tumeurs cutanées, Tumeurs du tissu vasculaire.
- métabolisme : Protéines proto-oncogènes c-myc, Tumeurs cutanées, Tumeurs du tissu vasculaire.
- Biopsie, Conformation des protéines, Humains, Immunohistochimie, Néovascularisation pathologique, Pronostic, Protéines proto-oncogènes c-myc, Relation structure-activité, Technique FISH, Transduction du signal, Valeur prédictive des tests.
English descriptors
- KwdEn :
- Biopsy, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Neoplasms, Vascular Tissue (genetics), Neoplasms, Vascular Tissue (metabolism), Neoplasms, Vascular Tissue (pathology), Neovascularization, Pathologic, Predictive Value of Tests, Prognosis, Protein Conformation, Proto-Oncogene Proteins c-myc (chemistry), Proto-Oncogene Proteins c-myc (genetics), Proto-Oncogene Proteins c-myc (metabolism), Signal Transduction, Skin Neoplasms (genetics), Skin Neoplasms (metabolism), Skin Neoplasms (pathology), Structure-Activity Relationship.
- MESH :
- chemical , chemistry : Proto-Oncogene Proteins c-myc.
- genetics : Neoplasms, Vascular Tissue, Proto-Oncogene Proteins c-myc, Skin Neoplasms.
- metabolism : Neoplasms, Vascular Tissue, Proto-Oncogene Proteins c-myc, Skin Neoplasms.
- pathology : Neoplasms, Vascular Tissue, Skin Neoplasms.
- Biopsy, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Neovascularization, Pathologic, Predictive Value of Tests, Prognosis, Protein Conformation, Signal Transduction, Structure-Activity Relationship.
Abstract
The c-myc proto-oncogene is involved in various cellular processes including cell growth, proliferation, and apoptosis. Overexpression and deregulated expression of the gene have been previously linked to several lineage-unrelated, aggressive, and poorly differentiated tumors. The expression of c-myc has also been implicated in hematopoiesis and has been shown to play a crucial role in angiogenesis via a vascular endothelial growth factor-dependent mechanism. This gives c-myc a dual oncogenic function in that tumor growth requires both cell proliferation and angiogenesis to ensure survival and confer an effective malignancy. Amplification of c-myc has been recently reported to be a recurrent genetic alteration in angiosarcomas secondary to irradiation and/or chronic lymphedema. Of note, however, no c-myc gene abnormalities have been demonstrated in cases of primary angiosarcomas or postradiation atypical vascular lesions. More recently, our own experience indicates that c-myc amplification is not normally found in the Kaposi sarcoma and cannot be correlated with expression of the c-Myc protein. This comprehensive review outlines the structure, normal functions, and effects of the deregulated expression of c-myc with particular emphasis on its role in angiogenesis and select cutaneous vascular neoplasms.
DOI: 10.1097/DAD.0b013e31827aad83
PubMed: 23221487
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Overexpression and deregulated expression of the gene have been previously linked to several lineage-unrelated, aggressive, and poorly differentiated tumors. The expression of c-myc has also been implicated in hematopoiesis and has been shown to play a crucial role in angiogenesis via a vascular endothelial growth factor-dependent mechanism. This gives c-myc a dual oncogenic function in that tumor growth requires both cell proliferation and angiogenesis to ensure survival and confer an effective malignancy. Amplification of c-myc has been recently reported to be a recurrent genetic alteration in angiosarcomas secondary to irradiation and/or chronic lymphedema. Of note, however, no c-myc gene abnormalities have been demonstrated in cases of primary angiosarcomas or postradiation atypical vascular lesions. More recently, our own experience indicates that c-myc amplification is not normally found in the Kaposi sarcoma and cannot be correlated with expression of the c-Myc protein. This comprehensive review outlines the structure, normal functions, and effects of the deregulated expression of c-myc with particular emphasis on its role in angiogenesis and select cutaneous vascular neoplasms.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23221487</PMID><DateCreated><Year>2013</Year><Month>04</Month><Day>19</Day></DateCreated><DateCompleted><Year>2013</Year><Month>10</Month><Day>17</Day></DateCompleted><DateRevised><Year>2013</Year><Month>04</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1533-0311</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>3</Issue><PubDate><Year>2013</Year><Month>May</Month></PubDate></JournalIssue><Title>The American Journal of dermatopathology</Title><ISOAbbreviation>Am J Dermatopathol</ISOAbbreviation></Journal><ArticleTitle>c-myc and cutaneous vascular neoplasms.</ArticleTitle><Pagination><MedlinePgn>364-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/DAD.0b013e31827aad83</ELocationID><Abstract><AbstractText>The c-myc proto-oncogene is involved in various cellular processes including cell growth, proliferation, and apoptosis. 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