Role of podoplanin expression in squamous cell carcinoma of upper aerodigestive tract.
Identifieur interne : 001D34 ( PubMed/Curation ); précédent : 001D33; suivant : 001D35Role of podoplanin expression in squamous cell carcinoma of upper aerodigestive tract.
Auteurs : Wen-Yu Chuang [Taïwan] ; Yu-Sun Chang ; Chi-Ju Yeh ; Yi-Chin Wu ; Chuen HsuehSource :
- Histology and histopathology [ 1699-5848 ] ; 2013.
Descripteurs français
- KwdFr :
- Agrégation plaquettaire (), Animaux, Anticorps monoclonaux (pharmacologie), Carcinome épidermoïde (métabolisme), Carcinome épidermoïde (secondaire), Glycoprotéines membranaires (immunologie), Glycoprotéines membranaires (métabolisme), Glycoprotéines membranaires (pharmacologie), Métastase lymphatique, Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (métabolisme), Pronostic, Souris, Souris nude, Thérapie moléculaire ciblée, Tumeurs de l'oesophage (anatomopathologie), Tumeurs de l'oesophage (métabolisme), Tumeurs de la tête et du cou (anatomopathologie), Tumeurs de la tête et du cou (métabolisme), Tumeurs expérimentales (traitement médicamenteux), Tumeurs primitives multiples.
- MESH :
- anatomopathologie : Noeuds lymphatiques, Tumeurs de l'oesophage, Tumeurs de la tête et du cou.
- immunologie : Glycoprotéines membranaires.
- métabolisme : Carcinome épidermoïde, Glycoprotéines membranaires, Noeuds lymphatiques, Tumeurs de l'oesophage, Tumeurs de la tête et du cou.
- pharmacologie : Anticorps monoclonaux, Glycoprotéines membranaires.
- secondaire : Carcinome épidermoïde.
- traitement médicamenteux : Tumeurs expérimentales.
- Agrégation plaquettaire, Animaux, Métastase lymphatique, Pronostic, Souris, Souris nude, Thérapie moléculaire ciblée, Tumeurs primitives multiples.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (pharmacology), Carcinoma, Squamous Cell (metabolism), Carcinoma, Squamous Cell (secondary), Esophageal Neoplasms (metabolism), Esophageal Neoplasms (pathology), Head and Neck Neoplasms (metabolism), Head and Neck Neoplasms (pathology), Lymph Nodes (metabolism), Lymph Nodes (pathology), Lymphatic Metastasis, Membrane Glycoproteins (immunology), Membrane Glycoproteins (metabolism), Membrane Glycoproteins (pharmacology), Mice, Mice, Nude, Molecular Targeted Therapy, Neoplasms, Experimental (drug therapy), Neoplasms, Multiple Primary, Platelet Aggregation (drug effects), Prognosis.
- MESH :
- chemical , immunology : Membrane Glycoproteins.
- chemical , metabolism : Membrane Glycoproteins.
- chemical , pharmacology : Antibodies, Monoclonal, Membrane Glycoproteins.
- drug effects : Platelet Aggregation.
- drug therapy : Neoplasms, Experimental.
- metabolism : Carcinoma, Squamous Cell, Esophageal Neoplasms, Head and Neck Neoplasms, Lymph Nodes.
- pathology : Esophageal Neoplasms, Head and Neck Neoplasms, Lymph Nodes.
- secondary : Carcinoma, Squamous Cell.
- Animals, Lymphatic Metastasis, Mice, Mice, Nude, Molecular Targeted Therapy, Neoplasms, Multiple Primary, Prognosis.
Abstract
Podoplanin, a type-1 transmembrane glycoprotein, was originally named due to its expression in renal podocytes of rats. It was subsequently detected in a variety of normal human tissues, including lymphatic endothelium. Although podoplanin has been identified as the endogenous ligand of C-type lectin-like receptor 2 (CLEC-2) on platelets, its physiological functions and pathways remain largely unknown. A role in lymphangiogenesis has been suggested, since podoplanin-deficient mice were found to die at birth with a phenotype of dilated, malfunctioning lymphatic vessels and lymphedema. Podoplanin is invariably expressed in some tumors, such as lymphangioma, seminoma and follicular dendritic cell tumor, but tumor cell expression of podoplanin is highly variable in squamous cell carcinoma (SCC). It has been found that high podoplanin expression is associated with lymph node metastasis and poor prognosis in SCC of the upper aerodigestive tract. Now there is growing evidence that podoplanin is also involved in carcinogenesis, cell motility, tumor invasiveness, platelet aggregation and hematogenous metastasis. Additionally, animal studies confirmed some in vivo effects of podoplanin-overexpressing tumors, including formation of more tumor lymphatic vessels, larger lymph node metastases, more platelet aggregation, and more pulmonary metastases. Several recently developed anti-podoplanin antibodies, such as NZ-1, P2-0 and hP2-0, have been shown to attenuate podoplanin-induced platelet aggregation and prevent experimental hematogenous metastasis in nude mice. These antibodies may be applied in preclinical and clinical studies to evaluate the possibility of podoplanin-targeted therapy.
DOI: 10.14670/HH-28.293
PubMed: 23348382
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<term>Carcinoma, Squamous Cell (secondary)</term>
<term>Esophageal Neoplasms (metabolism)</term>
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<term>Head and Neck Neoplasms (metabolism)</term>
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<term>Neoplasms, Experimental (drug therapy)</term>
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<term>Platelet Aggregation (drug effects)</term>
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<term>Carcinome épidermoïde (secondaire)</term>
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<term>Souris</term>
<term>Souris nude</term>
<term>Thérapie moléculaire ciblée</term>
<term>Tumeurs de l'oesophage (anatomopathologie)</term>
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<term>Esophageal Neoplasms</term>
<term>Head and Neck Neoplasms</term>
<term>Lymph Nodes</term>
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<term>Glycoprotéines membranaires</term>
<term>Noeuds lymphatiques</term>
<term>Tumeurs de l'oesophage</term>
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<front><div type="abstract" xml:lang="en">Podoplanin, a type-1 transmembrane glycoprotein, was originally named due to its expression in renal podocytes of rats. It was subsequently detected in a variety of normal human tissues, including lymphatic endothelium. Although podoplanin has been identified as the endogenous ligand of C-type lectin-like receptor 2 (CLEC-2) on platelets, its physiological functions and pathways remain largely unknown. A role in lymphangiogenesis has been suggested, since podoplanin-deficient mice were found to die at birth with a phenotype of dilated, malfunctioning lymphatic vessels and lymphedema. Podoplanin is invariably expressed in some tumors, such as lymphangioma, seminoma and follicular dendritic cell tumor, but tumor cell expression of podoplanin is highly variable in squamous cell carcinoma (SCC). It has been found that high podoplanin expression is associated with lymph node metastasis and poor prognosis in SCC of the upper aerodigestive tract. Now there is growing evidence that podoplanin is also involved in carcinogenesis, cell motility, tumor invasiveness, platelet aggregation and hematogenous metastasis. Additionally, animal studies confirmed some in vivo effects of podoplanin-overexpressing tumors, including formation of more tumor lymphatic vessels, larger lymph node metastases, more platelet aggregation, and more pulmonary metastases. Several recently developed anti-podoplanin antibodies, such as NZ-1, P2-0 and hP2-0, have been shown to attenuate podoplanin-induced platelet aggregation and prevent experimental hematogenous metastasis in nude mice. These antibodies may be applied in preclinical and clinical studies to evaluate the possibility of podoplanin-targeted therapy.</div>
</front>
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<Abstract><AbstractText>Podoplanin, a type-1 transmembrane glycoprotein, was originally named due to its expression in renal podocytes of rats. It was subsequently detected in a variety of normal human tissues, including lymphatic endothelium. Although podoplanin has been identified as the endogenous ligand of C-type lectin-like receptor 2 (CLEC-2) on platelets, its physiological functions and pathways remain largely unknown. A role in lymphangiogenesis has been suggested, since podoplanin-deficient mice were found to die at birth with a phenotype of dilated, malfunctioning lymphatic vessels and lymphedema. Podoplanin is invariably expressed in some tumors, such as lymphangioma, seminoma and follicular dendritic cell tumor, but tumor cell expression of podoplanin is highly variable in squamous cell carcinoma (SCC). It has been found that high podoplanin expression is associated with lymph node metastasis and poor prognosis in SCC of the upper aerodigestive tract. Now there is growing evidence that podoplanin is also involved in carcinogenesis, cell motility, tumor invasiveness, platelet aggregation and hematogenous metastasis. Additionally, animal studies confirmed some in vivo effects of podoplanin-overexpressing tumors, including formation of more tumor lymphatic vessels, larger lymph node metastases, more platelet aggregation, and more pulmonary metastases. Several recently developed anti-podoplanin antibodies, such as NZ-1, P2-0 and hP2-0, have been shown to attenuate podoplanin-induced platelet aggregation and prevent experimental hematogenous metastasis in nude mice. These antibodies may be applied in preclinical and clinical studies to evaluate the possibility of podoplanin-targeted therapy.</AbstractText>
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