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Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss.

Identifieur interne : 001C79 ( PubMed/Curation ); précédent : 001C78; suivant : 001C80

Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss.

Auteurs : J S Ferguson [Royaume-Uni] ; W E Yeshanehe ; W. Yeshanehe ; P J Matts ; P. Matts ; G. Davey ; P S Mortimer ; P. Mortimer ; L C Fuller ; C. Fuller

Source :

RBID : pubmed:23445314

Descripteurs français

English descriptors

Abstract

Podoconiosis is a common cause of lymphoedema in barefoot workers in Ethiopia and other countries. It has severe consequences for patients' physical function, quality of life and economic status.

DOI: 10.1111/bjd.12134
PubMed: 23445314

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pubmed:23445314

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<name sortKey="Ferguson, J S" sort="Ferguson, J S" uniqKey="Ferguson J" first="J S" last="Ferguson">J S Ferguson</name>
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<nlm:affiliation>Department of Dermatology, St George's Hospital, London, UK. jsferg@gmail.com</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">P S Mortimer</name>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Child</term>
<term>Elephantiasis (physiopathology)</term>
<term>Epidermis (physiology)</term>
<term>Female</term>
<term>Foot</term>
<term>Humans</term>
<term>Lymphedema (physiopathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Water Loss, Insensible (physiology)</term>
<term>Water-Electrolyte Imbalance (physiopathology)</term>
<term>Young Adult</term>
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<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Déperdition hydrique (physiologie)</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Mâle</term>
<term>Pied</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Troubles de l'équilibre hydroélectrolytique (physiopathologie)</term>
<term>Éléphantiasis (physiopathologie)</term>
<term>Épiderme (physiologie)</term>
<term>Études cas-témoins</term>
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<term>Déperdition hydrique</term>
<term>Épiderme</term>
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<term>Epidermis</term>
<term>Water Loss, Insensible</term>
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<term>Lymphoedème</term>
<term>Troubles de l'équilibre hydroélectrolytique</term>
<term>Éléphantiasis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Elephantiasis</term>
<term>Lymphedema</term>
<term>Water-Electrolyte Imbalance</term>
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<term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Child</term>
<term>Female</term>
<term>Foot</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
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<term>Adulte d'âge moyen</term>
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<front>
<div type="abstract" xml:lang="en">Podoconiosis is a common cause of lymphoedema in barefoot workers in Ethiopia and other countries. It has severe consequences for patients' physical function, quality of life and economic status.</div>
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<DateCreated>
<Year>2013</Year>
<Month>02</Month>
<Day>28</Day>
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<DateCompleted>
<Year>2013</Year>
<Month>08</Month>
<Day>19</Day>
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<DateRevised>
<Year>2017</Year>
<Month>09</Month>
<Day>02</Day>
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<ISSN IssnType="Electronic">1365-2133</ISSN>
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<Volume>168</Volume>
<Issue>3</Issue>
<PubDate>
<Year>2013</Year>
<Month>Mar</Month>
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<Title>The British journal of dermatology</Title>
<ISOAbbreviation>Br. J. Dermatol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Podoconiosis is a common cause of lymphoedema in barefoot workers in Ethiopia and other countries. It has severe consequences for patients' physical function, quality of life and economic status.</AbstractText>
<AbstractText Label="AIMS" NlmCategory="OBJECTIVE">To investigate stratum corneum (SC) hydration and transepidermal water loss (TEWL) in patients with podoconiosis compared with controls.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In total, 55 patients and 20 controls were recruited. For each study subject, SC and TEWL measurements were taken, along with foot and lower leg circumferences. Measurements were compared between the patient and control groups.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Foot circumferences tended to be higher in patients with podoconiosis, with the mean foot:leg circumference ratio being 1·19 (95% confidence interval 1·11-1·28) times that for controls (P = 0·001). There was no detectable difference between patients and controls in TEWL values (P > 0·05); however, SC hydration was significantly lower in patients vs. controls for the foot (P = 0·004) and lower leg (P = 0·046) sites.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Patients with podoconiosis have significantly lower SC hydration in the skin of their lower legs and feet than controls, which may lead to cracking and splitting, and increased risk of lymphoedema and infection.</AbstractText>
<CopyrightInformation>© 2012 The Authors. BJD © 2012 British Association of Dermatologists.</CopyrightInformation>
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<LastName>Ferguson</LastName>
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<Language>eng</Language>
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<RefSource>Br J Dermatol. 2013 Sep;169(3):726</RefSource>
<Note>Yeshanehe, W [corrected to Yeshanehe, W E]; Matts, P [ corrected to Matts, P J]; Mortimer, P [corrected to Mortimer, P S]; Fuller, C [corrected to Fuller, L C]</Note>
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