Frequency and risk factors of lower limb lymphedema following lymphadenectomy in patients with gynecological malignancies.
Identifieur interne : 001B94 ( PubMed/Curation ); précédent : 001B93; suivant : 001B95Frequency and risk factors of lower limb lymphedema following lymphadenectomy in patients with gynecological malignancies.
Auteurs : N. Graf ; K. Rufibach ; A M Schmidt ; M. Fehr ; D. Fink ; A C BaegeSource :
- European journal of gynaecological oncology [ 0392-2936 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Lymphadénectomie.
- épidémiologie : Lymphoedème.
- étiologie : Lymphoedème.
- Facteurs de risque, Femelle, Humains, Membre inférieur, Prévalence, Tumeurs de l'appareil génital féminin, Études rétrospectives.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Lymph Node Excision.
- epidemiology : Lymphedema.
- etiology : Lymphedema.
- surgery : Genital Neoplasms, Female.
- Female, Humans, Lower Extremity, Prevalence, Retrospective Studies, Risk Factors.
Abstract
Lower limb lymphedema (LLL) is a major cause of morbidity in patients with gynecological malignancies after surgical treatment involving lymph node (LN) dissection. The aim of this study was to estimate the prevalence of LLL in such patients and detect risk factors for its occurrence.
PubMed: 23589994
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N. Graf<affiliation><nlm:affiliation>Department of Gynecology, University Hospital of Zurich, Zurich.</nlm:affiliation><wicri:noCountry code="subField">Zurich</wicri:noCountry></affiliation>Le document en format XML
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Fink</name></author><author><name sortKey="Baege, A C" sort="Baege, A C" uniqKey="Baege A" first="A C" last="Baege">A C Baege</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23589994</idno><idno type="pmid">23589994</idno><idno type="wicri:Area/PubMed/Corpus">001B94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B94</idno><idno type="wicri:Area/PubMed/Curation">001B94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Frequency and risk factors of lower limb lymphedema following lymphadenectomy in patients with gynecological malignancies.</title><author><name sortKey="Graf, N" sort="Graf, N" uniqKey="Graf N" first="N" last="Graf">N. Graf</name><affiliation><nlm:affiliation>Department of Gynecology, University Hospital of Zurich, Zurich.</nlm:affiliation><wicri:noCountry code="subField">Zurich</wicri:noCountry></affiliation></author><author><name sortKey="Rufibach, K" sort="Rufibach, K" uniqKey="Rufibach K" first="K" last="Rufibach">K. Rufibach</name></author><author><name sortKey="Schmidt, A M" sort="Schmidt, A M" uniqKey="Schmidt A" first="A M" last="Schmidt">A M Schmidt</name></author><author><name sortKey="Fehr, M" sort="Fehr, M" uniqKey="Fehr M" first="M" last="Fehr">M. Fehr</name></author><author><name sortKey="Fink, D" sort="Fink, D" uniqKey="Fink D" first="D" last="Fink">D. Fink</name></author><author><name sortKey="Baege, A C" sort="Baege, A C" uniqKey="Baege A" first="A C" last="Baege">A C Baege</name></author></analytic><series><title level="j">European journal of gynaecological oncology</title><idno type="ISSN">0392-2936</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female</term><term>Genital Neoplasms, Female (surgery)</term><term>Humans</term><term>Lower Extremity</term><term>Lymph Node Excision (adverse effects)</term><term>Lymphedema (epidemiology)</term><term>Lymphedema (etiology)</term><term>Prevalence</term><term>Retrospective Studies</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Lymphadénectomie (effets indésirables)</term><term>Lymphoedème (épidémiologie)</term><term>Lymphoedème (étiologie)</term><term>Membre inférieur</term><term>Prévalence</term><term>Tumeurs de l'appareil génital féminin ()</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymph Node Excision</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Lymphadénectomie</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Genital Neoplasms, Female</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Lower Extremity</term><term>Prevalence</term><term>Retrospective Studies</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Membre inférieur</term><term>Prévalence</term><term>Tumeurs de l'appareil génital féminin</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lower limb lymphedema (LLL) is a major cause of morbidity in patients with gynecological malignancies after surgical treatment involving lymph node (LN) dissection. The aim of this study was to estimate the prevalence of LLL in such patients and detect risk factors for its occurrence.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23589994</PMID><DateCreated><Year>2013</Year><Month>04</Month><Day>17</Day></DateCreated><DateCompleted><Year>2013</Year><Month>08</Month><Day>21</Day></DateCompleted><DateRevised><Year>2013</Year><Month>04</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0392-2936</ISSN><JournalIssue CitedMedium="Print"><Volume>34</Volume><Issue>1</Issue><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>European journal of gynaecological oncology</Title><ISOAbbreviation>Eur. J. Gynaecol. Oncol.</ISOAbbreviation></Journal><ArticleTitle>Frequency and risk factors of lower limb lymphedema following lymphadenectomy in patients with gynecological malignancies.</ArticleTitle><Pagination><MedlinePgn>23-7</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Lower limb lymphedema (LLL) is a major cause of morbidity in patients with gynecological malignancies after surgical treatment involving lymph node (LN) dissection. The aim of this study was to estimate the prevalence of LLL in such patients and detect risk factors for its occurrence.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">A retrospective analysis of all patients undergoing lymphadenectomy in newly-diagnosed gynecological malignancies at the University Hospital of Zurich between 2000 and 2007 was performed. Data from 313 patients were collected. Twenty patients with pre-existing edema or missing information were excluded before analysis. Time-to-LLL was estimated using the Kaplan-Meier estimate and potential risk factors were evaluated by a Cox regression model.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Estimated prevalence of LLL one year after surgery was 32%, increasing to 58% eight years after surgery. Median time to diagnosis of LLL was 5.2 years. The number of removed lymph nodes was significantly associated with time-to-LLL. Diagnosis of postoperative lymphocysts and local infections were accompanied by a significantly elevated risk for the development of LLL. Furthermore, time-to-LLL decreased with a higher body mass index (BMI) of the patient. In contrast, chemo- and radiotherapy, age, positive LNs, site of lymphadenectomy, and type of cancer were not observed to be associated with the occurrence of LLL.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">LLL is a frequent postoperative complication in patients undergoing lymphadenectomy for gynecological malignancies. It is thus imperative to sufficiently educate patients about the risk and symptoms of LLL prior to surgery. The data clearly show an association between time-to-LLL and number of dissected LNs, stressing the need to prospectively analyze the prevalence of LLL and carefully plan LN sampling as increasing knowledge is gained regarding the therapeutic benefit of sentinel and systemic lymphadenectomy in patients with different stages of gynecological malignancies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Graf</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Gynecology, University Hospital of Zurich, Zurich.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rufibach</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Fehr</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Fink</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Baege</LastName><ForeName>A C</ForeName><Initials>AC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Eur J Gynaecol Oncol</MedlineTA><NlmUniqueID>8100357</NlmUniqueID><ISSNLinking>0392-2936</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005833" MajorTopicYN="N">Genital Neoplasms, Female</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D035002" MajorTopicYN="N">Lower Extremity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>8</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23589994</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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