LymphedemaV1, PubMed, Curation, bibRecord, 001881

Immunology of lymphatic filariasis.

Identifieur interne : 001881 ( PubMed/Curation ); précédent : 001880; suivant : 001882

Immunology of lymphatic filariasis.

Auteurs : S. Babu [Inde] ; T B Nutman

Source :

Parasite immunology [ 1365-3024 ] ; 2014.

RBID : pubmed:24134686

Descripteurs français

KwdFr :
- Animaux, Brugia (immunologie), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Humains, Immunité cellulaire, Interleukine-10 (génétique), Interleukine-10 (métabolisme), Lymphocytes T CD4+ (métabolisme), Lymphocytes T CD4+ (physiologie), Modèles animaux de maladie humaine, Wuchereria bancrofti (immunologie).
MESH :
- génétique : Interleukine-10.
- immunologie : Brugia, Filariose lymphatique, Wuchereria bancrofti.
- métabolisme : Interleukine-10, Lymphocytes T CD4+.
- parasitologie : Filariose lymphatique.
- physiologie : Lymphocytes T CD4+.
- Animaux, Humains, Immunité cellulaire, Modèles animaux de maladie humaine.

English descriptors

KwdEn :
- Animals, Brugia (immunology), CD4-Positive T-Lymphocytes (metabolism), CD4-Positive T-Lymphocytes (physiology), Disease Models, Animal, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Humans, Immunity, Cellular, Interleukin-10 (genetics), Interleukin-10 (metabolism), Wuchereria bancrofti (immunology).
MESH :
- chemical , genetics : Interleukin-10.
- immunology : Brugia, Elephantiasis, Filarial, Wuchereria bancrofti.
- metabolism : CD4-Positive T-Lymphocytes, Interleukin-10.
- parasitology : Elephantiasis, Filarial.
- physiology : CD4-Positive T-Lymphocytes.
- Animals, Disease Models, Animal, Humans, Immunity, Cellular.

Abstract

The immune responses to filarial parasites encompass a complex network of innate and adaptive cells whose interaction with the parasite underlies a spectrum of clinical manifestations. The predominant immunological feature of lymphatic filariasis is an antigen-specific Th2 response and an expansion of IL-10 producing CD4(+) T cells that is accompanied by a muted Th1 response. This antigen-specific T-cell hyporesponsiveness appears to be crucial for the maintenance of the sustained, long-standing infection often with high parasite densities. While the correlates of protective immunity to lymphatic filariasis are still incompletely understood, primarily due to the lack of suitable animal models to study susceptibility, it is clear that T cells and to a certain extent B cells are required for protective immunity. Host immune responses, especially CD4(+) T-cell responses clearly play a role in mediating pathological manifestations of LF, including lymphedema, hydrocele and elephantiasis. The main underlying defect in the development of clinical pathology appears to be a failure to induce T-cell hyporesponsiveness in the face of antigenic stimulation. Finally, another intriguing feature of filarial infections is their propensity to induce bystander effects on a variety of immune responses, including responses to vaccinations, allergens and to other infectious agents. The complexity of the immune response to filarial infection therefore provides an important gateway to understanding the regulation of immune responses to chronic infections, in general.

DOI: 10.1111/pim.12081
PubMed: 24134686

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Le document en format XML

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<term>Interleukin-10</term>
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<term>Lymphocytes T CD4+</term>
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<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term>
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<front><div type="abstract" xml:lang="en">The immune responses to filarial parasites encompass a complex network of innate and adaptive cells whose interaction with the parasite underlies a spectrum of clinical manifestations. The predominant immunological feature of lymphatic filariasis is an antigen-specific Th2 response and an expansion of IL-10 producing CD4(+) T cells that is accompanied by a muted Th1 response. This antigen-specific T-cell hyporesponsiveness appears to be crucial for the maintenance of the sustained, long-standing infection often with high parasite densities. While the correlates of protective immunity to lymphatic filariasis are still incompletely understood, primarily due to the lack of suitable animal models to study susceptibility, it is clear that T cells and to a certain extent B cells are required for protective immunity. Host immune responses, especially CD4(+) T-cell responses clearly play a role in mediating pathological manifestations of LF, including lymphedema, hydrocele and elephantiasis. The main underlying defect in the development of clinical pathology appears to be a failure to induce T-cell hyporesponsiveness in the face of antigenic stimulation. Finally, another intriguing feature of filarial infections is their propensity to induce bystander effects on a variety of immune responses, including responses to vaccinations, allergens and to other infectious agents. The complexity of the immune response to filarial infection therefore provides an important gateway to understanding the regulation of immune responses to chronic infections, in general.</div>
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<Title>Parasite immunology</Title>
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<Abstract><AbstractText>The immune responses to filarial parasites encompass a complex network of innate and adaptive cells whose interaction with the parasite underlies a spectrum of clinical manifestations. The predominant immunological feature of lymphatic filariasis is an antigen-specific Th2 response and an expansion of IL-10 producing CD4(+) T cells that is accompanied by a muted Th1 response. This antigen-specific T-cell hyporesponsiveness appears to be crucial for the maintenance of the sustained, long-standing infection often with high parasite densities. While the correlates of protective immunity to lymphatic filariasis are still incompletely understood, primarily due to the lack of suitable animal models to study susceptibility, it is clear that T cells and to a certain extent B cells are required for protective immunity. Host immune responses, especially CD4(+) T-cell responses clearly play a role in mediating pathological manifestations of LF, including lymphedema, hydrocele and elephantiasis. The main underlying defect in the development of clinical pathology appears to be a failure to induce T-cell hyporesponsiveness in the face of antigenic stimulation. Finally, another intriguing feature of filarial infections is their propensity to induce bystander effects on a variety of immune responses, including responses to vaccinations, allergens and to other infectious agents. The complexity of the immune response to filarial infection therefore provides an important gateway to understanding the regulation of immune responses to chronic infections, in general.</AbstractText>
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<CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 2005 Jan;35(1):189-97</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2005 Mar 15;191(6):1018-26</RefSource>
<PMID Version="1">15717282</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2005 Apr 15;174(8):4924-33</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2005 Jul;73(7):4034-42</RefSource>
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</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2005 Jul 15;175(2):1170-6</RefSource>
<PMID Version="1">16002719</PMID>
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<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2005 Aug 1;175(3):1827-33</RefSource>
<PMID Version="1">16034125</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2009 Dec;5(12):e1000688</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2010 Apr;10(4):278-84</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2010 Oct;83(4):884-90</RefSource>
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{{Explor lien
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   |area=    LymphedemaV1
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   |type=    RBID
   |clé=     pubmed:24134686
   |texte=   Immunology of lymphatic filariasis.
}}

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This area was generated with Dilib version V0.6.31.
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	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Immunology of lymphatic filariasis.

Immunology of lymphatic filariasis.

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