FOXC2 mutations in familial and sporadic spinal extradural arachnoid cyst.
Identifieur interne : 001808 ( PubMed/Curation ); précédent : 001807; suivant : 001809FOXC2 mutations in familial and sporadic spinal extradural arachnoid cyst.
Auteurs : Yoji Ogura [Japon] ; Shoji Yabuki ; Aritoshi Iida ; Ikuyo Kou ; Masahiro Nakajima ; Hiroki Kano ; Masaaki Shiina ; Shinichi Kikuchi ; Yoshiaki Toyama ; Kazuhiro Ogata ; Masaya Nakamura ; Morio Matsumoto ; Shiro IkegawaSource :
- PloS one [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Forkhead Transcription Factors.
- chemical : DNA Primers.
- genetics : Arachnoid Cysts, Spinal Diseases.
- Animals, Base Sequence, COS Cells, Cercopithecus aethiops, Female, HeLa Cells, Humans, Male, Mutation, Pedigree, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Spinal extradural arachnoid cyst (SEDAC) is a cyst in the spinal canal that protrudes into the epidural space from a defect in the dura mater. Most cases are sporadic; however, three familial SEDAC cases have been reported, suggesting genetic etiological factors. All familial cases are associated with lymphedema-distichiasis syndrome (LDS), whose causal gene is FOXC2. However, FOXC2 mutation analysis has been performed in only 1 family, and no mutation analysis has been performed on sporadic (non-familial) SEDACs. We recruited 17 SEDAC subjects consisting of 2 familial and 7 sporadic cases and examined FOXC2 mutations by Sanger sequencing and structural abnormalities by TaqMan copy number assay. We identified 2 novel FOXC2 mutations in 2 familial cases. Incomplete LDS penetrance was noted in both families. Four subjects presented with SEDACs only. Thus, SEDAC caused by the heterozygous FOXC2 loss-of-function mutation should be considered a feature of LDS, although it often manifests as the sole symptom. Seven sporadic SEDAC subjects had no FOXC2 mutations, no symptoms of LDS, and showed differing clinical characteristics from those who had FOXC2 mutations, suggesting that other gene(s) besides FOXC2 are likely to be involved in SEDAC.
DOI: 10.1371/journal.pone.0080548
PubMed: 24278289
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Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN, Tokyo, Japan ; Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Yabuki, Shoji" sort="Yabuki, Shoji" uniqKey="Yabuki S" first="Shoji" last="Yabuki">Shoji Yabuki</name></author><author><name sortKey="Iida, Aritoshi" sort="Iida, Aritoshi" uniqKey="Iida A" first="Aritoshi" last="Iida">Aritoshi Iida</name></author><author><name sortKey="Kou, Ikuyo" sort="Kou, Ikuyo" uniqKey="Kou I" first="Ikuyo" last="Kou">Ikuyo Kou</name></author><author><name sortKey="Nakajima, Masahiro" sort="Nakajima, Masahiro" uniqKey="Nakajima M" first="Masahiro" last="Nakajima">Masahiro Nakajima</name></author><author><name sortKey="Kano, Hiroki" sort="Kano, Hiroki" uniqKey="Kano H" first="Hiroki" last="Kano">Hiroki Kano</name></author><author><name sortKey="Shiina, Masaaki" sort="Shiina, Masaaki" uniqKey="Shiina M" first="Masaaki" last="Shiina">Masaaki Shiina</name></author><author><name sortKey="Kikuchi, Shinichi" sort="Kikuchi, Shinichi" uniqKey="Kikuchi S" first="Shinichi" last="Kikuchi">Shinichi Kikuchi</name></author><author><name sortKey="Toyama, Yoshiaki" sort="Toyama, Yoshiaki" uniqKey="Toyama Y" first="Yoshiaki" last="Toyama">Yoshiaki Toyama</name></author><author><name sortKey="Ogata, Kazuhiro" sort="Ogata, Kazuhiro" uniqKey="Ogata K" first="Kazuhiro" last="Ogata">Kazuhiro Ogata</name></author><author><name sortKey="Nakamura, Masaya" sort="Nakamura, Masaya" uniqKey="Nakamura M" first="Masaya" last="Nakamura">Masaya Nakamura</name></author><author><name sortKey="Matsumoto, Morio" sort="Matsumoto, Morio" uniqKey="Matsumoto M" first="Morio" last="Matsumoto">Morio Matsumoto</name></author><author><name sortKey="Ikegawa, Shiro" sort="Ikegawa, Shiro" uniqKey="Ikegawa S" first="Shiro" last="Ikegawa">Shiro Ikegawa</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Arachnoid Cysts (genetics)</term><term>Base Sequence</term><term>COS Cells</term><term>Cercopithecus aethiops</term><term>DNA Primers</term><term>Female</term><term>Forkhead Transcription Factors (genetics)</term><term>HeLa Cells</term><term>Humans</term><term>Male</term><term>Mutation</term><term>Pedigree</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Spinal Diseases (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amorces ADN</term><term>Animaux</term><term>Cellules COS</term><term>Cellules HeLa</term><term>Cercopithecus aethiops</term><term>Facteurs de transcription Forkhead (génétique)</term><term>Femelle</term><term>Humains</term><term>Kystes arachnoïdiens (génétique)</term><term>Maladies du rachis (génétique)</term><term>Mutation</term><term>Mâle</term><term>Pedigree</term><term>RT-PCR</term><term>Séquence nucléotidique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Forkhead Transcription Factors</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA Primers</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arachnoid Cysts</term><term>Spinal Diseases</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription Forkhead</term><term>Kystes arachnoïdiens</term><term>Maladies du rachis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>COS Cells</term><term>Cercopithecus aethiops</term><term>Female</term><term>HeLa Cells</term><term>Humans</term><term>Male</term><term>Mutation</term><term>Pedigree</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Amorces ADN</term><term>Animaux</term><term>Cellules COS</term><term>Cellules HeLa</term><term>Cercopithecus aethiops</term><term>Femelle</term><term>Humains</term><term>Mutation</term><term>Mâle</term><term>Pedigree</term><term>RT-PCR</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Spinal extradural arachnoid cyst (SEDAC) is a cyst in the spinal canal that protrudes into the epidural space from a defect in the dura mater. Most cases are sporadic; however, three familial SEDAC cases have been reported, suggesting genetic etiological factors. All familial cases are associated with lymphedema-distichiasis syndrome (LDS), whose causal gene is FOXC2. However, FOXC2 mutation analysis has been performed in only 1 family, and no mutation analysis has been performed on sporadic (non-familial) SEDACs. We recruited 17 SEDAC subjects consisting of 2 familial and 7 sporadic cases and examined FOXC2 mutations by Sanger sequencing and structural abnormalities by TaqMan copy number assay. We identified 2 novel FOXC2 mutations in 2 familial cases. Incomplete LDS penetrance was noted in both families. Four subjects presented with SEDACs only. Thus, SEDAC caused by the heterozygous FOXC2 loss-of-function mutation should be considered a feature of LDS, although it often manifests as the sole symptom. Seven sporadic SEDAC subjects had no FOXC2 mutations, no symptoms of LDS, and showed differing clinical characteristics from those who had FOXC2 mutations, suggesting that other gene(s) besides FOXC2 are likely to be involved in SEDAC.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24278289</PMID><DateCreated><Year>2013</Year><Month>11</Month><Day>26</Day></DateCreated><DateCompleted><Year>2014</Year><Month>09</Month><Day>23</Day></DateCompleted><DateRevised><Year>2015</Year><Month>04</Month><Day>22</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>11</Issue><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>FOXC2 mutations in familial and sporadic spinal extradural arachnoid cyst.</ArticleTitle><Pagination><MedlinePgn>e80548</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0080548</ELocationID><Abstract><AbstractText>Spinal extradural arachnoid cyst (SEDAC) is a cyst in the spinal canal that protrudes into the epidural space from a defect in the dura mater. Most cases are sporadic; however, three familial SEDAC cases have been reported, suggesting genetic etiological factors. All familial cases are associated with lymphedema-distichiasis syndrome (LDS), whose causal gene is FOXC2. However, FOXC2 mutation analysis has been performed in only 1 family, and no mutation analysis has been performed on sporadic (non-familial) SEDACs. We recruited 17 SEDAC subjects consisting of 2 familial and 7 sporadic cases and examined FOXC2 mutations by Sanger sequencing and structural abnormalities by TaqMan copy number assay. We identified 2 novel FOXC2 mutations in 2 familial cases. Incomplete LDS penetrance was noted in both families. Four subjects presented with SEDACs only. Thus, SEDAC caused by the heterozygous FOXC2 loss-of-function mutation should be considered a feature of LDS, although it often manifests as the sole symptom. Seven sporadic SEDAC subjects had no FOXC2 mutations, no symptoms of LDS, and showed differing clinical characteristics from those who had FOXC2 mutations, suggesting that other gene(s) besides FOXC2 are likely to be involved in SEDAC.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ogura</LastName><ForeName>Yoji</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Laboratory of Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN, Tokyo, Japan ; Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yabuki</LastName><ForeName>Shoji</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Iida</LastName><ForeName>Aritoshi</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Kou</LastName><ForeName>Ikuyo</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Nakajima</LastName><ForeName>Masahiro</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kano</LastName><ForeName>Hiroki</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Shiina</LastName><ForeName>Masaaki</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kikuchi</LastName><ForeName>Shinichi</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Toyama</LastName><ForeName>Yoshiaki</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Ogata</LastName><ForeName>Kazuhiro</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Nakamura</LastName><ForeName>Masaya</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Matsumoto</LastName><ForeName>Morio</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ikegawa</LastName><ForeName>Shiro</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>11</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017931">DNA Primers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051858">Forkhead Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C082078">mesenchyme fork head 1 protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Am J Med Genet A. 2007 Apr 15;143A(8):884-7</RefSource><PMID Version="1">17366583</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W382-8</RefSource><PMID Version="1">15980494</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Invest Dermatol. 2009 Feb;129(2):509-12</RefSource><PMID Version="1">18719607</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ophthalmic Genet. 2010 Jun;31(2):98-100</RefSource><PMID Version="1">20450314</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 2010 Mar;43(1):14-8</RefSource><PMID Version="1">20552815</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Med. 2010 Aug;12(8):532-5</RefSource><PMID Version="1">20535019</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Vasc Res. 2011;48(5):397-407</RefSource><PMID Version="1">21464574</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gene. 2012 Apr 25;498(1):96-9</RefSource><PMID Version="1">22349027</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Med Genet A. 2012 Apr;158A(4):839-49</RefSource><PMID Version="1">22407726</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Genet. 2012 Jun;81(6):542-54</RefSource><PMID Version="1">21457232</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 2012 Mar;45(1):3-12</RefSource><PMID Version="1">22768468</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEBS Lett. 2000 Mar 17;470(1):29-34</RefSource><PMID Version="1">10722840</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2000 Dec;67(6):1382-8</RefSource><PMID Version="1">11078474</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2001 Mar;68(3):627-41</RefSource><PMID Version="1">11179011</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 2001 Mar;34(1):1</RefSource><PMID Version="1">11307659</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2001 May 15;10(11):1185-9</RefSource><PMID Version="1">11371511</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Genet. 2001 Nov;38(11):761-6</RefSource><PMID Version="1">11694548</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Genet. 2002 Jul;39(7):478-83</RefSource><PMID Version="1">12114478</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Child Neurol. 2002 Oct;17(10):770-2</RefSource><PMID Version="1">12546433</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2003 May 15;12(10):1179-85</RefSource><PMID Version="1">12719382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J AAPOS. 2003 Oct;7(5):354-7</RefSource><PMID Version="1">14566319</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pediatr Neurosurg. 2004 Mar-Apr;40(2):70-4</RefSource><PMID Version="1">15292636</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Roentgenol Radium Ther Nucl Med. 1967 Sep;101(1):204-15</RefSource><PMID Version="1">6037336</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosurg. 1968 May;28(5):495-9</RefSource><PMID Version="1">5659579</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 1980 Apr;7(4):340-3</RefSource><PMID Version="1">7377759</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mayo Clin Proc. 1981 Feb;56(2):93-101</RefSource><PMID Version="1">6780735</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 1982 Sep;15(3):85-90</RefSource><PMID Version="1">7144249</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7628-31</RefSource><PMID Version="1">7689224</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Development. 1997 Nov;124(22):4627-38</RefSource><PMID Version="1">9409679</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Dermatol. 1999 Mar;135(3):347-8</RefSource><PMID Version="1">10086462</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosurg. 1999 Jul;91(1 Suppl):116-20</RefSource><PMID Version="1">10419356</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 2008 Sep;41(3):98-102</RefSource><PMID Version="1">19013876</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016080" MajorTopicYN="N">Arachnoid Cysts</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019556" MajorTopicYN="N">COS Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Cercopithecus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017931" MajorTopicYN="N">DNA Primers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051858" MajorTopicYN="N">Forkhead Transcription Factors</DescriptorName><QualifierName 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