LymphedemaV1, PubMed, Curation, bibRecord, 001673

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.

Identifieur interne : 001673 ( PubMed/Curation ); précédent : 001672; suivant : 001674

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.

Auteurs : Ludovic Le Guen [Australie] ; Terhi Karpanen ; Dörte Schulte ; Nicole C. Harris ; Katarzyna Koltowska ; Guy Roukens ; Neil I. Bower ; Andreas Van Impel ; Steven A. Stacker ; Marc G. Achen ; Stefan Schulte-Merker ; Benjamin M. Hogan

Source :

Development (Cambridge, England) [ 1477-9129 ] ; 2014.

RBID : pubmed:24523457

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Amino Acid Substitution, Animals, Base Sequence, DNA (genetics), Gene Expression Regulation, Developmental, Humans, Lymphangiogenesis (genetics), Lymphangiogenesis (physiology), MAP Kinase Signaling System, Mice, Molecular Sequence Data, Point Mutation, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Signal Transduction, Vascular Endothelial Growth Factor C (genetics), Vascular Endothelial Growth Factor C (metabolism), Vascular Endothelial Growth Factor Receptor-3 (genetics), Vascular Endothelial Growth Factor Receptor-3 (metabolism), Zebrafish (embryology), Zebrafish (genetics), Zebrafish (metabolism), Zebrafish Proteins (genetics), Zebrafish Proteins (metabolism).
MESH :
- chemical , genetics : DNA, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor Receptor-3, Zebrafish Proteins.
- embryology : Zebrafish.
- genetics : Lymphangiogenesis, Zebrafish.
- chemical , metabolism : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor Receptor-3, Zebrafish, Zebrafish Proteins.
- physiology : Lymphangiogenesis.
- Amino Acid Sequence, Amino Acid Substitution, Animals, Base Sequence, Gene Expression Regulation, Developmental, Humans, MAP Kinase Signaling System, Mice, Molecular Sequence Data, Point Mutation, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Signal Transduction.

Abstract

The VEGFC/VEGFR3 signaling pathway is essential for lymphangiogenesis (the formation of lymphatic vessels from pre-existing vasculature) during embryonic development, tissue regeneration and tumor progression. The recently identified secreted protein CCBE1 is indispensible for lymphangiogenesis during development. The role of CCBE1 orthologs is highly conserved in zebrafish, mice and humans with mutations in CCBE1 causing generalized lymphatic dysplasia and lymphedema (Hennekam syndrome). To date, the mechanism by which CCBE1 acts remains unknown. Here, we find that ccbe1 genetically interacts with both vegfc and vegfr3 in zebrafish. In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1, and Vegfc-driven sprouting is enhanced by local Ccbe1 overexpression. Moreover, Vegfc- and Vegfr3-dependent Erk signaling is impaired in the absence of Ccbe1. Finally, CCBE1 is capable of upregulating the levels of fully processed, mature VEGFC in vitro and the overexpression of mature VEGFC rescues ccbe1 loss-of-function phenotypes in zebrafish. Taken together, these data identify Ccbe1 as a crucial component of the Vegfc/Vegfr3 pathway in the embryo.

DOI: 10.1242/dev.100495
PubMed: 24523457

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001673

Links to Exploration step

pubmed:24523457

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.</title>
<author><name sortKey="Le Guen, Ludovic" sort="Le Guen, Ludovic" uniqKey="Le Guen L" first="Ludovic" last="Le Guen">Ludovic Le Guen</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4073, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4073</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karpanen, Terhi" sort="Karpanen, Terhi" uniqKey="Karpanen T" first="Terhi" last="Karpanen">Terhi Karpanen</name>
</author>
<author><name sortKey="Schulte, Dorte" sort="Schulte, Dorte" uniqKey="Schulte D" first="Dörte" last="Schulte">Dörte Schulte</name>
</author>
<author><name sortKey="Harris, Nicole C" sort="Harris, Nicole C" uniqKey="Harris N" first="Nicole C" last="Harris">Nicole C. Harris</name>
</author>
<author><name sortKey="Koltowska, Katarzyna" sort="Koltowska, Katarzyna" uniqKey="Koltowska K" first="Katarzyna" last="Koltowska">Katarzyna Koltowska</name>
</author>
<author><name sortKey="Roukens, Guy" sort="Roukens, Guy" uniqKey="Roukens G" first="Guy" last="Roukens">Guy Roukens</name>
</author>
<author><name sortKey="Bower, Neil I" sort="Bower, Neil I" uniqKey="Bower N" first="Neil I" last="Bower">Neil I. Bower</name>
</author>
<author><name sortKey="Van Impel, Andreas" sort="Van Impel, Andreas" uniqKey="Van Impel A" first="Andreas" last="Van Impel">Andreas Van Impel</name>
</author>
<author><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A" last="Stacker">Steven A. Stacker</name>
</author>
<author><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G" last="Achen">Marc G. Achen</name>
</author>
<author><name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name>
</author>
<author><name sortKey="Hogan, Benjamin M" sort="Hogan, Benjamin M" uniqKey="Hogan B" first="Benjamin M" last="Hogan">Benjamin M. Hogan</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24523457</idno>
<idno type="pmid">24523457</idno>
<idno type="doi">10.1242/dev.100495</idno>
<idno type="wicri:Area/PubMed/Corpus">001673</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001673</idno>
<idno type="wicri:Area/PubMed/Curation">001673</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001673</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.</title>
<author><name sortKey="Le Guen, Ludovic" sort="Le Guen, Ludovic" uniqKey="Le Guen L" first="Ludovic" last="Le Guen">Ludovic Le Guen</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4073, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4073</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karpanen, Terhi" sort="Karpanen, Terhi" uniqKey="Karpanen T" first="Terhi" last="Karpanen">Terhi Karpanen</name>
</author>
<author><name sortKey="Schulte, Dorte" sort="Schulte, Dorte" uniqKey="Schulte D" first="Dörte" last="Schulte">Dörte Schulte</name>
</author>
<author><name sortKey="Harris, Nicole C" sort="Harris, Nicole C" uniqKey="Harris N" first="Nicole C" last="Harris">Nicole C. Harris</name>
</author>
<author><name sortKey="Koltowska, Katarzyna" sort="Koltowska, Katarzyna" uniqKey="Koltowska K" first="Katarzyna" last="Koltowska">Katarzyna Koltowska</name>
</author>
<author><name sortKey="Roukens, Guy" sort="Roukens, Guy" uniqKey="Roukens G" first="Guy" last="Roukens">Guy Roukens</name>
</author>
<author><name sortKey="Bower, Neil I" sort="Bower, Neil I" uniqKey="Bower N" first="Neil I" last="Bower">Neil I. Bower</name>
</author>
<author><name sortKey="Van Impel, Andreas" sort="Van Impel, Andreas" uniqKey="Van Impel A" first="Andreas" last="Van Impel">Andreas Van Impel</name>
</author>
<author><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A" last="Stacker">Steven A. Stacker</name>
</author>
<author><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G" last="Achen">Marc G. Achen</name>
</author>
<author><name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name>
</author>
<author><name sortKey="Hogan, Benjamin M" sort="Hogan, Benjamin M" uniqKey="Hogan B" first="Benjamin M" last="Hogan">Benjamin M. Hogan</name>
</author>
</analytic>
<series><title level="j">Development (Cambridge, England)</title>
<idno type="eISSN">1477-9129</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Amino Acid Substitution</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>DNA (genetics)</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Humans</term>
<term>Lymphangiogenesis (genetics)</term>
<term>Lymphangiogenesis (physiology)</term>
<term>MAP Kinase Signaling System</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Point Mutation</term>
<term>Sequence Homology, Amino Acid</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Signal Transduction</term>
<term>Vascular Endothelial Growth Factor C (genetics)</term>
<term>Vascular Endothelial Growth Factor C (metabolism)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (genetics)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (metabolism)</term>
<term>Zebrafish (embryology)</term>
<term>Zebrafish (genetics)</term>
<term>Zebrafish (metabolism)</term>
<term>Zebrafish Proteins (genetics)</term>
<term>Zebrafish Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN (génétique)</term>
<term>Animaux</term>
<term>Danio zébré (embryologie)</term>
<term>Danio zébré (génétique)</term>
<term>Danio zébré (métabolisme)</term>
<term>Données de séquences moléculaires</term>
<term>Facteur de croissance endothéliale vasculaire de type C (génétique)</term>
<term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term>
<term>Humains</term>
<term>Lymphangiogenèse (génétique)</term>
<term>Lymphangiogenèse (physiologie)</term>
<term>Mutation ponctuelle</term>
<term>Protéines de poisson-zèbre (génétique)</term>
<term>Protéines de poisson-zèbre (métabolisme)</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire (génétique)</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme)</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Souris</term>
<term>Substitution d'acide aminé</term>
<term>Système de signalisation des MAP kinases</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA</term>
<term>Vascular Endothelial Growth Factor C</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
<term>Zebrafish Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Danio zébré</term>
</keywords>
<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Zebrafish</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphangiogenesis</term>
<term>Zebrafish</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN</term>
<term>Danio zébré</term>
<term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Lymphangiogenèse</term>
<term>Protéines de poisson-zèbre</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
<term>Zebrafish</term>
<term>Zebrafish Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Danio zébré</term>
<term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Protéines de poisson-zèbre</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Amino Acid Substitution</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Humans</term>
<term>MAP Kinase Signaling System</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Point Mutation</term>
<term>Sequence Homology, Amino Acid</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Mutation ponctuelle</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Souris</term>
<term>Substitution d'acide aminé</term>
<term>Système de signalisation des MAP kinases</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The VEGFC/VEGFR3 signaling pathway is essential for lymphangiogenesis (the formation of lymphatic vessels from pre-existing vasculature) during embryonic development, tissue regeneration and tumor progression. The recently identified secreted protein CCBE1 is indispensible for lymphangiogenesis during development. The role of CCBE1 orthologs is highly conserved in zebrafish, mice and humans with mutations in CCBE1 causing generalized lymphatic dysplasia and lymphedema (Hennekam syndrome). To date, the mechanism by which CCBE1 acts remains unknown. Here, we find that ccbe1 genetically interacts with both vegfc and vegfr3 in zebrafish. In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1, and Vegfc-driven sprouting is enhanced by local Ccbe1 overexpression. Moreover, Vegfc- and Vegfr3-dependent Erk signaling is impaired in the absence of Ccbe1. Finally, CCBE1 is capable of upregulating the levels of fully processed, mature VEGFC in vitro and the overexpression of mature VEGFC rescues ccbe1 loss-of-function phenotypes in zebrafish. Taken together, these data identify Ccbe1 as a crucial component of the Vegfc/Vegfr3 pathway in the embryo.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24523457</PMID>
<DateCreated><Year>2014</Year>
<Month>03</Month>
<Day>05</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>05</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>03</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1477-9129</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>141</Volume>
<Issue>6</Issue>
<PubDate><Year>2014</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Development (Cambridge, England)</Title>
<ISOAbbreviation>Development</ISOAbbreviation>
</Journal>
<ArticleTitle>Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.</ArticleTitle>
<Pagination><MedlinePgn>1239-49</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1242/dev.100495</ELocationID>
<Abstract><AbstractText>The VEGFC/VEGFR3 signaling pathway is essential for lymphangiogenesis (the formation of lymphatic vessels from pre-existing vasculature) during embryonic development, tissue regeneration and tumor progression. The recently identified secreted protein CCBE1 is indispensible for lymphangiogenesis during development. The role of CCBE1 orthologs is highly conserved in zebrafish, mice and humans with mutations in CCBE1 causing generalized lymphatic dysplasia and lymphedema (Hennekam syndrome). To date, the mechanism by which CCBE1 acts remains unknown. Here, we find that ccbe1 genetically interacts with both vegfc and vegfr3 in zebrafish. In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1, and Vegfc-driven sprouting is enhanced by local Ccbe1 overexpression. Moreover, Vegfc- and Vegfr3-dependent Erk signaling is impaired in the absence of Ccbe1. Finally, CCBE1 is capable of upregulating the levels of fully processed, mature VEGFC in vitro and the overexpression of mature VEGFC rescues ccbe1 loss-of-function phenotypes in zebrafish. Taken together, these data identify Ccbe1 as a crucial component of the Vegfc/Vegfr3 pathway in the embryo.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Le Guen</LastName>
<ForeName>Ludovic</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4073, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Karpanen</LastName>
<ForeName>Terhi</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schulte</LastName>
<ForeName>Dörte</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Harris</LastName>
<ForeName>Nicole C</ForeName>
<Initials>NC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Koltowska</LastName>
<ForeName>Katarzyna</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Roukens</LastName>
<ForeName>Guy</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bower</LastName>
<ForeName>Neil I</ForeName>
<Initials>NI</Initials>
</Author>
<Author ValidYN="Y"><LastName>van Impel</LastName>
<ForeName>Andreas</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Stacker</LastName>
<ForeName>Steven A</ForeName>
<Initials>SA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Achen</LastName>
<ForeName>Marc G</ForeName>
<Initials>MG</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schulte-Merker</LastName>
<ForeName>Stefan</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hogan</LastName>
<ForeName>Benjamin M</ForeName>
<Initials>BM</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>02</Month>
<Day>12</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Development</MedlineTA>
<NlmUniqueID>8701744</NlmUniqueID>
<ISSNLinking>0950-1991</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D042582">Vascular Endothelial Growth Factor C</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029961">Zebrafish Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C493178">vascular endothelial growth factor C, zebrafish</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9007-49-2</RegistryNumber>
<NameOfSubstance UI="D004247">DNA</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
<NameOfSubstance UI="D040321">Vascular Endothelial Growth Factor Receptor-3</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019943" MajorTopicYN="N">Amino Acid Substitution</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004247" MajorTopicYN="N">DNA</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018507" MajorTopicYN="N">Gene Expression Regulation, Developmental</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042583" MajorTopicYN="N">Lymphangiogenesis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020935" MajorTopicYN="N">MAP Kinase Signaling System</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017354" MajorTopicYN="N">Point Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017386" MajorTopicYN="N">Sequence Homology, Amino Acid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012689" MajorTopicYN="N">Sequence Homology, Nucleic Acid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042582" MajorTopicYN="N">Vascular Endothelial Growth Factor C</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D040321" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-3</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015027" MajorTopicYN="N">Zebrafish</DescriptorName>
<QualifierName UI="Q000196" MajorTopicYN="Y">embryology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029961" MajorTopicYN="N">Zebrafish Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Angiogenesis</Keyword>
<Keyword MajorTopicYN="N">Lymphangiogenesis</Keyword>
<Keyword MajorTopicYN="N">Lymphedema</Keyword>
<Keyword MajorTopicYN="N">Vasculature</Keyword>
<Keyword MajorTopicYN="N">Zebrafish</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>2</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>2</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>5</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">24523457</ArticleId>
<ArticleId IdType="pii">dev.100495</ArticleId>
<ArticleId IdType="doi">10.1242/dev.100495</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001673 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001673 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    PubMed
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:24523457
   |texte=   Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i   -Sk "pubmed:24523457" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki