Global abnormalities in lymphatic function following systemic therapy in patients with breast cancer.
Identifieur interne : 001016 ( PubMed/Curation ); précédent : 001015; suivant : 001017Global abnormalities in lymphatic function following systemic therapy in patients with breast cancer.
Auteurs : S K Bains [Royaume-Uni] ; A M Peters ; C. Zammit ; N. Ryan ; J. Ballinger ; D M Glass ; S. Allen ; A W B. Stanton ; P S Mortimer ; A D PurushothamSource :
- The British journal of surgery [ 1365-2168 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Vaisseaux lymphatiques.
- physiopathologie : Lymphoedème, Tumeurs du sein.
- étiologie : Lymphoedème.
- Adulte d'âge moyen, Femelle, Humains, Jambe, Lymphadénectomie, Lymphoedème, Lymphoscintigraphie, Résultat thérapeutique, Tumeurs du sein.
English descriptors
- KwdEn :
- Breast Neoplasms (complications), Breast Neoplasms (physiopathology), Breast Neoplasms (surgery), Female, Humans, Leg, Lymph Node Excision (methods), Lymphatic Vessels (physiology), Lymphedema (etiology), Lymphedema (physiopathology), Lymphedema (surgery), Lymphoscintigraphy (methods), Middle Aged, Treatment Outcome.
- MESH :
- complications : Breast Neoplasms.
- etiology : Lymphedema.
- methods : Lymph Node Excision, Lymphoscintigraphy.
- physiology : Lymphatic Vessels.
- physiopathology : Breast Neoplasms, Lymphedema.
- surgery : Breast Neoplasms, Lymphedema.
- Female, Humans, Leg, Middle Aged, Treatment Outcome.
Abstract
Breast cancer-related lymphoedema (BCRL) is a result of interaction between several pathophysiological processes, and is not simply a 'stopcock' effect resulting from removal of axillary lymph nodes. The aim of this study was to test the hypothesis that there is a constitutional 'global' lymphatic dysfunction in patients who develop BCRL.
DOI: 10.1002/bjs.9766
PubMed: 25727718
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pubmed:25727718Le document en format XML
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Zammit</name></author><author><name sortKey="Ryan, N" sort="Ryan, N" uniqKey="Ryan N" first="N" last="Ryan">N. Ryan</name></author><author><name sortKey="Ballinger, J" sort="Ballinger, J" uniqKey="Ballinger J" first="J" last="Ballinger">J. Ballinger</name></author><author><name sortKey="Glass, D M" sort="Glass, D M" uniqKey="Glass D" first="D M" last="Glass">D M Glass</name></author><author><name sortKey="Allen, S" sort="Allen, S" uniqKey="Allen S" first="S" last="Allen">S. Allen</name></author><author><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">P S Mortimer</name></author><author><name sortKey="Purushotham, A D" sort="Purushotham, A D" uniqKey="Purushotham A" first="A D" last="Purushotham">A D Purushotham</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25727718</idno><idno type="pmid">25727718</idno><idno type="doi">10.1002/bjs.9766</idno><idno type="wicri:Area/PubMed/Corpus">001016</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001016</idno><idno type="wicri:Area/PubMed/Curation">001016</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001016</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Global abnormalities in lymphatic function following systemic therapy in patients with breast cancer.</title><author><name sortKey="Bains, S K" sort="Bains, S K" uniqKey="Bains S" first="S K" last="Bains">S K Bains</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Studies, King's College London, St George's, University of London, London, UK; Departments of Breast Surgery, St George's, University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Studies, King's College London, St George's, University of London, London, UK; Departments of Breast Surgery, St George's, University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Peters, A M" sort="Peters, A M" uniqKey="Peters A" first="A M" last="Peters">A M Peters</name></author><author><name sortKey="Zammit, C" sort="Zammit, C" uniqKey="Zammit C" first="C" last="Zammit">C. Zammit</name></author><author><name sortKey="Ryan, N" sort="Ryan, N" uniqKey="Ryan N" first="N" last="Ryan">N. Ryan</name></author><author><name sortKey="Ballinger, J" sort="Ballinger, J" uniqKey="Ballinger J" first="J" last="Ballinger">J. Ballinger</name></author><author><name sortKey="Glass, D M" sort="Glass, D M" uniqKey="Glass D" first="D M" last="Glass">D M Glass</name></author><author><name sortKey="Allen, S" sort="Allen, S" uniqKey="Allen S" first="S" last="Allen">S. Allen</name></author><author><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">P S Mortimer</name></author><author><name sortKey="Purushotham, A D" sort="Purushotham, A D" uniqKey="Purushotham A" first="A D" last="Purushotham">A D Purushotham</name></author></analytic><series><title level="j">The British journal of surgery</title><idno type="eISSN">1365-2168</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (complications)</term><term>Breast Neoplasms (physiopathology)</term><term>Breast Neoplasms (surgery)</term><term>Female</term><term>Humans</term><term>Leg</term><term>Lymph Node Excision (methods)</term><term>Lymphatic Vessels (physiology)</term><term>Lymphedema (etiology)</term><term>Lymphedema (physiopathology)</term><term>Lymphedema (surgery)</term><term>Lymphoscintigraphy (methods)</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jambe</term><term>Lymphadénectomie ()</term><term>Lymphoedème ()</term><term>Lymphoedème (physiopathologie)</term><term>Lymphoedème (étiologie)</term><term>Lymphoscintigraphie ()</term><term>Résultat thérapeutique</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (physiopathologie)</term><term>Vaisseaux lymphatiques (physiologie)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymph Node Excision</term><term>Lymphoscintigraphy</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Breast Neoplasms</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Leg</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jambe</term><term>Lymphadénectomie</term><term>Lymphoedème</term><term>Lymphoscintigraphie</term><term>Résultat thérapeutique</term><term>Tumeurs du sein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Breast cancer-related lymphoedema (BCRL) is a result of interaction between several pathophysiological processes, and is not simply a 'stopcock' effect resulting from removal of axillary lymph nodes. The aim of this study was to test the hypothesis that there is a constitutional 'global' lymphatic dysfunction in patients who develop BCRL.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25727718</PMID><DateCreated><Year>2015</Year><Month>03</Month><Day>13</Day></DateCreated><DateCompleted><Year>2015</Year><Month>05</Month><Day>05</Day></DateCompleted><DateRevised><Year>2015</Year><Month>03</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2168</ISSN><JournalIssue CitedMedium="Internet"><Volume>102</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>Apr</Month></PubDate></JournalIssue><Title>The British journal of surgery</Title><ISOAbbreviation>Br J Surg</ISOAbbreviation></Journal><ArticleTitle>Global abnormalities in lymphatic function following systemic therapy in patients with breast cancer.</ArticleTitle><Pagination><MedlinePgn>534-40</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/bjs.9766</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Breast cancer-related lymphoedema (BCRL) is a result of interaction between several pathophysiological processes, and is not simply a 'stopcock' effect resulting from removal of axillary lymph nodes. The aim of this study was to test the hypothesis that there is a constitutional 'global' lymphatic dysfunction in patients who develop BCRL.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Lower-limb lymphoscintigraphy was performed in 30 women who had undergone axillary lymph node dissection at least 3 years previously, of whom 15 had BCRL and 15 did not. No patient had any clinical abnormality of the lower limb. The control group comprised 24 women with no history of cancer or lower-limb lymphoedema. (99m) Tc-Nanocoll was injected subcutaneously into the first webspace of each foot, followed by whole-body imaging. Scans were reported as abnormal if there was delay in lymph transport or rerouting through skin or deep system. Quantification was expressed as the percentage injected activity accumulating in ilioinguinal nodes.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Mean(s.d.) ilioinguinal nodal accumulation at 150 min was significantly lower in women with BCRL than in those without (2·7(2·5) versus 5·9(4·8) per cent respectively; P = 0·006). Abnormal findings on lower-limb lymphoscintigraphy were observed in 17 of the 30 patients: ten of the 15 women who had BCRL and seven of the 15 who did not. None of the 24 control subjects had abnormal scan findings.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Women with BCRL had reduced lower-limb lymph drainage, supporting the hypothesis of a predisposition to BCRL. A surprisingly high proportion of patients with breast cancer also demonstrated lymphatic dysfunction, despite clinically normal lower limbs. Possible explanations could be a systemic effect of breast cancer or its treatment, or an unidentified association between breast cancer and lymphatic dysfunction.</AbstractText><AbstractText Label="REGISTRATION NUMBER" NlmCategory="BACKGROUND">ISRCTN84866416 ( http://www.isrctn.com).</AbstractText><CopyrightInformation>© 2015 BJS Society Ltd Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bains</LastName><ForeName>S K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Division of Cancer Studies, King's College London, St George's, University of London, London, UK; Departments of Breast Surgery, St George's, University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Zammit</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Ryan</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Ballinger</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Glass</LastName><ForeName>D M</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Allen</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Stanton</LastName><ForeName>A W B</ForeName><Initials>AW</Initials></Author><Author ValidYN="Y"><LastName>Mortimer</LastName><ForeName>P S</ForeName><Initials>PS</Initials></Author><Author ValidYN="Y"><LastName>Purushotham</LastName><ForeName>A D</ForeName><Initials>AD</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ISRCTN</DataBankName><AccessionNumberList><AccessionNumber>ISRCTN84866416</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D018848">Controlled Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>02</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Surg</MedlineTA><NlmUniqueID>0372553</NlmUniqueID><ISSNLinking>0007-1323</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007866" MajorTopicYN="N">Leg</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D061305" MajorTopicYN="N">Lymphoscintigraphy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>06</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>08</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>12</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25727718</ArticleId><ArticleId IdType="doi">10.1002/bjs.9766</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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