LymphedemaV1, PubMed, Curation, bibRecord, 000E61

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.

Identifieur interne : 000E61 ( PubMed/Curation ); précédent : 000E60; suivant : 000E62

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.

Auteurs : Johanna Liebl [Allemagne] ; Siwei Zhang [Allemagne] ; Markus Moser [Allemagne] ; Yan Agalarov [Suisse] ; Cansaran Saygili Demir [Suisse] ; Bianca Hager [Allemagne] ; James A. Bibb [États-Unis] ; Ralf H. Adams [Allemagne] ; Friedemann Kiefer [Allemagne] ; Naoyuki Miura [Japon] ; Tatiana V. Petrova [Suisse] ; Angelika M. Vollmar [Allemagne] ; Stefan Zahler [Allemagne]

Source :

Nature communications [ 2041-1723 ] ; 2015.

RBID : pubmed:26027726

Descripteurs français

English descriptors

KwdEn :
- Animals, Cyclin-Dependent Kinase 5 (genetics), Cyclin-Dependent Kinase 5 (metabolism), Endothelial Cells (cytology), Endothelial Cells (metabolism), Forkhead Transcription Factors (genetics), Forkhead Transcription Factors (metabolism), Human Umbilical Vein Endothelial Cells, Humans, Lymphangiogenesis (genetics), Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Mice, Mice, Knockout, Phosphorylation, Real-Time Polymerase Chain Reaction, Stress, Mechanical.
MESH :
- chemical , genetics : Cyclin-Dependent Kinase 5, Forkhead Transcription Factors.
- chemical , metabolism : Cyclin-Dependent Kinase 5, Forkhead Transcription Factors.
- cytology : Endothelial Cells.
- genetics : Lymphangiogenesis.
- metabolism : Endothelial Cells, Lymphatic Vessels.
- pathology : Lymphatic Vessels.
- Animals, Human Umbilical Vein Endothelial Cells, Humans, Mice, Mice, Knockout, Phosphorylation, Real-Time Polymerase Chain Reaction, Stress, Mechanical.

Abstract

The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show that cyclin-dependent kinase 5 (Cdk5) is an essential regulator of lymphatic vessel development. Endothelial-specific Cdk5 knockdown causes congenital lymphatic dysfunction and lymphedema due to defective lymphatic vessel patterning and valve formation. We identify the transcription factor Foxc2 as a key substrate of Cdk5 in the lymphatic vasculature, mechanistically linking Cdk5 to lymphatic development and valve morphogenesis. Collectively, our findings show that Cdk5-Foxc2 interaction represents a critical regulator of lymphatic vessel development and the transcriptional network underlying lymphatic vascular remodeling.

DOI: 10.1038/ncomms8274
PubMed: 26027726

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<term>Réaction de polymérisation en chaine en temps réel</term>
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<term>Souris knockout</term>
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<front><div type="abstract" xml:lang="en">The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show that cyclin-dependent kinase 5 (Cdk5) is an essential regulator of lymphatic vessel development. Endothelial-specific Cdk5 knockdown causes congenital lymphatic dysfunction and lymphedema due to defective lymphatic vessel patterning and valve formation. We identify the transcription factor Foxc2 as a key substrate of Cdk5 in the lymphatic vasculature, mechanistically linking Cdk5 to lymphatic development and valve morphogenesis. Collectively, our findings show that Cdk5-Foxc2 interaction represents a critical regulator of lymphatic vessel development and the transcriptional network underlying lymphatic vascular remodeling.</div>
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<Abstract><AbstractText>The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show that cyclin-dependent kinase 5 (Cdk5) is an essential regulator of lymphatic vessel development. Endothelial-specific Cdk5 knockdown causes congenital lymphatic dysfunction and lymphedema due to defective lymphatic vessel patterning and valve formation. We identify the transcription factor Foxc2 as a key substrate of Cdk5 in the lymphatic vasculature, mechanistically linking Cdk5 to lymphatic development and valve morphogenesis. Collectively, our findings show that Cdk5-Foxc2 interaction represents a critical regulator of lymphatic vessel development and the transcriptional network underlying lymphatic vascular remodeling.</AbstractText>
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   |texte=   Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.
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	Serveur d'exploration sur le lymphœdème
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Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.

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