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Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations.

Identifieur interne : 000939 ( PubMed/Curation ); précédent : 000938; suivant : 000940

Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations.

Auteurs : Judith A E M. Zecha [Pays-Bas] ; Judith E. Raber-Durlacher [Pays-Bas] ; Raj G. Nair [Australie] ; Joel B. Epstein [États-Unis] ; Stephen T. Sonis [États-Unis] ; Sharon Elad [États-Unis] ; Michael R. Hamblin [États-Unis] ; Andrei Barasch [États-Unis] ; Cesar A. Migliorati [États-Unis] ; Dan M J. Milstein [Pays-Bas] ; Marie-Thérèse Genot [Belgique] ; Liset Lansaat [Pays-Bas] ; Ron Van Der Brink [États-Unis] ; Josep Arnabat-Dominguez [Espagne] ; Lisette Van Der Molen [Pays-Bas] ; Irene Jacobi [Pays-Bas] ; Judi Van Diessen [Pays-Bas] ; Jan De Lange [Pays-Bas] ; Ludi E. Smeele [Pays-Bas] ; Mark M. Schubert [États-Unis] ; René-Jean Bensadoun [France]

Source :

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [ 1433-7339 ] ; 2016.

RBID : pubmed:26984240

Descripteurs français

KwdFr :
- Chimioradiothérapie (effets indésirables), Effets secondaires indésirables des médicaments (), Effets secondaires indésirables des médicaments (étiologie), Humains, Photothérapie de faible intensité (), Photothérapie de faible intensité (effets indésirables), Photothérapie de faible intensité (normes), Tumeurs de la tête et du cou (), Tumeurs de la tête et du cou (radiothérapie), Tumeurs de la tête et du cou (traitement médicamenteux).
MESH :
- effets indésirables : Chimioradiothérapie, Photothérapie de faible intensité.
- normes : Photothérapie de faible intensité.
- radiothérapie : Tumeurs de la tête et du cou.
- traitement médicamenteux : Tumeurs de la tête et du cou.
- étiologie : Effets secondaires indésirables des médicaments.
- Effets secondaires indésirables des médicaments, Humains, Photothérapie de faible intensité, Tumeurs de la tête et du cou.

English descriptors

KwdEn :
- Chemoradiotherapy (adverse effects), Drug-Related Side Effects and Adverse Reactions (etiology), Drug-Related Side Effects and Adverse Reactions (therapy), Head and Neck Neoplasms (drug therapy), Head and Neck Neoplasms (radiotherapy), Head and Neck Neoplasms (therapy), Humans, Low-Level Light Therapy (adverse effects), Low-Level Light Therapy (methods), Low-Level Light Therapy (standards).
MESH :
- adverse effects : Chemoradiotherapy, Low-Level Light Therapy.
- drug therapy : Head and Neck Neoplasms.
- etiology : Drug-Related Side Effects and Adverse Reactions.
- methods : Low-Level Light Therapy.
- radiotherapy : Head and Neck Neoplasms.
- standards : Low-Level Light Therapy.
- therapy : Drug-Related Side Effects and Adverse Reactions, Head and Neck Neoplasms.
- Humans.

Abstract

There is a large body of evidence supporting the efficacy of low level laser therapy (LLLT), more recently termed photobiomodulation (PBM), for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, together with a better understanding of mechanisms involved, may expand the applications for PBM in the management of other complications associated with HNC treatment. This article (part 1) describes PBM mechanisms of action, dosimetry, and safety aspects and, in doing so, provides a basis for a companion paper (part 2) which describes the potential breadth of potential applications of PBM in the management of side-effects of (chemo)radiation therapy in patients being treated for HNC and proposes PBM parameters.

DOI: 10.1007/s00520-016-3152-z
PubMed: 26984240

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<author><name sortKey="Zecha, Judith A E M" sort="Zecha, Judith A E M" uniqKey="Zecha J" first="Judith A E M" last="Zecha">Judith A E M. Zecha</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam</wicri:regionArea>
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<author><name sortKey="Raber Durlacher, Judith E" sort="Raber Durlacher, Judith E" uniqKey="Raber Durlacher J" first="Judith E" last="Raber-Durlacher">Judith E. Raber-Durlacher</name>
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<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam</wicri:regionArea>
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<author><name sortKey="Nair, Raj G" sort="Nair, Raj G" uniqKey="Nair R" first="Raj G" last="Nair">Raj G. Nair</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Haematology and Oncology/Cancer Services, Gold Coast University Hospital, Queensland Health, Gold Coast, QLD, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Haematology and Oncology/Cancer Services, Gold Coast University Hospital, Queensland Health, Gold Coast, QLD</wicri:regionArea>
</affiliation>
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<author><name sortKey="Epstein, Joel B" sort="Epstein, Joel B" uniqKey="Epstein J" first="Joel B" last="Epstein">Joel B. Epstein</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Sonis, Stephen T" sort="Sonis, Stephen T" uniqKey="Sonis S" first="Stephen T" last="Sonis">Stephen T. Sonis</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
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<author><name sortKey="Elad, Sharon" sort="Elad, Sharon" uniqKey="Elad S" first="Sharon" last="Elad">Sharon Elad</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Oral Medicine, Eastman Institute for Oral Health, and Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, 14620</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamblin, Michael R" sort="Hamblin, Michael R" uniqKey="Hamblin M" first="Michael R" last="Hamblin">Michael R. Hamblin</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114</wicri:regionArea>
</affiliation>
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<author><name sortKey="Barasch, Andrei" sort="Barasch, Andrei" uniqKey="Barasch A" first="Andrei" last="Barasch">Andrei Barasch</name>
<affiliation wicri:level="1"><nlm:affiliation>Weill Cornell Medical Center, Division of Oncology, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Weill Cornell Medical Center, Division of Oncology, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Migliorati, Cesar A" sort="Migliorati, Cesar A" uniqKey="Migliorati C" first="Cesar A" last="Migliorati">Cesar A. Migliorati</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic Sciences and Oral Medicine, University of Tennessee Health Science Center, College of Dentistry, 875 Union Ave. Suite N231, Memphis, TN, 38163, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Diagnostic Sciences and Oral Medicine, University of Tennessee Health Science Center, College of Dentistry, 875 Union Ave. Suite N231, Memphis, TN, 38163</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Milstein, Dan M J" sort="Milstein, Dan M J" uniqKey="Milstein D" first="Dan M J" last="Milstein">Dan M J. Milstein</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Genot, Marie Therese" sort="Genot, Marie Therese" uniqKey="Genot M" first="Marie-Thérèse" last="Genot">Marie-Thérèse Genot</name>
<affiliation wicri:level="1"><nlm:affiliation>Laser Therapy Unit, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laser Therapy Unit, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels</wicri:regionArea>
</affiliation>
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<author><name sortKey="Lansaat, Liset" sort="Lansaat, Liset" uniqKey="Lansaat L" first="Liset" last="Lansaat">Liset Lansaat</name>
<affiliation wicri:level="1"><nlm:affiliation>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Brink, Ron" sort="Van Der Brink, Ron" uniqKey="Van Der Brink R" first="Ron" last="Van Der Brink">Ron Van Der Brink</name>
<affiliation wicri:level="1"><nlm:affiliation>City of Hope, Duarte, CA, 91010, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>City of Hope, Duarte, CA, 91010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnabat Dominguez, Josep" sort="Arnabat Dominguez, Josep" uniqKey="Arnabat Dominguez J" first="Josep" last="Arnabat-Dominguez">Josep Arnabat-Dominguez</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral Surgery, Faculty of Dentistry, University of Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Oral Surgery, Faculty of Dentistry, University of Barcelona, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Molen, Lisette" sort="Van Der Molen, Lisette" uniqKey="Van Der Molen L" first="Lisette" last="Van Der Molen">Lisette Van Der Molen</name>
<affiliation wicri:level="1"><nlm:affiliation>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jacobi, Irene" sort="Jacobi, Irene" uniqKey="Jacobi I" first="Irene" last="Jacobi">Irene Jacobi</name>
<affiliation wicri:level="1"><nlm:affiliation>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Diessen, Judi" sort="Van Diessen, Judi" uniqKey="Van Diessen J" first="Judi" last="Van Diessen">Judi Van Diessen</name>
<affiliation wicri:level="1"><nlm:affiliation>Antoni van Leeuwenhoek Department Radiation Oncology Amsterdam, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Antoni van Leeuwenhoek Department Radiation Oncology Amsterdam, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Lange, Jan" sort="De Lange, Jan" uniqKey="De Lange J" first="Jan" last="De Lange">Jan De Lange</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smeele, Ludi E" sort="Smeele, Ludi E" uniqKey="Smeele L" first="Ludi E" last="Smeele">Ludi E. Smeele</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schubert, Mark M" sort="Schubert, Mark M" uniqKey="Schubert M" first="Mark M" last="Schubert">Mark M. Schubert</name>
<affiliation wicri:level="1"><nlm:affiliation>Seattle Cancer Care Alliance (SCCA), 825 Eastlake Ave E Ste G6900, Seattle, WA, 98109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Seattle Cancer Care Alliance (SCCA), 825 Eastlake Ave E Ste G6900, Seattle, WA, 98109</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bensadoun, Rene Jean" sort="Bensadoun, Rene Jean" uniqKey="Bensadoun R" first="René-Jean" last="Bensadoun">René-Jean Bensadoun</name>
<affiliation wicri:level="1"><nlm:affiliation>World Association for Laser Therapy (WALT) Scientific Secretary, Centre de Haute Energie (CHE), 10 Bd Pasteur, 06000, Nice, France. renejean.bensadoun@che-nice.com.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>World Association for Laser Therapy (WALT) Scientific Secretary, Centre de Haute Energie (CHE), 10 Bd Pasteur, 06000, Nice</wicri:regionArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations.</title>
<author><name sortKey="Zecha, Judith A E M" sort="Zecha, Judith A E M" uniqKey="Zecha J" first="Judith A E M" last="Zecha">Judith A E M. Zecha</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Raber Durlacher, Judith E" sort="Raber Durlacher, Judith E" uniqKey="Raber Durlacher J" first="Judith E" last="Raber-Durlacher">Judith E. Raber-Durlacher</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nair, Raj G" sort="Nair, Raj G" uniqKey="Nair R" first="Raj G" last="Nair">Raj G. Nair</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Haematology and Oncology/Cancer Services, Gold Coast University Hospital, Queensland Health, Gold Coast, QLD, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Haematology and Oncology/Cancer Services, Gold Coast University Hospital, Queensland Health, Gold Coast, QLD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Epstein, Joel B" sort="Epstein, Joel B" uniqKey="Epstein J" first="Joel B" last="Epstein">Joel B. Epstein</name>
<affiliation wicri:level="1"><nlm:affiliation>Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sonis, Stephen T" sort="Sonis, Stephen T" uniqKey="Sonis S" first="Stephen T" last="Sonis">Stephen T. Sonis</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Oral Medicine, Brigham and Women's Hospital and the Dana-Farber Cancer Institute and Biomodels LLC, Boston, MA, 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Oral Medicine, Brigham and Women's Hospital and the Dana-Farber Cancer Institute and Biomodels LLC, Boston, MA, 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Elad, Sharon" sort="Elad, Sharon" uniqKey="Elad S" first="Sharon" last="Elad">Sharon Elad</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Oral Medicine, Eastman Institute for Oral Health, and Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, 14620, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Oral Medicine, Eastman Institute for Oral Health, and Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, 14620</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamblin, Michael R" sort="Hamblin, Michael R" uniqKey="Hamblin M" first="Michael R" last="Hamblin">Michael R. Hamblin</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barasch, Andrei" sort="Barasch, Andrei" uniqKey="Barasch A" first="Andrei" last="Barasch">Andrei Barasch</name>
<affiliation wicri:level="1"><nlm:affiliation>Weill Cornell Medical Center, Division of Oncology, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Weill Cornell Medical Center, Division of Oncology, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Migliorati, Cesar A" sort="Migliorati, Cesar A" uniqKey="Migliorati C" first="Cesar A" last="Migliorati">Cesar A. Migliorati</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic Sciences and Oral Medicine, University of Tennessee Health Science Center, College of Dentistry, 875 Union Ave. Suite N231, Memphis, TN, 38163, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Diagnostic Sciences and Oral Medicine, University of Tennessee Health Science Center, College of Dentistry, 875 Union Ave. Suite N231, Memphis, TN, 38163</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Milstein, Dan M J" sort="Milstein, Dan M J" uniqKey="Milstein D" first="Dan M J" last="Milstein">Dan M J. Milstein</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Genot, Marie Therese" sort="Genot, Marie Therese" uniqKey="Genot M" first="Marie-Thérèse" last="Genot">Marie-Thérèse Genot</name>
<affiliation wicri:level="1"><nlm:affiliation>Laser Therapy Unit, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laser Therapy Unit, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lansaat, Liset" sort="Lansaat, Liset" uniqKey="Lansaat L" first="Liset" last="Lansaat">Liset Lansaat</name>
<affiliation wicri:level="1"><nlm:affiliation>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Brink, Ron" sort="Van Der Brink, Ron" uniqKey="Van Der Brink R" first="Ron" last="Van Der Brink">Ron Van Der Brink</name>
<affiliation wicri:level="1"><nlm:affiliation>City of Hope, Duarte, CA, 91010, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>City of Hope, Duarte, CA, 91010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnabat Dominguez, Josep" sort="Arnabat Dominguez, Josep" uniqKey="Arnabat Dominguez J" first="Josep" last="Arnabat-Dominguez">Josep Arnabat-Dominguez</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral Surgery, Faculty of Dentistry, University of Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Oral Surgery, Faculty of Dentistry, University of Barcelona, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Molen, Lisette" sort="Van Der Molen, Lisette" uniqKey="Van Der Molen L" first="Lisette" last="Van Der Molen">Lisette Van Der Molen</name>
<affiliation wicri:level="1"><nlm:affiliation>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jacobi, Irene" sort="Jacobi, Irene" uniqKey="Jacobi I" first="Irene" last="Jacobi">Irene Jacobi</name>
<affiliation wicri:level="1"><nlm:affiliation>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Diessen, Judi" sort="Van Diessen, Judi" uniqKey="Van Diessen J" first="Judi" last="Van Diessen">Judi Van Diessen</name>
<affiliation wicri:level="1"><nlm:affiliation>Antoni van Leeuwenhoek Department Radiation Oncology Amsterdam, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Antoni van Leeuwenhoek Department Radiation Oncology Amsterdam, Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Lange, Jan" sort="De Lange, Jan" uniqKey="De Lange J" first="Jan" last="De Lange">Jan De Lange</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smeele, Ludi E" sort="Smeele, Ludi E" uniqKey="Smeele L" first="Ludi E" last="Smeele">Ludi E. Smeele</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schubert, Mark M" sort="Schubert, Mark M" uniqKey="Schubert M" first="Mark M" last="Schubert">Mark M. Schubert</name>
<affiliation wicri:level="1"><nlm:affiliation>Seattle Cancer Care Alliance (SCCA), 825 Eastlake Ave E Ste G6900, Seattle, WA, 98109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Seattle Cancer Care Alliance (SCCA), 825 Eastlake Ave E Ste G6900, Seattle, WA, 98109</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bensadoun, Rene Jean" sort="Bensadoun, Rene Jean" uniqKey="Bensadoun R" first="René-Jean" last="Bensadoun">René-Jean Bensadoun</name>
<affiliation wicri:level="1"><nlm:affiliation>World Association for Laser Therapy (WALT) Scientific Secretary, Centre de Haute Energie (CHE), 10 Bd Pasteur, 06000, Nice, France. renejean.bensadoun@che-nice.com.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>World Association for Laser Therapy (WALT) Scientific Secretary, Centre de Haute Energie (CHE), 10 Bd Pasteur, 06000, Nice</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer</title>
<idno type="eISSN">1433-7339</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chemoradiotherapy (adverse effects)</term>
<term>Drug-Related Side Effects and Adverse Reactions (etiology)</term>
<term>Drug-Related Side Effects and Adverse Reactions (therapy)</term>
<term>Head and Neck Neoplasms (drug therapy)</term>
<term>Head and Neck Neoplasms (radiotherapy)</term>
<term>Head and Neck Neoplasms (therapy)</term>
<term>Humans</term>
<term>Low-Level Light Therapy (adverse effects)</term>
<term>Low-Level Light Therapy (methods)</term>
<term>Low-Level Light Therapy (standards)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Chimioradiothérapie (effets indésirables)</term>
<term>Effets secondaires indésirables des médicaments ()</term>
<term>Effets secondaires indésirables des médicaments (étiologie)</term>
<term>Humains</term>
<term>Photothérapie de faible intensité ()</term>
<term>Photothérapie de faible intensité (effets indésirables)</term>
<term>Photothérapie de faible intensité (normes)</term>
<term>Tumeurs de la tête et du cou ()</term>
<term>Tumeurs de la tête et du cou (radiothérapie)</term>
<term>Tumeurs de la tête et du cou (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Chemoradiotherapy</term>
<term>Low-Level Light Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Head and Neck Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Chimioradiothérapie</term>
<term>Photothérapie de faible intensité</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Low-Level Light Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Photothérapie de faible intensité</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Head and Neck Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs de la tête et du cou</term>
</keywords>
<keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Low-Level Light Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term>
<term>Head and Neck Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs de la tête et du cou</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term>
<term>Humains</term>
<term>Photothérapie de faible intensité</term>
<term>Tumeurs de la tête et du cou</term>
</keywords>
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<front><div type="abstract" xml:lang="en">There is a large body of evidence supporting the efficacy of low level laser therapy (LLLT), more recently termed photobiomodulation (PBM), for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, together with a better understanding of mechanisms involved, may expand the applications for PBM in the management of other complications associated with HNC treatment. This article (part 1) describes PBM mechanisms of action, dosimetry, and safety aspects and, in doing so, provides a basis for a companion paper (part 2) which describes the potential breadth of potential applications of PBM in the management of side-effects of (chemo)radiation therapy in patients being treated for HNC and proposes PBM parameters.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26984240</PMID>
<DateCreated><Year>2016</Year>
<Month>04</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>05</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>06</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1433-7339</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>24</Volume>
<Issue>6</Issue>
<PubDate><Year>2016</Year>
<Month>06</Month>
</PubDate>
</JournalIssue>
<Title>Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer</Title>
<ISOAbbreviation>Support Care Cancer</ISOAbbreviation>
</Journal>
<ArticleTitle>Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations.</ArticleTitle>
<Pagination><MedlinePgn>2781-92</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00520-016-3152-z</ELocationID>
<Abstract><AbstractText Label="PURPOSE">There is a large body of evidence supporting the efficacy of low level laser therapy (LLLT), more recently termed photobiomodulation (PBM), for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, together with a better understanding of mechanisms involved, may expand the applications for PBM in the management of other complications associated with HNC treatment. This article (part 1) describes PBM mechanisms of action, dosimetry, and safety aspects and, in doing so, provides a basis for a companion paper (part 2) which describes the potential breadth of potential applications of PBM in the management of side-effects of (chemo)radiation therapy in patients being treated for HNC and proposes PBM parameters.</AbstractText>
<AbstractText Label="METHODS">This study is a narrative non-systematic review.</AbstractText>
<AbstractText Label="RESULTS">We review PBM mechanisms of action and dosimetric considerations. Virtually, all conditions modulated by PBM (e.g., ulceration, inflammation, lymphedema, pain, fibrosis, neurological and muscular injury) are thought to be involved in the pathogenesis of (chemo)radiation therapy-induced complications in patients treated for HNC. The impact of PBM on tumor behavior and tumor response to treatment has been insufficiently studied. In vitro studies assessing the effect of PBM on tumor cells report conflicting results, perhaps attributable to inconsistencies of PBM power and dose. Nonetheless, the biological bases for the broad clinical activities ascribed to PBM have also been noted to be similar to those activities and pathways associated with negative tumor behaviors and impeded response to treatment. While there are no anecdotal descriptions of poor tumor outcomes in patients treated with PBM, confirming its neutrality with respect to cancer responsiveness is a critical priority.</AbstractText>
<AbstractText Label="CONCLUSION">Based on its therapeutic effects, PBM may have utility in a broad range of oral, oropharyngeal, facial, and neck complications of HNC treatment. Although evidence suggests that PBM using LLLT is safe in HNC patients, more research is imperative and vigilance remains warranted to detect any potential adverse effects of PBM on cancer treatment outcomes and survival.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zecha</LastName>
<ForeName>Judith A E M</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Raber-Durlacher</LastName>
<ForeName>Judith E</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Dental Interaction and Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nair</LastName>
<ForeName>Raj G</ForeName>
<Initials>RG</Initials>
<AffiliationInfo><Affiliation>Department of Haematology and Oncology/Cancer Services, Gold Coast University Hospital, Queensland Health, Gold Coast, QLD, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Epstein</LastName>
<ForeName>Joel B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo><Affiliation>Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Otolaryngology and Head and Neck Surgery, City of Hope, Duarte, CA, 91010, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sonis</LastName>
<ForeName>Stephen T</ForeName>
<Initials>ST</Initials>
<AffiliationInfo><Affiliation>Division of Oral Medicine, Brigham and Women's Hospital and the Dana-Farber Cancer Institute and Biomodels LLC, Boston, MA, 02115, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Elad</LastName>
<ForeName>Sharon</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Oral Medicine, Eastman Institute for Oral Health, and Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, 14620, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hamblin</LastName>
<ForeName>Michael R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Dermatology, Harvard Medical School, Boston, MA, 02115, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard-MIT Division of Health Science and Technology, Cambridge, MA, 02139, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barasch</LastName>
<ForeName>Andrei</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Weill Cornell Medical Center, Division of Oncology, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Migliorati</LastName>
<ForeName>Cesar A</ForeName>
<Initials>CA</Initials>
<AffiliationInfo><Affiliation>Department of Diagnostic Sciences and Oral Medicine, University of Tennessee Health Science Center, College of Dentistry, 875 Union Ave. Suite N231, Memphis, TN, 38163, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Milstein</LastName>
<ForeName>Dan M J</ForeName>
<Initials>DM</Initials>
<AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Genot</LastName>
<ForeName>Marie-Thérèse</ForeName>
<Initials>MT</Initials>
<AffiliationInfo><Affiliation>Laser Therapy Unit, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lansaat</LastName>
<ForeName>Liset</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van der Brink</LastName>
<ForeName>Ron</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>City of Hope, Duarte, CA, 91010, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arnabat-Dominguez</LastName>
<ForeName>Josep</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Oral Surgery, Faculty of Dentistry, University of Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van der Molen</LastName>
<ForeName>Lisette</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jacobi</LastName>
<ForeName>Irene</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Diessen</LastName>
<ForeName>Judi</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Antoni van Leeuwenhoek Department Radiation Oncology Amsterdam, Netherlands Cancer Institute, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Lange</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smeele</LastName>
<ForeName>Ludi E</ForeName>
<Initials>LE</Initials>
<AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Antoni van Leeuwenhoek Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schubert</LastName>
<ForeName>Mark M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>Seattle Cancer Care Alliance (SCCA), 825 Eastlake Ave E Ste G6900, Seattle, WA, 98109, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bensadoun</LastName>
<ForeName>René-Jean</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo><Affiliation>World Association for Laser Therapy (WALT) Scientific Secretary, Centre de Haute Energie (CHE), 10 Bd Pasteur, 06000, Nice, France. renejean.bensadoun@che-nice.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 AI050875</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>03</Month>
<Day>16</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Support Care Cancer</MedlineTA>
<NlmUniqueID>9302957</NlmUniqueID>
<ISSNLinking>0941-4355</ISSNLinking>
</MedlineJournalInfo>
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<Keyword MajorTopicYN="Y">Low level laser therapy</Keyword>
<Keyword MajorTopicYN="Y">Low level light therapy</Keyword>
<Keyword MajorTopicYN="Y">Mucositis</Keyword>
<Keyword MajorTopicYN="Y">Orofacial complications</Keyword>
<Keyword MajorTopicYN="Y">Photobiomodulation</Keyword>
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Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations.

Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations.

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