Yellow nail syndrome after allogeneic haematopoietic stem cell transplantation in two patients with multiple myeloma.
Identifieur interne : 000876 ( PubMed/Curation ); précédent : 000875; suivant : 000877Yellow nail syndrome after allogeneic haematopoietic stem cell transplantation in two patients with multiple myeloma.
Auteurs : Céline Gregoire [Belgique] ; Julien Guiot [Belgique] ; Gaëlle Vertenoeil [Belgique] ; Évelyne Willems [Belgique] ; Kaoutar Hafraoui [Belgique] ; Jean-Louis Corhay [Belgique] ; Renaud Louis [Belgique] ; Yves Beguin [Belgique]Source :
- Acta clinica Belgica [ 2295-3337 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Diagnostic différentiel, Glucocorticoïdes (usage thérapeutique), Humains, Maladie du greffon contre l'hôte (), Myélome multiple (), Mâle, Syndrome des ongles jaunes (diagnostic), Syndrome des ongles jaunes (traitement médicamenteux), Syndrome des ongles jaunes (étiologie), Transplantation de cellules souches hématopoïétiques (effets indésirables).
- MESH :
- diagnostic : Syndrome des ongles jaunes.
- effets indésirables : Transplantation de cellules souches hématopoïétiques.
- traitement médicamenteux : Syndrome des ongles jaunes.
- usage thérapeutique : Glucocorticoïdes.
- étiologie : Syndrome des ongles jaunes.
- Adulte, Adulte d'âge moyen, Diagnostic différentiel, Humains, Maladie du greffon contre l'hôte, Myélome multiple, Mâle.
English descriptors
- KwdEn :
- Adult, Diagnosis, Differential, Glucocorticoids (therapeutic use), Graft vs Host Disease (complications), Hematopoietic Stem Cell Transplantation (adverse effects), Humans, Male, Middle Aged, Multiple Myeloma (surgery), Yellow Nail Syndrome (diagnosis), Yellow Nail Syndrome (drug therapy), Yellow Nail Syndrome (etiology).
- MESH :
- chemical , therapeutic use : Glucocorticoids.
- adverse effects : Hematopoietic Stem Cell Transplantation.
- complications : Graft vs Host Disease.
- diagnosis : Yellow Nail Syndrome.
- drug therapy : Yellow Nail Syndrome.
- etiology : Yellow Nail Syndrome.
- surgery : Multiple Myeloma.
- Adult, Diagnosis, Differential, Humans, Male, Middle Aged.
Abstract
Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology characterized by the triad of yellow nails, lymphoedema and respiratory manifestations. About 200 cases have been reported, but a lot of patients probably elude proper diagnosis because of both variability of symptoms and ignorance of this syndrome by many physicians. The pathogenesis remains unclear, and could involve functional lymphatic abnormalities, microvasculopathy or lymphocyte deficiency, but none of these hypotheses seems fully satisfactory.
DOI: 10.1080/17843286.2015.1122872
PubMed: 27075800
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<term>Diagnosis, Differential</term>
<term>Glucocorticoids (therapeutic use)</term>
<term>Graft vs Host Disease (complications)</term>
<term>Hematopoietic Stem Cell Transplantation (adverse effects)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple Myeloma (surgery)</term>
<term>Yellow Nail Syndrome (diagnosis)</term>
<term>Yellow Nail Syndrome (drug therapy)</term>
<term>Yellow Nail Syndrome (etiology)</term>
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<term>Adulte d'âge moyen</term>
<term>Diagnostic différentiel</term>
<term>Glucocorticoïdes (usage thérapeutique)</term>
<term>Humains</term>
<term>Maladie du greffon contre l'hôte ()</term>
<term>Myélome multiple ()</term>
<term>Mâle</term>
<term>Syndrome des ongles jaunes (diagnostic)</term>
<term>Syndrome des ongles jaunes (traitement médicamenteux)</term>
<term>Syndrome des ongles jaunes (étiologie)</term>
<term>Transplantation de cellules souches hématopoïétiques (effets indésirables)</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Yellow Nail Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome des ongles jaunes</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Yellow Nail Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Transplantation de cellules souches hématopoïétiques</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Multiple Myeloma</term>
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<term>Diagnosis, Differential</term>
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<term>Middle Aged</term>
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<term>Adulte d'âge moyen</term>
<term>Diagnostic différentiel</term>
<term>Humains</term>
<term>Maladie du greffon contre l'hôte</term>
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<front><div type="abstract" xml:lang="en">Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology characterized by the triad of yellow nails, lymphoedema and respiratory manifestations. About 200 cases have been reported, but a lot of patients probably elude proper diagnosis because of both variability of symptoms and ignorance of this syndrome by many physicians. The pathogenesis remains unclear, and could involve functional lymphatic abnormalities, microvasculopathy or lymphocyte deficiency, but none of these hypotheses seems fully satisfactory.</div>
</front>
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<DateCreated><Year>2016</Year>
<Month>04</Month>
<Day>14</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>04</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>04</Month>
<Day>04</Day>
</DateRevised>
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<Issue>6</Issue>
<PubDate><Year>2016</Year>
<Month>Dec</Month>
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<Title>Acta clinica Belgica</Title>
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<ArticleTitle>Yellow nail syndrome after allogeneic haematopoietic stem cell transplantation in two patients with multiple myeloma.</ArticleTitle>
<Pagination><MedlinePgn>428-430</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVE AND IMPORTANCE" NlmCategory="OBJECTIVE">Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology characterized by the triad of yellow nails, lymphoedema and respiratory manifestations. About 200 cases have been reported, but a lot of patients probably elude proper diagnosis because of both variability of symptoms and ignorance of this syndrome by many physicians. The pathogenesis remains unclear, and could involve functional lymphatic abnormalities, microvasculopathy or lymphocyte deficiency, but none of these hypotheses seems fully satisfactory.</AbstractText>
<AbstractText Label="CLINICAL PRESENTATION" NlmCategory="METHODS">We report for the first time two cases of YNS associated with multiple myeloma relapsing after non-myeloablative haematopoietic cell transplantation (HCT). In these two cases, onset or worsening of YNS symptoms followed graft-versus-host disease (GvHD) manifestations.</AbstractText>
<AbstractText Label="INTERVENTION" NlmCategory="METHODS">Corticosteroids given to treat GvHD also improved YNS manifestations.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">YNS after HCT might be a microvascular manifestation of endothelial GvHD and corticosteroids might be an effective treatment.</AbstractText>
</Abstract>
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<ForeName>Céline</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>a Department of Medicine, Division of Hematology , CHU of Liège and University of Liège , Liège , Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guiot</LastName>
<ForeName>Julien</ForeName>
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<AffiliationInfo><Affiliation>b Department of Medicine, Division of Pneumology , CHU of Liège and University of Liège , Liège , Belgium.</Affiliation>
</AffiliationInfo>
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<ForeName>Gaëlle</ForeName>
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<AffiliationInfo><Affiliation>a Department of Medicine, Division of Hematology , CHU of Liège and University of Liège , Liège , Belgium.</Affiliation>
</AffiliationInfo>
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<ForeName>Évelyne</ForeName>
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</AffiliationInfo>
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<AffiliationInfo><Affiliation>a Department of Medicine, Division of Hematology , CHU of Liège and University of Liège , Liège , Belgium.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Corhay</LastName>
<ForeName>Jean-Louis</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>b Department of Medicine, Division of Pneumology , CHU of Liège and University of Liège , Liège , Belgium.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Louis</LastName>
<ForeName>Renaud</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>b Department of Medicine, Division of Pneumology , CHU of Liège and University of Liège , Liège , Belgium.</Affiliation>
</AffiliationInfo>
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<ForeName>Yves</ForeName>
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</AffiliationInfo>
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<MeshHeading><DescriptorName UI="D005938" MajorTopicYN="N">Glucocorticoids</DescriptorName>
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<MeshHeading><DescriptorName UI="D009101" MajorTopicYN="N">Multiple Myeloma</DescriptorName>
<QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056684" MajorTopicYN="N">Yellow Nail Syndrome</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Allogeneic haematopoietic cell transplantation</Keyword>
<Keyword MajorTopicYN="Y">Graft-versus-host-disease</Keyword>
<Keyword MajorTopicYN="Y">Multiple myeloma</Keyword>
<Keyword MajorTopicYN="Y">Yellow nail syndrome</Keyword>
</KeywordList>
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<Month>4</Month>
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