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Endometrial Cancer and the Role of Lymphadenectomy.

Identifieur interne : 000770 ( PubMed/Curation ); précédent : 000769; suivant : 000771

Endometrial Cancer and the Role of Lymphadenectomy.

Auteurs : Leslie H. Clark ; John T. Soper [États-Unis]

Source :

RBID : pubmed:27302186

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English descriptors

Abstract

The role of lymph node dissection in early-stage endometrial cancer is highly debated, but staging and prognosis are dependent on knowledge of lymph node metastasis.

DOI: 10.1097/OGX.0000000000000321
PubMed: 27302186

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Leslie H. Clark
<affiliation>
<nlm:affiliation>Clinical Fellow.</nlm:affiliation>
<wicri:noCountry code="no comma">Clinical Fellow.</wicri:noCountry>
</affiliation>

Le document en format XML

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<title xml:lang="en">Endometrial Cancer and the Role of Lymphadenectomy.</title>
<author>
<name sortKey="Clark, Leslie H" sort="Clark, Leslie H" uniqKey="Clark L" first="Leslie H" last="Clark">Leslie H. Clark</name>
<affiliation>
<nlm:affiliation>Clinical Fellow.</nlm:affiliation>
<wicri:noCountry code="no comma">Clinical Fellow.</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Soper, John T" sort="Soper, John T" uniqKey="Soper J" first="John T" last="Soper">John T. Soper</name>
<affiliation wicri:level="2">
<nlm:affiliation>Professor, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Professor, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea>
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<title xml:lang="en">Endometrial Cancer and the Role of Lymphadenectomy.</title>
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<name sortKey="Clark, Leslie H" sort="Clark, Leslie H" uniqKey="Clark L" first="Leslie H" last="Clark">Leslie H. Clark</name>
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<nlm:affiliation>Clinical Fellow.</nlm:affiliation>
<wicri:noCountry code="no comma">Clinical Fellow.</wicri:noCountry>
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<author>
<name sortKey="Soper, John T" sort="Soper, John T" uniqKey="Soper J" first="John T" last="Soper">John T. Soper</name>
<affiliation wicri:level="2">
<nlm:affiliation>Professor, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Caroline du Nord</region>
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<wicri:cityArea>Professor, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea>
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<series>
<title level="j">Obstetrical & gynecological survey</title>
<idno type="eISSN">1533-9866</idno>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Endometrial Neoplasms (pathology)</term>
<term>Endometrial Neoplasms (surgery)</term>
<term>Female</term>
<term>Humans</term>
<term>Lymph Node Excision (adverse effects)</term>
<term>Lymphatic Metastasis</term>
<term>Lymphedema (etiology)</term>
<term>Magnetic Resonance Imaging</term>
<term>Neoplasm Staging (methods)</term>
<term>Prognosis</term>
<term>Risk Factors</term>
<term>Sentinel Lymph Node (diagnostic imaging)</term>
<term>Sentinel Lymph Node (pathology)</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Lymphadénectomie (effets indésirables)</term>
<term>Lymphoedème (étiologie)</term>
<term>Métastase lymphatique</term>
<term>Noeud lymphatique sentinelle (anatomopathologie)</term>
<term>Noeud lymphatique sentinelle (imagerie diagnostique)</term>
<term>Pronostic</term>
<term>Stade de la tumeur ()</term>
<term>Tomodensitométrie</term>
<term>Tumeurs de l'endomètre ()</term>
<term>Tumeurs de l'endomètre (anatomopathologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en">
<term>Lymph Node Excision</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Noeud lymphatique sentinelle</term>
<term>Tumeurs de l'endomètre</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en">
<term>Sentinel Lymph Node</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr">
<term>Lymphadénectomie</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr">
<term>Noeud lymphatique sentinelle</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en">
<term>Neoplasm Staging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Endometrial Neoplasms</term>
<term>Sentinel Lymph Node</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Endometrial Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr">
<term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Female</term>
<term>Humans</term>
<term>Lymphatic Metastasis</term>
<term>Magnetic Resonance Imaging</term>
<term>Prognosis</term>
<term>Risk Factors</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Métastase lymphatique</term>
<term>Pronostic</term>
<term>Stade de la tumeur</term>
<term>Tomodensitométrie</term>
<term>Tumeurs de l'endomètre</term>
</keywords>
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<front>
<div type="abstract" xml:lang="en">The role of lymph node dissection in early-stage endometrial cancer is highly debated, but staging and prognosis are dependent on knowledge of lymph node metastasis.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">27302186</PMID>
<DateCreated>
<Year>2016</Year>
<Month>06</Month>
<Day>15</Day>
</DateCreated>
<DateCompleted>
<Year>2017</Year>
<Month>02</Month>
<Day>27</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>02</Month>
<Day>27</Day>
</DateRevised>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Electronic">1533-9866</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>71</Volume>
<Issue>6</Issue>
<PubDate>
<Year>2016</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Obstetrical & gynecological survey</Title>
<ISOAbbreviation>Obstet Gynecol Surv</ISOAbbreviation>
</Journal>
<ArticleTitle>Endometrial Cancer and the Role of Lymphadenectomy.</ArticleTitle>
<Pagination>
<MedlinePgn>353-60</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1097/OGX.0000000000000321</ELocationID>
<Abstract>
<AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">The role of lymph node dissection in early-stage endometrial cancer is highly debated, but staging and prognosis are dependent on knowledge of lymph node metastasis.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We sought to review the available data on the use of lymph node assessment in presumed early-stage endometrial cancer.</AbstractText>
<AbstractText Label="EVIDENCE ACQUISITION" NlmCategory="METHODS">A comprehensive literature review was performed using MEDLINE, the Cochrane Collaborative Database, and PubMed.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">There is limited retrospective data that suggest a therapeutic benefit to lymphadenectomy. Prospective randomized trials have not shown a benefit to lymphadenectomy in low-risk patients, but found significant morbidity in patients undergoing lymphadenectomy. Selective lymph node assessment should be used in low-risk endometrial cancer. Sentinel lymph node assessment is emerging as a potential strategy for lymph node assessment.</AbstractText>
<AbstractText Label="CONCLUSIONS AND RELEVANCE" NlmCategory="CONCLUSIONS">Selective use of lymphadenectomy in early-stage endometrial cancer can reduce the morbidity associated with lymph node dissection without compromising clinical outcomes. Multiple strategies are available including sentinel lymph nodes and risk factor based lymphadenectomy.</AbstractText>
</Abstract>
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<LastName>Clark</LastName>
<ForeName>Leslie H</ForeName>
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<Affiliation>Clinical Fellow.</Affiliation>
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<LastName>Soper</LastName>
<ForeName>John T</ForeName>
<Initials>JT</Initials>
<AffiliationInfo>
<Affiliation>Professor, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
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<Country>United States</Country>
<MedlineTA>Obstet Gynecol Surv</MedlineTA>
<NlmUniqueID>0401007</NlmUniqueID>
<ISSNLinking>0029-7828</ISSNLinking>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D016889" MajorTopicYN="N">Endometrial Neoplasms</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008197" MajorTopicYN="Y">Lymph Node Excision</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName>
</MeshHeading>
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<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
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<DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000071036" MajorTopicYN="N">Sentinel Lymph Node</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
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<Year>2016</Year>
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