Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation.
Identifieur interne : 000728 ( PubMed/Curation ); précédent : 000727; suivant : 000729Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation.
Auteurs : John D. Welsh [États-Unis] ; Mark L. Kahn [États-Unis] ; Daniel T. Sweet [États-Unis]Source :
- Blood [ 1528-0020 ] ; 2016.
Descripteurs français
- KwdFr :
- Activation plaquettaire, Animaux, Chylothorax (anatomopathologie), Chylothorax (métabolisme), Chylothorax (physiopathologie), Glycoprotéines membranaires (métabolisme), Humains, Lectines de type C (métabolisme), Lymphoedème (anatomopathologie), Lymphoedème (métabolisme), Lymphoedème (physiopathologie), Plaquettes (anatomopathologie), Plaquettes (métabolisme), Souris, Thrombose (anatomopathologie), Thrombose (métabolisme), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- anatomopathologie : Chylothorax, Lymphoedème, Plaquettes, Thrombose, Vaisseaux lymphatiques.
- métabolisme : Chylothorax, Glycoprotéines membranaires, Lectines de type C, Lymphoedème, Plaquettes, Thrombose, Vaisseaux lymphatiques.
- physiopathologie : Chylothorax, Lymphoedème.
- Activation plaquettaire, Animaux, Humains, Souris.
English descriptors
- KwdEn :
- Animals, Blood Platelets (metabolism), Blood Platelets (pathology), Chylothorax (metabolism), Chylothorax (pathology), Chylothorax (physiopathology), Humans, Lectins, C-Type (metabolism), Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphedema (metabolism), Lymphedema (pathology), Lymphedema (physiopathology), Membrane Glycoproteins (metabolism), Mice, Platelet Activation, Thrombosis (metabolism), Thrombosis (pathology).
- MESH :
- chemical , metabolism : Lectins, C-Type, Membrane Glycoproteins.
- metabolism : Blood Platelets, Chylothorax, Lymphatic Vessels, Lymphedema, Thrombosis.
- pathology : Blood Platelets, Chylothorax, Lymphatic Vessels, Lymphedema, Thrombosis.
- physiopathology : Chylothorax, Lymphedema.
- Animals, Humans, Mice, Platelet Activation.
Abstract
Aside from the established role for platelets in regulating hemostasis and thrombosis, recent research has revealed a discrete role for platelets in the separation of the blood and lymphatic vascular systems. Platelets are activated by interaction with lymphatic endothelial cells at the lymphovenous junction, the site in the body where the lymphatic system drains into the blood vascular system, resulting in a platelet plug that, with the lymphovenous valve, prevents blood from entering the lymphatic circulation. This process, known as "lymphovenous hemostasis," is mediated by activation of platelet CLEC-2 receptors by the transmembrane ligand podoplanin expressed by lymphatic endothelial cells. Lymphovenous hemostasis is required for normal lymph flow, and mice deficient in lymphovenous hemostasis exhibit lymphedema and sometimes chylothorax phenotypes indicative of lymphatic insufficiency. Unexpectedly, the loss of lymph flow in these mice causes defects in maturation of collecting lymphatic vessels and lymphatic valve formation, uncovering an important role for fluid flow in driving endothelial cell signaling during development of collecting lymphatics. This article summarizes the current understanding of lymphovenous hemostasis and its effect on lymphatic vessel maturation and synthesizes the outstanding questions in the field, with relationship to human disease.
DOI: 10.1182/blood-2016-04-636415
PubMed: 27385789
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000728
Links to Exploration step
pubmed:27385789Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation.</title>
<author><name sortKey="Welsh, John D" sort="Welsh, John D" uniqKey="Welsh J" first="John D" last="Welsh">John D. Welsh</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kahn, Mark L" sort="Kahn, Mark L" uniqKey="Kahn M" first="Mark L" last="Kahn">Mark L. Kahn</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sweet, Daniel T" sort="Sweet, Daniel T" uniqKey="Sweet D" first="Daniel T" last="Sweet">Daniel T. Sweet</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27385789</idno>
<idno type="pmid">27385789</idno>
<idno type="doi">10.1182/blood-2016-04-636415</idno>
<idno type="wicri:Area/PubMed/Corpus">000728</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000728</idno>
<idno type="wicri:Area/PubMed/Curation">000728</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000728</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation.</title>
<author><name sortKey="Welsh, John D" sort="Welsh, John D" uniqKey="Welsh J" first="John D" last="Welsh">John D. Welsh</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kahn, Mark L" sort="Kahn, Mark L" uniqKey="Kahn M" first="Mark L" last="Kahn">Mark L. Kahn</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sweet, Daniel T" sort="Sweet, Daniel T" uniqKey="Sweet D" first="Daniel T" last="Sweet">Daniel T. Sweet</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Blood Platelets (metabolism)</term>
<term>Blood Platelets (pathology)</term>
<term>Chylothorax (metabolism)</term>
<term>Chylothorax (pathology)</term>
<term>Chylothorax (physiopathology)</term>
<term>Humans</term>
<term>Lectins, C-Type (metabolism)</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Lymphatic Vessels (pathology)</term>
<term>Lymphedema (metabolism)</term>
<term>Lymphedema (pathology)</term>
<term>Lymphedema (physiopathology)</term>
<term>Membrane Glycoproteins (metabolism)</term>
<term>Mice</term>
<term>Platelet Activation</term>
<term>Thrombosis (metabolism)</term>
<term>Thrombosis (pathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation plaquettaire</term>
<term>Animaux</term>
<term>Chylothorax (anatomopathologie)</term>
<term>Chylothorax (métabolisme)</term>
<term>Chylothorax (physiopathologie)</term>
<term>Glycoprotéines membranaires (métabolisme)</term>
<term>Humains</term>
<term>Lectines de type C (métabolisme)</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (métabolisme)</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Plaquettes (anatomopathologie)</term>
<term>Plaquettes (métabolisme)</term>
<term>Souris</term>
<term>Thrombose (anatomopathologie)</term>
<term>Thrombose (métabolisme)</term>
<term>Vaisseaux lymphatiques (anatomopathologie)</term>
<term>Vaisseaux lymphatiques (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lectins, C-Type</term>
<term>Membrane Glycoproteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Chylothorax</term>
<term>Lymphoedème</term>
<term>Plaquettes</term>
<term>Thrombose</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Blood Platelets</term>
<term>Chylothorax</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
<term>Thrombosis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chylothorax</term>
<term>Glycoprotéines membranaires</term>
<term>Lectines de type C</term>
<term>Lymphoedème</term>
<term>Plaquettes</term>
<term>Thrombose</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Blood Platelets</term>
<term>Chylothorax</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
<term>Thrombosis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Chylothorax</term>
<term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Chylothorax</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Mice</term>
<term>Platelet Activation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation plaquettaire</term>
<term>Animaux</term>
<term>Humains</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Aside from the established role for platelets in regulating hemostasis and thrombosis, recent research has revealed a discrete role for platelets in the separation of the blood and lymphatic vascular systems. Platelets are activated by interaction with lymphatic endothelial cells at the lymphovenous junction, the site in the body where the lymphatic system drains into the blood vascular system, resulting in a platelet plug that, with the lymphovenous valve, prevents blood from entering the lymphatic circulation. This process, known as "lymphovenous hemostasis," is mediated by activation of platelet CLEC-2 receptors by the transmembrane ligand podoplanin expressed by lymphatic endothelial cells. Lymphovenous hemostasis is required for normal lymph flow, and mice deficient in lymphovenous hemostasis exhibit lymphedema and sometimes chylothorax phenotypes indicative of lymphatic insufficiency. Unexpectedly, the loss of lymph flow in these mice causes defects in maturation of collecting lymphatic vessels and lymphatic valve formation, uncovering an important role for fluid flow in driving endothelial cell signaling during development of collecting lymphatics. This article summarizes the current understanding of lymphovenous hemostasis and its effect on lymphatic vessel maturation and synthesizes the outstanding questions in the field, with relationship to human disease.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27385789</PMID>
<DateCreated><Year>2016</Year>
<Month>09</Month>
<Day>02</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>08</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>08</Month>
<Day>04</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1528-0020</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>128</Volume>
<Issue>9</Issue>
<PubDate><Year>2016</Year>
<Month>Sep</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Blood</Title>
<ISOAbbreviation>Blood</ISOAbbreviation>
</Journal>
<ArticleTitle>Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation.</ArticleTitle>
<Pagination><MedlinePgn>1169-73</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1182/blood-2016-04-636415</ELocationID>
<Abstract><AbstractText>Aside from the established role for platelets in regulating hemostasis and thrombosis, recent research has revealed a discrete role for platelets in the separation of the blood and lymphatic vascular systems. Platelets are activated by interaction with lymphatic endothelial cells at the lymphovenous junction, the site in the body where the lymphatic system drains into the blood vascular system, resulting in a platelet plug that, with the lymphovenous valve, prevents blood from entering the lymphatic circulation. This process, known as "lymphovenous hemostasis," is mediated by activation of platelet CLEC-2 receptors by the transmembrane ligand podoplanin expressed by lymphatic endothelial cells. Lymphovenous hemostasis is required for normal lymph flow, and mice deficient in lymphovenous hemostasis exhibit lymphedema and sometimes chylothorax phenotypes indicative of lymphatic insufficiency. Unexpectedly, the loss of lymph flow in these mice causes defects in maturation of collecting lymphatic vessels and lymphatic valve formation, uncovering an important role for fluid flow in driving endothelial cell signaling during development of collecting lymphatics. This article summarizes the current understanding of lymphovenous hemostasis and its effect on lymphatic vessel maturation and synthesizes the outstanding questions in the field, with relationship to human disease.</AbstractText>
<CopyrightInformation>© 2016 by The American Society of Hematology.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Welsh</LastName>
<ForeName>John D</ForeName>
<Initials>JD</Initials>
<AffiliationInfo><Affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kahn</LastName>
<ForeName>Mark L</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sweet</LastName>
<ForeName>Daniel T</ForeName>
<Initials>DT</Initials>
<AffiliationInfo><Affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>07</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Blood</MedlineTA>
<NlmUniqueID>7603509</NlmUniqueID>
<ISSNLinking>0006-4971</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C104778">CLEC2B protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D037181">Lectins, C-Type</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C117468">PDPN protein, human</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001792" MajorTopicYN="N">Blood Platelets</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002916" MajorTopicYN="N">Chylothorax</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D037181" MajorTopicYN="N">Lectins, C-Type</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015539" MajorTopicYN="Y">Platelet Activation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013927" MajorTopicYN="N">Thrombosis</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>04</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>07</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>7</Month>
<Day>8</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>7</Month>
<Day>8</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>8</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27385789</ArticleId>
<ArticleId IdType="pii">blood-2016-04-636415</ArticleId>
<ArticleId IdType="doi">10.1182/blood-2016-04-636415</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000728 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000728 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:27385789 |texte= Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:27385789" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |