Determinants of parasite drug resistance in human lymphatic filariasis.
Identifieur interne : 000513 ( PubMed/Curation ); précédent : 000512; suivant : 000514Determinants of parasite drug resistance in human lymphatic filariasis.
Auteurs : F. Cobo [Espagne]Source :
- Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia [ 1988-9518 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- parasitologie : Filariose lymphatique.
- pharmacologie : Filaricides.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Filaricides.
- Humains, Résistance aux substances.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Filaricides.
- drug therapy : Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- chemical , therapeutic use : Filaricides.
- Drug Resistance, Humans.
Abstract
Infection with filarial nematodes remains endemic in several countries worldwide and some of these infections are commonly associated with severe disease. The elimination of lymphatic filariasis relies on drug administration using the three drugs currently available for treatment: diethylcarbamazine, albendazole, and ivermectin. However, development of drug resistance is a reported phenomenon. The issue of resistance to antihelminthics used in humans has become increasing importance since the global program to eliminate lymphatic filariasis is implemented in larger population groups and the duration of the program is increasing. Recently, ivermectin resistance has been reported in Ghana, and widespread of resistance to benzimidazole (such as albendazole) is present because specific mutations in the gene encoding β-tubulin have been associated with drug resistance. Moreover, it is well known that diethylcarbamazine susceptibility is not 100% for lymphatic filariasis treatment. A review of the mechanisms of resistance to these antihelminthics is necessary in order to optimize the treatment for human lymphatic filariasis.
PubMed: 27858056
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Cobo</name><affiliation wicri:level="1"><nlm:affiliation>Dr. Fernando Cobo, Department of Microbiology and Parasitology Hospital Universitario Virgen de las Nieves Avda Fuerzas Armadas, 2 - 18014 Granada, Spain. fernando.cobo.sspa@juntadeandalucia.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Dr. Fernando Cobo, Department of Microbiology and Parasitology Hospital Universitario Virgen de las Nieves Avda Fuerzas Armadas, 2 - 18014 Granada</wicri:regionArea></affiliation></author></analytic><series><title level="j">Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia</title><idno type="eISSN">1988-9518</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Drug Resistance</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Filaricides (pharmacology)</term><term>Filaricides (therapeutic use)</term><term>Humans</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Filaricides (pharmacologie)</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Résistance aux substances</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Filaricides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Filaricides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Resistance</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Résistance aux substances</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infection with filarial nematodes remains endemic in several countries worldwide and some of these infections are commonly associated with severe disease. The elimination of lymphatic filariasis relies on drug administration using the three drugs currently available for treatment: diethylcarbamazine, albendazole, and ivermectin. However, development of drug resistance is a reported phenomenon. The issue of resistance to antihelminthics used in humans has become increasing importance since the global program to eliminate lymphatic filariasis is implemented in larger population groups and the duration of the program is increasing. Recently, ivermectin resistance has been reported in Ghana, and widespread of resistance to benzimidazole (such as albendazole) is present because specific mutations in the gene encoding β-tubulin have been associated with drug resistance. Moreover, it is well known that diethylcarbamazine susceptibility is not 100% for lymphatic filariasis treatment. A review of the mechanisms of resistance to these antihelminthics is necessary in order to optimize the treatment for human lymphatic filariasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27858056</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>18</Day></DateCreated><DateCompleted><Year>2017</Year><Month>04</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>04</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1988-9518</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia</Title><ISOAbbreviation>Rev Esp Quimioter</ISOAbbreviation></Journal><ArticleTitle>Determinants of parasite drug resistance in human lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>288-295</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">cobo17nov2016</ELocationID><Abstract><AbstractText>Infection with filarial nematodes remains endemic in several countries worldwide and some of these infections are commonly associated with severe disease. The elimination of lymphatic filariasis relies on drug administration using the three drugs currently available for treatment: diethylcarbamazine, albendazole, and ivermectin. However, development of drug resistance is a reported phenomenon. The issue of resistance to antihelminthics used in humans has become increasing importance since the global program to eliminate lymphatic filariasis is implemented in larger population groups and the duration of the program is increasing. Recently, ivermectin resistance has been reported in Ghana, and widespread of resistance to benzimidazole (such as albendazole) is present because specific mutations in the gene encoding β-tubulin have been associated with drug resistance. Moreover, it is well known that diethylcarbamazine susceptibility is not 100% for lymphatic filariasis treatment. A review of the mechanisms of resistance to these antihelminthics is necessary in order to optimize the treatment for human lymphatic filariasis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cobo</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Dr. Fernando Cobo, Department of Microbiology and Parasitology Hospital Universitario Virgen de las Nieves Avda Fuerzas Armadas, 2 - 18014 Granada, Spain. fernando.cobo.sspa@juntadeandalucia.es.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Spain</Country><MedlineTA>Rev Esp Quimioter</MedlineTA><NlmUniqueID>9108821</NlmUniqueID><ISSNLinking>0214-3429</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005369">Filaricides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D004351" MajorTopicYN="N">Drug Resistance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005369" MajorTopicYN="N">Filaricides</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27858056</ArticleId><ArticleId IdType="pii">cobo17nov2016</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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