Establishment of an Acquired Lymphedema Model in the Mouse Hindlimb: Technical Refinement and Molecular Characteristics.
Identifieur interne : 000439 ( PubMed/Curation ); précédent : 000438; suivant : 000440Establishment of an Acquired Lymphedema Model in the Mouse Hindlimb: Technical Refinement and Molecular Characteristics.
Auteurs : Daisuke Iwasaki ; Yuhei Yamamoto ; Naoki Murao ; Akihiko Oyama ; Emi Funayama ; Hiroshi FurukawaSource :
- Plastic and reconstructive surgery [ 1529-4242 ] ; 2017.
Descripteurs français
- KwdFr :
- ARN (analyse), ARN messager (analyse), Animaux, Facteur de croissance endothéliale vasculaire de type A (analyse), Facteur de croissance endothéliale vasculaire de type C (analyse), Immunohistochimie, Lymphe (physiologie), Lymphoedème (anatomopathologie), Lymphoedème (étiologie), Lymphographie, Membre pelvien, Modèles animaux de maladie humaine, Mâle, Noeuds lymphatiques (), Protéines suppresseurs de tumeurs (analyse), Protéines à homéodomaine (analyse), Réaction de polymérisation en chaine en temps réel, Récepteur-3 au facteur croissance endothéliale vasculaire (analyse), Souris, Souris de lignée C57BL, Système lymphatique (physiologie), Vert indocyanine.
- MESH :
- analyse : ARN, ARN messager, Facteur de croissance endothéliale vasculaire de type A, Facteur de croissance endothéliale vasculaire de type C, Protéines suppresseurs de tumeurs, Protéines à homéodomaine, Récepteur-3 au facteur croissance endothéliale vasculaire.
- anatomopathologie : Lymphoedème.
- physiologie : Lymphe, Système lymphatique.
- étiologie : Lymphoedème.
- Animaux, Immunohistochimie, Lymphographie, Membre pelvien, Modèles animaux de maladie humaine, Mâle, Noeuds lymphatiques, Réaction de polymérisation en chaine en temps réel, Souris, Souris de lignée C57BL, Vert indocyanine.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Hindlimb, Homeodomain Proteins (analysis), Immunohistochemistry, Indocyanine Green, Lymph (physiology), Lymph Nodes (surgery), Lymphatic System (physiology), Lymphedema (etiology), Lymphedema (pathology), Lymphography, Male, Mice, Mice, Inbred C57BL, RNA (analysis), RNA, Messenger (analysis), Real-Time Polymerase Chain Reaction, Tumor Suppressor Proteins (analysis), Vascular Endothelial Growth Factor A (analysis), Vascular Endothelial Growth Factor C (analysis), Vascular Endothelial Growth Factor Receptor-3 (analysis).
- MESH :
- chemical , analysis : Homeodomain Proteins, RNA, RNA, Messenger, Tumor Suppressor Proteins, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor Receptor-3.
- etiology : Lymphedema.
- pathology : Lymphedema.
- physiology : Lymph, Lymphatic System.
- surgery : Lymph Nodes.
- Animals, Disease Models, Animal, Hindlimb, Immunohistochemistry, Indocyanine Green, Lymphography, Male, Mice, Mice, Inbred C57BL, Real-Time Polymerase Chain Reaction.
Abstract
The pathophysiology of secondary lymphedema remains poorly understood. This study aimed to establish a consistent mouse hindlimb lymphedema model for further investigation of the mechanism and treatment of lymphedema.
DOI: 10.1097/PRS.0000000000002887
PubMed: 28027235
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Daisuke Iwasaki<affiliation><nlm:affiliation>Sapporo, Hokkaido, Japan From the Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido.</nlm:affiliation>
<wicri:noCountry code="subField">University of Hokkaido</wicri:noCountry>
</affiliation>
Le document en format XML
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<author><name sortKey="Yamamoto, Yuhei" sort="Yamamoto, Yuhei" uniqKey="Yamamoto Y" first="Yuhei" last="Yamamoto">Yuhei Yamamoto</name>
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<term>Immunohistochemistry</term>
<term>Indocyanine Green</term>
<term>Lymph (physiology)</term>
<term>Lymph Nodes (surgery)</term>
<term>Lymphatic System (physiology)</term>
<term>Lymphedema (etiology)</term>
<term>Lymphedema (pathology)</term>
<term>Lymphography</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>RNA (analysis)</term>
<term>RNA, Messenger (analysis)</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Tumor Suppressor Proteins (analysis)</term>
<term>Vascular Endothelial Growth Factor A (analysis)</term>
<term>Vascular Endothelial Growth Factor C (analysis)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (analysis)</term>
</keywords>
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<term>ARN messager (analyse)</term>
<term>Animaux</term>
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<term>Facteur de croissance endothéliale vasculaire de type C (analyse)</term>
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<term>Lymphe (physiologie)</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (étiologie)</term>
<term>Lymphographie</term>
<term>Membre pelvien</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Noeuds lymphatiques ()</term>
<term>Protéines suppresseurs de tumeurs (analyse)</term>
<term>Protéines à homéodomaine (analyse)</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
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<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Système lymphatique (physiologie)</term>
<term>Vert indocyanine</term>
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<term>Vascular Endothelial Growth Factor A</term>
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<term>ARN messager</term>
<term>Facteur de croissance endothéliale vasculaire de type A</term>
<term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Protéines à homéodomaine</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphe</term>
<term>Système lymphatique</term>
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<term>Lymphatic System</term>
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<term>Disease Models, Animal</term>
<term>Hindlimb</term>
<term>Immunohistochemistry</term>
<term>Indocyanine Green</term>
<term>Lymphography</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Real-Time Polymerase Chain Reaction</term>
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<term>Immunohistochimie</term>
<term>Lymphographie</term>
<term>Membre pelvien</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Noeuds lymphatiques</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
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<front><div type="abstract" xml:lang="en">The pathophysiology of secondary lymphedema remains poorly understood. This study aimed to establish a consistent mouse hindlimb lymphedema model for further investigation of the mechanism and treatment of lymphedema.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28027235</PMID>
<DateCreated><Year>2016</Year>
<Month>12</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>06</Month>
<Day>01</Day>
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<DateRevised><Year>2017</Year>
<Month>08</Month>
<Day>17</Day>
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<JournalIssue CitedMedium="Internet"><Volume>139</Volume>
<Issue>1</Issue>
<PubDate><Year>2017</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Plastic and reconstructive surgery</Title>
<ISOAbbreviation>Plast. Reconstr. Surg.</ISOAbbreviation>
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<ArticleTitle>Establishment of an Acquired Lymphedema Model in the Mouse Hindlimb: Technical Refinement and Molecular Characteristics.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The pathophysiology of secondary lymphedema remains poorly understood. This study aimed to establish a consistent mouse hindlimb lymphedema model for further investigation of the mechanism and treatment of lymphedema.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The authors developed a novel postsurgical lymphedema model in the mouse hindlimb by modifying previously described methods. Lymphedema in the hindlimb was created by removing both the inguinal and popliteal lymph nodes together with the surrounding fat pads, followed by silicone splint placement in the inguinal region. Using this modified mouse model, the authors analyzed lymphatic function, histologic changes, and the expression of lymphangiogenic factors including vascular endothelial growth factor C at various time points.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The splinted lymphedema model showed a significant increase of edema formation in the hindlimb compared with the sham surgery control animals. Indocyanine green lymphography revealed lymphatic drainage impairment shown by dermal backflow and rerouting of lymph flow in the lymphedema model. Histopathologic and immunohistochemical examinations showed a significant increase of skin thickness and abnormally dilated lymphatics in the lymphedema model. The expression of lymphangiogenic factors in lymphedematous tissues of the splinted lymphedema model was significantly increased compared with controls, depending on the degree of lymphedema.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This splinted lymphedema model closely simulates the volume response, histopathology, and lymphography characteristics of human acquired lymphedema. Given these similarities to human lymphedema, this refinement of a mouse hindlimb model of acquired lymphedema represents a promising platform for the study of lymphatic vascular insufficiency and for the evaluation of new therapeutic modalities.</AbstractText>
</Abstract>
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<AffiliationInfo><Affiliation>Sapporo, Hokkaido, Japan From the Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido.</Affiliation>
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