LymphedemaV1, PubMed, Curation, bibRecord, 000358

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

Identifieur interne : 000358 ( PubMed/Curation ); précédent : 000357; suivant : 000359

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

Auteurs : Heinrich Schlums [Suède] ; Moonjung Jung [États-Unis] ; Hongya Han [Suède] ; Jakob Theorell [Suède] ; Venetia Bigley [Royaume-Uni] ; Samuel C C. Chiang [Suède] ; David S J. Allan [États-Unis] ; Jan K. Davidson-Moncada [États-Unis] ; Rachel E. Dickinson [Royaume-Uni] ; Tim D. Holmes [Suède] ; Amy P. Hsu [États-Unis] ; Danielle Townsley [États-Unis] ; Thomas Winkler [États-Unis] ; Weixin Wang ; P L Aukrust [Norvège] ; Ingvild Nord Y [Norvège] ; Katherine R. Calvo ; Steve M. Holland [États-Unis] ; Matthew Collin [Royaume-Uni] ; Cynthia E. Dunbar [États-Unis] ; Yenan T. Bryceson [Suède]

Source :

Blood [ 1528-0020 ] ; 2017.

RBID : pubmed:28209719

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adult, Calmodulin-Binding Proteins (genetics), Calmodulin-Binding Proteins (immunology), Cell Proliferation, Child, Female, GATA2 Transcription Factor (genetics), GATA2 Transcription Factor (immunology), Hematopoietic Stem Cells (immunology), Humans, Interleukin-12 (genetics), Interleukin-12 (immunology), Interleukin-18 (genetics), Interleukin-18 (immunology), Killer Cells, Natural (immunology), Male, Middle Aged, Mutation, RNA-Binding Proteins (genetics), RNA-Binding Proteins (immunology), Receptors, IgE (genetics), Receptors, IgE (immunology), Syk Kinase (genetics), Syk Kinase (immunology), Transcription Factors (genetics), Transcription Factors (immunology).
MESH :
- chemical , genetics : Calmodulin-Binding Proteins, GATA2 Transcription Factor, Interleukin-12, Interleukin-18, RNA-Binding Proteins, Receptors, IgE, Syk Kinase, Transcription Factors.
- chemical , immunology : Calmodulin-Binding Proteins, GATA2 Transcription Factor, Interleukin-12, Interleukin-18, RNA-Binding Proteins, Receptors, IgE, Syk Kinase, Transcription Factors.
- immunology : Hematopoietic Stem Cells, Killer Cells, Natural.
- Adolescent, Adult, Cell Proliferation, Child, Female, Humans, Male, Middle Aged, Mutation.

Abstract

Heterozygous GATA2 mutation is associated with immunodeficiency, lymphedema, and myelodysplastic syndrome. Disease presentation is variable, often coinciding with loss of circulating dendritic cells, monocytes, B cells, and natural killer (NK) cells. Nonetheless, in a proportion of patients carrying GATA2 mutation, NK cells persist. We found that peripheral blood NK cells in symptomatic patients uniformly lacked expression of the transcription factor promyelocytic leukemia zinc finger (PLZF), as well as expression of intracellular signaling proteins FcεRγ, spleen tyrosine kinase (SYK), and EWS/FLI1-Activated Transcript 2 (EAT-2) in a variegated manner. Moreover, consistent with an adaptive identity, NK cells from patients with GATA2 mutation displayed altered expression of cytotoxic granule constituents and produced interferon-γ upon Fc-receptor engagement but not following combined interleukin-12 (IL-12) and IL-18 stimulation. Canonical, PLZF-expressing NK cells were retained in asymptomatic carriers of GATA2 mutation. Developmentally, GATA-binding protein-2 (GATA-2) was expressed in hematopoietic stem cells, but not in NK-cell progenitors, CD3(-)CD56(bright), canonical, or adaptive CD3(-)CD56(dim) NK cells. Peripheral blood NK cells from individuals with GATA2 mutation proliferated normally in vitro, whereas lineage-negative progenitors displayed impaired NK-cell differentiation. In summary, adaptive NK cells can persist in patients with GATA2 mutation, even after NK-cell progenitors expire. Moreover, our data suggest that adaptive NK cells are more long-lived than canonical, immunoregulatory NK cells.

DOI: 10.1182/blood-2016-08-734236
PubMed: 28209719

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Weixin Wang

<affiliation><nlm:affiliation>Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD; and.</nlm:affiliation>
<wicri:noCountry code="subField">MD; and</wicri:noCountry>
</affiliation>

Katherine R. Calvo

<affiliation><nlm:affiliation>Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD; and.</nlm:affiliation>
<wicri:noCountry code="subField">MD; and</wicri:noCountry>
</affiliation>

Le document en format XML

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<author><name sortKey="Aukrust, P L" sort="Aukrust, P L" uniqKey="Aukrust P" first="P L" last="Aukrust">P L Aukrust</name>
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<author><name sortKey="Collin, Matthew" sort="Collin, Matthew" uniqKey="Collin M" first="Matthew" last="Collin">Matthew Collin</name>
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<author><name sortKey="Dunbar, Cynthia E" sort="Dunbar, Cynthia E" uniqKey="Dunbar C" first="Cynthia E" last="Dunbar">Cynthia E. Dunbar</name>
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<author><name sortKey="Bryceson, Yenan T" sort="Bryceson, Yenan T" uniqKey="Bryceson Y" first="Yenan T" last="Bryceson">Yenan T. Bryceson</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.</title>
<author><name sortKey="Schlums, Heinrich" sort="Schlums, Heinrich" uniqKey="Schlums H" first="Heinrich" last="Schlums">Heinrich Schlums</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
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</affiliation>
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<author><name sortKey="Jung, Moonjung" sort="Jung, Moonjung" uniqKey="Jung M" first="Moonjung" last="Jung">Moonjung Jung</name>
<affiliation wicri:level="2"><nlm:affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
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<author><name sortKey="Han, Hongya" sort="Han, Hongya" uniqKey="Han H" first="Hongya" last="Han">Hongya Han</name>
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<country xml:lang="fr">Suède</country>
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<author><name sortKey="Theorell, Jakob" sort="Theorell, Jakob" uniqKey="Theorell J" first="Jakob" last="Theorell">Jakob Theorell</name>
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<country xml:lang="fr">Suède</country>
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<author><name sortKey="Bigley, Venetia" sort="Bigley, Venetia" uniqKey="Bigley V" first="Venetia" last="Bigley">Venetia Bigley</name>
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</affiliation>
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<author><name sortKey="Chiang, Samuel C C" sort="Chiang, Samuel C C" uniqKey="Chiang S" first="Samuel C C" last="Chiang">Samuel C C. Chiang</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea>
</affiliation>
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<author><name sortKey="Allan, David S J" sort="Allan, David S J" uniqKey="Allan D" first="David S J" last="Allan">David S J. Allan</name>
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<author><name sortKey="Davidson Moncada, Jan K" sort="Davidson Moncada, Jan K" uniqKey="Davidson Moncada J" first="Jan K" last="Davidson-Moncada">Jan K. Davidson-Moncada</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
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<author><name sortKey="Dickinson, Rachel E" sort="Dickinson, Rachel E" uniqKey="Dickinson R" first="Rachel E" last="Dickinson">Rachel E. Dickinson</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Holmes, Tim D" sort="Holmes, Tim D" uniqKey="Holmes T" first="Tim D" last="Holmes">Tim D. Holmes</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea>
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<author><name sortKey="Hsu, Amy P" sort="Hsu, Amy P" uniqKey="Hsu A" first="Amy P" last="Hsu">Amy P. Hsu</name>
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<author><name sortKey="Townsley, Danielle" sort="Townsley, Danielle" uniqKey="Townsley D" first="Danielle" last="Townsley">Danielle Townsley</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Winkler, Thomas" sort="Winkler, Thomas" uniqKey="Winkler T" first="Thomas" last="Winkler">Thomas Winkler</name>
<affiliation wicri:level="2"><nlm:affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
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<author><name sortKey="Wang, Weixin" sort="Wang, Weixin" uniqKey="Wang W" first="Weixin" last="Wang">Weixin Wang</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD; and.</nlm:affiliation>
<wicri:noCountry code="subField">MD; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Aukrust, P L" sort="Aukrust, P L" uniqKey="Aukrust P" first="P L" last="Aukrust">P L Aukrust</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nord Y, Ingvild" sort="Nord Y, Ingvild" uniqKey="Nord Y I" first="Ingvild" last="Nord Y">Ingvild Nord Y</name>
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<country xml:lang="fr">Norvège</country>
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<author><name sortKey="Calvo, Katherine R" sort="Calvo, Katherine R" uniqKey="Calvo K" first="Katherine R" last="Calvo">Katherine R. Calvo</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD; and.</nlm:affiliation>
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<author><name sortKey="Holland, Steve M" sort="Holland, Steve M" uniqKey="Holland S" first="Steve M" last="Holland">Steve M. Holland</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Collin, Matthew" sort="Collin, Matthew" uniqKey="Collin M" first="Matthew" last="Collin">Matthew Collin</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
</affiliation>
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<author><name sortKey="Dunbar, Cynthia E" sort="Dunbar, Cynthia E" uniqKey="Dunbar C" first="Cynthia E" last="Dunbar">Cynthia E. Dunbar</name>
<affiliation wicri:level="2"><nlm:affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bryceson, Yenan T" sort="Bryceson, Yenan T" uniqKey="Bryceson Y" first="Yenan T" last="Bryceson">Yenan T. Bryceson</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea>
</affiliation>
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<series><title level="j">Blood</title>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2017" type="published">2017</date>
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<term>Adult</term>
<term>Calmodulin-Binding Proteins (genetics)</term>
<term>Calmodulin-Binding Proteins (immunology)</term>
<term>Cell Proliferation</term>
<term>Child</term>
<term>Female</term>
<term>GATA2 Transcription Factor (genetics)</term>
<term>GATA2 Transcription Factor (immunology)</term>
<term>Hematopoietic Stem Cells (immunology)</term>
<term>Humans</term>
<term>Interleukin-12 (genetics)</term>
<term>Interleukin-12 (immunology)</term>
<term>Interleukin-18 (genetics)</term>
<term>Interleukin-18 (immunology)</term>
<term>Killer Cells, Natural (immunology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>RNA-Binding Proteins (genetics)</term>
<term>RNA-Binding Proteins (immunology)</term>
<term>Receptors, IgE (genetics)</term>
<term>Receptors, IgE (immunology)</term>
<term>Syk Kinase (genetics)</term>
<term>Syk Kinase (immunology)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (immunology)</term>
</keywords>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Cellules souches hématopoïétiques (immunologie)</term>
<term>Cellules tueuses naturelles (immunologie)</term>
<term>Enfant</term>
<term>Facteur de transcription GATA-2 (génétique)</term>
<term>Facteur de transcription GATA-2 (immunologie)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (immunologie)</term>
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<term>Humains</term>
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<term>Interleukine-12 (immunologie)</term>
<term>Interleukine-18 (génétique)</term>
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<term>Mutation</term>
<term>Mâle</term>
<term>Prolifération cellulaire</term>
<term>Protéines de liaison à l'ARN (génétique)</term>
<term>Protéines de liaison à l'ARN (immunologie)</term>
<term>Protéines de liaison à la calmoduline (génétique)</term>
<term>Protéines de liaison à la calmoduline (immunologie)</term>
<term>Récepteurs aux IgE (génétique)</term>
<term>Récepteurs aux IgE (immunologie)</term>
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<term>Syk kinase (immunologie)</term>
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<term>GATA2 Transcription Factor</term>
<term>Interleukin-12</term>
<term>Interleukin-18</term>
<term>RNA-Binding Proteins</term>
<term>Receptors, IgE</term>
<term>Syk Kinase</term>
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<term>Interleukin-18</term>
<term>RNA-Binding Proteins</term>
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<term>Cellules tueuses naturelles</term>
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<term>Facteurs de transcription</term>
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<term>Syk kinase</term>
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<term>Killer Cells, Natural</term>
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<term>Cell Proliferation</term>
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<term>Female</term>
<term>Humans</term>
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<term>Mutation</term>
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<term>Femelle</term>
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<front><div type="abstract" xml:lang="en">Heterozygous GATA2 mutation is associated with immunodeficiency, lymphedema, and myelodysplastic syndrome. Disease presentation is variable, often coinciding with loss of circulating dendritic cells, monocytes, B cells, and natural killer (NK) cells. Nonetheless, in a proportion of patients carrying GATA2 mutation, NK cells persist. We found that peripheral blood NK cells in symptomatic patients uniformly lacked expression of the transcription factor promyelocytic leukemia zinc finger (PLZF), as well as expression of intracellular signaling proteins FcεRγ, spleen tyrosine kinase (SYK), and EWS/FLI1-Activated Transcript 2 (EAT-2) in a variegated manner. Moreover, consistent with an adaptive identity, NK cells from patients with GATA2 mutation displayed altered expression of cytotoxic granule constituents and produced interferon-γ upon Fc-receptor engagement but not following combined interleukin-12 (IL-12) and IL-18 stimulation. Canonical, PLZF-expressing NK cells were retained in asymptomatic carriers of GATA2 mutation. Developmentally, GATA-binding protein-2 (GATA-2) was expressed in hematopoietic stem cells, but not in NK-cell progenitors, CD3(-)CD56(bright), canonical, or adaptive CD3(-)CD56(dim) NK cells. Peripheral blood NK cells from individuals with GATA2 mutation proliferated normally in vitro, whereas lineage-negative progenitors displayed impaired NK-cell differentiation. In summary, adaptive NK cells can persist in patients with GATA2 mutation, even after NK-cell progenitors expire. Moreover, our data suggest that adaptive NK cells are more long-lived than canonical, immunoregulatory NK cells.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28209719</PMID>
<DateCreated><Year>2017</Year>
<Month>02</Month>
<Day>17</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>08</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>08</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1528-0020</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>129</Volume>
<Issue>14</Issue>
<PubDate><Year>2017</Year>
<Month>Apr</Month>
<Day>06</Day>
</PubDate>
</JournalIssue>
<Title>Blood</Title>
<ISOAbbreviation>Blood</ISOAbbreviation>
</Journal>
<ArticleTitle>Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.</ArticleTitle>
<Pagination><MedlinePgn>1927-1939</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1182/blood-2016-08-734236</ELocationID>
<Abstract><AbstractText>Heterozygous GATA2 mutation is associated with immunodeficiency, lymphedema, and myelodysplastic syndrome. Disease presentation is variable, often coinciding with loss of circulating dendritic cells, monocytes, B cells, and natural killer (NK) cells. Nonetheless, in a proportion of patients carrying GATA2 mutation, NK cells persist. We found that peripheral blood NK cells in symptomatic patients uniformly lacked expression of the transcription factor promyelocytic leukemia zinc finger (PLZF), as well as expression of intracellular signaling proteins FcεRγ, spleen tyrosine kinase (SYK), and EWS/FLI1-Activated Transcript 2 (EAT-2) in a variegated manner. Moreover, consistent with an adaptive identity, NK cells from patients with GATA2 mutation displayed altered expression of cytotoxic granule constituents and produced interferon-γ upon Fc-receptor engagement but not following combined interleukin-12 (IL-12) and IL-18 stimulation. Canonical, PLZF-expressing NK cells were retained in asymptomatic carriers of GATA2 mutation. Developmentally, GATA-binding protein-2 (GATA-2) was expressed in hematopoietic stem cells, but not in NK-cell progenitors, CD3(-)CD56(bright), canonical, or adaptive CD3(-)CD56(dim) NK cells. Peripheral blood NK cells from individuals with GATA2 mutation proliferated normally in vitro, whereas lineage-negative progenitors displayed impaired NK-cell differentiation. In summary, adaptive NK cells can persist in patients with GATA2 mutation, even after NK-cell progenitors expire. Moreover, our data suggest that adaptive NK cells are more long-lived than canonical, immunoregulatory NK cells.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schlums</LastName>
<ForeName>Heinrich</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jung</LastName>
<ForeName>Moonjung</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Han</LastName>
<ForeName>Hongya</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Theorell</LastName>
<ForeName>Jakob</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bigley</LastName>
<ForeName>Venetia</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chiang</LastName>
<ForeName>Samuel C C</ForeName>
<Initials>SC</Initials>
<AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Allan</LastName>
<ForeName>David S J</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Davidson-Moncada</LastName>
<ForeName>Jan K</ForeName>
<Initials>JK</Initials>
<AffiliationInfo><Affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dickinson</LastName>
<ForeName>Rachel E</ForeName>
<Initials>RE</Initials>
<AffiliationInfo><Affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holmes</LastName>
<ForeName>Tim D</ForeName>
<Initials>TD</Initials>
<AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Broegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, Bergen, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hsu</LastName>
<ForeName>Amy P</ForeName>
<Initials>AP</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Townsley</LastName>
<ForeName>Danielle</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Winkler</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Weixin</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aukrust</LastName>
<ForeName>Pål</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nordøy</LastName>
<ForeName>Ingvild</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Calvo</LastName>
<ForeName>Katherine R</ForeName>
<Initials>KR</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holland</LastName>
<ForeName>Steve M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Collin</LastName>
<ForeName>Matthew</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dunbar</LastName>
<ForeName>Cynthia E</ForeName>
<Initials>CE</Initials>
<AffiliationInfo><Affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bryceson</LastName>
<ForeName>Yenan T</ForeName>
<Initials>YT</Initials>
<AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Broegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, Bergen, Norway.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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</PublicationTypeList>
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<Month>02</Month>
<Day>16</Day>
</ArticleDate>
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<MedlineTA>Blood</MedlineTA>
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<ISSNLinking>0006-4971</ISSNLinking>
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</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C500986">EWSR1 protein, human</NameOfSubstance>
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Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

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