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Factors Associated with Lymphosclerosis: An Analysis on 962 Lymphatic Vessels.

Identifieur interne : 000149 ( PubMed/Curation ); précédent : 000148; suivant : 000150

Factors Associated with Lymphosclerosis: An Analysis on 962 Lymphatic Vessels.

Auteurs : Takumi Yamamoto [Japon] ; Nana Yamamoto ; Hidehiko Yoshimatsu ; Mitsunaga Narushima ; Isao Koshima

Source :

RBID : pubmed:28609348

Abstract

Lymphaticovenular anastomosis (LVA) is a useful treatment option for compression-refractory lower extremity lymphedema (LEL), but its efficacy largely depends on severity of lymphosclerosis. To maximize LVA efficacy, it is important to elucidate factors associated with severe lymphosclerosis (SLS).

DOI: 10.1097/PRS.0000000000003690
PubMed: 28609348

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pubmed:28609348

Le document en format XML

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<title xml:lang="en">Factors Associated with Lymphosclerosis: An Analysis on 962 Lymphatic Vessels.</title>
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<name sortKey="Yamamoto, Takumi" sort="Yamamoto, Takumi" uniqKey="Yamamoto T" first="Takumi" last="Yamamoto">Takumi Yamamoto</name>
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<nlm:affiliation>1 Department of Plastic Surgery, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan 2 Department of Plastic and Reconstructive Surgery, the University of Tokyo Hospital, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1 Department of Plastic Surgery, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan 2 Department of Plastic and Reconstructive Surgery, the University of Tokyo Hospital, Tokyo</wicri:regionArea>
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<name sortKey="Yamamoto, Nana" sort="Yamamoto, Nana" uniqKey="Yamamoto N" first="Nana" last="Yamamoto">Nana Yamamoto</name>
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<name sortKey="Yoshimatsu, Hidehiko" sort="Yoshimatsu, Hidehiko" uniqKey="Yoshimatsu H" first="Hidehiko" last="Yoshimatsu">Hidehiko Yoshimatsu</name>
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<name sortKey="Narushima, Mitsunaga" sort="Narushima, Mitsunaga" uniqKey="Narushima M" first="Mitsunaga" last="Narushima">Mitsunaga Narushima</name>
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<name sortKey="Koshima, Isao" sort="Koshima, Isao" uniqKey="Koshima I" first="Isao" last="Koshima">Isao Koshima</name>
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<nlm:affiliation>1 Department of Plastic Surgery, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan 2 Department of Plastic and Reconstructive Surgery, the University of Tokyo Hospital, Tokyo, Japan.</nlm:affiliation>
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<name sortKey="Yamamoto, Nana" sort="Yamamoto, Nana" uniqKey="Yamamoto N" first="Nana" last="Yamamoto">Nana Yamamoto</name>
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<name sortKey="Yoshimatsu, Hidehiko" sort="Yoshimatsu, Hidehiko" uniqKey="Yoshimatsu H" first="Hidehiko" last="Yoshimatsu">Hidehiko Yoshimatsu</name>
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<name sortKey="Narushima, Mitsunaga" sort="Narushima, Mitsunaga" uniqKey="Narushima M" first="Mitsunaga" last="Narushima">Mitsunaga Narushima</name>
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<name sortKey="Koshima, Isao" sort="Koshima, Isao" uniqKey="Koshima I" first="Isao" last="Koshima">Isao Koshima</name>
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<title level="j">Plastic and reconstructive surgery</title>
<idno type="eISSN">1529-4242</idno>
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<div type="abstract" xml:lang="en">Lymphaticovenular anastomosis (LVA) is a useful treatment option for compression-refractory lower extremity lymphedema (LEL), but its efficacy largely depends on severity of lymphosclerosis. To maximize LVA efficacy, it is important to elucidate factors associated with severe lymphosclerosis (SLS).</div>
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<DateCreated>
<Year>2017</Year>
<Month>06</Month>
<Day>13</Day>
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<DateRevised>
<Year>2017</Year>
<Month>06</Month>
<Day>13</Day>
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<ISSN IssnType="Electronic">1529-4242</ISSN>
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<PubDate>
<Year>2017</Year>
<Month>Jun</Month>
<Day>12</Day>
</PubDate>
</JournalIssue>
<Title>Plastic and reconstructive surgery</Title>
<ISOAbbreviation>Plast. Reconstr. Surg.</ISOAbbreviation>
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<ArticleTitle>Factors Associated with Lymphosclerosis: An Analysis on 962 Lymphatic Vessels.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.1097/PRS.0000000000003690</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lymphaticovenular anastomosis (LVA) is a useful treatment option for compression-refractory lower extremity lymphedema (LEL), but its efficacy largely depends on severity of lymphosclerosis. To maximize LVA efficacy, it is important to elucidate factors associated with severe lymphosclerosis (SLS).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Medical charts of 134 LEL patients who underwent preoperative indocyanine green (ICG) lymphography and LVA were reviewed to obtain data of clinical demographics, ICG lymphography findings, and intraoperative findings. Based on intraoperative findings of lymphatic vessels, severity of lymphosclerosis were classified into s0, s1, s2, and s3. Lymphatic vessels with s3 sclerosis was defined as SLS. Logistic regression analysis was used to identify independent factors associated with SLS.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In total, 962 lymphatic vessels were analyzed, among which SLS was observed in 97 (10.1%). Multivariate analysis revealed that independent factors associated with SLS were higher body mass index (odds ration [OR], 1.803; 95% confidence interval [CI], 1.041-3.123; P = 0.035), incision site in the thigh/foot compared with in the groin (OR, 2.355/4.471; 95% CI 1.201-4.617/2.135-9.362; P = 0.013/< 0.001), and S-region/D-region on ICG lymphography compared with L-region (OR, 83.134/1441.126; 95% CI, 11.296-611.843/146.782-14149.195; P < 0.001/< 0.001). Inverse associations were observed in positive history of radiation (OR 0.461; 95% CI, 0.269-0.788; P = 0.005).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Independent factors associated with SLS were clarified. ICG lymphography pattern had the strongest association with SLS. D-region on ICG lymphography should be avoided for LVA.</AbstractText>
</Abstract>
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