LymphedemaV1, PubMed, Curation, bibRecord, 000090

Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes.

Identifieur interne : 000090 ( PubMed/Curation ); précédent : 000089; suivant : 000091

Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes.

Auteurs : Ulrich F. Prodjinotho [Allemagne] ; Charlotte Von Horn [Allemagne] ; Alex Y. Debrah [Ghana] ; Linda Batsa Debrah [Ghana] ; Anna Albers [Allemagne] ; Laura E. Layland [Allemagne] ; Achim Hoerauf [Allemagne] ; Tomabu Adjobimey [Allemagne]

Source :

PLoS neglected tropical diseases [ 1935-2735 ] ; 2017.

RBID : pubmed:28742098

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (immunologie), Brugia malayi, Cytokines (immunologie), Dégranulation cellulaire, Essais contrôlés randomisés comme sujet, Filariose lymphatique (immunologie), Granulocytes (immunologie), Humains, Immunoglobuline E (sang), Immunoglobuline G (sang), Jeune adulte, Mâle, Test ELISA, Études cas-témoins.
MESH :
- immunologie : Antigènes d'helminthe, Cytokines, Filariose lymphatique, Granulocytes.
- sang : Anticorps antihelminthe, Immunoglobuline E, Immunoglobuline G.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Brugia malayi, Dégranulation cellulaire, Essais contrôlés randomisés comme sujet, Humains, Jeune adulte, Mâle, Test ELISA, Études cas-témoins.

English descriptors

KwdEn :
- Adolescent, Adult, Animals, Antibodies, Helminth (blood), Antigens, Helminth (immunology), Brugia malayi, Case-Control Studies, Cell Degranulation, Cytokines (immunology), Elephantiasis, Filarial (immunology), Enzyme-Linked Immunosorbent Assay, Granulocytes (immunology), Humans, Immunoglobulin E (blood), Immunoglobulin G (blood), Male, Middle Aged, Randomized Controlled Trials as Topic, Young Adult.
MESH :
- chemical , blood : Antibodies, Helminth, Immunoglobulin E, Immunoglobulin G.
- chemical , immunology : Antigens, Helminth, Cytokines.
- immunology : Elephantiasis, Filarial, Granulocytes.
- Adolescent, Adult, Animals, Brugia malayi, Case-Control Studies, Cell Degranulation, Enzyme-Linked Immunosorbent Assay, Humans, Male, Middle Aged, Randomized Controlled Trials as Topic, Young Adult.

Abstract

Helminth parasites are known to be efficient modulators of their host's immune system. To guarantee their own survival, they induce alongside the classical Th2 a strong regulatory response with high levels of anti-inflammatory cytokines and elevated plasma levels of IgG4. This particular antibody was shown in different models to exhibit immunosuppressive properties. How IgG4 affects the etiopathology of lymphatic filariasis (LF) is however not well characterized. Here we investigate the impact of plasma and affinity-purified IgG/IgG4 fractions from endemic normals (EN) and LF infected pathology patients (CP), asymptomatic microfilaraemic (Mf+) and amicrofilaraemic (Mf-) individuals on IgE/IL3 activated granulocytes. The activation and degranulation states were investigated by monitoring the expression of CD63/HLADR and the release of granule contents (neutrophil elastase (NE), eosinophil cationic protein (ECP) and histamine) respectively by flow cytometry and ELISA. We could show that the activation of granulocytes was inhibited in the presence of plasma from EN and Mf+ individuals whereas those of Mf- and CP presented no effect. This inhibitory capacity was impaired upon depletion of IgG in Mf+ individuals but persisted in IgG-depleted plasma from EN, where it strongly correlated with the expression of IgA. In addition, IgA-depleted fractions failed to suppress granulocyte activation. Strikingly, affinity-purified IgG4 antibodies from EN, Mf+ and Mf- individuals bound granulocytes and inhibited activation and the release of ECP, NE and histamine. In contrast, IgG4 from CP could not bind granulocytes and presented no suppressive capacity. Reduction of both the affinity to, and the suppressive properties of anti-inflammatory IgG4 on granulocytes was reached only when FcγRI and II were blocked simultaneously. These data indicate that IgG4 antibodies from Mf+, Mf- and EN, in contrast to those of CP, natively exhibit FcγRI/II-dependent suppressive properties on granulocytes. Our findings suggest that quantitative and qualitative alterations in IgG4 molecules are associated with the different clinical phenotypes in LF endemic regions.

DOI: 10.1371/journal.pntd.0005777
PubMed: 28742098

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<term>Antibodies, Helminth (blood)</term>
<term>Antigens, Helminth (immunology)</term>
<term>Brugia malayi</term>
<term>Case-Control Studies</term>
<term>Cell Degranulation</term>
<term>Cytokines (immunology)</term>
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<term>Granulocytes (immunology)</term>
<term>Humans</term>
<term>Immunoglobulin E (blood)</term>
<term>Immunoglobulin G (blood)</term>
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<term>Animaux</term>
<term>Anticorps antihelminthe (sang)</term>
<term>Antigènes d'helminthe (immunologie)</term>
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<term>Cytokines</term>
<term>Filariose lymphatique</term>
<term>Granulocytes</term>
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<term>Granulocytes</term>
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<term>Immunoglobuline E</term>
<term>Immunoglobuline G</term>
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<term>Adult</term>
<term>Animals</term>
<term>Brugia malayi</term>
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<term>Cell Degranulation</term>
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<term>Middle Aged</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Brugia malayi</term>
<term>Dégranulation cellulaire</term>
<term>Essais contrôlés randomisés comme sujet</term>
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<front><div type="abstract" xml:lang="en">Helminth parasites are known to be efficient modulators of their host's immune system. To guarantee their own survival, they induce alongside the classical Th2 a strong regulatory response with high levels of anti-inflammatory cytokines and elevated plasma levels of IgG4. This particular antibody was shown in different models to exhibit immunosuppressive properties. How IgG4 affects the etiopathology of lymphatic filariasis (LF) is however not well characterized. Here we investigate the impact of plasma and affinity-purified IgG/IgG4 fractions from endemic normals (EN) and LF infected pathology patients (CP), asymptomatic microfilaraemic (Mf+) and amicrofilaraemic (Mf-) individuals on IgE/IL3 activated granulocytes. The activation and degranulation states were investigated by monitoring the expression of CD63/HLADR and the release of granule contents (neutrophil elastase (NE), eosinophil cationic protein (ECP) and histamine) respectively by flow cytometry and ELISA. We could show that the activation of granulocytes was inhibited in the presence of plasma from EN and Mf+ individuals whereas those of Mf- and CP presented no effect. This inhibitory capacity was impaired upon depletion of IgG in Mf+ individuals but persisted in IgG-depleted plasma from EN, where it strongly correlated with the expression of IgA. In addition, IgA-depleted fractions failed to suppress granulocyte activation. Strikingly, affinity-purified IgG4 antibodies from EN, Mf+ and Mf- individuals bound granulocytes and inhibited activation and the release of ECP, NE and histamine. In contrast, IgG4 from CP could not bind granulocytes and presented no suppressive capacity. Reduction of both the affinity to, and the suppressive properties of anti-inflammatory IgG4 on granulocytes was reached only when FcγRI and II were blocked simultaneously. These data indicate that IgG4 antibodies from Mf+, Mf- and EN, in contrast to those of CP, natively exhibit FcγRI/II-dependent suppressive properties on granulocytes. Our findings suggest that quantitative and qualitative alterations in IgG4 molecules are associated with the different clinical phenotypes in LF endemic regions.</div>
</front>
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<Abstract><AbstractText>Helminth parasites are known to be efficient modulators of their host's immune system. To guarantee their own survival, they induce alongside the classical Th2 a strong regulatory response with high levels of anti-inflammatory cytokines and elevated plasma levels of IgG4. This particular antibody was shown in different models to exhibit immunosuppressive properties. How IgG4 affects the etiopathology of lymphatic filariasis (LF) is however not well characterized. Here we investigate the impact of plasma and affinity-purified IgG/IgG4 fractions from endemic normals (EN) and LF infected pathology patients (CP), asymptomatic microfilaraemic (Mf+) and amicrofilaraemic (Mf-) individuals on IgE/IL3 activated granulocytes. The activation and degranulation states were investigated by monitoring the expression of CD63/HLADR and the release of granule contents (neutrophil elastase (NE), eosinophil cationic protein (ECP) and histamine) respectively by flow cytometry and ELISA. We could show that the activation of granulocytes was inhibited in the presence of plasma from EN and Mf+ individuals whereas those of Mf- and CP presented no effect. This inhibitory capacity was impaired upon depletion of IgG in Mf+ individuals but persisted in IgG-depleted plasma from EN, where it strongly correlated with the expression of IgA. In addition, IgA-depleted fractions failed to suppress granulocyte activation. Strikingly, affinity-purified IgG4 antibodies from EN, Mf+ and Mf- individuals bound granulocytes and inhibited activation and the release of ECP, NE and histamine. In contrast, IgG4 from CP could not bind granulocytes and presented no suppressive capacity. Reduction of both the affinity to, and the suppressive properties of anti-inflammatory IgG4 on granulocytes was reached only when FcγRI and II were blocked simultaneously. These data indicate that IgG4 antibodies from Mf+, Mf- and EN, in contrast to those of CP, natively exhibit FcγRI/II-dependent suppressive properties on granulocytes. Our findings suggest that quantitative and qualitative alterations in IgG4 molecules are associated with the different clinical phenotypes in LF endemic regions.</AbstractText>
</Abstract>
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<ForeName>Charlotte</ForeName>
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<Author ValidYN="Y"><LastName>Debrah</LastName>
<ForeName>Alex Y</ForeName>
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<AffiliationInfo><Affiliation>Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</Affiliation>
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<AffiliationInfo><Affiliation>Faculty of Allied Health Sciences and School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</Affiliation>
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<Author ValidYN="Y"><LastName>Batsa Debrah</LastName>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Albers</LastName>
<ForeName>Anna</ForeName>
<Initials>A</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Layland</LastName>
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<Initials>LE</Initials>
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</AffiliationInfo>
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<ForeName>Achim</ForeName>
<Initials>A</Initials>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Bonn-Cologne Site, German Center for Infectious Disease Research (DZIF), Bonn, Germany.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Adjobimey</LastName>
<ForeName>Tomabu</ForeName>
<Initials>T</Initials>
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<AffiliationInfo><Affiliation>Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculté des Sciences et Techniques (FAST), Université d'Abomey-Calavi, Abomey-Calavi, Bénin.</Affiliation>
</AffiliationInfo>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Infect Dis. 2008 Dec;21(6):673-81</RefSource>
<PMID Version="1">18978537</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1989 Dec;86(23):9465-9</RefSource>
<PMID Version="1">2512581</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Parasitol. 2003 Dec;89(6):1129-35</RefSource>
<PMID Version="1">14740899</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 1982 May;31(3 Pt 1):477-85</RefSource>
<PMID Version="1">7081541</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2009;3(4):e420</RefSource>
<PMID Version="1">19381284</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Vaccine Immunol. 2014 Jul;21(7):960-5</RefSource>
<PMID Version="1">24807054</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2014 Dec;36(12):713-20</RefSource>
<PMID Version="1">25124516</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1990 Mar 1;171(3):597-613</RefSource>
<PMID Version="1">2137852</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2010 Jul;78(7):3160-7</RefSource>
<PMID Version="1">20404082</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Monogr Allergy. 1986;19:7-35</RefSource>
<PMID Version="1">2945094</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Parasitol. 1996 Apr;82(3):255-66</RefSource>
<PMID Version="1">8631377</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Pathol. 2008 Jan;214(2):161-78</RefSource>
<PMID Version="1">18161744</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Respir Res. 2011 Jan 14;12:10</RefSource>
<PMID Version="1">21235798</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Hum Reprod Sci. 2011 Jan;4(1):8-11</RefSource>
<PMID Version="1">21772732</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2002 Jan;109(2):161-8</RefSource>
<PMID Version="1">11805126</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Exp Allergy. 2009 Apr;39(4):469-77</RefSource>
<PMID Version="1">19222496</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Microcirculation. 2013 Jul;20(5):349-64</RefSource>
<PMID Version="1">23237232</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Front Immunol. 2014 Oct 20;5:520</RefSource>
<PMID Version="1">25368619</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Immunol. 2005 Aug;17(4):359-65</RefSource>
<PMID Version="1">15955682</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1981 Aug;127(2):716-25</RefSource>
<PMID Version="1">7195919</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2011 Jul;79(7):2770-8</RefSource>
<PMID Version="1">21482685</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int Arch Allergy Appl Immunol. 1978;56(2):123-7</RefSource>
<PMID Version="1">563850</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2009 Dec;5(12):e1000688</RefSource>
<PMID Version="1">20011114</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 1994 Jun;144(6):1369-80</RefSource>
<PMID Version="1">8203473</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunol Rev. 2015 Nov;268(1):123-38</RefSource>
<PMID Version="1">26497517</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2012;6(4):e1611</RefSource>
<PMID Version="1">22509424</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biomed Biotechnol. 2011;2011:821578</RefSource>
<PMID Version="1">22219659</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2009 Jun;80(6):956-63</RefSource>
<PMID Version="1">19478258</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2006 Mar;116(3):833-41</RefSource>
<PMID Version="1">16498503</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 1985 Sep;7(5):517-26</RefSource>
<PMID Version="1">2933630</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Immunol. 2003 Dec;40(9):585-93</RefSource>
<PMID Version="1">14597161</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2006 Mar 1;176(5):3248-56</RefSource>
<PMID Version="1">16493086</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Parasitol. 1981 Aug;52(1):147-59</RefSource>
<PMID Version="1">6972325</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1990 Apr 15;144(8):3166-73</RefSource>
<PMID Version="1">2324497</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunology. 2002 Jan;105(1):9-19</RefSource>
<PMID Version="1">11849310</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Vet Pathol. 1982 Jul;19(4):355-64</RefSource>
<PMID Version="1">7090139</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Wkly Epidemiol Rec. 2015 Sep 18;90(38):489-504</RefSource>
<PMID Version="1">26387149</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2010 Aug;32(8):532-40</RefSource>
<PMID Version="1">20626808</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2009 Apr 16;113(16):3716-25</RefSource>
<PMID Version="1">19018092</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Immunol. 2015 Oct;67(2 Pt A):171-82</RefSource>
<PMID Version="1">25900877</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Semin Immunopathol. 2012 Nov;34(6):847-61</RefSource>
<PMID Version="1">23053393</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2007 Oct 31;1(1):e67</RefSource>
<PMID Version="1">17989784</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1992 May 1;148(9):2731-7</RefSource>
<PMID Version="1">1573266</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2016 Oct 8;388(10053):1545-1602</RefSource>
<PMID Version="1">27733282</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>MAbs. 2014;6(6):1377-84</RefSource>
<PMID Version="1">25484046</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2007 Sep 14;317(5844):1554-7</RefSource>
<PMID Version="1">17872445</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trop Med Int Health. 2016 Feb;21(2):236-44</RefSource>
<PMID Version="1">26584839</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Microbiol Spectr. 2014 Aug 15;2(4):1-17</RefSource>
<PMID Version="1">25215264</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Acta Trop. 2011 Sep;120 Suppl 1:S23-32</RefSource>
<PMID Version="1">20673752</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Hematol. 2001 Jan;8(1):28-33</RefSource>
<PMID Version="1">11138623</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 1990 Mar;12(2):213-28</RefSource>
<PMID Version="1">2320381</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Allergy. 2015 Jun;70(6):720-4</RefSource>
<PMID Version="1">25758595</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Vet Parasitol. 2001 Sep 12;100(1-2):33-44</RefSource>
<PMID Version="1">11522404</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2002 Aug;2(8):580-92</RefSource>
<PMID Version="1">12154377</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Microbiol. 2008 Sep;10(9):1757-64</RefSource>
<PMID Version="1">18505479</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2005 Feb;5(2):136-48</RefSource>
<PMID Version="1">15688041</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2014 Oct 1;210(7):1133-44</RefSource>
<PMID Version="1">24737802</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Sci Rep. 2014 Mar 11;4:4347</RefSource>
<PMID Version="1">24614541</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Med Chem. 2012;19(10):1567-86</RefSource>
<PMID Version="1">22360486</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Trop Med Parasitol. 2010 Sep;104(6):455-64</RefSource>
<PMID Version="1">20863434</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2014 Aug;36(8):338-46</RefSource>
<PMID Version="1">24134686</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2008 Feb 1;111(3):1456-63</RefSource>
<PMID Version="1">18024795</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunol Rev. 2015 Nov;268(1):139-59</RefSource>
<PMID Version="1">26497518</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1987 Oct 15;139(8):2794-8</RefSource>
<PMID Version="1">3309059</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2008 Aug 1;198(3):434-43</RefSource>
<PMID Version="1">18588480</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2014 Aug;15(8):707-16</RefSource>
<PMID Version="1">25045879</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Pharmacol Exp Ther. 1990 Jul;254(1):98-103</RefSource>
<PMID Version="1">1694896</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 1993 May;15(5):291-6</RefSource>
<PMID Version="1">8332384</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2015 Sep 15;195(6):2529-39</RefSource>
<PMID Version="1">26276876</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Histol Histopathol. 2010 Oct;25(10 ):1341-54</RefSource>
<PMID Version="1">20712018</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2010 Jan;32(1):1-19</RefSource>
<PMID Version="1">20042003</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2014 Mar 13;10 (3):e1003988</RefSource>
<PMID Version="1">24626328</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Allergy Clin Immunol. 2014 Dec;134(6):1394-1401.e4</RefSource>
<PMID Version="1">25112697</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Tissue Res. 2011 Jan;343(1):57-83</RefSource>
<PMID Version="1">21042920</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Front Immunol. 2013 Aug 28;4:240</RefSource>
<PMID Version="1">24009607</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Allergy Clin Immunol. 2012 Sep;130(3):663-670.e3</RefSource>
<PMID Version="1">22583928</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2013 Apr;123(4):1457-74</RefSource>
<PMID Version="1">23454746</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2014 May;36(5):207-17</RefSource>
<PMID Version="1">24495228</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2005 Jan 15;174(2):1063-72</RefSource>
<PMID Version="1">15634931</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 1980 Aug;56(2):237-45</RefSource>
<PMID Version="1">6249429</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1985 Apr;134(4):2707-12</RefSource>
<PMID Version="1">2579154</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2002 Jun 1;99(11):4039-47</RefSource>
<PMID Version="1">12010805</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cryobiology. 2014 Feb;68(1):35-42</RefSource>
<PMID Version="1">24269528</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Allergy. 1993 Aug;48(6):437-42</RefSource>
<PMID Version="1">8238799</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2012 Feb 1;30(4):426-32</RefSource>
<PMID Version="1">22203761</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2012 Aug;122(8):2711-9</RefSource>
<PMID Version="1">22850880</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1986 Mar 1;136(5):1859-63</RefSource>
<PMID Version="1">3950405</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Innate Immun. 2014 Jan;20(1):12-23</RefSource>
<PMID Version="1">23529856</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2003 Sep;3(9):733-44</RefSource>
<PMID Version="1">12949497</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2006 Sep;2(9):e92</RefSource>
<PMID Version="1">17044733</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Exp Immunol. 1986 May;64(2):415-22</RefSource>
<PMID Version="1">3488859</PMID>
</CommentsCorrections>
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   |texte=   Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes.
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Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes.

Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes.

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