(3-14C) coumarin distribution in rat tissues after the injection of a single dose.
Identifieur interne : 007119 ( PubMed/Corpus ); précédent : 007118; suivant : 007120(3-14C) coumarin distribution in rat tissues after the injection of a single dose.
Auteurs : N B PillerSource :
- Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie [ 0300-9130 ] ; 1977.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Coumarins.
- Animals, Female, Rats, Tissue Distribution.
Abstract
Experimentally it has been shown that coumarin is a very effective therapy in the treatment of high protein oedemas. This study reports on the distribution of a single dose of 3-14C-coumarin in rats. Blood levels of coumarin were always much lower than those of the tissues at similar times. The half life of 3-14C-coumarin and its labelled metabolites was found to be about 43 hours. This ties in fairly well with the optimum frequencies of the administration of the drug which was found to be 24 hours. At this time, skin and muscle levels (the tissues most effected in lymphoedema and in thermal oedema) were maximal.
PubMed: 910088
Links to Exploration step
pubmed:910088Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">(3-14C) coumarin distribution in rat tissues after the injection of a single dose.</title><author><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N B" last="Piller">N B Piller</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1977">1977</date><idno type="RBID">pubmed:910088</idno><idno type="pmid">910088</idno><idno type="wicri:Area/PubMed/Corpus">007119</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">007119</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">(3-14C) coumarin distribution in rat tissues after the injection of a single dose.</title><author><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N B" last="Piller">N B Piller</name></author></analytic><series><title level="j">Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie</title><idno type="ISSN">0300-9130</idno><imprint><date when="1977" type="published">1977</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coumarins (metabolism)</term><term>Female</term><term>Rats</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Coumarins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Rats</term><term>Tissue Distribution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Experimentally it has been shown that coumarin is a very effective therapy in the treatment of high protein oedemas. This study reports on the distribution of a single dose of 3-14C-coumarin in rats. Blood levels of coumarin were always much lower than those of the tissues at similar times. The half life of 3-14C-coumarin and its labelled metabolites was found to be about 43 hours. This ties in fairly well with the optimum frequencies of the administration of the drug which was found to be 24 hours. At this time, skin and muscle levels (the tissues most effected in lymphoedema and in thermal oedema) were maximal.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">910088</PMID><DateCreated><Year>1977</Year><Month>11</Month><Day>30</Day></DateCreated><DateCompleted><Year>1977</Year><Month>11</Month><Day>30</Day></DateCompleted><DateRevised><Year>2003</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0300-9130</ISSN><JournalIssue CitedMedium="Print"><Volume>171</Volume><Issue>1</Issue><PubDate><Year>1977</Year><Month>Aug</Month><Day>16</Day></PubDate></JournalIssue><Title>Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie</Title><ISOAbbreviation>Res Exp Med (Berl)</ISOAbbreviation></Journal><ArticleTitle>(3-14C) coumarin distribution in rat tissues after the injection of a single dose.</ArticleTitle><Pagination><MedlinePgn>93-100</MedlinePgn></Pagination><Abstract><AbstractText>Experimentally it has been shown that coumarin is a very effective therapy in the treatment of high protein oedemas. This study reports on the distribution of a single dose of 3-14C-coumarin in rats. Blood levels of coumarin were always much lower than those of the tissues at similar times. The half life of 3-14C-coumarin and its labelled metabolites was found to be about 43 hours. This ties in fairly well with the optimum frequencies of the administration of the drug which was found to be 24 hours. At this time, skin and muscle levels (the tissues most effected in lymphoedema and in thermal oedema) were maximal.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Piller</LastName><ForeName>N B</ForeName><Initials>NB</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Res Exp Med (Berl)</MedlineTA><NlmUniqueID>0324736</NlmUniqueID><ISSNLinking>0300-9130</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003374">Coumarins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003374" MajorTopicYN="N">Coumarins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014018" MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1977</Year><Month>8</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1977</Year><Month>8</Month><Day>16</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1977</Year><Month>8</Month><Day>16</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">910088</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007119 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 007119 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:910088
|texte= (3-14C) coumarin distribution in rat tissues after the injection of a single dose.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:910088" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |