A fine structural study of the removal of the effectiveness of benzo-pyrone treatment of lymphoedema by the destruction of the macrophages by silica.
Identifieur interne : 007054 ( PubMed/Corpus ); précédent : 007053; suivant : 007055A fine structural study of the removal of the effectiveness of benzo-pyrone treatment of lymphoedema by the destruction of the macrophages by silica.
Auteurs : J R Casley-Smith ; E. Földi-Börcsök ; M. FöldiSource :
- British journal of experimental pathology [ 0007-1021 ] ; 1978.
English descriptors
- KwdEn :
- Animals, Brain (ultrastructure), Cell Count, Coumarins (antagonists & inhibitors), Coumarins (therapeutic use), Diaphragm (ultrastructure), Lymphedema (drug therapy), Lymphedema (pathology), Macrophages (drug effects), Macrophages (ultrastructure), Male, Microscopy, Electron, Rats, Silicon Dioxide (pharmacology), Skin (ultrastructure).
- MESH :
- chemical , antagonists & inhibitors : Coumarins.
- chemical , pharmacology : Silicon Dioxide.
- chemical , therapeutic use : Coumarins.
- drug effects : Macrophages.
- drug therapy : Lymphedema.
- pathology : Lymphedema.
- ultrastructure : Brain, Diaphragm, Macrophages, Skin.
- Animals, Cell Count, Male, Microscopy, Electron, Rats.
Abstract
Macroscopical, light microscopical and electronmicroscopical observations were made of the diaphragm, skin and brain of rats, some of which were treated with intraperitoneal silica for 8 days (after being given it i.v. for 2 days). The diaphragms showed a most remarkable increase in fibroblast activity and fibrosis beneath the peritoneal mesothelium (which was disintegrating). Deep to this there were many disintegrating macrophages, and much oedema and increased protein concentration. Ligation of the cervical lymphatics produced the usual changes of lymphoedema in the skin and brain. This was greatly reduced in the animals treated with a mixture of benzo-pyrones. However, in those animals also treated with silica, the benzo-pyrones had no effect on the amount of oedema or of protein. In all the animals except those treated with silica, lymphoedema was accompanied by considerable numbers of macrophages entering the affected tissues; in those treated with silica, these numbers were greatly reduced.
PubMed: 207299
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pubmed:207299Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A fine structural study of the removal of the effectiveness of benzo-pyrone treatment of lymphoedema by the destruction of the macrophages by silica.</title><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></author><author><name sortKey="Foldi Borcsok, E" sort="Foldi Borcsok, E" uniqKey="Foldi Borcsok E" first="E" last="Földi-Börcsök">E. Földi-Börcsök</name></author><author><name sortKey="Foldi, M" sort="Foldi, M" uniqKey="Foldi M" first="M" last="Földi">M. Földi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1978">1978</date><idno type="RBID">pubmed:207299</idno><idno type="pmid">207299</idno><idno type="wicri:Area/PubMed/Corpus">007054</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">007054</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A fine structural study of the removal of the effectiveness of benzo-pyrone treatment of lymphoedema by the destruction of the macrophages by silica.</title><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></author><author><name sortKey="Foldi Borcsok, E" sort="Foldi Borcsok, E" uniqKey="Foldi Borcsok E" first="E" last="Földi-Börcsök">E. Földi-Börcsök</name></author><author><name sortKey="Foldi, M" sort="Foldi, M" uniqKey="Foldi M" first="M" last="Földi">M. Földi</name></author></analytic><series><title level="j">British journal of experimental pathology</title><idno type="ISSN">0007-1021</idno><imprint><date when="1978" type="published">1978</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (ultrastructure)</term><term>Cell Count</term><term>Coumarins (antagonists & inhibitors)</term><term>Coumarins (therapeutic use)</term><term>Diaphragm (ultrastructure)</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (pathology)</term><term>Macrophages (drug effects)</term><term>Macrophages (ultrastructure)</term><term>Male</term><term>Microscopy, Electron</term><term>Rats</term><term>Silicon Dioxide (pharmacology)</term><term>Skin (ultrastructure)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Coumarins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Silicon Dioxide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Coumarins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Brain</term><term>Diaphragm</term><term>Macrophages</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Count</term><term>Male</term><term>Microscopy, Electron</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Macroscopical, light microscopical and electronmicroscopical observations were made of the diaphragm, skin and brain of rats, some of which were treated with intraperitoneal silica for 8 days (after being given it i.v. for 2 days). The diaphragms showed a most remarkable increase in fibroblast activity and fibrosis beneath the peritoneal mesothelium (which was disintegrating). Deep to this there were many disintegrating macrophages, and much oedema and increased protein concentration. Ligation of the cervical lymphatics produced the usual changes of lymphoedema in the skin and brain. This was greatly reduced in the animals treated with a mixture of benzo-pyrones. However, in those animals also treated with silica, the benzo-pyrones had no effect on the amount of oedema or of protein. In all the animals except those treated with silica, lymphoedema was accompanied by considerable numbers of macrophages entering the affected tissues; in those treated with silica, these numbers were greatly reduced.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">207299</PMID><DateCreated><Year>1978</Year><Month>08</Month><Day>14</Day></DateCreated><DateCompleted><Year>1978</Year><Month>08</Month><Day>14</Day></DateCompleted><DateRevised><Year>2012</Year><Month>05</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0007-1021</ISSN><JournalIssue CitedMedium="Print"><Volume>59</Volume><Issue>2</Issue><PubDate><Year>1978</Year><Month>Apr</Month></PubDate></JournalIssue><Title>British journal of experimental pathology</Title><ISOAbbreviation>Br J Exp Pathol</ISOAbbreviation></Journal><ArticleTitle>A fine structural study of the removal of the effectiveness of benzo-pyrone treatment of lymphoedema by the destruction of the macrophages by silica.</ArticleTitle><Pagination><MedlinePgn>116-27</MedlinePgn></Pagination><Abstract><AbstractText>Macroscopical, light microscopical and electronmicroscopical observations were made of the diaphragm, skin and brain of rats, some of which were treated with intraperitoneal silica for 8 days (after being given it i.v. for 2 days). The diaphragms showed a most remarkable increase in fibroblast activity and fibrosis beneath the peritoneal mesothelium (which was disintegrating). Deep to this there were many disintegrating macrophages, and much oedema and increased protein concentration. Ligation of the cervical lymphatics produced the usual changes of lymphoedema in the skin and brain. This was greatly reduced in the animals treated with a mixture of benzo-pyrones. However, in those animals also treated with silica, the benzo-pyrones had no effect on the amount of oedema or of protein. In all the animals except those treated with silica, lymphoedema was accompanied by considerable numbers of macrophages entering the affected tissues; in those treated with silica, these numbers were greatly reduced.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Casley-Smith</LastName><ForeName>J R</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Földi-Börcsök</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Földi</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Exp Pathol</MedlineTA><NlmUniqueID>0372543</NlmUniqueID><ISSNLinking>0007-1021</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003374">Coumarins</NameOfSubstance></Chemical><Chemical><RegistryNumber>7631-86-9</RegistryNumber><NameOfSubstance UI="D012822">Silicon Dioxide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Angiologica. 1968;5(6):370-1</RefSource><PMID Version="1">5716208</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Klin Exp Dermatol. 1968;232(4):367-72</RefSource><PMID Version="1">5678277</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Anat (Basel). 1966;64(4):498-505</RefSource><PMID Version="1">5957959</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Exp Pathol. 1976 Apr;57(2):170-8</RefSource><PMID Version="1">178336</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arzneimittelforschung. 1977 Feb;27(2):367-78</RefSource><PMID 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Version="1">4703053</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Clin Nutr. 1973 Jul;26(7):696-701</RefSource><PMID Version="1">4714382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Angiologica. 1973;10(2):101-23</RefSource><PMID Version="1">4721151</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Exp Pathol. 1974 Feb;55(1):88-93</RefSource><PMID Version="1">4835800</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Ultrastruct Res. 1970 Jan;30(1):195-208</RefSource><PMID Version="1">4904253</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Angiologica. 1967;4(5):271-8</RefSource><PMID Version="1">4951619</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Angiologica. 1968;5(4):250-62</RefSource><PMID Version="1">5699286</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Experientia. 1968 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RefType="Cites"><RefSource>Angiologica. 1971;8(1):31-42</RefSource><PMID Version="1">5112984</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Angiologica. 1969;6(5):275-9</RefSource><PMID Version="1">5344347</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Angiologica. 1968;5(1):55-63</RefSource><PMID Version="1">5637028</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Angiologica. 1968;5(6):372-6</RefSource><PMID Version="1">5716209</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002452" MajorTopicYN="N">Cell Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003374" MajorTopicYN="N">Coumarins</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003964" MajorTopicYN="N">Diaphragm</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008854" MajorTopicYN="N">Microscopy, Electron</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012822" MajorTopicYN="N">Silicon Dioxide</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC2041340</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1978</Year><Month>4</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1978</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1978</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">207299</ArticleId><ArticleId IdType="pmc">PMC2041340</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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