Cellular immune competence in bancroftian filariasis.
Identifieur interne : 006701 ( PubMed/Corpus ); précédent : 006700; suivant : 006702Cellular immune competence in bancroftian filariasis.
Auteurs : S S Mistry ; D. SubrahmanyamSource :
- The Journal of tropical medicine and hygiene [ 0022-5304 ] ; 1985.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Wuchereria bancrofti.
- chemical , pharmacology : Mitogens.
- Adult, Humans, Lymphocyte Activation.
Abstract
Lymphocyte proliferative responses to homologous and heterologous filarial antigens, mitogens and purified protein derivatives (PPD) were analysed in a group of 37 subjects from an area endemic for bancroftian filarial infection. The majority of the subjects without any clinical or parasitological evidence of filariasis (endemic normals) reacted with homologous microfilarial antigens only. Non-treated patients with patent microfilaraemia, did not respond to homologous of heterologous microfilarial antigens. In contrast, diethylcarbamazine (DEC)-treated microfilaraemic patients, reacted with homologous filarial antigens. Patients with elephantiasis reacted to microfilarial and adult worm antigens. Response to PPD was marginally depressed in patent microfilaraemic patients and a rise was observed in elephantiasis cases. Endemic normals exhibited normal response to PPD. Responses to mitogens were depressed throughout the course of the infection.
PubMed: 3915514
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pubmed:3915514Le document en format XML
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Subrahmanyam</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1985">1985</date><idno type="RBID">pubmed:3915514</idno><idno type="pmid">3915514</idno><idno type="wicri:Area/PubMed/Corpus">006701</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">006701</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cellular immune competence in bancroftian filariasis.</title><author><name sortKey="Mistry, S S" sort="Mistry, S S" uniqKey="Mistry S" first="S S" last="Mistry">S S Mistry</name></author><author><name sortKey="Subrahmanyam, D" sort="Subrahmanyam, D" uniqKey="Subrahmanyam D" first="D" last="Subrahmanyam">D. Subrahmanyam</name></author></analytic><series><title level="j">The Journal of tropical medicine and hygiene</title><idno type="ISSN">0022-5304</idno><imprint><date when="1985" type="published">1985</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, Helminth (immunology)</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Filariasis (immunology)</term><term>Humans</term><term>Lymphocyte Activation</term><term>Mitogens (pharmacology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Mitogens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Lymphocyte Activation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphocyte proliferative responses to homologous and heterologous filarial antigens, mitogens and purified protein derivatives (PPD) were analysed in a group of 37 subjects from an area endemic for bancroftian filarial infection. The majority of the subjects without any clinical or parasitological evidence of filariasis (endemic normals) reacted with homologous microfilarial antigens only. Non-treated patients with patent microfilaraemia, did not respond to homologous of heterologous microfilarial antigens. In contrast, diethylcarbamazine (DEC)-treated microfilaraemic patients, reacted with homologous filarial antigens. Patients with elephantiasis reacted to microfilarial and adult worm antigens. Response to PPD was marginally depressed in patent microfilaraemic patients and a rise was observed in elephantiasis cases. Endemic normals exhibited normal response to PPD. Responses to mitogens were depressed throughout the course of the infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3915514</PMID><DateCreated><Year>1986</Year><Month>09</Month><Day>17</Day></DateCreated><DateCompleted><Year>1986</Year><Month>09</Month><Day>17</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-5304</ISSN><JournalIssue CitedMedium="Print"><Volume>88</Volume><Issue>6</Issue><PubDate><Year>1985</Year><Month>Dec</Month></PubDate></JournalIssue><Title>The Journal of tropical medicine and hygiene</Title><ISOAbbreviation>J Trop Med Hyg</ISOAbbreviation></Journal><ArticleTitle>Cellular immune competence in bancroftian filariasis.</ArticleTitle><Pagination><MedlinePgn>383-8</MedlinePgn></Pagination><Abstract><AbstractText>Lymphocyte proliferative responses to homologous and heterologous filarial antigens, mitogens and purified protein derivatives (PPD) were analysed in a group of 37 subjects from an area endemic for bancroftian filarial infection. The majority of the subjects without any clinical or parasitological evidence of filariasis (endemic normals) reacted with homologous microfilarial antigens only. Non-treated patients with patent microfilaraemia, did not respond to homologous of heterologous microfilarial antigens. In contrast, diethylcarbamazine (DEC)-treated microfilaraemic patients, reacted with homologous filarial antigens. Patients with elephantiasis reacted to microfilarial and adult worm antigens. Response to PPD was marginally depressed in patent microfilaraemic patients and a rise was observed in elephantiasis cases. Endemic normals exhibited normal response to PPD. Responses to mitogens were depressed throughout the course of the infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mistry</LastName><ForeName>S S</ForeName><Initials>SS</Initials></Author><Author ValidYN="Y"><LastName>Subrahmanyam</LastName><ForeName>D</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Trop Med Hyg</MedlineTA><NlmUniqueID>0406044</NlmUniqueID><ISSNLinking>0022-5304</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008934">Mitogens</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="N">Brugia</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008934" MajorTopicYN="N">Mitogens</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1985</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1985</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1985</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3915514</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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