Effectiveness of spaced doses of diethylcarbamazine citrate for the control of bancroftian filariasis.
Identifieur interne : 005F87 ( PubMed/Corpus ); précédent : 005F86; suivant : 005F88Effectiveness of spaced doses of diethylcarbamazine citrate for the control of bancroftian filariasis.
Auteurs : M L Eberhard ; P J Lammie ; J M Roberts ; R C LowrieSource :
- Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) [ 0177-2392 ] ; 1989.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Carrier State (drug therapy), Carrier State (prevention & control), Child, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (therapeutic use), Drug Administration Schedule, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (prevention & control), Female, Filariasis (prevention & control), Humans, Male, Middle Aged, Wuchereria bancrofti.
- MESH :
- chemical , administration & dosage : Diethylcarbamazine.
- drug therapy : Carrier State, Elephantiasis, Filarial.
- prevention & control : Carrier State, Elephantiasis, Filarial, Filariasis.
- chemical , therapeutic use : Diethylcarbamazine.
- Adolescent, Adult, Animals, Child, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Wuchereria bancrofti.
Abstract
Forty-seven Wuchereria bancrofti microfilaria carriers were treated once weekly for 12 weeks with 6 mg/kg DEC-C. Microfilaria densities ranged from 1 to 101 mf/20 cmm (MfD-50 of 9.75 mf/20 cmm) before treatment. Of 42 persons who completed treatment, 26 (62%) were microfilaria negative in 1-ml venous blood samples. Microfilaria densities in the 16 patients that remained positive ranged from 1 to 50 mf/ml (MfD-50 of 2.59 mf/ml). Weekly spaced doses of DEC-C resulted in a significant reduction in the number of microfilaria carriers posttreatment, and in the level of residual microfilaremia when compared to daily administration of the drug. Administration of spaced doses of DEC-C also resulted in better patient compliance with less dropout from the program. The reason DEC-C is more effective in spaced doses still remains unclear, but the role platelets or other cells may play in mediating the action of the drug may be linked to the administration schedule.
PubMed: 2672282
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pubmed:2672282Le document en format XML
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Microfilaria densities ranged from 1 to 101 mf/20 cmm (MfD-50 of 9.75 mf/20 cmm) before treatment. Of 42 persons who completed treatment, 26 (62%) were microfilaria negative in 1-ml venous blood samples. Microfilaria densities in the 16 patients that remained positive ranged from 1 to 50 mf/ml (MfD-50 of 2.59 mf/ml). Weekly spaced doses of DEC-C resulted in a significant reduction in the number of microfilaria carriers posttreatment, and in the level of residual microfilaremia when compared to daily administration of the drug. Administration of spaced doses of DEC-C also resulted in better patient compliance with less dropout from the program. The reason DEC-C is more effective in spaced doses still remains unclear, but the role platelets or other cells may play in mediating the action of the drug may be linked to the administration schedule.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2672282</PMID><DateCreated><Year>1989</Year><Month>10</Month><Day>10</Day></DateCreated><DateCompleted><Year>1989</Year><Month>10</Month><Day>10</Day></DateCompleted><DateRevised><Year>2015</Year><Month>08</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0177-2392</ISSN><JournalIssue CitedMedium="Print"><Volume>40</Volume><Issue>2</Issue><PubDate><Year>1989</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)</Title><ISOAbbreviation>Trop. Med. Parasitol.</ISOAbbreviation></Journal><ArticleTitle>Effectiveness of spaced doses of diethylcarbamazine citrate for the control of bancroftian filariasis.</ArticleTitle><Pagination><MedlinePgn>111-3</MedlinePgn></Pagination><Abstract><AbstractText>Forty-seven Wuchereria bancrofti microfilaria carriers were treated once weekly for 12 weeks with 6 mg/kg DEC-C. Microfilaria densities ranged from 1 to 101 mf/20 cmm (MfD-50 of 9.75 mf/20 cmm) before treatment. Of 42 persons who completed treatment, 26 (62%) were microfilaria negative in 1-ml venous blood samples. Microfilaria densities in the 16 patients that remained positive ranged from 1 to 50 mf/ml (MfD-50 of 2.59 mf/ml). Weekly spaced doses of DEC-C resulted in a significant reduction in the number of microfilaria carriers posttreatment, and in the level of residual microfilaremia when compared to daily administration of the drug. Administration of spaced doses of DEC-C also resulted in better patient compliance with less dropout from the program. The reason DEC-C is more effective in spaced doses still remains unclear, but the role platelets or other cells may play in mediating the action of the drug may be linked to the administration schedule.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Eberhard</LastName><ForeName>M L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>ICIDR, Tulane University Medical Center, New Orleans, Louisiana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lammie</LastName><ForeName>P J</ForeName><Initials>PJ</Initials></Author><Author ValidYN="Y"><LastName>Roberts</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Lowrie</LastName><ForeName>R C</ForeName><Initials>RC</Initials><Suffix>Jr</Suffix></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AI-16315</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Trop Med Parasitol</MedlineTA><NlmUniqueID>8503728</NlmUniqueID><ISSNLinking>0177-2392</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>V867Q8X3ZD</RegistryNumber><NameOfSubstance UI="D004049">Diethylcarbamazine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002353" MajorTopicYN="N">Carrier State</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004049" MajorTopicYN="N">Diethylcarbamazine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004334" MajorTopicYN="N">Drug Administration Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1989</Year><Month>6</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>3</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1989</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2672282</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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