Brugia malayi and Brugia pahangi: transmission blocking activity of ivermectin and brugian filarial infections in Aedes aegypti.
Identifieur interne : 005C92 ( PubMed/Corpus ); précédent : 005C91; suivant : 005C93Brugia malayi and Brugia pahangi: transmission blocking activity of ivermectin and brugian filarial infections in Aedes aegypti.
Auteurs : U R Rao ; B H Kwa ; J K Nayar ; A C VickerySource :
- Experimental parasitology [ 0014-4894 ] ; 1990.
English descriptors
- KwdEn :
- Aedes (parasitology), Animals, Brugia (drug effects), Brugia (growth & development), Brugia (metabolism), Elephantiasis, Filarial (transmission), Female, Gerbillinae, Insect Vectors (growth & development), Insect Vectors (parasitology), Ivermectin (pharmacology), Larva (drug effects), Larva (growth & development), Lectins (metabolism), Male, Microfilariae (drug effects), Microfilariae (metabolism).
- MESH :
- chemical , metabolism : Lectins.
- chemical , pharmacology : Ivermectin.
- drug effects : Brugia, Larva, Microfilariae.
- growth & development : Brugia, Insect Vectors, Larva.
- metabolism : Brugia, Microfilariae.
- parasitology : Aedes, Insect Vectors.
- transmission : Elephantiasis, Filarial.
- Animals, Female, Gerbillinae, Male.
Abstract
Brugia malayi- or Brugia pahangi-infected, microfilaremic jirds (Meriones unguiculatus) were treated with ivermectin at a single dose of 200 micrograms/kg body weight, administered subcutaneously. After different time intervals, Aedes aegypti mosquitoes were fed on treated or untreated jirds. Sausage stage, L2, and L3 larvae failed to develop in mosquitoes that fed on jirds from 15 to 30 days post-treatment. After 1 month, the numbers of L3 larvae recovered from mosquitoes fed on treated B. pahangi jirds were comparable to controls. However, the number of L3's recovered from mosquitoes fed on B. malayi jirds remained significantly lower than controls, 2 and 3 months after treatment. This reduction suggests that ivermectin may be more effective in blocking transmission of B. malayi than B. pahangi. Ivermectin treatment had no effect on the mean number of circulating microfilariae in treated jirds. Therefore, mosquitoes ingested comparable numbers of microfilariae when compared to those mosquitoes fed on untreated controls. Only in the case of jirds infected with B. malayi did the circulating microfilarial counts fall 30 days after treatment. The failure of microfilariae to develop to the L3 stage in mosquitoes fed on jirds within 30 days of treatment was not due to failure of mosquitoes to ingest microfilariae. Brugia malayi microfilariae also failed to develop to L3 in mosquitoes that were allowed to feed on microfilaremic jird blood treated with ivermectin (50 ng/ml) in vitro, indicating its efficacy at low concentrations. In addition to N-acetyl glucosamine, microfilariae obtained for a period of 15 days from ivermectin-treated but not control jirds showed D-mannose, N-acetyl galactosamine, and L-fucose moieties on the surface of the sheath.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed: 2209785
Links to Exploration step
pubmed:2209785Le document en format XML
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<author><name sortKey="Rao, U R" sort="Rao, U R" uniqKey="Rao U" first="U R" last="Rao">U R Rao</name>
<affiliation><nlm:affiliation>College of Public Health, Department of Environmental and Occupational Health, University of South Florida, Tampa.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Kwa, B H" sort="Kwa, B H" uniqKey="Kwa B" first="B H" last="Kwa">B H Kwa</name>
</author>
<author><name sortKey="Nayar, J K" sort="Nayar, J K" uniqKey="Nayar J" first="J K" last="Nayar">J K Nayar</name>
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<author><name sortKey="Vickery, A C" sort="Vickery, A C" uniqKey="Vickery A" first="A C" last="Vickery">A C Vickery</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Brugia malayi and Brugia pahangi: transmission blocking activity of ivermectin and brugian filarial infections in Aedes aegypti.</title>
<author><name sortKey="Rao, U R" sort="Rao, U R" uniqKey="Rao U" first="U R" last="Rao">U R Rao</name>
<affiliation><nlm:affiliation>College of Public Health, Department of Environmental and Occupational Health, University of South Florida, Tampa.</nlm:affiliation>
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<author><name sortKey="Kwa, B H" sort="Kwa, B H" uniqKey="Kwa B" first="B H" last="Kwa">B H Kwa</name>
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<author><name sortKey="Nayar, J K" sort="Nayar, J K" uniqKey="Nayar J" first="J K" last="Nayar">J K Nayar</name>
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<author><name sortKey="Vickery, A C" sort="Vickery, A C" uniqKey="Vickery A" first="A C" last="Vickery">A C Vickery</name>
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<series><title level="j">Experimental parasitology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aedes (parasitology)</term>
<term>Animals</term>
<term>Brugia (drug effects)</term>
<term>Brugia (growth & development)</term>
<term>Brugia (metabolism)</term>
<term>Elephantiasis, Filarial (transmission)</term>
<term>Female</term>
<term>Gerbillinae</term>
<term>Insect Vectors (growth & development)</term>
<term>Insect Vectors (parasitology)</term>
<term>Ivermectin (pharmacology)</term>
<term>Larva (drug effects)</term>
<term>Larva (growth & development)</term>
<term>Lectins (metabolism)</term>
<term>Male</term>
<term>Microfilariae (drug effects)</term>
<term>Microfilariae (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lectins</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ivermectin</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brugia</term>
<term>Larva</term>
<term>Microfilariae</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia</term>
<term>Insect Vectors</term>
<term>Larva</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brugia</term>
<term>Microfilariae</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Aedes</term>
<term>Insect Vectors</term>
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<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Elephantiasis, Filarial</term>
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<front><div type="abstract" xml:lang="en">Brugia malayi- or Brugia pahangi-infected, microfilaremic jirds (Meriones unguiculatus) were treated with ivermectin at a single dose of 200 micrograms/kg body weight, administered subcutaneously. After different time intervals, Aedes aegypti mosquitoes were fed on treated or untreated jirds. Sausage stage, L2, and L3 larvae failed to develop in mosquitoes that fed on jirds from 15 to 30 days post-treatment. After 1 month, the numbers of L3 larvae recovered from mosquitoes fed on treated B. pahangi jirds were comparable to controls. However, the number of L3's recovered from mosquitoes fed on B. malayi jirds remained significantly lower than controls, 2 and 3 months after treatment. This reduction suggests that ivermectin may be more effective in blocking transmission of B. malayi than B. pahangi. Ivermectin treatment had no effect on the mean number of circulating microfilariae in treated jirds. Therefore, mosquitoes ingested comparable numbers of microfilariae when compared to those mosquitoes fed on untreated controls. Only in the case of jirds infected with B. malayi did the circulating microfilarial counts fall 30 days after treatment. The failure of microfilariae to develop to the L3 stage in mosquitoes fed on jirds within 30 days of treatment was not due to failure of mosquitoes to ingest microfilariae. Brugia malayi microfilariae also failed to develop to L3 in mosquitoes that were allowed to feed on microfilaremic jird blood treated with ivermectin (50 ng/ml) in vitro, indicating its efficacy at low concentrations. In addition to N-acetyl glucosamine, microfilariae obtained for a period of 15 days from ivermectin-treated but not control jirds showed D-mannose, N-acetyl galactosamine, and L-fucose moieties on the surface of the sheath.(ABSTRACT TRUNCATED AT 250 WORDS)</div>
</front>
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<Title>Experimental parasitology</Title>
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<ArticleTitle>Brugia malayi and Brugia pahangi: transmission blocking activity of ivermectin and brugian filarial infections in Aedes aegypti.</ArticleTitle>
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<Abstract><AbstractText>Brugia malayi- or Brugia pahangi-infected, microfilaremic jirds (Meriones unguiculatus) were treated with ivermectin at a single dose of 200 micrograms/kg body weight, administered subcutaneously. After different time intervals, Aedes aegypti mosquitoes were fed on treated or untreated jirds. Sausage stage, L2, and L3 larvae failed to develop in mosquitoes that fed on jirds from 15 to 30 days post-treatment. After 1 month, the numbers of L3 larvae recovered from mosquitoes fed on treated B. pahangi jirds were comparable to controls. However, the number of L3's recovered from mosquitoes fed on B. malayi jirds remained significantly lower than controls, 2 and 3 months after treatment. This reduction suggests that ivermectin may be more effective in blocking transmission of B. malayi than B. pahangi. Ivermectin treatment had no effect on the mean number of circulating microfilariae in treated jirds. Therefore, mosquitoes ingested comparable numbers of microfilariae when compared to those mosquitoes fed on untreated controls. Only in the case of jirds infected with B. malayi did the circulating microfilarial counts fall 30 days after treatment. The failure of microfilariae to develop to the L3 stage in mosquitoes fed on jirds within 30 days of treatment was not due to failure of mosquitoes to ingest microfilariae. Brugia malayi microfilariae also failed to develop to L3 in mosquitoes that were allowed to feed on microfilaremic jird blood treated with ivermectin (50 ng/ml) in vitro, indicating its efficacy at low concentrations. In addition to N-acetyl glucosamine, microfilariae obtained for a period of 15 days from ivermectin-treated but not control jirds showed D-mannose, N-acetyl galactosamine, and L-fucose moieties on the surface of the sheath.(ABSTRACT TRUNCATED AT 250 WORDS)</AbstractText>
</Abstract>
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<MeshHeading><DescriptorName UI="D005849" MajorTopicYN="N">Gerbillinae</DescriptorName>
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<MeshHeading><DescriptorName UI="D008842" MajorTopicYN="N">Microfilariae</DescriptorName>
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