Lymphoedema/hypercalcaemia syndrome mediated by parathyroid-hormone-related protein.
Identifieur interne : 005C06 ( PubMed/Corpus ); précédent : 005C05; suivant : 005C07Lymphoedema/hypercalcaemia syndrome mediated by parathyroid-hormone-related protein.
Auteurs : S. Braude ; A. Graham ; D. MitchellSource :
- Lancet (London, England) [ 0140-6736 ] ; 1991.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Parathyroid Hormone.
- blood : Hypercalcemia, Lymphedema.
- complications : Hypercalcemia, Lymphedema.
- diagnosis : Hyperparathyroidism.
- chemical , metabolism : Proteins.
- Adult, Female, Humans, Parathyroid Hormone-Related Protein, Syndrome.
Abstract
A 24-year-old woman presented with a cryptogenic, hypercalcaemic syndrome with metastatic pulmonary calcification and leg and massive breast enlargement and bilateral chylous pleural effusions compatible with a generalised lymphatic abnormality. The patient's serum parathyroid hormone-related protein concentration was very high at a time when she was significantly hypercalcaemic, implying that the hypercalcaemia was mediated by this protein.
PubMed: 1670789
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pubmed:1670789Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphoedema/hypercalcaemia syndrome mediated by parathyroid-hormone-related protein.</title>
<author><name sortKey="Braude, S" sort="Braude, S" uniqKey="Braude S" first="S" last="Braude">S. Braude</name>
<affiliation><nlm:affiliation>Royal Brompton, National Heart Hospital, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Graham, A" sort="Graham, A" uniqKey="Graham A" first="A" last="Graham">A. Graham</name>
</author>
<author><name sortKey="Mitchell, D" sort="Mitchell, D" uniqKey="Mitchell D" first="D" last="Mitchell">D. Mitchell</name>
</author>
</titleStmt>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Lymphoedema/hypercalcaemia syndrome mediated by parathyroid-hormone-related protein.</title>
<author><name sortKey="Braude, S" sort="Braude, S" uniqKey="Braude S" first="S" last="Braude">S. Braude</name>
<affiliation><nlm:affiliation>Royal Brompton, National Heart Hospital, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Graham, A" sort="Graham, A" uniqKey="Graham A" first="A" last="Graham">A. Graham</name>
</author>
<author><name sortKey="Mitchell, D" sort="Mitchell, D" uniqKey="Mitchell D" first="D" last="Mitchell">D. Mitchell</name>
</author>
</analytic>
<series><title level="j">Lancet (London, England)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="1991" type="published">1991</date>
</imprint>
</series>
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</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Hypercalcemia (blood)</term>
<term>Hypercalcemia (complications)</term>
<term>Hyperparathyroidism (diagnosis)</term>
<term>Lymphedema (blood)</term>
<term>Lymphedema (complications)</term>
<term>Parathyroid Hormone (blood)</term>
<term>Parathyroid Hormone-Related Protein</term>
<term>Proteins (metabolism)</term>
<term>Syndrome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Parathyroid Hormone</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hypercalcemia</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypercalcemia</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hyperparathyroidism</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proteins</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Parathyroid Hormone-Related Protein</term>
<term>Syndrome</term>
</keywords>
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<front><div type="abstract" xml:lang="en">A 24-year-old woman presented with a cryptogenic, hypercalcaemic syndrome with metastatic pulmonary calcification and leg and massive breast enlargement and bilateral chylous pleural effusions compatible with a generalised lymphatic abnormality. The patient's serum parathyroid hormone-related protein concentration was very high at a time when she was significantly hypercalcaemic, implying that the hypercalcaemia was mediated by this protein.</div>
</front>
</TEI>
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<DateCreated><Year>1991</Year>
<Month>02</Month>
<Day>13</Day>
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<DateCompleted><Year>1991</Year>
<Month>02</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>06</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0140-6736</ISSN>
<JournalIssue CitedMedium="Print"><Volume>337</Volume>
<Issue>8734</Issue>
<PubDate><Year>1991</Year>
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<Title>Lancet (London, England)</Title>
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<ArticleTitle>Lymphoedema/hypercalcaemia syndrome mediated by parathyroid-hormone-related protein.</ArticleTitle>
<Pagination><MedlinePgn>140-1</MedlinePgn>
</Pagination>
<Abstract><AbstractText>A 24-year-old woman presented with a cryptogenic, hypercalcaemic syndrome with metastatic pulmonary calcification and leg and massive breast enlargement and bilateral chylous pleural effusions compatible with a generalised lymphatic abnormality. The patient's serum parathyroid hormone-related protein concentration was very high at a time when she was significantly hypercalcaemic, implying that the hypercalcaemia was mediated by this protein.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Braude</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Royal Brompton, National Heart Hospital, London, UK.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Graham</LastName>
<ForeName>A</ForeName>
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<Author ValidYN="Y"><LastName>Mitchell</LastName>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C470121">PTHLH protein, human</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<MeshHeading><DescriptorName UI="D006934" MajorTopicYN="N">Hypercalcemia</DescriptorName>
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<MeshHeading><DescriptorName UI="D006961" MajorTopicYN="N">Hyperparathyroidism</DescriptorName>
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<MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010281" MajorTopicYN="N">Parathyroid Hormone</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044162" MajorTopicYN="N">Parathyroid Hormone-Related Protein</DescriptorName>
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<MeshHeading><DescriptorName UI="D011506" MajorTopicYN="N">Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D013577" MajorTopicYN="N">Syndrome</DescriptorName>
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