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Circulating filarial antigen in cats infected with Brugia pahangi is indicative of the presence of adult worms.

Identifieur interne : 005B19 ( PubMed/Corpus ); précédent : 005B18; suivant : 005B20

Circulating filarial antigen in cats infected with Brugia pahangi is indicative of the presence of adult worms.

Auteurs : H. Kumar ; C. Baldwin ; D W Birch ; D A Denham ; F. De Medeiros ; I T Midwinter ; A. Smail

Source :

RBID : pubmed:1923565

English descriptors

Abstract

Using counterimmunoelectrophoresis with rabbit antisera raised against soluble extracts of adult females of Brugia pahangi parasite antigen was detected in the serum of all cats repeatedly infected with B. pahangi. Antigen was never detected in uninfected cats. The antigen was associated with the presence of adult worms. Antigen was detected consistently in a cat that was amicrofilaraemic but at autopsy harboured only two or three adult worms. Conversely, some cats showed slowly declining numbers of microfilariae and, in these, circulating antigen declined before the number of microfilariae. Eventually no antigen was detectable in circulation whereas microfilariae, although in diminishing numbers, were still present. At autopsy no adult worms were found in these cats. Antigen also appeared in several cats before they became microfilaraemic.

PubMed: 1923565

Links to Exploration step

pubmed:1923565

Le document en format XML

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<title xml:lang="en">Circulating filarial antigen in cats infected with Brugia pahangi is indicative of the presence of adult worms.</title>
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<name sortKey="Kumar, H" sort="Kumar, H" uniqKey="Kumar H" first="H" last="Kumar">H. Kumar</name>
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<nlm:affiliation>London School of Hygiene and Tropical Medicine, UK.</nlm:affiliation>
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<name sortKey="Baldwin, C" sort="Baldwin, C" uniqKey="Baldwin C" first="C" last="Baldwin">C. Baldwin</name>
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<name sortKey="Birch, D W" sort="Birch, D W" uniqKey="Birch D" first="D W" last="Birch">D W Birch</name>
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<name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name>
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<name sortKey="De Medeiros, F" sort="De Medeiros, F" uniqKey="De Medeiros F" first="F" last="De Medeiros">F. De Medeiros</name>
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<name sortKey="Midwinter, I T" sort="Midwinter, I T" uniqKey="Midwinter I" first="I T" last="Midwinter">I T Midwinter</name>
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<name sortKey="Smail, A" sort="Smail, A" uniqKey="Smail A" first="A" last="Smail">A. Smail</name>
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<term>Cats</term>
<term>Counterimmunoelectrophoresis</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Female</term>
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<div type="abstract" xml:lang="en">Using counterimmunoelectrophoresis with rabbit antisera raised against soluble extracts of adult females of Brugia pahangi parasite antigen was detected in the serum of all cats repeatedly infected with B. pahangi. Antigen was never detected in uninfected cats. The antigen was associated with the presence of adult worms. Antigen was detected consistently in a cat that was amicrofilaraemic but at autopsy harboured only two or three adult worms. Conversely, some cats showed slowly declining numbers of microfilariae and, in these, circulating antigen declined before the number of microfilariae. Eventually no antigen was detectable in circulation whereas microfilariae, although in diminishing numbers, were still present. At autopsy no adult worms were found in these cats. Antigen also appeared in several cats before they became microfilaraemic.</div>
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<AbstractText>Using counterimmunoelectrophoresis with rabbit antisera raised against soluble extracts of adult females of Brugia pahangi parasite antigen was detected in the serum of all cats repeatedly infected with B. pahangi. Antigen was never detected in uninfected cats. The antigen was associated with the presence of adult worms. Antigen was detected consistently in a cat that was amicrofilaraemic but at autopsy harboured only two or three adult worms. Conversely, some cats showed slowly declining numbers of microfilariae and, in these, circulating antigen declined before the number of microfilariae. Eventually no antigen was detectable in circulation whereas microfilariae, although in diminishing numbers, were still present. At autopsy no adult worms were found in these cats. Antigen also appeared in several cats before they became microfilaraemic.</AbstractText>
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