Bancroftian filariasis: long-term effects of treatment with diethylcarbamazine in a Haitian population.
Identifieur interne : 005A41 ( PubMed/Corpus ); précédent : 005A40; suivant : 005A42Bancroftian filariasis: long-term effects of treatment with diethylcarbamazine in a Haitian population.
Auteurs : M L Eberhard ; J W Dickerson ; A W Hightower ; P J LammieSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1991.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Diethylcarbamazine.
- chemical , therapeutic use : Diethylcarbamazine.
- geographic : Haiti.
- drug therapy : Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- Animals, Follow-Up Studies, Humans, Treatment Outcome, Wuchereria bancrofti.
Abstract
Two groups of Wuchereria bancrofti-infected Haitians who had undergone treatment with diethylcarbamazine (DEC) were followed for up to five years after treatment to document the long-term effects of treatment on adult worms and microfilariae and on the recurrence of infection. One group of 69 persons who had received 12 daily treatments had a significant decrease in microfilaria levels until year 4, when a small number of individuals experienced a resurgence of this parasite stage in the peripheral blood. In a second group of 57 persons who had been treated weekly for 12 consecutive weeks, there was a greater reduction in the microfilaria levels following treatment, and for the full four years of followup, these levels remained more depressed than those of the group that received daily treatment. Our results indicate that DEC kills or permanently sterilizes adult W. bancrofti. Furthermore, these results demonstrate conclusively that in Haiti, the use of DEC provides long-term benefits to treated persons, even though they continue to reside in an area with endemic filariasis.
PubMed: 1763800
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One group of 69 persons who had received 12 daily treatments had a significant decrease in microfilaria levels until year 4, when a small number of individuals experienced a resurgence of this parasite stage in the peripheral blood. In a second group of 57 persons who had been treated weekly for 12 consecutive weeks, there was a greater reduction in the microfilaria levels following treatment, and for the full four years of followup, these levels remained more depressed than those of the group that received daily treatment. Our results indicate that DEC kills or permanently sterilizes adult W. bancrofti. Furthermore, these results demonstrate conclusively that in Haiti, the use of DEC provides long-term benefits to treated persons, even though they continue to reside in an area with endemic filariasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1763800</PMID><DateCreated><Year>1992</Year><Month>02</Month><Day>10</Day></DateCreated><DateCompleted><Year>1992</Year><Month>02</Month><Day>10</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9637</ISSN><JournalIssue CitedMedium="Print"><Volume>45</Volume><Issue>6</Issue><PubDate><Year>1991</Year><Month>Dec</Month></PubDate></JournalIssue><Title>The American journal of tropical medicine and hygiene</Title><ISOAbbreviation>Am. J. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Bancroftian filariasis: long-term effects of treatment with diethylcarbamazine in a Haitian population.</ArticleTitle><Pagination><MedlinePgn>728-33</MedlinePgn></Pagination><Abstract><AbstractText>Two groups of Wuchereria bancrofti-infected Haitians who had undergone treatment with diethylcarbamazine (DEC) were followed for up to five years after treatment to document the long-term effects of treatment on adult worms and microfilariae and on the recurrence of infection. One group of 69 persons who had received 12 daily treatments had a significant decrease in microfilaria levels until year 4, when a small number of individuals experienced a resurgence of this parasite stage in the peripheral blood. In a second group of 57 persons who had been treated weekly for 12 consecutive weeks, there was a greater reduction in the microfilaria levels following treatment, and for the full four years of followup, these levels remained more depressed than those of the group that received daily treatment. Our results indicate that DEC kills or permanently sterilizes adult W. bancrofti. Furthermore, these results demonstrate conclusively that in Haiti, the use of DEC provides long-term benefits to treated persons, even though they continue to reside in an area with endemic filariasis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Eberhard</LastName><ForeName>M L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dickerson</LastName><ForeName>J W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Hightower</LastName><ForeName>A W</ForeName><Initials>AW</Initials></Author><Author ValidYN="Y"><LastName>Lammie</LastName><ForeName>P J</ForeName><Initials>PJ</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>Y02-00005-01</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Trop Med Hyg</MedlineTA><NlmUniqueID>0370507</NlmUniqueID><ISSNLinking>0002-9637</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>V867Q8X3ZD</RegistryNumber><NameOfSubstance UI="D004049">Diethylcarbamazine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004049" MajorTopicYN="N">Diethylcarbamazine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006205" MajorTopicYN="N" Type="Geographic">Haiti</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="Y">Wuchereria bancrofti</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1763800</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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