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Lymphatic imaging in experimental filariasis using magnetic resonance.

Identifieur interne : 005955 ( PubMed/Corpus ); précédent : 005954; suivant : 005956

Lymphatic imaging in experimental filariasis using magnetic resonance.

Auteurs : T C Case ; E. Unger ; M J Bernas ; M H Witte ; C L Witte ; G. Mcneill ; C. Crandall ; R. Crandall

Source :

RBID : pubmed:1601619

English descriptors

Abstract

To evaluate acquired lymphatic abnormalities caused by filariasis, the authors examined the peripheral lymphatic system in normal ferrets and those chronically infected with Brugia malayi using magnetic resonance imaging (MRI). The findings were compared with previously obtained lymphangioscintigraphic (LAS) images in ferrets both with and without experimental filariasis.

PubMed: 1601619

Links to Exploration step

pubmed:1601619

Le document en format XML

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<title xml:lang="en">Lymphatic imaging in experimental filariasis using magnetic resonance.</title>
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<name sortKey="Case, T C" sort="Case, T C" uniqKey="Case T" first="T C" last="Case">T C Case</name>
<affiliation>
<nlm:affiliation>Department of Surgery, University of Arizona, Tucson.</nlm:affiliation>
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<author>
<name sortKey="Unger, E" sort="Unger, E" uniqKey="Unger E" first="E" last="Unger">E. Unger</name>
</author>
<author>
<name sortKey="Bernas, M J" sort="Bernas, M J" uniqKey="Bernas M" first="M J" last="Bernas">M J Bernas</name>
</author>
<author>
<name sortKey="Witte, M H" sort="Witte, M H" uniqKey="Witte M" first="M H" last="Witte">M H Witte</name>
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<author>
<name sortKey="Witte, C L" sort="Witte, C L" uniqKey="Witte C" first="C L" last="Witte">C L Witte</name>
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<author>
<name sortKey="Mcneill, G" sort="Mcneill, G" uniqKey="Mcneill G" first="G" last="Mcneill">G. Mcneill</name>
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<name sortKey="Crandall, C" sort="Crandall, C" uniqKey="Crandall C" first="C" last="Crandall">C. Crandall</name>
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<name sortKey="Crandall, R" sort="Crandall, R" uniqKey="Crandall R" first="R" last="Crandall">R. Crandall</name>
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<name sortKey="Unger, E" sort="Unger, E" uniqKey="Unger E" first="E" last="Unger">E. Unger</name>
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<name sortKey="Bernas, M J" sort="Bernas, M J" uniqKey="Bernas M" first="M J" last="Bernas">M J Bernas</name>
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<name sortKey="Witte, M H" sort="Witte, M H" uniqKey="Witte M" first="M H" last="Witte">M H Witte</name>
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<name sortKey="Witte, C L" sort="Witte, C L" uniqKey="Witte C" first="C L" last="Witte">C L Witte</name>
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<name sortKey="Mcneill, G" sort="Mcneill, G" uniqKey="Mcneill G" first="G" last="Mcneill">G. Mcneill</name>
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<name sortKey="Crandall, C" sort="Crandall, C" uniqKey="Crandall C" first="C" last="Crandall">C. Crandall</name>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Animals</term>
<term>Brugia</term>
<term>Elephantiasis, Filarial (diagnosis)</term>
<term>Ferrets</term>
<term>Lymphatic System (pathology)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Lymphatic System</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Brugia</term>
<term>Ferrets</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
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<front>
<div type="abstract" xml:lang="en">To evaluate acquired lymphatic abnormalities caused by filariasis, the authors examined the peripheral lymphatic system in normal ferrets and those chronically infected with Brugia malayi using magnetic resonance imaging (MRI). The findings were compared with previously obtained lymphangioscintigraphic (LAS) images in ferrets both with and without experimental filariasis.</div>
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<Year>1992</Year>
<Month>07</Month>
<Day>16</Day>
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<DateCompleted>
<Year>1992</Year>
<Month>07</Month>
<Day>16</Day>
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<DateRevised>
<Year>2010</Year>
<Month>03</Month>
<Day>24</Day>
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<Article PubModel="Print">
<Journal>
<ISSN IssnType="Print">0020-9996</ISSN>
<JournalIssue CitedMedium="Print">
<Volume>27</Volume>
<Issue>4</Issue>
<PubDate>
<Year>1992</Year>
<Month>Apr</Month>
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<Title>Investigative radiology</Title>
<ISOAbbreviation>Invest Radiol</ISOAbbreviation>
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<ArticleTitle>Lymphatic imaging in experimental filariasis using magnetic resonance.</ArticleTitle>
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<MedlinePgn>293-7</MedlinePgn>
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<AbstractText Label="RATIONALE AND OBJECTIVES" NlmCategory="OBJECTIVE">To evaluate acquired lymphatic abnormalities caused by filariasis, the authors examined the peripheral lymphatic system in normal ferrets and those chronically infected with Brugia malayi using magnetic resonance imaging (MRI). The findings were compared with previously obtained lymphangioscintigraphic (LAS) images in ferrets both with and without experimental filariasis.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Fifteen ferrets (11 infected with B. malayi and four noninfected controls) underwent whole body coronal MRI using a quadrature transmission-receive head coil at 0.5 Tesla operating at a resonant frequency of 21.5 mHz for protons with a 25-cm field of view.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In contrast to normal animals, infected ferrets showed dilated hindlimb dermal lymphatic collaterals, enlarged high-signal intensity groin lymph nodes with punctate low-signal intensity centers and separate low-signal intensity spots with irregular thin channels, suggestive of nests of viable adult nematodes within tortuous lymphatics and nodes. MRI correlated with the LAS findings, and the interpretations were supported by light, scanning electron, and video microscopy.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">T2-weighted MRI in conjunction with LAS accurately depicts the peripheral lymphatic system in filarial-infected ferrets. These two modalities are useful complementary techniques to examine disorders characterized by lymphatic insufficiency.</AbstractText>
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