Resistance and disease in Brugia malayi infection of ferrets following prior infection, injection of attenuated infective larvae and injections of larval extracts.
Identifieur interne : 005523 ( PubMed/Corpus ); précédent : 005522; suivant : 005524Resistance and disease in Brugia malayi infection of ferrets following prior infection, injection of attenuated infective larvae and injections of larval extracts.
Auteurs : R. Crandall ; C. Crandall ; J. Nayar ; T. DoyleSource :
- Parasite immunology [ 0141-9838 ] ; 1994.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (analysis), Brugia malayi (immunology), Brugia malayi (isolation & purification), Cell Extracts, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (pathology), Elephantiasis, Filarial (veterinary), Enzyme-Linked Immunosorbent Assay (veterinary), Ferrets (immunology), Ferrets (parasitology), Immunity, Injections, Larva (immunology), Lymphatic System (parasitology), Lymphatic System (pathology), Lymphedema (immunology), Lymphedema (pathology), Lymphedema (veterinary), Male, Th2 Cells (immunology).
- MESH :
- chemical , analysis : Antibodies, Helminth.
- immunology : Brugia malayi, Elephantiasis, Filarial, Ferrets, Larva, Lymphedema, Th2 Cells.
- isolation & purification : Brugia malayi.
- parasitology : Ferrets, Lymphatic System.
- pathology : Elephantiasis, Filarial, Lymphatic System, Lymphedema.
- veterinary : Elephantiasis, Filarial, Enzyme-Linked Immunosorbent Assay, Lymphedema.
- Animals, Cell Extracts, Immunity, Injections, Male.
Abstract
A partial resistance expressed by a 53% to 78% reduction in lymphatic filariae from a challenge infection was induced in ferrets (Mustela putorius furo) by a prior infection and by injection of radiation attenuated infective larvae (L3) but not by injections of lyophilized microfilariae (mf) or L3. Equivalent acquired resistance was demonstrated with and without overt filarial disease. A prior infection resulted in peripheral lymphoedema in approximately one-third of the amicrofilaraemic resistant ferrets following challenge infection and injection of attenuated larvae resulted in inflammatory responses characteristic of a hyper-responsive syndrome in one-half of the amicrofilaraemic ferrets. Injections of lyophilized mf inhibited microfilaraemia and promoted development of lymphostatic disease. A limited examination of immune responses and histopathology suggested that disease in partially resistant ferrets was associated with high TH2 dependent responses directed, at least in part, to mature filariae and to mf. Mechanisms of resistance were not identified.
PubMed: 7808763
Links to Exploration step
pubmed:7808763Le document en format XML
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<author><name sortKey="Crandall, R" sort="Crandall, R" uniqKey="Crandall R" first="R" last="Crandall">R. Crandall</name>
<affiliation><nlm:affiliation>Department of Immunology and Medical Microbiology, University of Florida, Gainesville.</nlm:affiliation>
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<author><name sortKey="Crandall, C" sort="Crandall, C" uniqKey="Crandall C" first="C" last="Crandall">C. Crandall</name>
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<author><name sortKey="Nayar, J" sort="Nayar, J" uniqKey="Nayar J" first="J" last="Nayar">J. Nayar</name>
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<author><name sortKey="Doyle, T" sort="Doyle, T" uniqKey="Doyle T" first="T" last="Doyle">T. Doyle</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Resistance and disease in Brugia malayi infection of ferrets following prior infection, injection of attenuated infective larvae and injections of larval extracts.</title>
<author><name sortKey="Crandall, R" sort="Crandall, R" uniqKey="Crandall R" first="R" last="Crandall">R. Crandall</name>
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<author><name sortKey="Crandall, C" sort="Crandall, C" uniqKey="Crandall C" first="C" last="Crandall">C. Crandall</name>
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<author><name sortKey="Nayar, J" sort="Nayar, J" uniqKey="Nayar J" first="J" last="Nayar">J. Nayar</name>
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<author><name sortKey="Doyle, T" sort="Doyle, T" uniqKey="Doyle T" first="T" last="Doyle">T. Doyle</name>
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<series><title level="j">Parasite immunology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Helminth (analysis)</term>
<term>Brugia malayi (immunology)</term>
<term>Brugia malayi (isolation & purification)</term>
<term>Cell Extracts</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (pathology)</term>
<term>Elephantiasis, Filarial (veterinary)</term>
<term>Enzyme-Linked Immunosorbent Assay (veterinary)</term>
<term>Ferrets (immunology)</term>
<term>Ferrets (parasitology)</term>
<term>Immunity</term>
<term>Injections</term>
<term>Larva (immunology)</term>
<term>Lymphatic System (parasitology)</term>
<term>Lymphatic System (pathology)</term>
<term>Lymphedema (immunology)</term>
<term>Lymphedema (pathology)</term>
<term>Lymphedema (veterinary)</term>
<term>Male</term>
<term>Th2 Cells (immunology)</term>
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<term>Elephantiasis, Filarial</term>
<term>Ferrets</term>
<term>Larva</term>
<term>Lymphedema</term>
<term>Th2 Cells</term>
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<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Brugia malayi</term>
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<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Ferrets</term>
<term>Lymphatic System</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Lymphatic System</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Extracts</term>
<term>Immunity</term>
<term>Injections</term>
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<front><div type="abstract" xml:lang="en">A partial resistance expressed by a 53% to 78% reduction in lymphatic filariae from a challenge infection was induced in ferrets (Mustela putorius furo) by a prior infection and by injection of radiation attenuated infective larvae (L3) but not by injections of lyophilized microfilariae (mf) or L3. Equivalent acquired resistance was demonstrated with and without overt filarial disease. A prior infection resulted in peripheral lymphoedema in approximately one-third of the amicrofilaraemic resistant ferrets following challenge infection and injection of attenuated larvae resulted in inflammatory responses characteristic of a hyper-responsive syndrome in one-half of the amicrofilaraemic ferrets. Injections of lyophilized mf inhibited microfilaraemia and promoted development of lymphostatic disease. A limited examination of immune responses and histopathology suggested that disease in partially resistant ferrets was associated with high TH2 dependent responses directed, at least in part, to mature filariae and to mf. Mechanisms of resistance were not identified.</div>
</front>
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<ArticleTitle>Resistance and disease in Brugia malayi infection of ferrets following prior infection, injection of attenuated infective larvae and injections of larval extracts.</ArticleTitle>
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<Abstract><AbstractText>A partial resistance expressed by a 53% to 78% reduction in lymphatic filariae from a challenge infection was induced in ferrets (Mustela putorius furo) by a prior infection and by injection of radiation attenuated infective larvae (L3) but not by injections of lyophilized microfilariae (mf) or L3. Equivalent acquired resistance was demonstrated with and without overt filarial disease. A prior infection resulted in peripheral lymphoedema in approximately one-third of the amicrofilaraemic resistant ferrets following challenge infection and injection of attenuated larvae resulted in inflammatory responses characteristic of a hyper-responsive syndrome in one-half of the amicrofilaraemic ferrets. Injections of lyophilized mf inhibited microfilaraemia and promoted development of lymphostatic disease. A limited examination of immune responses and histopathology suggested that disease in partially resistant ferrets was associated with high TH2 dependent responses directed, at least in part, to mature filariae and to mf. Mechanisms of resistance were not identified.</AbstractText>
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