A ten-year observation on experimental infection of periodic Brugia malayi in man.
Identifieur interne : 005486 ( PubMed/Corpus ); précédent : 005485; suivant : 005487A ten-year observation on experimental infection of periodic Brugia malayi in man.
Auteurs : P Y Wang ; T M Zhen ; Z Z Wang ; Z F Gu ; S P Ren ; L H Liu ; L W Hou ; J L LiuSource :
- The Journal of tropical medicine and hygiene [ 0022-5304 ] ; 1994.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Antibodies, Helminth (biosynthesis), Brugia malayi (growth & development), Brugia malayi (immunology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (pathology), Enzyme-Linked Immunosorbent Assay, Eosinophilia, Female, Humans, Leukocyte Count, Lymph Nodes (pathology), Lymphangiectasis, Lymphangitis, Lymphatic System (pathology), Lymphography, Male, Microfilariae (growth & development), Parasitemia (immunology), Parasitemia (parasitology), Parasitemia (pathology), Periodicity, Rosette Formation, Skin (pathology).
- MESH :
- chemical , biosynthesis : Antibodies, Helminth.
- growth & development : Brugia malayi, Microfilariae.
- immunology : Brugia malayi, Elephantiasis, Filarial, Parasitemia.
- parasitology : Elephantiasis, Filarial, Parasitemia.
- pathology : Elephantiasis, Filarial, Lymph Nodes, Lymphatic System, Parasitemia, Skin.
- Adolescent, Adult, Animals, Enzyme-Linked Immunosorbent Assay, Eosinophilia, Female, Humans, Leukocyte Count, Lymphangiectasis, Lymphangitis, Lymphography, Male, Periodicity, Rosette Formation.
Abstract
This paper reports the results of 10 years of observations on the clinical manifestations, pathology and immunity to filariasis and aetiological biology of filariae in three volunteers (first author and his family members) who were inoculated experimentally with infective larvae of periodic Brugia malayi in 1981. The changes in clinical symptoms and signs were recorded systematically. Microfilariae were first detected at 41 and 46 weeks after inoculation in two subjects and remained detectable in small numbers until 8-8.5 years after infection. The microfilarial density fluctuated at 1-2 mf 120 microliters-1. Thereafter no microfilariae were detected in 12 blood sample examinations, suggesting that the adult reproductive period of periodic B. malayi could last up to 8-9 years in the human body. Eosinophilia occurred mainly before and at the initial stage of microfilaraemia. An increase in the lymphocytes was observed to some extent at 2-156 weeks after infection. Biopsy at the inoculation site 6 weeks after inoculation showed infiltration of the lymph node by inflammatory cells, mainly eosinocytes, lymphocytes and monocytes. Lymphangiectasis and lymphostasis were observed in both limbs and pelvic regions by lymphangiogram taken 11 weeks after inoculation. Antibodies against B. malayi first appeared at 2-5 weeks after infection, peaked at 12-56 weeks and thereafter declined gradually. Subjects A and C became antibody free but subject B remained positive to antibody against B. malayi 10 years after infection. E-rosette forming lymphocytes became lower than normal at 11 weeks and recovered to normal within 10 years after infection.
PubMed: 7932922
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A ten-year observation on experimental infection of periodic Brugia malayi in man.</title><author><name sortKey="Wang, P Y" sort="Wang, P Y" uniqKey="Wang P" first="P Y" last="Wang">P Y Wang</name><affiliation><nlm:affiliation>Shandong Institute of Parasitic Diseases, Jining, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhen, T M" sort="Zhen, T M" uniqKey="Zhen T" first="T M" last="Zhen">T M Zhen</name></author><author><name sortKey="Wang, Z Z" sort="Wang, Z Z" uniqKey="Wang Z" first="Z Z" last="Wang">Z Z Wang</name></author><author><name sortKey="Gu, Z F" sort="Gu, Z F" uniqKey="Gu Z" first="Z F" last="Gu">Z F Gu</name></author><author><name sortKey="Ren, S P" sort="Ren, S P" uniqKey="Ren S" first="S P" last="Ren">S P Ren</name></author><author><name sortKey="Liu, L H" sort="Liu, L H" uniqKey="Liu L" first="L H" last="Liu">L H Liu</name></author><author><name sortKey="Hou, L W" sort="Hou, L W" uniqKey="Hou L" first="L W" last="Hou">L W Hou</name></author><author><name sortKey="Liu, J L" sort="Liu, J L" uniqKey="Liu J" first="J L" last="Liu">J L Liu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:7932922</idno><idno type="pmid">7932922</idno><idno type="wicri:Area/PubMed/Corpus">005486</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005486</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A ten-year observation on experimental infection of periodic Brugia malayi in man.</title><author><name sortKey="Wang, P Y" sort="Wang, P Y" uniqKey="Wang P" first="P Y" last="Wang">P Y Wang</name><affiliation><nlm:affiliation>Shandong Institute of Parasitic Diseases, Jining, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhen, T M" sort="Zhen, T M" uniqKey="Zhen T" first="T M" last="Zhen">T M Zhen</name></author><author><name sortKey="Wang, Z Z" sort="Wang, Z Z" uniqKey="Wang Z" first="Z Z" last="Wang">Z Z Wang</name></author><author><name sortKey="Gu, Z F" sort="Gu, Z F" uniqKey="Gu Z" first="Z F" last="Gu">Z F Gu</name></author><author><name sortKey="Ren, S P" sort="Ren, S P" uniqKey="Ren S" first="S P" last="Ren">S P Ren</name></author><author><name sortKey="Liu, L H" sort="Liu, L H" uniqKey="Liu L" first="L H" last="Liu">L H Liu</name></author><author><name sortKey="Hou, L W" sort="Hou, L W" uniqKey="Hou L" first="L W" last="Hou">L W Hou</name></author><author><name sortKey="Liu, J L" sort="Liu, J L" uniqKey="Liu J" first="J L" last="Liu">J L Liu</name></author></analytic><series><title level="j">The Journal of tropical medicine and hygiene</title><idno type="ISSN">0022-5304</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antibodies, Helminth (biosynthesis)</term><term>Brugia malayi (growth & development)</term><term>Brugia malayi (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Elephantiasis, Filarial (pathology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Eosinophilia</term><term>Female</term><term>Humans</term><term>Leukocyte Count</term><term>Lymph Nodes (pathology)</term><term>Lymphangiectasis</term><term>Lymphangitis</term><term>Lymphatic System (pathology)</term><term>Lymphography</term><term>Male</term><term>Microfilariae (growth & development)</term><term>Parasitemia (immunology)</term><term>Parasitemia (parasitology)</term><term>Parasitemia (pathology)</term><term>Periodicity</term><term>Rosette Formation</term><term>Skin (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia malayi</term><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymph Nodes</term><term>Lymphatic System</term><term>Parasitemia</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Eosinophilia</term><term>Female</term><term>Humans</term><term>Leukocyte Count</term><term>Lymphangiectasis</term><term>Lymphangitis</term><term>Lymphography</term><term>Male</term><term>Periodicity</term><term>Rosette Formation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This paper reports the results of 10 years of observations on the clinical manifestations, pathology and immunity to filariasis and aetiological biology of filariae in three volunteers (first author and his family members) who were inoculated experimentally with infective larvae of periodic Brugia malayi in 1981. The changes in clinical symptoms and signs were recorded systematically. Microfilariae were first detected at 41 and 46 weeks after inoculation in two subjects and remained detectable in small numbers until 8-8.5 years after infection. The microfilarial density fluctuated at 1-2 mf 120 microliters-1. Thereafter no microfilariae were detected in 12 blood sample examinations, suggesting that the adult reproductive period of periodic B. malayi could last up to 8-9 years in the human body. Eosinophilia occurred mainly before and at the initial stage of microfilaraemia. An increase in the lymphocytes was observed to some extent at 2-156 weeks after infection. Biopsy at the inoculation site 6 weeks after inoculation showed infiltration of the lymph node by inflammatory cells, mainly eosinocytes, lymphocytes and monocytes. Lymphangiectasis and lymphostasis were observed in both limbs and pelvic regions by lymphangiogram taken 11 weeks after inoculation. Antibodies against B. malayi first appeared at 2-5 weeks after infection, peaked at 12-56 weeks and thereafter declined gradually. Subjects A and C became antibody free but subject B remained positive to antibody against B. malayi 10 years after infection. E-rosette forming lymphocytes became lower than normal at 11 weeks and recovered to normal within 10 years after infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7932922</PMID><DateCreated><Year>1994</Year><Month>11</Month><Day>10</Day></DateCreated><DateCompleted><Year>1994</Year><Month>11</Month><Day>10</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-5304</ISSN><JournalIssue CitedMedium="Print"><Volume>97</Volume><Issue>5</Issue><PubDate><Year>1994</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The Journal of tropical medicine and hygiene</Title><ISOAbbreviation>J Trop Med Hyg</ISOAbbreviation></Journal><ArticleTitle>A ten-year observation on experimental infection of periodic Brugia malayi in man.</ArticleTitle><Pagination><MedlinePgn>269-76</MedlinePgn></Pagination><Abstract><AbstractText>This paper reports the results of 10 years of observations on the clinical manifestations, pathology and immunity to filariasis and aetiological biology of filariae in three volunteers (first author and his family members) who were inoculated experimentally with infective larvae of periodic Brugia malayi in 1981. The changes in clinical symptoms and signs were recorded systematically. Microfilariae were first detected at 41 and 46 weeks after inoculation in two subjects and remained detectable in small numbers until 8-8.5 years after infection. The microfilarial density fluctuated at 1-2 mf 120 microliters-1. Thereafter no microfilariae were detected in 12 blood sample examinations, suggesting that the adult reproductive period of periodic B. malayi could last up to 8-9 years in the human body. Eosinophilia occurred mainly before and at the initial stage of microfilaraemia. An increase in the lymphocytes was observed to some extent at 2-156 weeks after infection. Biopsy at the inoculation site 6 weeks after inoculation showed infiltration of the lymph node by inflammatory cells, mainly eosinocytes, lymphocytes and monocytes. Lymphangiectasis and lymphostasis were observed in both limbs and pelvic regions by lymphangiogram taken 11 weeks after inoculation. Antibodies against B. malayi first appeared at 2-5 weeks after infection, peaked at 12-56 weeks and thereafter declined gradually. Subjects A and C became antibody free but subject B remained positive to antibody against B. malayi 10 years after infection. E-rosette forming lymphocytes became lower than normal at 11 weeks and recovered to normal within 10 years after infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>P Y</ForeName><Initials>PY</Initials><AffiliationInfo><Affiliation>Shandong Institute of Parasitic Diseases, Jining, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhen</LastName><ForeName>T M</ForeName><Initials>TM</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Z Z</ForeName><Initials>ZZ</Initials></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Z F</ForeName><Initials>ZF</Initials></Author><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>S P</ForeName><Initials>SP</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>L H</ForeName><Initials>LH</Initials></Author><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>L W</ForeName><Initials>LW</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>J L</ForeName><Initials>JL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Trop Med Hyg</MedlineTA><NlmUniqueID>0406044</NlmUniqueID><ISSNLinking>0022-5304</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017178" MajorTopicYN="Y">Brugia malayi</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004802" MajorTopicYN="N">Eosinophilia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007958" MajorTopicYN="N">Leukocyte Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008200" MajorTopicYN="N">Lymphangiectasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008205" MajorTopicYN="N">Lymphangitis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008220" MajorTopicYN="N">Lymphography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008842" MajorTopicYN="N">Microfilariae</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018512" MajorTopicYN="N">Parasitemia</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010507" MajorTopicYN="Y">Periodicity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012397" MajorTopicYN="N">Rosette Formation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1994</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1994</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1994</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7932922</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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