Predominant CD8+ infiltrate in limb biopsies of individuals with filarial lymphedema and elephantiasis.
Identifieur interne : 005293 ( PubMed/Corpus ); précédent : 005292; suivant : 005294Predominant CD8+ infiltrate in limb biopsies of individuals with filarial lymphedema and elephantiasis.
Auteurs : D O Freedman ; T D Horn ; C M Maia E Silva ; C. Braga ; A. MacielSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1995.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (analysis), Antibodies, Monoclonal, Antigens, CD3 (analysis), Biopsy, Needle, CD4-CD8 Ratio, CD8-Positive T-Lymphocytes (pathology), Chemotaxis, Leukocyte, Elephantiasis, Filarial (diagnostic imaging), Elephantiasis, Filarial (etiology), Elephantiasis, Filarial (pathology), Extremities, Humans, Immunoenzyme Techniques, Lymphatic System (pathology), Lymphedema (diagnostic imaging), Lymphedema (etiology), Lymphedema (pathology), Lymphoscintigraphy, Organotechnetium Compounds, Skin (pathology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , analysis : Antibodies, Helminth, Antigens, CD3.
- diagnostic imaging : Elephantiasis, Filarial, Lymphedema.
- etiology : Elephantiasis, Filarial, Lymphedema.
- immunology : Wuchereria bancrofti.
- pathology : CD8-Positive T-Lymphocytes, Elephantiasis, Filarial, Lymphatic System, Lymphedema, Skin.
- Animals, Antibodies, Monoclonal, Biopsy, Needle, CD4-CD8 Ratio, Chemotaxis, Leukocyte, Extremities, Humans, Immunoenzyme Techniques, Lymphoscintigraphy, Organotechnetium Compounds.
Abstract
In 34 individuals with a spectrum of clinical manifestations of Bancroftian filariasis, we investigated whether immunoperoxidase-stained, random, superficial dermal biopsies could further elucidate the nature of the diffuse damage to superficial lymphatics that had been recently demonstrated by radionuclide lymphoscintigraphy. A total of 78% and 68% of limbs from patients with clinical disease and asymptomatic microfilaremia, respectively, contained EN4+PAL-E- lymphatic vessels that were abnormally dilated. The majority of subjects, regardless of clinical classification, had a CD3+ perivascular but not a perilymphatic infiltrate in tissues and no parasites were present. In contrast to those individuals with asymptomatic infection, a striking predominance of CD8+ T cells was found in the tissue of individuals with clinical disease. Tissue pathology consistent with cutaneous bacterial infection was not observed. The prominent perivenular and pericapillary mononuclear infiltrates likely indicate, in light of current understanding of lymphocyte recirculation, the extravasation of lymphocytes from the vascular circulation into the inflamed filarial tissue.
PubMed: 8561266
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pubmed:8561266Le document en format XML
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Maciel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:8561266</idno><idno type="pmid">8561266</idno><idno type="wicri:Area/PubMed/Corpus">005293</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005293</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Predominant CD8+ infiltrate in limb biopsies of individuals with filarial lymphedema and elephantiasis.</title><author><name sortKey="Freedman, D O" sort="Freedman, D O" uniqKey="Freedman D" first="D O" last="Freedman">D O Freedman</name><affiliation><nlm:affiliation>Division of Geographic Medicine, University of Alabama at Birmingham, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Horn, T D" sort="Horn, T D" uniqKey="Horn T" first="T D" last="Horn">T D Horn</name></author><author><name sortKey="Maia E Silva, C M" sort="Maia E Silva, C M" uniqKey="Maia E Silva C" first="C M" last="Maia E Silva">C M Maia E Silva</name></author><author><name sortKey="Braga, C" sort="Braga, C" uniqKey="Braga C" first="C" last="Braga">C. Braga</name></author><author><name sortKey="Maciel, A" sort="Maciel, A" uniqKey="Maciel A" first="A" last="Maciel">A. Maciel</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (analysis)</term><term>Antibodies, Monoclonal</term><term>Antigens, CD3 (analysis)</term><term>Biopsy, Needle</term><term>CD4-CD8 Ratio</term><term>CD8-Positive T-Lymphocytes (pathology)</term><term>Chemotaxis, Leukocyte</term><term>Elephantiasis, Filarial (diagnostic imaging)</term><term>Elephantiasis, Filarial (etiology)</term><term>Elephantiasis, Filarial (pathology)</term><term>Extremities</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Lymphatic System (pathology)</term><term>Lymphedema (diagnostic imaging)</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Lymphoscintigraphy</term><term>Organotechnetium Compounds</term><term>Skin (pathology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, CD3</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Elephantiasis, Filarial</term><term>Lymphatic System</term><term>Lymphedema</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal</term><term>Biopsy, Needle</term><term>CD4-CD8 Ratio</term><term>Chemotaxis, Leukocyte</term><term>Extremities</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Lymphoscintigraphy</term><term>Organotechnetium Compounds</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 34 individuals with a spectrum of clinical manifestations of Bancroftian filariasis, we investigated whether immunoperoxidase-stained, random, superficial dermal biopsies could further elucidate the nature of the diffuse damage to superficial lymphatics that had been recently demonstrated by radionuclide lymphoscintigraphy. A total of 78% and 68% of limbs from patients with clinical disease and asymptomatic microfilaremia, respectively, contained EN4+PAL-E- lymphatic vessels that were abnormally dilated. The majority of subjects, regardless of clinical classification, had a CD3+ perivascular but not a perilymphatic infiltrate in tissues and no parasites were present. In contrast to those individuals with asymptomatic infection, a striking predominance of CD8+ T cells was found in the tissue of individuals with clinical disease. Tissue pathology consistent with cutaneous bacterial infection was not observed. The prominent perivenular and pericapillary mononuclear infiltrates likely indicate, in light of current understanding of lymphocyte recirculation, the extravasation of lymphocytes from the vascular circulation into the inflamed filarial tissue.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8561266</PMID><DateCreated><Year>1996</Year><Month>02</Month><Day>27</Day></DateCreated><DateCompleted><Year>1996</Year><Month>02</Month><Day>27</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9637</ISSN><JournalIssue CitedMedium="Print"><Volume>53</Volume><Issue>6</Issue><PubDate><Year>1995</Year><Month>Dec</Month></PubDate></JournalIssue><Title>The American journal of tropical medicine and hygiene</Title><ISOAbbreviation>Am. J. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Predominant CD8+ infiltrate in limb biopsies of individuals with filarial lymphedema and elephantiasis.</ArticleTitle><Pagination><MedlinePgn>633-8</MedlinePgn></Pagination><Abstract><AbstractText>In 34 individuals with a spectrum of clinical manifestations of Bancroftian filariasis, we investigated whether immunoperoxidase-stained, random, superficial dermal biopsies could further elucidate the nature of the diffuse damage to superficial lymphatics that had been recently demonstrated by radionuclide lymphoscintigraphy. A total of 78% and 68% of limbs from patients with clinical disease and asymptomatic microfilaremia, respectively, contained EN4+PAL-E- lymphatic vessels that were abnormally dilated. The majority of subjects, regardless of clinical classification, had a CD3+ perivascular but not a perilymphatic infiltrate in tissues and no parasites were present. In contrast to those individuals with asymptomatic infection, a striking predominance of CD8+ T cells was found in the tissue of individuals with clinical disease. Tissue pathology consistent with cutaneous bacterial infection was not observed. The prominent perivenular and pericapillary mononuclear infiltrates likely indicate, in light of current understanding of lymphocyte recirculation, the extravasation of lymphocytes from the vascular circulation into the inflamed filarial tissue.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Freedman</LastName><ForeName>D O</ForeName><Initials>DO</Initials><AffiliationInfo><Affiliation>Division of Geographic Medicine, University of Alabama at Birmingham, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horn</LastName><ForeName>T D</ForeName><Initials>TD</Initials></Author><Author ValidYN="Y"><LastName>Maia e Silva</LastName><ForeName>C M</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Braga</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Maciel</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI-31552</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Trop Med Hyg</MedlineTA><NlmUniqueID>0370507</NlmUniqueID><ISSNLinking>0002-9637</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017252">Antigens, CD3</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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System</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D061305" MajorTopicYN="N">Lymphoscintigraphy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015609" MajorTopicYN="N">Organotechnetium Compounds</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="Y">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8561266</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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