Radical radiotherapy versus brachytherapy plus surgery in carcinoma of the cervix 2A and 2B--long-term results from a randomized study 1968-1980.
Identifieur interne : 005245 ( PubMed/Corpus ); précédent : 005244; suivant : 005246Radical radiotherapy versus brachytherapy plus surgery in carcinoma of the cervix 2A and 2B--long-term results from a randomized study 1968-1980.
Auteurs : K. Sundf R ; C G Trope ; K E Kj RstadSource :
- Acta oncologica (Stockholm, Sweden) [ 0284-186X ] ; 1996.
English descriptors
- KwdEn :
- Adult, Brachytherapy, Carcinoma, Squamous Cell (mortality), Carcinoma, Squamous Cell (radiotherapy), Carcinoma, Squamous Cell (surgery), Female, Humans, Hysterectomy, Longitudinal Studies, Lymph Node Excision, Lymphatic Metastasis, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy, High-Energy, Random Allocation, Treatment Outcome, Uterine Cervical Neoplasms (mortality), Uterine Cervical Neoplasms (radiotherapy), Uterine Cervical Neoplasms (surgery).
- MESH :
- mortality : Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- radiotherapy : Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- surgery : Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- Adult, Brachytherapy, Female, Humans, Hysterectomy, Longitudinal Studies, Lymph Node Excision, Lymphatic Metastasis, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy, High-Energy, Random Allocation, Treatment Outcome.
Abstract
To investigate whether surgery or radiotherapy should be preferred in the early stages of carcinoma of the cervix a randomized study was performed in which operable patients with small FIGO stage 2 squamous cell carcinoma were included. Of these patients, 122 were in stage 2A and 20 in stage 2B. The patients were treated with intracavitary radium, followed by either radical surgery with pelvic lymphadenectomy (Group A, 72 patients) or high-voltage external irradiation 40 Gy to a pelvic field (Group B, 70 patients). Postoperative irradiation 40 to 50 Gy was given in Group A if lymph node metastases were found at operation. Fourteen patients in Group A and 23 in Group B died of recurrent disease. The 5-, 10-, and 20-year survival in Group A was 87, 84 and 81% respectively compared with 72, 69, and 68% in Group B, p < 0.05. Twenty-three (34%) of 67 radically operated patients had metastases to pelvic lymph nodes. A high rate of pelvic and para-aortic recurrences accounts for the difference between Groups A and B. Young patients (<40 years) with large tumours had a high risk of recurrent disease. Severe urinary and gastrointestinal complications were more common in Group A, especially among patients given postoperative radiotherapy. Lymphoedema was seen almost exclusively in Group A. Two patients in Group A and one in Group B died of complications to treatment. The corrected 10-year survival of 69.5% as achieved in the radiotherapy arm of this series is comparable to other reported studies. The high survival rate in the operated group, despite a very high metastases rate, suggests that surgery is applicable also in stage 2 patients.
PubMed: 9073055
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pubmed:9073055Le document en format XML
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Sundf R</name><affiliation><nlm:affiliation>Department of Gynecologic Oncology, the Norwegian Radium Hospital, Oslo.</nlm:affiliation></affiliation></author><author><name sortKey="Trope, C G" sort="Trope, C G" uniqKey="Trope C" first="C G" last="Trope">C G Trope</name></author><author><name sortKey="Kj Rstad, K E" sort="Kj Rstad, K E" uniqKey="Kj Rstad K" first="K E" last="Kj Rstad">K E Kj Rstad</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996</date><idno type="RBID">pubmed:9073055</idno><idno type="pmid">9073055</idno><idno type="wicri:Area/PubMed/Corpus">005245</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005245</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Radical radiotherapy versus brachytherapy plus surgery in carcinoma of the cervix 2A and 2B--long-term results from a randomized study 1968-1980.</title><author><name sortKey="Sundf R, K" sort="Sundf R, K" uniqKey="Sundf R K" first="K" last="Sundf R">K. Sundf R</name><affiliation><nlm:affiliation>Department of Gynecologic Oncology, the Norwegian Radium Hospital, Oslo.</nlm:affiliation></affiliation></author><author><name sortKey="Trope, C G" sort="Trope, C G" uniqKey="Trope C" first="C G" last="Trope">C G Trope</name></author><author><name sortKey="Kj Rstad, K E" sort="Kj Rstad, K E" uniqKey="Kj Rstad K" first="K E" last="Kj Rstad">K E Kj Rstad</name></author></analytic><series><title level="j">Acta oncologica (Stockholm, Sweden)</title><idno type="ISSN">0284-186X</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brachytherapy</term><term>Carcinoma, Squamous Cell (mortality)</term><term>Carcinoma, Squamous Cell (radiotherapy)</term><term>Carcinoma, Squamous Cell (surgery)</term><term>Female</term><term>Humans</term><term>Hysterectomy</term><term>Longitudinal Studies</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local</term><term>Radiotherapy, High-Energy</term><term>Random Allocation</term><term>Treatment Outcome</term><term>Uterine Cervical Neoplasms (mortality)</term><term>Uterine Cervical Neoplasms (radiotherapy)</term><term>Uterine Cervical Neoplasms (surgery)</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Brachytherapy</term><term>Female</term><term>Humans</term><term>Hysterectomy</term><term>Longitudinal Studies</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local</term><term>Radiotherapy, High-Energy</term><term>Random Allocation</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate whether surgery or radiotherapy should be preferred in the early stages of carcinoma of the cervix a randomized study was performed in which operable patients with small FIGO stage 2 squamous cell carcinoma were included. Of these patients, 122 were in stage 2A and 20 in stage 2B. The patients were treated with intracavitary radium, followed by either radical surgery with pelvic lymphadenectomy (Group A, 72 patients) or high-voltage external irradiation 40 Gy to a pelvic field (Group B, 70 patients). Postoperative irradiation 40 to 50 Gy was given in Group A if lymph node metastases were found at operation. Fourteen patients in Group A and 23 in Group B died of recurrent disease. The 5-, 10-, and 20-year survival in Group A was 87, 84 and 81% respectively compared with 72, 69, and 68% in Group B, p < 0.05. Twenty-three (34%) of 67 radically operated patients had metastases to pelvic lymph nodes. A high rate of pelvic and para-aortic recurrences accounts for the difference between Groups A and B. Young patients (<40 years) with large tumours had a high risk of recurrent disease. Severe urinary and gastrointestinal complications were more common in Group A, especially among patients given postoperative radiotherapy. Lymphoedema was seen almost exclusively in Group A. Two patients in Group A and one in Group B died of complications to treatment. The corrected 10-year survival of 69.5% as achieved in the radiotherapy arm of this series is comparable to other reported studies. The high survival rate in the operated group, despite a very high metastases rate, suggests that surgery is applicable also in stage 2 patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9073055</PMID><DateCreated><Year>1997</Year><Month>04</Month><Day>11</Day></DateCreated><DateCompleted><Year>1997</Year><Month>04</Month><Day>11</Day></DateCompleted><DateRevised><Year>2009</Year><Month>05</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0284-186X</ISSN><JournalIssue CitedMedium="Print"><Volume>35 Suppl 8</Volume><PubDate><Year>1996</Year></PubDate></JournalIssue><Title>Acta oncologica (Stockholm, Sweden)</Title><ISOAbbreviation>Acta Oncol</ISOAbbreviation></Journal><ArticleTitle>Radical radiotherapy versus brachytherapy plus surgery in carcinoma of the cervix 2A and 2B--long-term results from a randomized study 1968-1980.</ArticleTitle><Pagination><MedlinePgn>99-107</MedlinePgn></Pagination><Abstract><AbstractText>To investigate whether surgery or radiotherapy should be preferred in the early stages of carcinoma of the cervix a randomized study was performed in which operable patients with small FIGO stage 2 squamous cell carcinoma were included. Of these patients, 122 were in stage 2A and 20 in stage 2B. The patients were treated with intracavitary radium, followed by either radical surgery with pelvic lymphadenectomy (Group A, 72 patients) or high-voltage external irradiation 40 Gy to a pelvic field (Group B, 70 patients). Postoperative irradiation 40 to 50 Gy was given in Group A if lymph node metastases were found at operation. Fourteen patients in Group A and 23 in Group B died of recurrent disease. The 5-, 10-, and 20-year survival in Group A was 87, 84 and 81% respectively compared with 72, 69, and 68% in Group B, p < 0.05. Twenty-three (34%) of 67 radically operated patients had metastases to pelvic lymph nodes. A high rate of pelvic and para-aortic recurrences accounts for the difference between Groups A and B. Young patients (<40 years) with large tumours had a high risk of recurrent disease. Severe urinary and gastrointestinal complications were more common in Group A, especially among patients given postoperative radiotherapy. Lymphoedema was seen almost exclusively in Group A. Two patients in Group A and one in Group B died of complications to treatment. The corrected 10-year survival of 69.5% as achieved in the radiotherapy arm of this series is comparable to other reported studies. The high survival rate in the operated group, despite a very high metastases rate, suggests that surgery is applicable also in stage 2 patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sundfør</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Gynecologic Oncology, the Norwegian Radium Hospital, Oslo.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trope</LastName><ForeName>C G</ForeName><Initials>CG</Initials></Author><Author ValidYN="Y"><LastName>Kjørstad</LastName><ForeName>K E</ForeName><Initials>KE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Acta Oncol</MedlineTA><NlmUniqueID>8709065</NlmUniqueID><ISSNLinking>0284-186X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001918" MajorTopicYN="Y">Brachytherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002294" MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007044" MajorTopicYN="N">Hysterectomy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009364" MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011882" MajorTopicYN="N">Radiotherapy, High-Energy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002583" MajorTopicYN="N">Uterine Cervical Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1996</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1996</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1996</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9073055</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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