Flow velocity of cutaneous lymphatic capillaries in patients with primary lymphedema.
Identifieur interne : 005007 ( PubMed/Corpus ); précédent : 005006; suivant : 005008Flow velocity of cutaneous lymphatic capillaries in patients with primary lymphedema.
Auteurs : M. Fischer ; U. Costanzo ; U. Hoffmann ; A. Bollinger ; U K FranzeckSource :
- International journal of microcirculation, clinical and experimental [ 0167-6865 ]
English descriptors
- KwdEn :
- Adult, Aged, Contrast Media, Dextrans, Female, Fluorescein-5-isothiocyanate (analogs & derivatives), Humans, Injections, Intralymphatic, Lymph (chemistry), Lymph (physiology), Lymphatic System (drug effects), Lymphatic System (physiology), Lymphedema (physiopathology), Male, Microscopy, Fluorescence, Microscopy, Video, Middle Aged, Skin Physiological Phenomena.
- MESH :
- chemical , analogs & derivatives : Fluorescein-5-isothiocyanate.
- chemical : Contrast Media, Dextrans.
- chemistry : Lymph.
- drug effects : Lymphatic System.
- physiology : Lymph, Lymphatic System.
- physiopathology : Lymphedema.
- Adult, Aged, Female, Humans, Injections, Intralymphatic, Male, Microscopy, Fluorescence, Microscopy, Video, Middle Aged, Skin Physiological Phenomena.
Abstract
For the first time measurements of lymph flow velocities in cutaneous microlymphatics of patients with lymphedema were performed and compared with healthy subjects. Flow velocity in single lymphatic skin capillaries was measured using fluorescence video microscopy after subepidermal microinjection of FITC-dextran 150,000 in 15 healthy volunteers and 16 patients with primary lymphedema. Initial filling of the lymphatic capillary network was fast with significantly higher mean velocities in patients with primary lymphedema than in healthy controls (890 +/- 43 vs. 550 +/- 390 microns/s, p < 0.05). The resting velocities were not significantly different between controls and patients (10.3 +/- 4.1 vs. 16.6 +/- 13.9 microns). In 12 out of the 16 lymphedema patients cutaneous backflow of the fluorescent contrast medium from deeper invisible lymphatics was observed. In 4 of these patients rhythmic reflux with a mean frequency of 1.4 +/- 0.5 cycles/min was measured by video densitometry in microlymphatics with a significantly (p < 0.01) enhanced diameter. Mean flow velocity (Vp) in these precollectors was significantly increased compared to the resting velocities (p < 0.01). On the basis of these results the hypothesis is advanced that rhythmic cutaneous backflow originates from intrinsic contractions of deeper lymph collector segments and is transmitted to the superficial microlymphatics through incompetent connecting channels. This newly recognized mechanism appears to be an important factor for the pathophysiology of lymphedema.
PubMed: 9272465
Links to Exploration step
pubmed:9272465Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Flow velocity of cutaneous lymphatic capillaries in patients with primary lymphedema.</title><author><name sortKey="Fischer, M" sort="Fischer, M" uniqKey="Fischer M" first="M" last="Fischer">M. Fischer</name><affiliation><nlm:affiliation>Department of Medicine, University Hospital, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Costanzo, U" sort="Costanzo, U" uniqKey="Costanzo U" first="U" last="Costanzo">U. Costanzo</name></author><author><name sortKey="Hoffmann, U" sort="Hoffmann, U" uniqKey="Hoffmann U" first="U" last="Hoffmann">U. Hoffmann</name></author><author><name sortKey="Bollinger, A" sort="Bollinger, A" uniqKey="Bollinger A" first="A" last="Bollinger">A. Bollinger</name></author><author><name sortKey="Franzeck, U K" sort="Franzeck, U K" uniqKey="Franzeck U" first="U K" last="Franzeck">U K Franzeck</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1997 May-Jun</MedlineDate></PubDate></date><idno type="RBID">pubmed:9272465</idno><idno type="pmid">9272465</idno><idno type="wicri:Area/PubMed/Corpus">005007</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005007</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Flow velocity of cutaneous lymphatic capillaries in patients with primary lymphedema.</title><author><name sortKey="Fischer, M" sort="Fischer, M" uniqKey="Fischer M" first="M" last="Fischer">M. Fischer</name><affiliation><nlm:affiliation>Department of Medicine, University Hospital, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Costanzo, U" sort="Costanzo, U" uniqKey="Costanzo U" first="U" last="Costanzo">U. Costanzo</name></author><author><name sortKey="Hoffmann, U" sort="Hoffmann, U" uniqKey="Hoffmann U" first="U" last="Hoffmann">U. Hoffmann</name></author><author><name sortKey="Bollinger, A" sort="Bollinger, A" uniqKey="Bollinger A" first="A" last="Bollinger">A. Bollinger</name></author><author><name sortKey="Franzeck, U K" sort="Franzeck, U K" uniqKey="Franzeck U" first="U K" last="Franzeck">U K Franzeck</name></author></analytic><series><title level="j">International journal of microcirculation, clinical and experimental</title><idno type="ISSN">0167-6865</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Contrast Media</term><term>Dextrans</term><term>Female</term><term>Fluorescein-5-isothiocyanate (analogs & derivatives)</term><term>Humans</term><term>Injections, Intralymphatic</term><term>Lymph (chemistry)</term><term>Lymph (physiology)</term><term>Lymphatic System (drug effects)</term><term>Lymphatic System (physiology)</term><term>Lymphedema (physiopathology)</term><term>Male</term><term>Microscopy, Fluorescence</term><term>Microscopy, Video</term><term>Middle Aged</term><term>Skin Physiological Phenomena</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Fluorescein-5-isothiocyanate</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Contrast Media</term><term>Dextrans</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Lymph</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph</term><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Injections, Intralymphatic</term><term>Male</term><term>Microscopy, Fluorescence</term><term>Microscopy, Video</term><term>Middle Aged</term><term>Skin Physiological Phenomena</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For the first time measurements of lymph flow velocities in cutaneous microlymphatics of patients with lymphedema were performed and compared with healthy subjects. Flow velocity in single lymphatic skin capillaries was measured using fluorescence video microscopy after subepidermal microinjection of FITC-dextran 150,000 in 15 healthy volunteers and 16 patients with primary lymphedema. Initial filling of the lymphatic capillary network was fast with significantly higher mean velocities in patients with primary lymphedema than in healthy controls (890 +/- 43 vs. 550 +/- 390 microns/s, p < 0.05). The resting velocities were not significantly different between controls and patients (10.3 +/- 4.1 vs. 16.6 +/- 13.9 microns). In 12 out of the 16 lymphedema patients cutaneous backflow of the fluorescent contrast medium from deeper invisible lymphatics was observed. In 4 of these patients rhythmic reflux with a mean frequency of 1.4 +/- 0.5 cycles/min was measured by video densitometry in microlymphatics with a significantly (p < 0.01) enhanced diameter. Mean flow velocity (Vp) in these precollectors was significantly increased compared to the resting velocities (p < 0.01). On the basis of these results the hypothesis is advanced that rhythmic cutaneous backflow originates from intrinsic contractions of deeper lymph collector segments and is transmitted to the superficial microlymphatics through incompetent connecting channels. This newly recognized mechanism appears to be an important factor for the pathophysiology of lymphedema.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9272465</PMID><DateCreated><Year>1997</Year><Month>10</Month><Day>07</Day></DateCreated><DateCompleted><Year>1997</Year><Month>10</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0167-6865</ISSN><JournalIssue CitedMedium="Print"><Volume>17</Volume><Issue>3</Issue><PubDate><MedlineDate>1997 May-Jun</MedlineDate></PubDate></JournalIssue><Title>International journal of microcirculation, clinical and experimental</Title><ISOAbbreviation>Int J Microcirc Clin Exp</ISOAbbreviation></Journal><ArticleTitle>Flow velocity of cutaneous lymphatic capillaries in patients with primary lymphedema.</ArticleTitle><Pagination><MedlinePgn>143-9</MedlinePgn></Pagination><Abstract><AbstractText>For the first time measurements of lymph flow velocities in cutaneous microlymphatics of patients with lymphedema were performed and compared with healthy subjects. Flow velocity in single lymphatic skin capillaries was measured using fluorescence video microscopy after subepidermal microinjection of FITC-dextran 150,000 in 15 healthy volunteers and 16 patients with primary lymphedema. Initial filling of the lymphatic capillary network was fast with significantly higher mean velocities in patients with primary lymphedema than in healthy controls (890 +/- 43 vs. 550 +/- 390 microns/s, p < 0.05). The resting velocities were not significantly different between controls and patients (10.3 +/- 4.1 vs. 16.6 +/- 13.9 microns). In 12 out of the 16 lymphedema patients cutaneous backflow of the fluorescent contrast medium from deeper invisible lymphatics was observed. In 4 of these patients rhythmic reflux with a mean frequency of 1.4 +/- 0.5 cycles/min was measured by video densitometry in microlymphatics with a significantly (p < 0.01) enhanced diameter. Mean flow velocity (Vp) in these precollectors was significantly increased compared to the resting velocities (p < 0.01). On the basis of these results the hypothesis is advanced that rhythmic cutaneous backflow originates from intrinsic contractions of deeper lymph collector segments and is transmitted to the superficial microlymphatics through incompetent connecting channels. This newly recognized mechanism appears to be an important factor for the pathophysiology of lymphedema.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, University Hospital, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Costanzo</LastName><ForeName>U</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Hoffmann</LastName><ForeName>U</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Bollinger</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Franzeck</LastName><ForeName>U K</ForeName><Initials>UK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Int J Microcirc Clin Exp</MedlineTA><NlmUniqueID>8400122</NlmUniqueID><ISSNLinking>0167-6865</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003287">Contrast Media</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003911">Dextrans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C015219">fluorescein isothiocyanate dextran</NameOfSubstance></Chemical><Chemical><RegistryNumber>I223NX31W9</RegistryNumber><NameOfSubstance UI="D016650">Fluorescein-5-isothiocyanate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003287" MajorTopicYN="N">Contrast Media</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003911" MajorTopicYN="N">Dextrans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016650" MajorTopicYN="N">Fluorescein-5-isothiocyanate</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007272" MajorTopicYN="N">Injections, Intralymphatic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008196" MajorTopicYN="N">Lymph</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008856" MajorTopicYN="N">Microscopy, Fluorescence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018715" MajorTopicYN="N">Microscopy, Video</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012879" MajorTopicYN="Y">Skin Physiological Phenomena</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>5</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1997</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9272465</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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