Massive localized lymphedema in the morbidly obese: a histologically distinct reactive lesion simulating liposarcoma.
Identifieur interne : 004E19 ( PubMed/Corpus ); précédent : 004E18; suivant : 004E20Massive localized lymphedema in the morbidly obese: a histologically distinct reactive lesion simulating liposarcoma.
Auteurs : G. Farshid ; S W WeissSource :
- The American journal of surgical pathology [ 0147-5185 ] ; 1998.
English descriptors
- KwdEn :
- Adipose Tissue (pathology), Adult, Aged, Diagnosis, Differential, Extremities (blood supply), Extremities (diagnostic imaging), Extremities (pathology), Female, Fibroma (pathology), Follow-Up Studies, Humans, Liposarcoma (pathology), Lymphatic System (pathology), Lymphedema (diagnostic imaging), Lymphedema (etiology), Lymphedema (pathology), Male, Middle Aged, Obesity, Morbid (complications), Obesity, Morbid (pathology), Skin (pathology), Tomography, X-Ray Computed.
- MESH :
- blood supply : Extremities.
- complications : Obesity, Morbid.
- diagnostic imaging : Extremities, Lymphedema.
- etiology : Lymphedema.
- pathology : Adipose Tissue, Extremities, Fibroma, Liposarcoma, Lymphatic System, Lymphedema, Obesity, Morbid, Skin.
- Adult, Aged, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Middle Aged, Tomography, X-Ray Computed.
Abstract
We report 14 cases of a soft tissue lesion in the limbs of morbidly obese adults that presents as a large mass and histologically simulates well-differentiated liposarcoma (WDL). Based on its distinctive clinical setting and morphologic identity to diffuse lymphedema we have termed this process massive localized lymphedema (MLL). All cases occurred in morbidly obese adults (mean weight 372 lbs; mean age 47 years). Women predominated (9 women; 5 men). The lesions affected the proximal medial aspect of the extremities (12 thigh; 2 arm) and were unilateral in all but two patients. Etiologically significant antecedent events include ipsilateral axillary lymphadenectomy in both patients with arm lesions, chronic lymphedema resulting from vein-stripping 10 years prior in one patient. inguinal lymphadenectomy for anal carcinoma in another patient, and significant blunt trauma to the inner thigh during a motor vehicle accident in a third patient. The tumors were long standing ( I-IO years) and extremely large (mean size 33.4 cm, 7408 g). Clinically, they were diffuse, ill-defined masses that histologically consisted of lobules of mature fat interrupted by expanded connective tissue septa. The constituents of the septa were fine, fibrillary collagen, edema fluid, and uniformly distributed fibroblasts. Clusters of capillaries were frequently found at the interface between fat and connective tissue. The widened septa simulated the fibrous bands of sclerosing WDL, but MLL lacks the degree of nuclear atypia seen in the former. The consistent clustering of reactive vessels at the interface between the fat and fibrous tissue also contrasted with WDL. Six patients experienced persistent or recurrent lesions within 10 months to 10 years. No aggressive growth or histologic progression was observed during this time, however. Awareness of the features of MLL is important to avoid misclassification of this reactive lesion with WDL.
PubMed: 9777990
Links to Exploration step
pubmed:9777990Le document en format XML
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<author><name sortKey="Farshid, G" sort="Farshid, G" uniqKey="Farshid G" first="G" last="Farshid">G. Farshid</name>
<affiliation><nlm:affiliation>Department of Pathology, University of Michigan Hospitals, Ann Arbor, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Weiss, S W" sort="Weiss, S W" uniqKey="Weiss S" first="S W" last="Weiss">S W Weiss</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Massive localized lymphedema in the morbidly obese: a histologically distinct reactive lesion simulating liposarcoma.</title>
<author><name sortKey="Farshid, G" sort="Farshid, G" uniqKey="Farshid G" first="G" last="Farshid">G. Farshid</name>
<affiliation><nlm:affiliation>Department of Pathology, University of Michigan Hospitals, Ann Arbor, USA.</nlm:affiliation>
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<author><name sortKey="Weiss, S W" sort="Weiss, S W" uniqKey="Weiss S" first="S W" last="Weiss">S W Weiss</name>
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<series><title level="j">The American journal of surgical pathology</title>
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<imprint><date when="1998" type="published">1998</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipose Tissue (pathology)</term>
<term>Adult</term>
<term>Aged</term>
<term>Diagnosis, Differential</term>
<term>Extremities (blood supply)</term>
<term>Extremities (diagnostic imaging)</term>
<term>Extremities (pathology)</term>
<term>Female</term>
<term>Fibroma (pathology)</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Liposarcoma (pathology)</term>
<term>Lymphatic System (pathology)</term>
<term>Lymphedema (diagnostic imaging)</term>
<term>Lymphedema (etiology)</term>
<term>Lymphedema (pathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Obesity, Morbid (complications)</term>
<term>Obesity, Morbid (pathology)</term>
<term>Skin (pathology)</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Extremities</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Obesity, Morbid</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Extremities</term>
<term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adipose Tissue</term>
<term>Extremities</term>
<term>Fibroma</term>
<term>Liposarcoma</term>
<term>Lymphatic System</term>
<term>Lymphedema</term>
<term>Obesity, Morbid</term>
<term>Skin</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Diagnosis, Differential</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Tomography, X-Ray Computed</term>
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<front><div type="abstract" xml:lang="en">We report 14 cases of a soft tissue lesion in the limbs of morbidly obese adults that presents as a large mass and histologically simulates well-differentiated liposarcoma (WDL). Based on its distinctive clinical setting and morphologic identity to diffuse lymphedema we have termed this process massive localized lymphedema (MLL). All cases occurred in morbidly obese adults (mean weight 372 lbs; mean age 47 years). Women predominated (9 women; 5 men). The lesions affected the proximal medial aspect of the extremities (12 thigh; 2 arm) and were unilateral in all but two patients. Etiologically significant antecedent events include ipsilateral axillary lymphadenectomy in both patients with arm lesions, chronic lymphedema resulting from vein-stripping 10 years prior in one patient. inguinal lymphadenectomy for anal carcinoma in another patient, and significant blunt trauma to the inner thigh during a motor vehicle accident in a third patient. The tumors were long standing ( I-IO years) and extremely large (mean size 33.4 cm, 7408 g). Clinically, they were diffuse, ill-defined masses that histologically consisted of lobules of mature fat interrupted by expanded connective tissue septa. The constituents of the septa were fine, fibrillary collagen, edema fluid, and uniformly distributed fibroblasts. Clusters of capillaries were frequently found at the interface between fat and connective tissue. The widened septa simulated the fibrous bands of sclerosing WDL, but MLL lacks the degree of nuclear atypia seen in the former. The consistent clustering of reactive vessels at the interface between the fat and fibrous tissue also contrasted with WDL. Six patients experienced persistent or recurrent lesions within 10 months to 10 years. No aggressive growth or histologic progression was observed during this time, however. Awareness of the features of MLL is important to avoid misclassification of this reactive lesion with WDL.</div>
</front>
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<DateCreated><Year>1998</Year>
<Month>10</Month>
<Day>28</Day>
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<DateCompleted><Year>1998</Year>
<Month>10</Month>
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<DateRevised><Year>2016</Year>
<Month>11</Month>
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<JournalIssue CitedMedium="Print"><Volume>22</Volume>
<Issue>10</Issue>
<PubDate><Year>1998</Year>
<Month>Oct</Month>
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<Title>The American journal of surgical pathology</Title>
<ISOAbbreviation>Am. J. Surg. Pathol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Massive localized lymphedema in the morbidly obese: a histologically distinct reactive lesion simulating liposarcoma.</ArticleTitle>
<Pagination><MedlinePgn>1277-83</MedlinePgn>
</Pagination>
<Abstract><AbstractText>We report 14 cases of a soft tissue lesion in the limbs of morbidly obese adults that presents as a large mass and histologically simulates well-differentiated liposarcoma (WDL). Based on its distinctive clinical setting and morphologic identity to diffuse lymphedema we have termed this process massive localized lymphedema (MLL). All cases occurred in morbidly obese adults (mean weight 372 lbs; mean age 47 years). Women predominated (9 women; 5 men). The lesions affected the proximal medial aspect of the extremities (12 thigh; 2 arm) and were unilateral in all but two patients. Etiologically significant antecedent events include ipsilateral axillary lymphadenectomy in both patients with arm lesions, chronic lymphedema resulting from vein-stripping 10 years prior in one patient. inguinal lymphadenectomy for anal carcinoma in another patient, and significant blunt trauma to the inner thigh during a motor vehicle accident in a third patient. The tumors were long standing ( I-IO years) and extremely large (mean size 33.4 cm, 7408 g). Clinically, they were diffuse, ill-defined masses that histologically consisted of lobules of mature fat interrupted by expanded connective tissue septa. The constituents of the septa were fine, fibrillary collagen, edema fluid, and uniformly distributed fibroblasts. Clusters of capillaries were frequently found at the interface between fat and connective tissue. The widened septa simulated the fibrous bands of sclerosing WDL, but MLL lacks the degree of nuclear atypia seen in the former. The consistent clustering of reactive vessels at the interface between the fat and fibrous tissue also contrasted with WDL. Six patients experienced persistent or recurrent lesions within 10 months to 10 years. No aggressive growth or histologic progression was observed during this time, however. Awareness of the features of MLL is important to avoid misclassification of this reactive lesion with WDL.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Farshid</LastName>
<ForeName>G</ForeName>
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<MeshHeading><DescriptorName UI="D008080" MajorTopicYN="N">Liposarcoma</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
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<NumberOfReferences>4</NumberOfReferences>
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