Comparative study of the clinical efficacy of two different coumarin dosages in the management of arm lymphedema after treatment for breast cancer.
Identifieur interne : 004C93 ( PubMed/Corpus ); précédent : 004C92; suivant : 004C94Comparative study of the clinical efficacy of two different coumarin dosages in the management of arm lymphedema after treatment for breast cancer.
Auteurs : A. Burgos ; A. Alcaide ; C. Alcoba ; J M Azcona ; J. Garrido ; C. Lorente ; E. Moreno ; E. Murillo ; J. Olsina-Pavia ; J. Olsina-Kissler ; E. Samaniego ; M. SerraSource :
- Lymphology [ 0024-7766 ] ; 1999.
English descriptors
- KwdEn :
- Arm, Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Breast Neoplasms (therapy), Combined Modality Therapy (adverse effects), Coumarins (administration & dosage), Coumarins (adverse effects), Coumarins (therapeutic use), Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Lymphedema (drug therapy), Lymphedema (etiology), Middle Aged, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Coumarins.
- adverse effects : Combined Modality Therapy, Coumarins.
- drug therapy : Lymphedema.
- etiology : Lymphedema.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- chemical , therapeutic use : Coumarins.
- therapy : Breast Neoplasms.
- Arm, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Middle Aged, Treatment Outcome.
Abstract
In a randomized, double-blind, parallel group study, we compared the clinical efficacy of coumarin 90 mg/day (Group A) with 135 mg/day (Group B) in 77 women (age 35-65 years) with lymphedema of the upper limb secondary to surgery and irradiation for treatment of breast cancer. During 12 months of coumarin therapy, the arm volume of lymphedema and a clinical score (degree of arm edema, heaviness, hardness, and neuralgia/dysesthesia) were determined. In both groups, the volume of arm lymphedema decreased (14.9% in Group A and 13.2% in Group B) (N.S.), the overall clinical score improved (12.9 +/- 4.3 to 5.7 +/- 3.5 in Group A and from 11.7 +/- 3.7 to 4.7 +/- 3.9 in Group B) (N.S.), and the overall efficacy of coumarin was similarly good or excellent (71.9% in Group A and 68.6% in Group B) (N.S.). Only mild to moderate side effects of drug therapy were recorded. Coumarin prevents a spontaneous trend toward an increase in arm lymphedema after treatment of breast cancer, decreases the severity of local symptoms, and overall improves the quality of life. No difference was found between the apparent benefits of coumarin at 90 mg/day compared with 135 mg/day.
PubMed: 10197321
Links to Exploration step
pubmed:10197321Le document en format XML
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<author><name sortKey="Burgos, A" sort="Burgos, A" uniqKey="Burgos A" first="A" last="Burgos">A. Burgos</name>
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<author><name sortKey="Alcoba, C" sort="Alcoba, C" uniqKey="Alcoba C" first="C" last="Alcoba">C. Alcoba</name>
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<author><name sortKey="Azcona, J M" sort="Azcona, J M" uniqKey="Azcona J" first="J M" last="Azcona">J M Azcona</name>
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<author><name sortKey="Garrido, J" sort="Garrido, J" uniqKey="Garrido J" first="J" last="Garrido">J. Garrido</name>
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<author><name sortKey="Lorente, C" sort="Lorente, C" uniqKey="Lorente C" first="C" last="Lorente">C. Lorente</name>
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<author><name sortKey="Moreno, E" sort="Moreno, E" uniqKey="Moreno E" first="E" last="Moreno">E. Moreno</name>
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<author><name sortKey="Murillo, E" sort="Murillo, E" uniqKey="Murillo E" first="E" last="Murillo">E. Murillo</name>
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<author><name sortKey="Olsina Pavia, J" sort="Olsina Pavia, J" uniqKey="Olsina Pavia J" first="J" last="Olsina-Pavia">J. Olsina-Pavia</name>
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<author><name sortKey="Alcaide, A" sort="Alcaide, A" uniqKey="Alcaide A" first="A" last="Alcaide">A. Alcaide</name>
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<series><title level="j">Lymphology</title>
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<term>Breast Neoplasms (radiotherapy)</term>
<term>Breast Neoplasms (surgery)</term>
<term>Breast Neoplasms (therapy)</term>
<term>Combined Modality Therapy (adverse effects)</term>
<term>Coumarins (administration & dosage)</term>
<term>Coumarins (adverse effects)</term>
<term>Coumarins (therapeutic use)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Lymphedema (drug therapy)</term>
<term>Lymphedema (etiology)</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Coumarins</term>
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<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Combined Modality Therapy</term>
<term>Coumarins</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Coumarins</term>
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<term>Dose-Response Relationship, Drug</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en">In a randomized, double-blind, parallel group study, we compared the clinical efficacy of coumarin 90 mg/day (Group A) with 135 mg/day (Group B) in 77 women (age 35-65 years) with lymphedema of the upper limb secondary to surgery and irradiation for treatment of breast cancer. During 12 months of coumarin therapy, the arm volume of lymphedema and a clinical score (degree of arm edema, heaviness, hardness, and neuralgia/dysesthesia) were determined. In both groups, the volume of arm lymphedema decreased (14.9% in Group A and 13.2% in Group B) (N.S.), the overall clinical score improved (12.9 +/- 4.3 to 5.7 +/- 3.5 in Group A and from 11.7 +/- 3.7 to 4.7 +/- 3.9 in Group B) (N.S.), and the overall efficacy of coumarin was similarly good or excellent (71.9% in Group A and 68.6% in Group B) (N.S.). Only mild to moderate side effects of drug therapy were recorded. Coumarin prevents a spontaneous trend toward an increase in arm lymphedema after treatment of breast cancer, decreases the severity of local symptoms, and overall improves the quality of life. No difference was found between the apparent benefits of coumarin at 90 mg/day compared with 135 mg/day.</div>
</front>
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<DateCreated><Year>1999</Year>
<Month>06</Month>
<Day>14</Day>
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<DateCompleted><Year>1999</Year>
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<DateRevised><Year>2012</Year>
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<ArticleTitle>Comparative study of the clinical efficacy of two different coumarin dosages in the management of arm lymphedema after treatment for breast cancer.</ArticleTitle>
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<Abstract><AbstractText>In a randomized, double-blind, parallel group study, we compared the clinical efficacy of coumarin 90 mg/day (Group A) with 135 mg/day (Group B) in 77 women (age 35-65 years) with lymphedema of the upper limb secondary to surgery and irradiation for treatment of breast cancer. During 12 months of coumarin therapy, the arm volume of lymphedema and a clinical score (degree of arm edema, heaviness, hardness, and neuralgia/dysesthesia) were determined. In both groups, the volume of arm lymphedema decreased (14.9% in Group A and 13.2% in Group B) (N.S.), the overall clinical score improved (12.9 +/- 4.3 to 5.7 +/- 3.5 in Group A and from 11.7 +/- 3.7 to 4.7 +/- 3.9 in Group B) (N.S.), and the overall efficacy of coumarin was similarly good or excellent (71.9% in Group A and 68.6% in Group B) (N.S.). Only mild to moderate side effects of drug therapy were recorded. Coumarin prevents a spontaneous trend toward an increase in arm lymphedema after treatment of breast cancer, decreases the severity of local symptoms, and overall improves the quality of life. No difference was found between the apparent benefits of coumarin at 90 mg/day compared with 135 mg/day.</AbstractText>
</Abstract>
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