Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis.
Identifieur interne : 004806 ( PubMed/Corpus ); précédent : 004805; suivant : 004807Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis.
Auteurs : C L King ; M. Connelly ; M P Alpers ; M. Bockarie ; J W KazuraSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2001.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Child, Cytokines (antagonists & inhibitors), Cytokines (biosynthesis), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (transmission), Female, Humans, Immune Tolerance (drug effects), Interleukin-4 (blood), Ionomycin (pharmacology), Lymphocyte Activation (drug effects), Male, Middle Aged, Papua New Guinea (epidemiology), Phytohemagglutinins (pharmacology), Severity of Illness Index, T-Lymphocytes (immunology), T-Lymphocytes (metabolism), Tetradecanoylphorbol Acetate (pharmacology), Th2 Cells (immunology), Th2 Cells (metabolism), Wuchereria bancrofti (immunology).
- MESH :
- chemical , antagonists & inhibitors : Cytokines.
- chemical , biosynthesis : Cytokines.
- chemical , blood : Interleukin-4.
- geographic , epidemiology : Papua New Guinea.
- drug effects : Immune Tolerance, Lymphocyte Activation.
- epidemiology : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, T-Lymphocytes, Th2 Cells, Wuchereria bancrofti.
- metabolism : T-Lymphocytes, Th2 Cells.
- parasitology : Elephantiasis, Filarial.
- chemical , pharmacology : Ionomycin, Phytohemagglutinins, Tetradecanoylphorbol Acetate.
- transmission : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Child, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Humans living in areas where filariasis is endemic vary greatly in their exposure to mosquito-borne infective third-stage larvae (L3) of these parasitic helminths. Because the intensity of exposure to Ags affects T cell differentiation and susceptibility to parasitic infections in murine models, we compared T cell and cytokine responses in 97 residents of two villages in Papua New Guinea, where transmission intensity of Wuchereria bancrofti differed by 63-fold (37 vs 2355 L3 per person per year). Residents of the high transmission village had 4- to 11-fold lower proliferation and IFN-gamma responses to filarial Ags, nonparasite Ag, and PHA by PBMC compared with the low transmission village (p < 0.01) even when subjects were matched for intensity of infection. In contrast, filarial Ag-driven IL-5 production was 5.5-fold greater (p < 0.001), and plasma IL-4 and TGF-beta levels were 4-fold and 34% higher, respectively, in residents of the high transmission village. IL-4 and IL-10 responses by PBMC differed little according to village, and increased production of the counterregulatory cytokines IL-10 or TGF-beta by PBMC did not correlate with weak proliferation and IFN-gamma responses. Plasma IL-5, IFN-gamma, and IL-10 levels were similar in the two villages. These data demonstrate that the intensity of exposure to L3 affects lymphocyte responsiveness and cytokine bias possibly by a mechanism that alters APC function.
PubMed: 11390495
Links to Exploration step
pubmed:11390495Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis.</title>
<author><name sortKey="King, C L" sort="King, C L" uniqKey="King C" first="C L" last="King">C L King</name>
<affiliation><nlm:affiliation>Division of Geographic Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. cxk21@po.cwru.edu</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Connelly, M" sort="Connelly, M" uniqKey="Connelly M" first="M" last="Connelly">M. Connelly</name>
</author>
<author><name sortKey="Alpers, M P" sort="Alpers, M P" uniqKey="Alpers M" first="M P" last="Alpers">M P Alpers</name>
</author>
<author><name sortKey="Bockarie, M" sort="Bockarie, M" uniqKey="Bockarie M" first="M" last="Bockarie">M. Bockarie</name>
</author>
<author><name sortKey="Kazura, J W" sort="Kazura, J W" uniqKey="Kazura J" first="J W" last="Kazura">J W Kazura</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2001">2001</date>
<idno type="RBID">pubmed:11390495</idno>
<idno type="pmid">11390495</idno>
<idno type="wicri:Area/PubMed/Corpus">004806</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004806</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis.</title>
<author><name sortKey="King, C L" sort="King, C L" uniqKey="King C" first="C L" last="King">C L King</name>
<affiliation><nlm:affiliation>Division of Geographic Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. cxk21@po.cwru.edu</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Connelly, M" sort="Connelly, M" uniqKey="Connelly M" first="M" last="Connelly">M. Connelly</name>
</author>
<author><name sortKey="Alpers, M P" sort="Alpers, M P" uniqKey="Alpers M" first="M P" last="Alpers">M P Alpers</name>
</author>
<author><name sortKey="Bockarie, M" sort="Bockarie, M" uniqKey="Bockarie M" first="M" last="Bockarie">M. Bockarie</name>
</author>
<author><name sortKey="Kazura, J W" sort="Kazura, J W" uniqKey="Kazura J" first="J W" last="Kazura">J W Kazura</name>
</author>
</analytic>
<series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title>
<idno type="ISSN">0022-1767</idno>
<imprint><date when="2001" type="published">2001</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Child</term>
<term>Cytokines (antagonists & inhibitors)</term>
<term>Cytokines (biosynthesis)</term>
<term>Elephantiasis, Filarial (epidemiology)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (parasitology)</term>
<term>Elephantiasis, Filarial (transmission)</term>
<term>Female</term>
<term>Humans</term>
<term>Immune Tolerance (drug effects)</term>
<term>Interleukin-4 (blood)</term>
<term>Ionomycin (pharmacology)</term>
<term>Lymphocyte Activation (drug effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Papua New Guinea (epidemiology)</term>
<term>Phytohemagglutinins (pharmacology)</term>
<term>Severity of Illness Index</term>
<term>T-Lymphocytes (immunology)</term>
<term>T-Lymphocytes (metabolism)</term>
<term>Tetradecanoylphorbol Acetate (pharmacology)</term>
<term>Th2 Cells (immunology)</term>
<term>Th2 Cells (metabolism)</term>
<term>Wuchereria bancrofti (immunology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Interleukin-4</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Papua New Guinea</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immune Tolerance</term>
<term>Lymphocyte Activation</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>T-Lymphocytes</term>
<term>Th2 Cells</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>T-Lymphocytes</term>
<term>Th2 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ionomycin</term>
<term>Phytohemagglutinins</term>
<term>Tetradecanoylphorbol Acetate</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Child</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Humans living in areas where filariasis is endemic vary greatly in their exposure to mosquito-borne infective third-stage larvae (L3) of these parasitic helminths. Because the intensity of exposure to Ags affects T cell differentiation and susceptibility to parasitic infections in murine models, we compared T cell and cytokine responses in 97 residents of two villages in Papua New Guinea, where transmission intensity of Wuchereria bancrofti differed by 63-fold (37 vs 2355 L3 per person per year). Residents of the high transmission village had 4- to 11-fold lower proliferation and IFN-gamma responses to filarial Ags, nonparasite Ag, and PHA by PBMC compared with the low transmission village (p < 0.01) even when subjects were matched for intensity of infection. In contrast, filarial Ag-driven IL-5 production was 5.5-fold greater (p < 0.001), and plasma IL-4 and TGF-beta levels were 4-fold and 34% higher, respectively, in residents of the high transmission village. IL-4 and IL-10 responses by PBMC differed little according to village, and increased production of the counterregulatory cytokines IL-10 or TGF-beta by PBMC did not correlate with weak proliferation and IFN-gamma responses. Plasma IL-5, IFN-gamma, and IL-10 levels were similar in the two villages. These data demonstrate that the intensity of exposure to L3 affects lymphocyte responsiveness and cytokine bias possibly by a mechanism that alters APC function.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11390495</PMID>
<DateCreated><Year>2001</Year>
<Month>06</Month>
<Day>06</Day>
</DateCreated>
<DateCompleted><Year>2001</Year>
<Month>08</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-1767</ISSN>
<JournalIssue CitedMedium="Print"><Volume>166</Volume>
<Issue>12</Issue>
<PubDate><Year>2001</Year>
<Month>Jun</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Journal of immunology (Baltimore, Md. : 1950)</Title>
<ISOAbbreviation>J. Immunol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis.</ArticleTitle>
<Pagination><MedlinePgn>7427-36</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Humans living in areas where filariasis is endemic vary greatly in their exposure to mosquito-borne infective third-stage larvae (L3) of these parasitic helminths. Because the intensity of exposure to Ags affects T cell differentiation and susceptibility to parasitic infections in murine models, we compared T cell and cytokine responses in 97 residents of two villages in Papua New Guinea, where transmission intensity of Wuchereria bancrofti differed by 63-fold (37 vs 2355 L3 per person per year). Residents of the high transmission village had 4- to 11-fold lower proliferation and IFN-gamma responses to filarial Ags, nonparasite Ag, and PHA by PBMC compared with the low transmission village (p < 0.01) even when subjects were matched for intensity of infection. In contrast, filarial Ag-driven IL-5 production was 5.5-fold greater (p < 0.001), and plasma IL-4 and TGF-beta levels were 4-fold and 34% higher, respectively, in residents of the high transmission village. IL-4 and IL-10 responses by PBMC differed little according to village, and increased production of the counterregulatory cytokines IL-10 or TGF-beta by PBMC did not correlate with weak proliferation and IFN-gamma responses. Plasma IL-5, IFN-gamma, and IL-10 levels were similar in the two villages. These data demonstrate that the intensity of exposure to L3 affects lymphocyte responsiveness and cytokine bias possibly by a mechanism that alters APC function.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>King</LastName>
<ForeName>C L</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>Division of Geographic Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. cxk21@po.cwru.edu</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Connelly</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Alpers</LastName>
<ForeName>M P</ForeName>
<Initials>MP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bockarie</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kazura</LastName>
<ForeName>J W</ForeName>
<Initials>JW</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>AI 01202</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>AI 33061</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>AI 35801</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Immunol</MedlineTA>
<NlmUniqueID>2985117R</NlmUniqueID>
<ISSNLinking>0022-1767</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010835">Phytohemagglutinins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>207137-56-2</RegistryNumber>
<NameOfSubstance UI="D015847">Interleukin-4</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>56092-81-0</RegistryNumber>
<NameOfSubstance UI="D015759">Ionomycin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>NI40JAQ945</RegistryNumber>
<NameOfSubstance UI="D013755">Tetradecanoylphorbol Acetate</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="Y">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007108" MajorTopicYN="N">Immune Tolerance</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015847" MajorTopicYN="N">Interleukin-4</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015759" MajorTopicYN="N">Ionomycin</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010219" MajorTopicYN="N" Type="Geographic">Papua New Guinea</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010835" MajorTopicYN="N">Phytohemagglutinins</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013755" MajorTopicYN="N">Tetradecanoylphorbol Acetate</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018418" MajorTopicYN="N">Th2 Cells</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year>
<Month>6</Month>
<Day>8</Day>
<Hour>10</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2001</Year>
<Month>8</Month>
<Day>24</Day>
<Hour>10</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2001</Year>
<Month>6</Month>
<Day>8</Day>
<Hour>10</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">11390495</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004806 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 004806 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:11390495 |texte= Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:11390495" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |