Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity.
Identifieur interne : 004393 ( PubMed/Corpus ); précédent : 004392; suivant : 004394Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity.
Auteurs : Edgar Lobos ; Thomas B. Nutman ; John S. Hothersall ; Salvador MoncadaSource :
- Infection and immunity [ 0019-9567 ] ; 2003.
English descriptors
- KwdEn :
- Adult, Animals, Brugia malayi (enzymology), Brugia malayi (immunology), Elephantiasis, Filarial (complications), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Female, Humans, Hypersensitivity, Immediate (etiology), Immunoglobulin E (blood), Immunoglobulin E (immunology), Immunoglobulin G (blood), Larva (enzymology), Larva (immunology), Male, Pulmonary Eosinophilia (etiology), Pulmonary Eosinophilia (immunology), Pulmonary Eosinophilia (physiopathology), Recombinant Proteins (genetics), Recombinant Proteins (immunology), Tropical Climate, gamma-Glutamyltransferase (genetics), gamma-Glutamyltransferase (immunology).
- MESH :
- chemical , blood : Immunoglobulin E, Immunoglobulin G.
- complications : Elephantiasis, Filarial.
- enzymology : Brugia malayi, Larva.
- etiology : Hypersensitivity, Immediate, Pulmonary Eosinophilia.
- chemical , genetics : Recombinant Proteins, gamma-Glutamyltransferase.
- immunology : Brugia malayi, Elephantiasis, Filarial, Immunoglobulin E, Larva, Pulmonary Eosinophilia, Recombinant Proteins, gamma-Glutamyltransferase.
- parasitology : Elephantiasis, Filarial.
- physiopathology : Pulmonary Eosinophilia.
- Adult, Animals, Female, Humans, Male, Tropical Climate.
Abstract
A major allergen of the lymphatic filarial nematode Brugia malayi, a homologue of gamma-glutamyl transpeptidase (gamma-GT), is involved in the pathology of tropical pulmonary eosinophilia (TPE) through its potent allergenicity and the induction of antibodies against the host pulmonary epithelium. To investigate the immunoglobulin G (IgG) subclass and IgE responses to recombinant B. malayi gamma-GT, we analyzed the results obtained from 51 patients with differing clinical manifestations of bancroftian filariasis. gamma-GT-specific IgG1, rather than IgG4, was the predominant IgG subclass, particularly in patients with TPE (geomean, 6,321 ng/ml; range, 78 to 354,867 ng/ml) and was 75 times higher than in patients with elephantiasis (CP) (P < 0.003) and 185 times higher than in endemic normal individuals (ENL) (P < 0.010). IgG2 responses were low and IgG3 was almost absent, with no significant differences among the groups. gamma-GT-specific IgG4 responses were significantly elevated in those with subclinical microfilaremia (MF) compared to the CP and ENL groups and correlated with the presence of circulating filarial antigen (CAg). More significantly, gamma-GT-specific IgE antibody levels were strikingly elevated in patients with TPE (geomean, 681 ng/ml; range, 61 to 23,841 ng/ml) and in the ENL group (geomean, 106 ng/ml; range, 13 to 1,405 ng/ml) whereas the gamma-GT-specific IgE level was 44 and 61 times lower in those with MF and CP, respectively (P < 0.001). Elevated gamma-GT-specific IgE/IgG4 ratios were demonstrated in patients with TPE (ratio, 45) and ENL (ratio, 107). Because expression of gamma-GT in Brugia infective third-stage larvae (L3) was demonstrated by immunoblot analysis, the elevated gamma-GT-specific IgE antibodies appear to be associated not only with pulmonary pathology but also with possible resistance to infection in lymphatic filariasis.
PubMed: 12540554
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pubmed:12540554Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity.</title><author><name sortKey="Lobos, Edgar" sort="Lobos, Edgar" uniqKey="Lobos E" first="Edgar" last="Lobos">Edgar Lobos</name><affiliation><nlm:affiliation>The Wolfson Institute for Biomedical Research, University College London, United Kingdom. lobe@medizin.uni-leipzig.de</nlm:affiliation></affiliation></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B" last="Nutman">Thomas B. Nutman</name></author><author><name sortKey="Hothersall, John S" sort="Hothersall, John S" uniqKey="Hothersall J" first="John S" last="Hothersall">John S. Hothersall</name></author><author><name sortKey="Moncada, Salvador" sort="Moncada, Salvador" uniqKey="Moncada S" first="Salvador" last="Moncada">Salvador Moncada</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12540554</idno><idno type="pmid">12540554</idno><idno type="wicri:Area/PubMed/Corpus">004393</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004393</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity.</title><author><name sortKey="Lobos, Edgar" sort="Lobos, Edgar" uniqKey="Lobos E" first="Edgar" last="Lobos">Edgar Lobos</name><affiliation><nlm:affiliation>The Wolfson Institute for Biomedical Research, University College London, United Kingdom. lobe@medizin.uni-leipzig.de</nlm:affiliation></affiliation></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B" last="Nutman">Thomas B. Nutman</name></author><author><name sortKey="Hothersall, John S" sort="Hothersall, John S" uniqKey="Hothersall J" first="John S" last="Hothersall">John S. Hothersall</name></author><author><name sortKey="Moncada, Salvador" sort="Moncada, Salvador" uniqKey="Moncada S" first="Salvador" last="Moncada">Salvador Moncada</name></author></analytic><series><title level="j">Infection and immunity</title><idno type="ISSN">0019-9567</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Brugia malayi (enzymology)</term><term>Brugia malayi (immunology)</term><term>Elephantiasis, Filarial (complications)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Humans</term><term>Hypersensitivity, Immediate (etiology)</term><term>Immunoglobulin E (blood)</term><term>Immunoglobulin E (immunology)</term><term>Immunoglobulin G (blood)</term><term>Larva (enzymology)</term><term>Larva (immunology)</term><term>Male</term><term>Pulmonary Eosinophilia (etiology)</term><term>Pulmonary Eosinophilia (immunology)</term><term>Pulmonary Eosinophilia (physiopathology)</term><term>Recombinant Proteins (genetics)</term><term>Recombinant Proteins (immunology)</term><term>Tropical Climate</term><term>gamma-Glutamyltransferase (genetics)</term><term>gamma-Glutamyltransferase (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin E</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Brugia malayi</term><term>Larva</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypersensitivity, Immediate</term><term>Pulmonary Eosinophilia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Recombinant Proteins</term><term>gamma-Glutamyltransferase</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Immunoglobulin E</term><term>Larva</term><term>Pulmonary Eosinophilia</term><term>Recombinant Proteins</term><term>gamma-Glutamyltransferase</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Pulmonary Eosinophilia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term><term>Tropical Climate</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A major allergen of the lymphatic filarial nematode Brugia malayi, a homologue of gamma-glutamyl transpeptidase (gamma-GT), is involved in the pathology of tropical pulmonary eosinophilia (TPE) through its potent allergenicity and the induction of antibodies against the host pulmonary epithelium. To investigate the immunoglobulin G (IgG) subclass and IgE responses to recombinant B. malayi gamma-GT, we analyzed the results obtained from 51 patients with differing clinical manifestations of bancroftian filariasis. gamma-GT-specific IgG1, rather than IgG4, was the predominant IgG subclass, particularly in patients with TPE (geomean, 6,321 ng/ml; range, 78 to 354,867 ng/ml) and was 75 times higher than in patients with elephantiasis (CP) (P < 0.003) and 185 times higher than in endemic normal individuals (ENL) (P < 0.010). IgG2 responses were low and IgG3 was almost absent, with no significant differences among the groups. gamma-GT-specific IgG4 responses were significantly elevated in those with subclinical microfilaremia (MF) compared to the CP and ENL groups and correlated with the presence of circulating filarial antigen (CAg). More significantly, gamma-GT-specific IgE antibody levels were strikingly elevated in patients with TPE (geomean, 681 ng/ml; range, 61 to 23,841 ng/ml) and in the ENL group (geomean, 106 ng/ml; range, 13 to 1,405 ng/ml) whereas the gamma-GT-specific IgE level was 44 and 61 times lower in those with MF and CP, respectively (P < 0.001). Elevated gamma-GT-specific IgE/IgG4 ratios were demonstrated in patients with TPE (ratio, 45) and ENL (ratio, 107). Because expression of gamma-GT in Brugia infective third-stage larvae (L3) was demonstrated by immunoblot analysis, the elevated gamma-GT-specific IgE antibodies appear to be associated not only with pulmonary pathology but also with possible resistance to infection in lymphatic filariasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12540554</PMID><DateCreated><Year>2003</Year><Month>01</Month><Day>23</Day></DateCreated><DateCompleted><Year>2003</Year><Month>02</Month><Day>26</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0019-9567</ISSN><JournalIssue CitedMedium="Print"><Volume>71</Volume><Issue>2</Issue><PubDate><Year>2003</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Infection and immunity</Title><ISOAbbreviation>Infect. Immun.</ISOAbbreviation></Journal><ArticleTitle>Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity.</ArticleTitle><Pagination><MedlinePgn>747-53</MedlinePgn></Pagination><Abstract><AbstractText>A major allergen of the lymphatic filarial nematode Brugia malayi, a homologue of gamma-glutamyl transpeptidase (gamma-GT), is involved in the pathology of tropical pulmonary eosinophilia (TPE) through its potent allergenicity and the induction of antibodies against the host pulmonary epithelium. To investigate the immunoglobulin G (IgG) subclass and IgE responses to recombinant B. malayi gamma-GT, we analyzed the results obtained from 51 patients with differing clinical manifestations of bancroftian filariasis. gamma-GT-specific IgG1, rather than IgG4, was the predominant IgG subclass, particularly in patients with TPE (geomean, 6,321 ng/ml; range, 78 to 354,867 ng/ml) and was 75 times higher than in patients with elephantiasis (CP) (P < 0.003) and 185 times higher than in endemic normal individuals (ENL) (P < 0.010). IgG2 responses were low and IgG3 was almost absent, with no significant differences among the groups. gamma-GT-specific IgG4 responses were significantly elevated in those with subclinical microfilaremia (MF) compared to the CP and ENL groups and correlated with the presence of circulating filarial antigen (CAg). More significantly, gamma-GT-specific IgE antibody levels were strikingly elevated in patients with TPE (geomean, 681 ng/ml; range, 61 to 23,841 ng/ml) and in the ENL group (geomean, 106 ng/ml; range, 13 to 1,405 ng/ml) whereas the gamma-GT-specific IgE level was 44 and 61 times lower in those with MF and CP, respectively (P < 0.001). Elevated gamma-GT-specific IgE/IgG4 ratios were demonstrated in patients with TPE (ratio, 45) and ENL (ratio, 107). Because expression of gamma-GT in Brugia infective third-stage larvae (L3) was demonstrated by immunoblot analysis, the elevated gamma-GT-specific IgE antibodies appear to be associated not only with pulmonary pathology but also with possible resistance to infection in lymphatic filariasis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lobos</LastName><ForeName>Edgar</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>The Wolfson Institute for Biomedical Research, University College London, United Kingdom. lobe@medizin.uni-leipzig.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nutman</LastName><ForeName>Thomas B</ForeName><Initials>TB</Initials></Author><Author ValidYN="Y"><LastName>Hothersall</LastName><ForeName>John S</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Moncada</LastName><ForeName>Salvador</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Infect Immun</MedlineTA><NlmUniqueID>0246127</NlmUniqueID><ISSNLinking>0019-9567</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>37341-29-0</RegistryNumber><NameOfSubstance UI="D007073">Immunoglobulin E</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.2.2</RegistryNumber><NameOfSubstance UI="D005723">gamma-Glutamyltransferase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Parasitol Today. 2000 Sep;16(9):373-80</RefSource><PMID Version="1">10951596</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 1982 May;31(3 Pt 1):477-85</RefSource><PMID Version="1">7081541</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1985 Aug;135(2):1415-20</RefSource><PMID Version="1">3891853</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am Rev Respir Dis. 1990 Nov;142(5):1088-92</RefSource><PMID Version="1">2173455</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Medicine (Baltimore). 1947 Dec;26(4):333-94</RefSource><PMID Version="1">20272684</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Parasitol. 1996 Apr;82(3):255-66</RefSource><PMID Version="1">8631377</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1991 Jan 17;349(6306):243-5</RefSource><PMID Version="1">1898985</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 1989 Dec;160(6):1042-50</RefSource><PMID Version="1">2685125</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 1993 Oct;168(4):1000-8</RefSource><PMID Version="1">7690821</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 1989 Jan;83(1):14-22</RefSource><PMID Version="1">2642916</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1981 Aug;127(2):716-25</RefSource><PMID Version="1">7195919</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 1995 Jun;95(6):2813-21</RefSource><PMID Version="1">7769121</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 1992 Jun;22(6):1483-94</RefSource><PMID Version="1">1601036</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 1991 Jul;88(1):346-50</RefSource><PMID Version="1">1829097</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Allergy. 1987 Feb;58(2):89-96, 99</RefSource><PMID Version="1">3544971</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int Immunol. 1998 Oct;10(10):1583-90</RefSource><PMID Version="1">9796925</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Immunol. 2001 Jul;22(7):372-7</RefSource><PMID Version="1">11429321</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Med. 1996 Nov;2(6):712-24</RefSource><PMID Version="1">8972486</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1981 Oct;127(4):1623-9</RefSource><PMID Version="1">7276575</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2001 Jul;23(7):389-99</RefSource><PMID Version="1">11472558</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 1985 Sep;7(5):517-26</RefSource><PMID Version="1">2933630</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2000 Sep;68(9):4913-22</RefSource><PMID Version="1">10948105</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Parasitol. 1981 Aug;52(1):147-59</RefSource><PMID Version="1">6972325</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vet Pathol. 1982 Jul;19(4):355-64</RefSource><PMID Version="1">7090139</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1987 Jun 1;138(11):3954-9</RefSource><PMID Version="1">3295043</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 1994 Jun 24;264(5167):1876-7</RefSource><PMID Version="1">8009216</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 1994 Sep;170(3):736-41</RefSource><PMID Version="1">8077740</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 1978 Sep;27(5):910-5</RefSource><PMID Version="1">717635</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunology. 1979 Nov;38(3):489-95</RefSource><PMID Version="1">521052</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1992 May 1;148(9):2731-7</RefSource><PMID Version="1">1573266</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int Arch Allergy Immunol. 1992;99(1):118-22</RefSource><PMID Version="1">1483058</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1992 Nov 1;149(9):3029-34</RefSource><PMID Version="1">1401928</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Med. 1992;43:417-24</RefSource><PMID Version="1">1580599</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1987 Oct 15;139(8):2794-8</RefSource><PMID Version="1">3309059</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1993 May 1;150(9):3941-50</RefSource><PMID Version="1">8473742</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 1993 Mar;61(3):1105-12</RefSource><PMID Version="1">8094378</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 1993 Apr;167(4):925-31</RefSource><PMID Version="1">8450257</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 1993 May;15(5):291-6</RefSource><PMID Version="1">8332384</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trop Med Parasitol. 1990 Dec;41(4):403-6</RefSource><PMID Version="1">2075384</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 1993 Jul;61(7):2827-33</RefSource><PMID Version="1">8514385</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Med. 2001 May;7(5):344-54</RefSource><PMID Version="1">11474580</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chem Immunol. 1997;66:1-25</RefSource><PMID Version="1">9103663</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int Arch Allergy Immunol. 1993;102(2):185-90</RefSource><PMID Version="1">8400897</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 1991 Nov;21(11):2679-86</RefSource><PMID Version="1">1936116</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1990 Dec 15;145(12):4298-305</RefSource><PMID Version="1">2258618</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 1995 Dec;172(6):1630-3</RefSource><PMID Version="1">7594734</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1985 Apr;134(4):2707-12</RefSource><PMID Version="1">2579154</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Peptides. 1999;20(9):1021-6</RefSource><PMID Version="1">10499418</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 1999 Feb;67(2):484-9</RefSource><PMID Version="1">9916049</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1986 Mar 1;136(5):1859-63</RefSource><PMID Version="1">3950405</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ciba Found Symp. 1989;147:153-60; discussion 160-70</RefSource><PMID Version="1">2515945</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 1995 Oct;63(10):3772-9</RefSource><PMID Version="1">7558279</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2001 Apr 30;19(23-24):3124-30</RefSource><PMID Version="1">11312007</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2001 Feb 1;344(5):350-62</RefSource><PMID Version="1">11172168</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017178" MajorTopicYN="N">Brugia malayi</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000276" 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|texte= Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity.
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