Molecular targeting of lymphatics for therapy.
Identifieur interne : 004086 ( PubMed/Corpus ); précédent : 004085; suivant : 004087Molecular targeting of lymphatics for therapy.
Auteurs : S A Stacker ; R A Hughes ; M G AchenSource :
- Current pharmaceutical design [ 1381-6128 ] ; 2004.
English descriptors
- KwdEn :
- Animals, Humans, Lymphangiogenesis, Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphatic Vessels (physiopathology), Lymphedema (metabolism), Lymphedema (pathology), Neoplasms (metabolism), Neoplasms (pathology), Signal Transduction (drug effects), Vascular Endothelial Growth Factor C (metabolism), Vascular Endothelial Growth Factor C (physiology), Vascular Endothelial Growth Factor D (metabolism), Vascular Endothelial Growth Factor D (physiology), Vascular Endothelial Growth Factor Receptor-3 (metabolism).
- MESH :
- chemical , metabolism : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Vascular Endothelial Growth Factor Receptor-3.
- drug effects : Signal Transduction.
- metabolism : Lymphatic Vessels, Lymphedema, Neoplasms.
- pathology : Lymphatic Vessels, Lymphedema, Neoplasms.
- chemical , physiology : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D.
- physiopathology : Lymphatic Vessels.
- Animals, Humans, Lymphangiogenesis.
Abstract
The dysfunction or proliferation of lymphatic vessels (lymphangiogenesis) is linked to a number of pathological conditions including lymphedema and cancer. The recent discovery and characterisation of the lymphangiogenic growth factors vascular endothelial growth factor-C (VEGF-C) and VEGF-D and of their receptor on lymphatic endothelial cells, VEGFR-3, has provided an understanding of the molecular mechanisms controlling the growth of lymphatic vessels. In addition, other genes and protein markers have been identified with specificity for lymphatic endothelium that have enhanced the characterization and isolation of lymphatic endothelial cells. Our growing understanding of the molecules that control lymphangiogenesis allows us to design more specific drugs with which to manipulate the relevant signalling pathways. Modulating these pathways and other molecules with specificity to the lymphatic system could offer alternative treatments for a number of important clinical conditions.
PubMed: 14754406
Links to Exploration step
pubmed:14754406Le document en format XML
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<author><name sortKey="Stacker, S A" sort="Stacker, S A" uniqKey="Stacker S" first="S A" last="Stacker">S A Stacker</name>
<affiliation><nlm:affiliation>Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia. Steven.stacker@ludwig.edu.au</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hughes, R A" sort="Hughes, R A" uniqKey="Hughes R" first="R A" last="Hughes">R A Hughes</name>
</author>
<author><name sortKey="Achen, M G" sort="Achen, M G" uniqKey="Achen M" first="M G" last="Achen">M G Achen</name>
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<author><name sortKey="Stacker, S A" sort="Stacker, S A" uniqKey="Stacker S" first="S A" last="Stacker">S A Stacker</name>
<affiliation><nlm:affiliation>Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia. Steven.stacker@ludwig.edu.au</nlm:affiliation>
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<author><name sortKey="Hughes, R A" sort="Hughes, R A" uniqKey="Hughes R" first="R A" last="Hughes">R A Hughes</name>
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<author><name sortKey="Achen, M G" sort="Achen, M G" uniqKey="Achen M" first="M G" last="Achen">M G Achen</name>
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<series><title level="j">Current pharmaceutical design</title>
<idno type="ISSN">1381-6128</idno>
<imprint><date when="2004" type="published">2004</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Lymphangiogenesis</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Lymphatic Vessels (pathology)</term>
<term>Lymphatic Vessels (physiopathology)</term>
<term>Lymphedema (metabolism)</term>
<term>Lymphedema (pathology)</term>
<term>Neoplasms (metabolism)</term>
<term>Neoplasms (pathology)</term>
<term>Signal Transduction (drug effects)</term>
<term>Vascular Endothelial Growth Factor C (metabolism)</term>
<term>Vascular Endothelial Growth Factor C (physiology)</term>
<term>Vascular Endothelial Growth Factor D (metabolism)</term>
<term>Vascular Endothelial Growth Factor D (physiology)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term>
<term>Vascular Endothelial Growth Factor D</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphatic Vessels</term>
<term>Lymphedema</term>
<term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Vessels</term>
<term>Lymphedema</term>
<term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term>
<term>Vascular Endothelial Growth Factor D</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Lymphangiogenesis</term>
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<front><div type="abstract" xml:lang="en">The dysfunction or proliferation of lymphatic vessels (lymphangiogenesis) is linked to a number of pathological conditions including lymphedema and cancer. The recent discovery and characterisation of the lymphangiogenic growth factors vascular endothelial growth factor-C (VEGF-C) and VEGF-D and of their receptor on lymphatic endothelial cells, VEGFR-3, has provided an understanding of the molecular mechanisms controlling the growth of lymphatic vessels. In addition, other genes and protein markers have been identified with specificity for lymphatic endothelium that have enhanced the characterization and isolation of lymphatic endothelial cells. Our growing understanding of the molecules that control lymphangiogenesis allows us to design more specific drugs with which to manipulate the relevant signalling pathways. Modulating these pathways and other molecules with specificity to the lymphatic system could offer alternative treatments for a number of important clinical conditions.</div>
</front>
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<DateRevised><Year>2009</Year>
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<Title>Current pharmaceutical design</Title>
<ISOAbbreviation>Curr. Pharm. Des.</ISOAbbreviation>
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<ArticleTitle>Molecular targeting of lymphatics for therapy.</ArticleTitle>
<Pagination><MedlinePgn>65-74</MedlinePgn>
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<Abstract><AbstractText>The dysfunction or proliferation of lymphatic vessels (lymphangiogenesis) is linked to a number of pathological conditions including lymphedema and cancer. The recent discovery and characterisation of the lymphangiogenic growth factors vascular endothelial growth factor-C (VEGF-C) and VEGF-D and of their receptor on lymphatic endothelial cells, VEGFR-3, has provided an understanding of the molecular mechanisms controlling the growth of lymphatic vessels. In addition, other genes and protein markers have been identified with specificity for lymphatic endothelium that have enhanced the characterization and isolation of lymphatic endothelial cells. Our growing understanding of the molecules that control lymphangiogenesis allows us to design more specific drugs with which to manipulate the relevant signalling pathways. Modulating these pathways and other molecules with specificity to the lymphatic system could offer alternative treatments for a number of important clinical conditions.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stacker</LastName>
<ForeName>S A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia. Steven.stacker@ludwig.edu.au</Affiliation>
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<MeshHeading><DescriptorName UI="D042583" MajorTopicYN="N">Lymphangiogenesis</DescriptorName>
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<MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName>
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<MeshHeading><DescriptorName UI="D040321" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-3</DescriptorName>
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