LymphedemaV1, PubMed, Corpus, bibRecord, 003F52

Antifilarial activity of Zoanthus species (Phylum Coelenterata, Class Anthzoa) against human lymphatic filaria, Brugia malayi.

Identifieur interne : 003F52 ( PubMed/Corpus ); précédent : 003F51; suivant : 003F53

Antifilarial activity of Zoanthus species (Phylum Coelenterata, Class Anthzoa) against human lymphatic filaria, Brugia malayi.

Auteurs : V. Lakshmi ; A. Saxena ; K. Pandey ; Preeti Bajpai ; Shailja Misra-Bhattacharya

Source :

Parasitology research [ 0932-0113 ] ; 2004.

RBID : pubmed:15258853

English descriptors

KwdEn :
- Animals, Brugia malayi (drug effects), Brugia malayi (physiology), Chemical Fractionation, Cnidaria (chemistry), Disease Models, Animal, Dose-Response Relationship, Drug, Elephantiasis, Filarial (drug therapy), Filaricides (pharmacology), Filaricides (therapeutic use), Humans, Muridae (parasitology), Tissue Extracts (chemistry), Tissue Extracts (pharmacology), Tissue Extracts (therapeutic use).
MESH :
- chemical , chemistry : Tissue Extracts.
- chemical , pharmacology : Filaricides, Tissue Extracts.
- chemistry : Cnidaria.
- drug effects : Brugia malayi.
- drug therapy : Elephantiasis, Filarial.
- parasitology : Muridae.
- physiology : Brugia malayi.
- chemical , therapeutic use : Filaricides, Tissue Extracts.
- Animals, Chemical Fractionation, Disease Models, Animal, Dose-Response Relationship, Drug, Humans.

Abstract

The chloroform methanol (1:1) extract of an unidentified green zoanthus (Phylum Coelenterata, Class Anthozoa) showed promising in vitro adulticidal activity with a lethal concentration of 125 microg/ml on Brugia malayi. This extract brought about a 52.2% reduction in circulating microfilariae of B. malayi when administered to infected Mastomys coucha at 250 mg/kg, orally for 5 consecutive days. Further fractionation of the extract led to the recovery of four fractions, which were evaluated simultaneously in both in vitro and in vivo systems against B. malayi. The chloroform fraction at 250 mg/kg orally for 5 days exhibited the highest macrofilaricidal action (42.5%), closely followed by the insoluble n-butanol fraction (34.3%), the soluble hexane fraction (32.4%), and the soluble n-butanol fraction (20.4%). In addition, the hexane soluble fraction caused 44.3% sterilization of the surviving female parasites. Two compounds isolated were found devoid of antifilarial activity.

DOI: 10.1007/s00436-004-1124-6
PubMed: 15258853

Links to Exploration step

pubmed:15258853

Le document en format XML

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<author><name sortKey="Lakshmi, V" sort="Lakshmi, V" uniqKey="Lakshmi V" first="V" last="Lakshmi">V. Lakshmi</name>
<affiliation><nlm:affiliation>Divisions of Medicinal Chemistry, Central Drug Research Institute, 226001, Lucknow, U.P., India.</nlm:affiliation>
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<author><name sortKey="Saxena, A" sort="Saxena, A" uniqKey="Saxena A" first="A" last="Saxena">A. Saxena</name>
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<author><name sortKey="Pandey, K" sort="Pandey, K" uniqKey="Pandey K" first="K" last="Pandey">K. Pandey</name>
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<author><name sortKey="Bajpai, Preeti" sort="Bajpai, Preeti" uniqKey="Bajpai P" first="Preeti" last="Bajpai">Preeti Bajpai</name>
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<author><name sortKey="Misra Bhattacharya, Shailja" sort="Misra Bhattacharya, Shailja" uniqKey="Misra Bhattacharya S" first="Shailja" last="Misra-Bhattacharya">Shailja Misra-Bhattacharya</name>
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<term>Cnidaria (chemistry)</term>
<term>Disease Models, Animal</term>
<term>Dose-Response Relationship, Drug</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Filaricides (pharmacology)</term>
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<term>Tissue Extracts (pharmacology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Filaricides</term>
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<front><div type="abstract" xml:lang="en">The chloroform methanol (1:1) extract of an unidentified green zoanthus (Phylum Coelenterata, Class Anthozoa) showed promising in vitro adulticidal activity with a lethal concentration of 125 microg/ml on Brugia malayi. This extract brought about a 52.2% reduction in circulating microfilariae of B. malayi when administered to infected Mastomys coucha at 250 mg/kg, orally for 5 consecutive days. Further fractionation of the extract led to the recovery of four fractions, which were evaluated simultaneously in both in vitro and in vivo systems against B. malayi. The chloroform fraction at 250 mg/kg orally for 5 days exhibited the highest macrofilaricidal action (42.5%), closely followed by the insoluble n-butanol fraction (34.3%), the soluble hexane fraction (32.4%), and the soluble n-butanol fraction (20.4%). In addition, the hexane soluble fraction caused 44.3% sterilization of the surviving female parasites. Two compounds isolated were found devoid of antifilarial activity.</div>
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<Title>Parasitology research</Title>
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<Abstract><AbstractText>The chloroform methanol (1:1) extract of an unidentified green zoanthus (Phylum Coelenterata, Class Anthozoa) showed promising in vitro adulticidal activity with a lethal concentration of 125 microg/ml on Brugia malayi. This extract brought about a 52.2% reduction in circulating microfilariae of B. malayi when administered to infected Mastomys coucha at 250 mg/kg, orally for 5 consecutive days. Further fractionation of the extract led to the recovery of four fractions, which were evaluated simultaneously in both in vitro and in vivo systems against B. malayi. The chloroform fraction at 250 mg/kg orally for 5 days exhibited the highest macrofilaricidal action (42.5%), closely followed by the insoluble n-butanol fraction (34.3%), the soluble hexane fraction (32.4%), and the soluble n-butanol fraction (20.4%). In addition, the hexane soluble fraction caused 44.3% sterilization of the surviving female parasites. Two compounds isolated were found devoid of antifilarial activity.</AbstractText>
<CopyrightInformation>Copyright 2004 Springer-Verlag</CopyrightInformation>
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Antifilarial activity of Zoanthus species (Phylum Coelenterata, Class Anthzoa) against human lymphatic filaria, Brugia malayi.

Antifilarial activity of Zoanthus species (Phylum Coelenterata, Class Anthzoa) against human lymphatic filaria, Brugia malayi.

Source :

English descriptors

Abstract

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