Impairment of lymph drainage in subfascial compartment of forearm in breast cancer-related lymphedema.
Identifieur interne : 003E17 ( PubMed/Corpus ); précédent : 003E16; suivant : 003E18Impairment of lymph drainage in subfascial compartment of forearm in breast cancer-related lymphedema.
Auteurs : A W B. Stanton ; R H Mellor ; G J Cook ; W E Svensson ; A M Peters ; J R Levick ; P S MortimerSource :
- Lymphatic research and biology [ 1539-6851 ] ; 2003.
English descriptors
- KwdEn :
- Aged, Breast Neoplasms (complications), Breast Neoplasms (pathology), Drainage, Female, Forearm (pathology), Gamma Cameras, Humans, Immunoglobulin G (metabolism), Lymph (metabolism), Lymph (physiology), Lymph Node Excision, Lymph Nodes (pathology), Lymphatic System (pathology), Lymphatic Vessels (pathology), Lymphedema (etiology), Lymphedema (pathology), Lymphography (methods), Mastectomy, Modified Radical, Middle Aged, Muscles (pathology), Radionuclide Imaging (methods), Technetium (pharmacokinetics), Temperature, Time Factors.
- MESH :
- chemical , metabolism : Immunoglobulin G.
- complications : Breast Neoplasms.
- etiology : Lymphedema.
- metabolism : Lymph.
- methods : Lymphography, Radionuclide Imaging.
- pathology : Breast Neoplasms, Forearm, Lymph Nodes, Lymphatic System, Lymphatic Vessels, Lymphedema, Muscles.
- chemical , pharmacokinetics : Technetium.
- physiology : Lymph.
- Aged, Drainage, Female, Gamma Cameras, Humans, Lymph Node Excision, Mastectomy, Modified Radical, Middle Aged, Temperature, Time Factors.
Abstract
In arm lymphedema secondary to axillary surgery and radiotherapy (breast cancer-related lymphedema), the swelling is largely epifascial and lymph flow per unit epifascial volume is impaired. The subfascial muscle compartment is not measurably swollen despite the iatrogenic damage to its axillary drainage pathway, but this could be due to its low compliance. Our aim was to test the hypothesis that subfascial lymph drainage too is impaired.
DOI: 10.1089/153968503321642615
PubMed: 15624420
Links to Exploration step
pubmed:15624420Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impairment of lymph drainage in subfascial compartment of forearm in breast cancer-related lymphedema.</title><author><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name><affiliation><nlm:affiliation>Department of Medicine, St George's Hospital Medical School, London. astanton@sghms.ac.uk</nlm:affiliation></affiliation></author><author><name sortKey="Mellor, R H" sort="Mellor, R H" uniqKey="Mellor R" first="R H" last="Mellor">R H Mellor</name></author><author><name sortKey="Cook, G J" sort="Cook, G J" uniqKey="Cook G" first="G J" last="Cook">G J Cook</name></author><author><name sortKey="Svensson, W E" sort="Svensson, W E" uniqKey="Svensson W" first="W E" last="Svensson">W E Svensson</name></author><author><name sortKey="Peters, A M" sort="Peters, A M" uniqKey="Peters A" first="A M" last="Peters">A M Peters</name></author><author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">P S Mortimer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:15624420</idno><idno type="pmid">15624420</idno><idno type="doi">10.1089/153968503321642615</idno><idno type="wicri:Area/PubMed/Corpus">003E17</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003E17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impairment of lymph drainage in subfascial compartment of forearm in breast cancer-related lymphedema.</title><author><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name><affiliation><nlm:affiliation>Department of Medicine, St George's Hospital Medical School, London. astanton@sghms.ac.uk</nlm:affiliation></affiliation></author><author><name sortKey="Mellor, R H" sort="Mellor, R H" uniqKey="Mellor R" first="R H" last="Mellor">R H Mellor</name></author><author><name sortKey="Cook, G J" sort="Cook, G J" uniqKey="Cook G" first="G J" last="Cook">G J Cook</name></author><author><name sortKey="Svensson, W E" sort="Svensson, W E" uniqKey="Svensson W" first="W E" last="Svensson">W E Svensson</name></author><author><name sortKey="Peters, A M" sort="Peters, A M" uniqKey="Peters A" first="A M" last="Peters">A M Peters</name></author><author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">P S Mortimer</name></author></analytic><series><title level="j">Lymphatic research and biology</title><idno type="ISSN">1539-6851</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Breast Neoplasms (complications)</term><term>Breast Neoplasms (pathology)</term><term>Drainage</term><term>Female</term><term>Forearm (pathology)</term><term>Gamma Cameras</term><term>Humans</term><term>Immunoglobulin G (metabolism)</term><term>Lymph (metabolism)</term><term>Lymph (physiology)</term><term>Lymph Node Excision</term><term>Lymph Nodes (pathology)</term><term>Lymphatic System (pathology)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Lymphography (methods)</term><term>Mastectomy, Modified Radical</term><term>Middle Aged</term><term>Muscles (pathology)</term><term>Radionuclide Imaging (methods)</term><term>Technetium (pharmacokinetics)</term><term>Temperature</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymph</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymphography</term><term>Radionuclide Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Forearm</term><term>Lymph Nodes</term><term>Lymphatic System</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Muscles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Technetium</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Drainage</term><term>Female</term><term>Gamma Cameras</term><term>Humans</term><term>Lymph Node Excision</term><term>Mastectomy, Modified Radical</term><term>Middle Aged</term><term>Temperature</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In arm lymphedema secondary to axillary surgery and radiotherapy (breast cancer-related lymphedema), the swelling is largely epifascial and lymph flow per unit epifascial volume is impaired. The subfascial muscle compartment is not measurably swollen despite the iatrogenic damage to its axillary drainage pathway, but this could be due to its low compliance. Our aim was to test the hypothesis that subfascial lymph drainage too is impaired.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15624420</PMID><DateCreated><Year>2004</Year><Month>12</Month><Day>30</Day></DateCreated><DateCompleted><Year>2005</Year><Month>02</Month><Day>01</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1539-6851</ISSN><JournalIssue CitedMedium="Print"><Volume>1</Volume><Issue>2</Issue><PubDate><Year>2003</Year></PubDate></JournalIssue><Title>Lymphatic research and biology</Title><ISOAbbreviation>Lymphat Res Biol</ISOAbbreviation></Journal><ArticleTitle>Impairment of lymph drainage in subfascial compartment of forearm in breast cancer-related lymphedema.</ArticleTitle><Pagination><MedlinePgn>121-32</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In arm lymphedema secondary to axillary surgery and radiotherapy (breast cancer-related lymphedema), the swelling is largely epifascial and lymph flow per unit epifascial volume is impaired. The subfascial muscle compartment is not measurably swollen despite the iatrogenic damage to its axillary drainage pathway, but this could be due to its low compliance. Our aim was to test the hypothesis that subfascial lymph drainage too is impaired.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Quantitative lymphoscintigraphy was used to measure the removal rate constant (local lymph flow per unit distribution volume) for technetium-99m-human immunoglobulin G injected intramuscularly in the forearms of nine women with unilateral lymphedema. The removal rate constant was on average 31% lower in the ipsilateral swollen forearm than in the contralateral forearm (swollen arm: -0.096+/-0.041% min(-1), contralateral arm: -0.138+/-0.037% min(-1); mean+/-SD, p = 0.037). The decrease in subfascial rate constant correlated strongly with increase in arm volume (r = -0.88, p = 0.002), even though the swelling is mainly epifascial. There was no convincing evidence of dermal backflow.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Lymph flow in the subfascial muscle compartment is decreased in breast cancer-related lymphedema. The correlation between impairment of subfascial drainage and epifascial arm swelling could be because both depend on the severity of axillary damage, or because loss of function in subfascial lymphatics impairs drainage from the epifascial to the subfascial system.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stanton</LastName><ForeName>A W B</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>Department of Medicine, St George's Hospital Medical School, London. astanton@sghms.ac.uk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mellor</LastName><ForeName>R H</ForeName><Initials>RH</Initials></Author><Author ValidYN="Y"><LastName>Cook</LastName><ForeName>G J</ForeName><Initials>GJ</Initials></Author><Author ValidYN="Y"><LastName>Svensson</LastName><ForeName>W E</ForeName><Initials>WE</Initials></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Levick</LastName><ForeName>J R</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Mortimer</LastName><ForeName>P S</ForeName><Initials>PS</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>WT063025</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lymphat Res Biol</MedlineTA><NlmUniqueID>101163587</NlmUniqueID><ISSNLinking>1539-6851</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-26-8</RegistryNumber><NameOfSubstance UI="D013667">Technetium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Int J Microcirc Clin Exp. 1992 Nov;11(4):359-73</RefSource><PMID Version="1">1459796</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta radiol. 1959 Jun;51(6):422-8</RefSource><PMID Version="1">13670005</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Radiol. 2001 Jul;42(4):409-16</RefSource><PMID Version="1">11442467</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Sci (Lond). 2001 Aug;101(2):131-40</RefSource><PMID Version="1">11473486</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Surg. 1966 Jan;53(1):4-14</RefSource><PMID Version="1">5901912</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Surgery. 1966 Jun;59(6):935-43</RefSource><PMID Version="1">4287138</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Radiol. 1973 Feb;46(542):120-4</RefSource><PMID Version="1">4686811</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Tohoku J Exp Med. 1976 Feb;118(2):163-71</RefSource><PMID Version="1">982430</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Biol Acad Sci Hung. 1980;31(1-3):191-200</RefSource><PMID Version="1">7223234</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 1983 Sep;16(3):139-42</RefSource><PMID Version="1">6632962</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Surgery. 1984 May;95(5):562-6</RefSource><PMID Version="1">6710353</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 1988 Sep;21(3):134-43</RefSource><PMID Version="1">3199873</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Radiol. 1995 Aug;50(8):541-4</RefSource><PMID Version="1">7656520</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 1997 Jun;30(2):77-97</RefSource><PMID Version="1">9215977</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004322" MajorTopicYN="N">Drainage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005542" MajorTopicYN="N">Forearm</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015902" MajorTopicYN="N">Gamma Cameras</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008196" MajorTopicYN="N">Lymph</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008220" MajorTopicYN="N">Lymphography</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015411" MajorTopicYN="N">Mastectomy, Modified Radical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009132" 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