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The lymphatic vasculature: recent progress and paradigms.

Identifieur interne : 003B81 ( PubMed/Corpus ); précédent : 003B80; suivant : 003B82

The lymphatic vasculature: recent progress and paradigms.

Auteurs : Guillermo Oliver ; Kari Alitalo

Source :

RBID : pubmed:16212503

English descriptors

Abstract

The field of lymphatic research has been recently invigorated by the identification of genes and mechanisms that control various aspects of lymphatic development. We are beginning to understand how, starting from a subgroup of embryonic venous endothelial cells, the whole lymphatic system forms in a stepwise manner. The generation of genetically engineered mice with defects in different steps of the lymphangiogenic program has provided models that are increasing our understanding of the lymphatic system in health and disease. This knowledge, in turn, should lead to the development of better diagnostic methods and treatments of lymphatic disorders and tumor metastasis.

DOI: 10.1146/annurev.cellbio.21.012704.132338
PubMed: 16212503

Links to Exploration step

pubmed:16212503

Le document en format XML

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