Clinical correlates of filarial infection in Haitian children: an association with interdigital lesions.
Identifieur interne : 003B78 ( PubMed/Corpus ); précédent : 003B77; suivant : 003B79Clinical correlates of filarial infection in Haitian children: an association with interdigital lesions.
Auteurs : Leanne M. Fox ; Susan F. Wilson ; David G. Addiss ; Jacky Louis-Charles ; Madsen V. Beau De Rochars ; Patrick J. LammieSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2005.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Antigens, Helminth (blood), Child, Child, Preschool, Elephantiasis, Filarial (diagnostic imaging), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (pathology), Female, Haiti (epidemiology), Humans, Lymph Nodes (pathology), Male, Multivariate Analysis, Toes (diagnostic imaging), Toes (parasitology), Toes (pathology), Ultrasonography, Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , blood : Antigens, Helminth.
- diagnostic imaging : Elephantiasis, Filarial, Toes.
- epidemiology : Elephantiasis, Filarial, Haiti.
- isolation & purification : Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial, Toes.
- pathology : Elephantiasis, Filarial, Lymph Nodes, Toes.
- Adolescent, Adult, Animals, Child, Child, Preschool, Female, Humans, Male, Multivariate Analysis, Ultrasonography.
Abstract
To assess clinical findings associated with Wuchereria bancrofti infection, 192 school children in a filariasis-endemic area of Haiti underwent physical and ultrasonographic examinations and testing for circulating filarial antigen (CFA). The CFA-positive children were more likely than CFA-negative children to have severe interdigital lesions (> or = 1 macerated lesion with involvement of > or = 4 toe web spaces) (P < 0.0001) and inguinal (P = 0.003) or crural (P = 0.004) lymph node pathology. In multivariate analysis, CFA positivity remained a significant predictor for severe interdigital lesions (P = 0.006) and inguinal lymph node pathology (P = 0.05). Ultrasound detected adult worms and lymphangectasia (diameter = 2.0-4.0 mm) in 11 (10.8%) CFA-positive children. Among CFA-positive children, ultrasonographic detection of adult worms was associated with inguinal (P = 0.01) and crural (P = 0.004) lymph node pathology and advanced pubertal stage (sexual maturity rating = 3-5) (P = 0.02). This is the first study to associate interdigital lesions with filarial infection in children.
PubMed: 16222022
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical correlates of filarial infection in Haitian children: an association with interdigital lesions.</title><author><name sortKey="Fox, Leanne M" sort="Fox, Leanne M" uniqKey="Fox L" first="Leanne M" last="Fox">Leanne M. Fox</name><affiliation><nlm:affiliation>Epidemic Intelligence Service, Epidemiology Program Office, and Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA. lfox@bu.edu</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, Susan F" sort="Wilson, Susan F" uniqKey="Wilson S" first="Susan F" last="Wilson">Susan F. Wilson</name></author><author><name sortKey="Addiss, David G" sort="Addiss, David G" uniqKey="Addiss D" first="David G" last="Addiss">David G. Addiss</name></author><author><name sortKey="Louis Charles, Jacky" sort="Louis Charles, Jacky" uniqKey="Louis Charles J" first="Jacky" last="Louis-Charles">Jacky Louis-Charles</name></author><author><name sortKey="Beau De Rochars, Madsen V" sort="Beau De Rochars, Madsen V" uniqKey="Beau De Rochars M" first="Madsen V" last="Beau De Rochars">Madsen V. Beau De Rochars</name></author><author><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J" last="Lammie">Patrick J. Lammie</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16222022</idno><idno type="pmid">16222022</idno><idno type="wicri:Area/PubMed/Corpus">003B78</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003B78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical correlates of filarial infection in Haitian children: an association with interdigital lesions.</title><author><name sortKey="Fox, Leanne M" sort="Fox, Leanne M" uniqKey="Fox L" first="Leanne M" last="Fox">Leanne M. Fox</name><affiliation><nlm:affiliation>Epidemic Intelligence Service, Epidemiology Program Office, and Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA. lfox@bu.edu</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, Susan F" sort="Wilson, Susan F" uniqKey="Wilson S" first="Susan F" last="Wilson">Susan F. Wilson</name></author><author><name sortKey="Addiss, David G" sort="Addiss, David G" uniqKey="Addiss D" first="David G" last="Addiss">David G. Addiss</name></author><author><name sortKey="Louis Charles, Jacky" sort="Louis Charles, Jacky" uniqKey="Louis Charles J" first="Jacky" last="Louis-Charles">Jacky Louis-Charles</name></author><author><name sortKey="Beau De Rochars, Madsen V" sort="Beau De Rochars, Madsen V" uniqKey="Beau De Rochars M" first="Madsen V" last="Beau De Rochars">Madsen V. Beau De Rochars</name></author><author><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J" last="Lammie">Patrick J. Lammie</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antigens, Helminth (blood)</term><term>Child</term><term>Child, Preschool</term><term>Elephantiasis, Filarial (diagnostic imaging)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Elephantiasis, Filarial (pathology)</term><term>Female</term><term>Haiti (epidemiology)</term><term>Humans</term><term>Lymph Nodes (pathology)</term><term>Male</term><term>Multivariate Analysis</term><term>Toes (diagnostic imaging)</term><term>Toes (parasitology)</term><term>Toes (pathology)</term><term>Ultrasonography</term><term>Wuchereria bancrofti (isolation & purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Toes</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Haiti</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Toes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymph Nodes</term><term>Toes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Male</term><term>Multivariate Analysis</term><term>Ultrasonography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess clinical findings associated with Wuchereria bancrofti infection, 192 school children in a filariasis-endemic area of Haiti underwent physical and ultrasonographic examinations and testing for circulating filarial antigen (CFA). The CFA-positive children were more likely than CFA-negative children to have severe interdigital lesions (> or = 1 macerated lesion with involvement of > or = 4 toe web spaces) (P < 0.0001) and inguinal (P = 0.003) or crural (P = 0.004) lymph node pathology. In multivariate analysis, CFA positivity remained a significant predictor for severe interdigital lesions (P = 0.006) and inguinal lymph node pathology (P = 0.05). Ultrasound detected adult worms and lymphangectasia (diameter = 2.0-4.0 mm) in 11 (10.8%) CFA-positive children. Among CFA-positive children, ultrasonographic detection of adult worms was associated with inguinal (P = 0.01) and crural (P = 0.004) lymph node pathology and advanced pubertal stage (sexual maturity rating = 3-5) (P = 0.02). This is the first study to associate interdigital lesions with filarial infection in children.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16222022</PMID><DateCreated><Year>2005</Year><Month>10</Month><Day>13</Day></DateCreated><DateCompleted><Year>2006</Year><Month>01</Month><Day>05</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9637</ISSN><JournalIssue CitedMedium="Print"><Volume>73</Volume><Issue>4</Issue><PubDate><Year>2005</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The American journal of tropical medicine and hygiene</Title><ISOAbbreviation>Am. J. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Clinical correlates of filarial infection in Haitian children: an association with interdigital lesions.</ArticleTitle><Pagination><MedlinePgn>759-65</MedlinePgn></Pagination><Abstract><AbstractText>To assess clinical findings associated with Wuchereria bancrofti infection, 192 school children in a filariasis-endemic area of Haiti underwent physical and ultrasonographic examinations and testing for circulating filarial antigen (CFA). The CFA-positive children were more likely than CFA-negative children to have severe interdigital lesions (> or = 1 macerated lesion with involvement of > or = 4 toe web spaces) (P < 0.0001) and inguinal (P = 0.003) or crural (P = 0.004) lymph node pathology. In multivariate analysis, CFA positivity remained a significant predictor for severe interdigital lesions (P = 0.006) and inguinal lymph node pathology (P = 0.05). Ultrasound detected adult worms and lymphangectasia (diameter = 2.0-4.0 mm) in 11 (10.8%) CFA-positive children. Among CFA-positive children, ultrasonographic detection of adult worms was associated with inguinal (P = 0.01) and crural (P = 0.004) lymph node pathology and advanced pubertal stage (sexual maturity rating = 3-5) (P = 0.02). This is the first study to associate interdigital lesions with filarial infection in children.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>LeAnne M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Epidemic Intelligence Service, Epidemiology Program Office, and Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA. lfox@bu.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>Susan F</ForeName><Initials>SF</Initials></Author><Author ValidYN="Y"><LastName>Addiss</LastName><ForeName>David G</ForeName><Initials>DG</Initials></Author><Author ValidYN="Y"><LastName>Louis-Charles</LastName><ForeName>Jacky</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Beau de Rochars</LastName><ForeName>Madsen V</ForeName><Initials>MV</Initials></Author><Author ValidYN="Y"><LastName>Lammie</LastName><ForeName>Patrick J</ForeName><Initials>PJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Trop Med Hyg</MedlineTA><NlmUniqueID>0370507</NlmUniqueID><ISSNLinking>0002-9637</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006205" MajorTopicYN="N">Haiti</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014034" MajorTopicYN="N">Toes</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014463" MajorTopicYN="N">Ultrasonography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>10</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>1</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>10</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16222022</ArticleId><ArticleId IdType="pii">73/4/759</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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