Impact of dose and volume on lymphedema.
Identifieur interne : 003B51 ( PubMed/Corpus ); précédent : 003B50; suivant : 003B52Impact of dose and volume on lymphedema.
Auteurs : Luigia Nardone ; Giovanni Palazzoni ; Elisa D'Angelo ; Francesco Deodato ; M Antonietta Gambacorta ; Francesco Miccichè ; Alessio G. MorgantiSource :
- Rays [ 0390-7740 ]
English descriptors
- KwdEn :
- Arm, Axilla, Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Dose-Response Relationship, Radiation, Female, Humans, Lymphatic Irradiation (adverse effects), Lymphedema (etiology), Lymphedema (prevention & control), Radiotherapy Dosage, Radiotherapy, Adjuvant, Risk Factors, Severity of Illness Index.
- MESH :
- adverse effects : Lymphatic Irradiation.
- etiology : Lymphedema.
- prevention & control : Lymphedema.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- Arm, Axilla, Dose-Response Relationship, Radiation, Female, Humans, Radiotherapy Dosage, Radiotherapy, Adjuvant, Risk Factors, Severity of Illness Index.
Abstract
Lymphedema represents one of the major problem of morbidity in breast cancer therapy. Approximately 15-30% of patients show more or less severe lymphedema of the arm, following cancer therapy. Main pathogenetic mechanisms, risk factors, main grading criteria and scales as LENT-SOMA, CTCv2, CTCAE v3 are presented. A close correlation has been documented between the extent of axillary dissection and the association with radiotherapy in determining an increased risk of lymphedema. Details of surgery and radiotherapy are relevant in the definition of the risk of edema of the arm. Because the axillary area does not correspond to an organ, evaluable parameters as V20 and Dmean available for other organs are not applicable. There is some evidence of a correlation between the irradiation volume and the development of lymphedema. Data of the impact of the dose and its fractionation on the development of lymphedema are contrasting. The monitoring system of late toxicity used by the authors is presented.
PubMed: 16294908
Links to Exploration step
pubmed:16294908Le document en format XML
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Gemelh 8, 00168 Roma, Italy. lnardone@rm.unicatt.it</nlm:affiliation></affiliation></author><author><name sortKey="Palazzoni, Giovanni" sort="Palazzoni, Giovanni" uniqKey="Palazzoni G" first="Giovanni" last="Palazzoni">Giovanni Palazzoni</name></author><author><name sortKey="D Angelo, Elisa" sort="D Angelo, Elisa" uniqKey="D Angelo E" first="Elisa" last="D'Angelo">Elisa D'Angelo</name></author><author><name sortKey="Deodato, Francesco" sort="Deodato, Francesco" uniqKey="Deodato F" first="Francesco" last="Deodato">Francesco Deodato</name></author><author><name sortKey="Gambacorta, M Antonietta" sort="Gambacorta, M Antonietta" uniqKey="Gambacorta M" first="M Antonietta" last="Gambacorta">M Antonietta Gambacorta</name></author><author><name sortKey="Micciche, Francesco" sort="Micciche, Francesco" uniqKey="Micciche F" first="Francesco" last="Miccichè">Francesco Miccichè</name></author><author><name sortKey="Morganti, Alessio G" sort="Morganti, Alessio G" uniqKey="Morganti A" first="Alessio G" last="Morganti">Alessio G. 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Gemelh 8, 00168 Roma, Italy. lnardone@rm.unicatt.it</nlm:affiliation></affiliation></author><author><name sortKey="Palazzoni, Giovanni" sort="Palazzoni, Giovanni" uniqKey="Palazzoni G" first="Giovanni" last="Palazzoni">Giovanni Palazzoni</name></author><author><name sortKey="D Angelo, Elisa" sort="D Angelo, Elisa" uniqKey="D Angelo E" first="Elisa" last="D'Angelo">Elisa D'Angelo</name></author><author><name sortKey="Deodato, Francesco" sort="Deodato, Francesco" uniqKey="Deodato F" first="Francesco" last="Deodato">Francesco Deodato</name></author><author><name sortKey="Gambacorta, M Antonietta" sort="Gambacorta, M Antonietta" uniqKey="Gambacorta M" first="M Antonietta" last="Gambacorta">M Antonietta Gambacorta</name></author><author><name sortKey="Micciche, Francesco" sort="Micciche, Francesco" uniqKey="Micciche F" first="Francesco" last="Miccichè">Francesco Miccichè</name></author><author><name sortKey="Morganti, Alessio G" sort="Morganti, Alessio G" uniqKey="Morganti A" first="Alessio G" last="Morganti">Alessio G. Morganti</name></author></analytic><series><title level="j">Rays</title><idno type="ISSN">0390-7740</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arm</term><term>Axilla</term><term>Breast Neoplasms (radiotherapy)</term><term>Breast Neoplasms (surgery)</term><term>Dose-Response Relationship, Radiation</term><term>Female</term><term>Humans</term><term>Lymphatic Irradiation (adverse effects)</term><term>Lymphedema (etiology)</term><term>Lymphedema (prevention & control)</term><term>Radiotherapy Dosage</term><term>Radiotherapy, Adjuvant</term><term>Risk Factors</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymphatic Irradiation</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Arm</term><term>Axilla</term><term>Dose-Response Relationship, Radiation</term><term>Female</term><term>Humans</term><term>Radiotherapy Dosage</term><term>Radiotherapy, Adjuvant</term><term>Risk Factors</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema represents one of the major problem of morbidity in breast cancer therapy. Approximately 15-30% of patients show more or less severe lymphedema of the arm, following cancer therapy. Main pathogenetic mechanisms, risk factors, main grading criteria and scales as LENT-SOMA, CTCv2, CTCAE v3 are presented. A close correlation has been documented between the extent of axillary dissection and the association with radiotherapy in determining an increased risk of lymphedema. Details of surgery and radiotherapy are relevant in the definition of the risk of edema of the arm. Because the axillary area does not correspond to an organ, evaluable parameters as V20 and Dmean available for other organs are not applicable. There is some evidence of a correlation between the irradiation volume and the development of lymphedema. Data of the impact of the dose and its fractionation on the development of lymphedema are contrasting. The monitoring system of late toxicity used by the authors is presented.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16294908</PMID><DateCreated><Year>2005</Year><Month>11</Month><Day>18</Day></DateCreated><DateCompleted><Year>2006</Year><Month>01</Month><Day>03</Day></DateCompleted><DateRevised><Year>2005</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0390-7740</ISSN><JournalIssue CitedMedium="Print"><Volume>30</Volume><Issue>2</Issue><PubDate><MedlineDate>2005 Apr-Jun</MedlineDate></PubDate></JournalIssue><Title>Rays</Title><ISOAbbreviation>Rays</ISOAbbreviation></Journal><ArticleTitle>Impact of dose and volume on lymphedema.</ArticleTitle><Pagination><MedlinePgn>149-55</MedlinePgn></Pagination><Abstract><AbstractText>Lymphedema represents one of the major problem of morbidity in breast cancer therapy. Approximately 15-30% of patients show more or less severe lymphedema of the arm, following cancer therapy. Main pathogenetic mechanisms, risk factors, main grading criteria and scales as LENT-SOMA, CTCv2, CTCAE v3 are presented. A close correlation has been documented between the extent of axillary dissection and the association with radiotherapy in determining an increased risk of lymphedema. Details of surgery and radiotherapy are relevant in the definition of the risk of edema of the arm. Because the axillary area does not correspond to an organ, evaluable parameters as V20 and Dmean available for other organs are not applicable. There is some evidence of a correlation between the irradiation volume and the development of lymphedema. Data of the impact of the dose and its fractionation on the development of lymphedema are contrasting. The monitoring system of late toxicity used by the authors is presented.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nardone</LastName><ForeName>Luigia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Cattedra di Radioterapia, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Largo A. Gemelh 8, 00168 Roma, Italy. lnardone@rm.unicatt.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palazzoni</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>D'Angelo</LastName><ForeName>Elisa</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Deodato</LastName><ForeName>Francesco</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Gambacorta</LastName><ForeName>M Antonietta</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Miccichè</LastName><ForeName>Francesco</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Morganti</LastName><ForeName>Alessio G</ForeName><Initials>AG</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Rays</MedlineTA><NlmUniqueID>7707724</NlmUniqueID><ISSNLinking>0390-7740</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001132" MajorTopicYN="N">Arm</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001365" MajorTopicYN="N">Axilla</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004307" MajorTopicYN="N">Dose-Response Relationship, Radiation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015182" MajorTopicYN="N">Lymphatic Irradiation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011879" MajorTopicYN="N">Radiotherapy Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>31</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>11</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>1</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>11</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16294908</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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