Impact of dose and volume on lymphedema.
Identifieur interne : 003B51 ( PubMed/Corpus ); précédent : 003B50; suivant : 003B52Impact of dose and volume on lymphedema.
Auteurs : Luigia Nardone ; Giovanni Palazzoni ; Elisa D'Angelo ; Francesco Deodato ; M Antonietta Gambacorta ; Francesco Miccichè ; Alessio G. MorgantiSource :
- Rays [ 0390-7740 ]
English descriptors
- KwdEn :
- Arm, Axilla, Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Dose-Response Relationship, Radiation, Female, Humans, Lymphatic Irradiation (adverse effects), Lymphedema (etiology), Lymphedema (prevention & control), Radiotherapy Dosage, Radiotherapy, Adjuvant, Risk Factors, Severity of Illness Index.
- MESH :
- adverse effects : Lymphatic Irradiation.
- etiology : Lymphedema.
- prevention & control : Lymphedema.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- Arm, Axilla, Dose-Response Relationship, Radiation, Female, Humans, Radiotherapy Dosage, Radiotherapy, Adjuvant, Risk Factors, Severity of Illness Index.
Abstract
Lymphedema represents one of the major problem of morbidity in breast cancer therapy. Approximately 15-30% of patients show more or less severe lymphedema of the arm, following cancer therapy. Main pathogenetic mechanisms, risk factors, main grading criteria and scales as LENT-SOMA, CTCv2, CTCAE v3 are presented. A close correlation has been documented between the extent of axillary dissection and the association with radiotherapy in determining an increased risk of lymphedema. Details of surgery and radiotherapy are relevant in the definition of the risk of edema of the arm. Because the axillary area does not correspond to an organ, evaluable parameters as V20 and Dmean available for other organs are not applicable. There is some evidence of a correlation between the irradiation volume and the development of lymphedema. Data of the impact of the dose and its fractionation on the development of lymphedema are contrasting. The monitoring system of late toxicity used by the authors is presented.
PubMed: 16294908
Links to Exploration step
pubmed:16294908Le document en format XML
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<author><name sortKey="Nardone, Luigia" sort="Nardone, Luigia" uniqKey="Nardone L" first="Luigia" last="Nardone">Luigia Nardone</name>
<affiliation><nlm:affiliation>Cattedra di Radioterapia, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Largo A. Gemelh 8, 00168 Roma, Italy. lnardone@rm.unicatt.it</nlm:affiliation>
</affiliation>
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<author><name sortKey="Palazzoni, Giovanni" sort="Palazzoni, Giovanni" uniqKey="Palazzoni G" first="Giovanni" last="Palazzoni">Giovanni Palazzoni</name>
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<author><name sortKey="D Angelo, Elisa" sort="D Angelo, Elisa" uniqKey="D Angelo E" first="Elisa" last="D'Angelo">Elisa D'Angelo</name>
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<author><name sortKey="Deodato, Francesco" sort="Deodato, Francesco" uniqKey="Deodato F" first="Francesco" last="Deodato">Francesco Deodato</name>
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<author><name sortKey="Gambacorta, M Antonietta" sort="Gambacorta, M Antonietta" uniqKey="Gambacorta M" first="M Antonietta" last="Gambacorta">M Antonietta Gambacorta</name>
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<author><name sortKey="Micciche, Francesco" sort="Micciche, Francesco" uniqKey="Micciche F" first="Francesco" last="Miccichè">Francesco Miccichè</name>
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<author><name sortKey="Morganti, Alessio G" sort="Morganti, Alessio G" uniqKey="Morganti A" first="Alessio G" last="Morganti">Alessio G. Morganti</name>
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<affiliation><nlm:affiliation>Cattedra di Radioterapia, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Largo A. Gemelh 8, 00168 Roma, Italy. lnardone@rm.unicatt.it</nlm:affiliation>
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<author><name sortKey="Palazzoni, Giovanni" sort="Palazzoni, Giovanni" uniqKey="Palazzoni G" first="Giovanni" last="Palazzoni">Giovanni Palazzoni</name>
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<author><name sortKey="D Angelo, Elisa" sort="D Angelo, Elisa" uniqKey="D Angelo E" first="Elisa" last="D'Angelo">Elisa D'Angelo</name>
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<author><name sortKey="Deodato, Francesco" sort="Deodato, Francesco" uniqKey="Deodato F" first="Francesco" last="Deodato">Francesco Deodato</name>
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<author><name sortKey="Gambacorta, M Antonietta" sort="Gambacorta, M Antonietta" uniqKey="Gambacorta M" first="M Antonietta" last="Gambacorta">M Antonietta Gambacorta</name>
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<author><name sortKey="Micciche, Francesco" sort="Micciche, Francesco" uniqKey="Micciche F" first="Francesco" last="Miccichè">Francesco Miccichè</name>
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<author><name sortKey="Morganti, Alessio G" sort="Morganti, Alessio G" uniqKey="Morganti A" first="Alessio G" last="Morganti">Alessio G. Morganti</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arm</term>
<term>Axilla</term>
<term>Breast Neoplasms (radiotherapy)</term>
<term>Breast Neoplasms (surgery)</term>
<term>Dose-Response Relationship, Radiation</term>
<term>Female</term>
<term>Humans</term>
<term>Lymphatic Irradiation (adverse effects)</term>
<term>Lymphedema (etiology)</term>
<term>Lymphedema (prevention & control)</term>
<term>Radiotherapy Dosage</term>
<term>Radiotherapy, Adjuvant</term>
<term>Risk Factors</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymphatic Irradiation</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Arm</term>
<term>Axilla</term>
<term>Dose-Response Relationship, Radiation</term>
<term>Female</term>
<term>Humans</term>
<term>Radiotherapy Dosage</term>
<term>Radiotherapy, Adjuvant</term>
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<front><div type="abstract" xml:lang="en">Lymphedema represents one of the major problem of morbidity in breast cancer therapy. Approximately 15-30% of patients show more or less severe lymphedema of the arm, following cancer therapy. Main pathogenetic mechanisms, risk factors, main grading criteria and scales as LENT-SOMA, CTCv2, CTCAE v3 are presented. A close correlation has been documented between the extent of axillary dissection and the association with radiotherapy in determining an increased risk of lymphedema. Details of surgery and radiotherapy are relevant in the definition of the risk of edema of the arm. Because the axillary area does not correspond to an organ, evaluable parameters as V20 and Dmean available for other organs are not applicable. There is some evidence of a correlation between the irradiation volume and the development of lymphedema. Data of the impact of the dose and its fractionation on the development of lymphedema are contrasting. The monitoring system of late toxicity used by the authors is presented.</div>
</front>
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<DateCreated><Year>2005</Year>
<Month>11</Month>
<Day>18</Day>
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<DateCompleted><Year>2006</Year>
<Month>01</Month>
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<DateRevised><Year>2005</Year>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0390-7740</ISSN>
<JournalIssue CitedMedium="Print"><Volume>30</Volume>
<Issue>2</Issue>
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<Title>Rays</Title>
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<ArticleTitle>Impact of dose and volume on lymphedema.</ArticleTitle>
<Pagination><MedlinePgn>149-55</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Lymphedema represents one of the major problem of morbidity in breast cancer therapy. Approximately 15-30% of patients show more or less severe lymphedema of the arm, following cancer therapy. Main pathogenetic mechanisms, risk factors, main grading criteria and scales as LENT-SOMA, CTCv2, CTCAE v3 are presented. A close correlation has been documented between the extent of axillary dissection and the association with radiotherapy in determining an increased risk of lymphedema. Details of surgery and radiotherapy are relevant in the definition of the risk of edema of the arm. Because the axillary area does not correspond to an organ, evaluable parameters as V20 and Dmean available for other organs are not applicable. There is some evidence of a correlation between the irradiation volume and the development of lymphedema. Data of the impact of the dose and its fractionation on the development of lymphedema are contrasting. The monitoring system of late toxicity used by the authors is presented.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nardone</LastName>
<ForeName>Luigia</ForeName>
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<AffiliationInfo><Affiliation>Cattedra di Radioterapia, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Largo A. Gemelh 8, 00168 Roma, Italy. lnardone@rm.unicatt.it</Affiliation>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D001132" MajorTopicYN="N">Arm</DescriptorName>
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<MeshHeading><DescriptorName UI="D001365" MajorTopicYN="N">Axilla</DescriptorName>
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<MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName>
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<MeshHeading><DescriptorName UI="D015182" MajorTopicYN="N">Lymphatic Irradiation</DescriptorName>
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<MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName>
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<MeshHeading><DescriptorName UI="D011879" MajorTopicYN="N">Radiotherapy Dosage</DescriptorName>
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<MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName>
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<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
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<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
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<NumberOfReferences>31</NumberOfReferences>
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