Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: long-term results of the ARCOSEIN multicenter randomized study.
Identifieur interne : 003A50 ( PubMed/Corpus ); précédent : 003A49; suivant : 003A51Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: long-term results of the ARCOSEIN multicenter randomized study.
Auteurs : Alain Toledano ; Pascal Garaud ; Daniel Serin ; Alain Fourquet ; Jean-Francois Bosset ; Noel Breteau ; Gilles Body ; David Azria ; Olivier Le Floch ; Gilles CalaisSource :
- International journal of radiation oncology, biology, physics [ 0360-3016 ] ; 2006.
English descriptors
- KwdEn :
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Breast Neoplasms (drug therapy), Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Chemotherapy, Adjuvant, Combined Modality Therapy (methods), Cyclophosphamide (administration & dosage), Female, Fluorouracil (administration & dosage), Humans, Mastectomy, Segmental, Middle Aged, Mitoxantrone (administration & dosage), Neoplasm Recurrence, Local, Prospective Studies, Radiotherapy Dosage, Skin Pigmentation.
- MESH :
- chemical , administration & dosage : Cyclophosphamide, Fluorouracil, Mitoxantrone.
- drug therapy : Breast Neoplasms.
- methods : Combined Modality Therapy.
- pathology : Breast Neoplasms.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adult, Aged, Chemotherapy, Adjuvant, Female, Humans, Mastectomy, Segmental, Middle Aged, Neoplasm Recurrence, Local, Prospective Studies, Radiotherapy Dosage, Skin Pigmentation.
Abstract
In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies.
DOI: 10.1016/j.ijrobp.2005.12.020
PubMed: 16542788
Links to Exploration step
pubmed:16542788Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: long-term results of the ARCOSEIN multicenter randomized study.</title><author><name sortKey="Toledano, Alain" sort="Toledano, Alain" uniqKey="Toledano A" first="Alain" last="Toledano">Alain Toledano</name><affiliation><nlm:affiliation>Department of Radiotherapy, Hospital Tenon AP-HP, Paris, France. alain.toledano@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Garaud, Pascal" sort="Garaud, Pascal" uniqKey="Garaud P" first="Pascal" last="Garaud">Pascal Garaud</name></author><author><name sortKey="Serin, Daniel" sort="Serin, Daniel" uniqKey="Serin D" first="Daniel" last="Serin">Daniel Serin</name></author><author><name sortKey="Fourquet, Alain" sort="Fourquet, Alain" uniqKey="Fourquet A" first="Alain" last="Fourquet">Alain Fourquet</name></author><author><name sortKey="Bosset, Jean Francois" sort="Bosset, Jean Francois" uniqKey="Bosset J" first="Jean-Francois" last="Bosset">Jean-Francois Bosset</name></author><author><name sortKey="Breteau, Noel" sort="Breteau, Noel" uniqKey="Breteau N" first="Noel" last="Breteau">Noel Breteau</name></author><author><name sortKey="Body, Gilles" sort="Body, Gilles" uniqKey="Body G" first="Gilles" last="Body">Gilles Body</name></author><author><name sortKey="Azria, David" sort="Azria, David" uniqKey="Azria D" first="David" last="Azria">David Azria</name></author><author><name sortKey="Le Floch, Olivier" sort="Le Floch, Olivier" uniqKey="Le Floch O" first="Olivier" last="Le Floch">Olivier Le Floch</name></author><author><name sortKey="Calais, Gilles" sort="Calais, Gilles" uniqKey="Calais G" first="Gilles" last="Calais">Gilles Calais</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16542788</idno><idno type="pmid">16542788</idno><idno type="doi">10.1016/j.ijrobp.2005.12.020</idno><idno type="wicri:Area/PubMed/Corpus">003A50</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003A50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: long-term results of the ARCOSEIN multicenter randomized study.</title><author><name sortKey="Toledano, Alain" sort="Toledano, Alain" uniqKey="Toledano A" first="Alain" last="Toledano">Alain Toledano</name><affiliation><nlm:affiliation>Department of Radiotherapy, Hospital Tenon AP-HP, Paris, France. alain.toledano@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Garaud, Pascal" sort="Garaud, Pascal" uniqKey="Garaud P" first="Pascal" last="Garaud">Pascal Garaud</name></author><author><name sortKey="Serin, Daniel" sort="Serin, Daniel" uniqKey="Serin D" first="Daniel" last="Serin">Daniel Serin</name></author><author><name sortKey="Fourquet, Alain" sort="Fourquet, Alain" uniqKey="Fourquet A" first="Alain" last="Fourquet">Alain Fourquet</name></author><author><name sortKey="Bosset, Jean Francois" sort="Bosset, Jean Francois" uniqKey="Bosset J" first="Jean-Francois" last="Bosset">Jean-Francois Bosset</name></author><author><name sortKey="Breteau, Noel" sort="Breteau, Noel" uniqKey="Breteau N" first="Noel" last="Breteau">Noel Breteau</name></author><author><name sortKey="Body, Gilles" sort="Body, Gilles" uniqKey="Body G" first="Gilles" last="Body">Gilles Body</name></author><author><name sortKey="Azria, David" sort="Azria, David" uniqKey="Azria D" first="David" last="Azria">David Azria</name></author><author><name sortKey="Le Floch, Olivier" sort="Le Floch, Olivier" uniqKey="Le Floch O" first="Olivier" last="Le Floch">Olivier Le Floch</name></author><author><name sortKey="Calais, Gilles" sort="Calais, Gilles" uniqKey="Calais G" first="Gilles" last="Calais">Gilles Calais</name></author></analytic><series><title level="j">International journal of radiation oncology, biology, physics</title><idno type="ISSN">0360-3016</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Breast Neoplasms (drug therapy)</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (radiotherapy)</term><term>Breast Neoplasms (surgery)</term><term>Chemotherapy, Adjuvant</term><term>Combined Modality Therapy (methods)</term><term>Cyclophosphamide (administration & dosage)</term><term>Female</term><term>Fluorouracil (administration & dosage)</term><term>Humans</term><term>Mastectomy, Segmental</term><term>Middle Aged</term><term>Mitoxantrone (administration & dosage)</term><term>Neoplasm Recurrence, Local</term><term>Prospective Studies</term><term>Radiotherapy Dosage</term><term>Skin Pigmentation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cyclophosphamide</term><term>Fluorouracil</term><term>Mitoxantrone</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Combined Modality Therapy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Chemotherapy, Adjuvant</term><term>Female</term><term>Humans</term><term>Mastectomy, Segmental</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local</term><term>Prospective Studies</term><term>Radiotherapy Dosage</term><term>Skin Pigmentation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16542788</PMID><DateCreated><Year>2006</Year><Month>05</Month><Day>12</Day></DateCreated><DateCompleted><Year>2006</Year><Month>06</Month><Day>26</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0360-3016</ISSN><JournalIssue CitedMedium="Print"><Volume>65</Volume><Issue>2</Issue><PubDate><Year>2006</Year><Month>Jun</Month><Day>01</Day></PubDate></JournalIssue><Title>International journal of radiation oncology, biology, physics</Title><ISOAbbreviation>Int. J. Radiat. Oncol. Biol. Phys.</ISOAbbreviation></Journal><ArticleTitle>Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: long-term results of the ARCOSEIN multicenter randomized study.</ArticleTitle><Pagination><MedlinePgn>324-32</MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies.</AbstractText><AbstractText Label="METHODS AND MATERIALS" NlmCategory="METHODS">A total of 297 patients from the 5 larger participating institutions were asked to report for a follow-up examination. Seventy-two percent (214 patients) were eligible for evaluation of late toxicity. After breast-conserving surgery, patients were treated either with sequential treatment with CT first followed by RT (Arm A) or CT administered concurrently with RT (Arm B). In all patients, CT regimen consisted of mitoxantrone (12 mg/m2), 5-FU (500 mg/m2), and cyclophosphamide (500 mg/m2), 6 cycles (Day 1 to Day 21). Conventional RT was delivered to the whole breast by administration of a 2 Gy per fraction protocol to a total dose of 50 Gy (+/- boost to the primary tumor bed). The assessment of toxicity was blinded to treatment and was graded by the radiation oncologist, according to the LENT/SOMA scale. Skin pigmentation was also evaluated according to a personal 5-points scoring system (excellent, good, moderate, poor, very poor).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among the 214 evaluable patients, 107 were treated in each arm. The 2 populations were homogeneous for patient, tumor, and treatment characteristics. Subcutaneous fibrosis (SF), telangectasia (T), skin pigmentation (SP), and breast atrophy (BA) were significantly increased in Arm B. No statistical difference was observed between the 2 arms of the study concerning Grade 2 or higher pain, breast edema, or lymphedema. No deaths were caused by late toxicity.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">After breast-conserving surgery, the concurrent use of CT with RT is significantly associated with an increase incidence of Grade 2 or greater late side effects.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Toledano</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Radiotherapy, Hospital Tenon AP-HP, Paris, France. alain.toledano@gmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garaud</LastName><ForeName>Pascal</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Serin</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Fourquet</LastName><ForeName>Alain</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Bosset</LastName><ForeName>Jean-Francois</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Breteau</LastName><ForeName>Noel</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Body</LastName><ForeName>Gilles</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Azria</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Le Floch</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Calais</LastName><ForeName>Gilles</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D017428">Clinical Trial, Phase III</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2006</Year><Month>03</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Radiat Oncol Biol Phys</MedlineTA><NlmUniqueID>7603616</NlmUniqueID><ISSNLinking>0360-3016</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>8N3DW7272P</RegistryNumber><NameOfSubstance UI="D003520">Cyclophosphamide</NameOfSubstance></Chemical><Chemical><RegistryNumber>BZ114NVM5P</RegistryNumber><NameOfSubstance UI="D008942">Mitoxantrone</NameOfSubstance></Chemical><Chemical><RegistryNumber>U3P01618RT</RegistryNumber><NameOfSubstance UI="D005472">Fluorouracil</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Int J Radiat Oncol Biol Phys. 2006 Sep 1;66(1):314; author reply 314-5</RefSource><PMID Version="1">16904531</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000971" MajorTopicYN="N">Antineoplastic Combined Chemotherapy Protocols</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017024" MajorTopicYN="N">Chemotherapy, Adjuvant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003520" MajorTopicYN="N">Cyclophosphamide</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005472" MajorTopicYN="N">Fluorouracil</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015412" MajorTopicYN="N">Mastectomy, Segmental</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008942" MajorTopicYN="N">Mitoxantrone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009364" MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011879" MajorTopicYN="N">Radiotherapy Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012880" MajorTopicYN="N">Skin Pigmentation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>10</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2005</Year><Month>12</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2005</Year><Month>12</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>3</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>6</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>3</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16542788</ArticleId><ArticleId IdType="pii">S0360-3016(05)03094-4</ArticleId><ArticleId IdType="doi">10.1016/j.ijrobp.2005.12.020</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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