New insights into the molecular control of the lymphatic vascular system and its role in disease.
Identifieur interne : 003881 ( PubMed/Corpus ); précédent : 003880; suivant : 003882New insights into the molecular control of the lymphatic vascular system and its role in disease.
Auteurs : Leah N. Cueni ; Michael DetmarSource :
- The Journal of investigative dermatology [ 0022-202X ] ; 2006.
English descriptors
- KwdEn :
- Animals, Chemokine CCL21, Chemokines, CC (physiology), Endothelium, Lymphatic (physiology), Glycoproteins (physiology), Humans, Lymphangiogenesis, Lymphatic Metastasis, Lymphatic Vessels (anatomy & histology), Lymphatic Vessels (embryology), Lymphatic Vessels (physiology), Lymphedema (genetics), Lymphedema (therapy), Sarcoma, Kaposi (etiology), Vascular Endothelial Growth Factor C (physiology), Vascular Endothelial Growth Factor D (physiology), Vascular Endothelial Growth Factor Receptor-3 (physiology), Vesicular Transport Proteins.
- MESH :
- chemical , physiology : Chemokines, CC, Glycoproteins, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Vascular Endothelial Growth Factor Receptor-3.
- chemical : Chemokine CCL21, Vesicular Transport Proteins.
- anatomy & histology : Lymphatic Vessels.
- embryology : Lymphatic Vessels.
- etiology : Sarcoma, Kaposi.
- genetics : Lymphedema.
- physiology : Endothelium, Lymphatic, Lymphatic Vessels.
- therapy : Lymphedema.
- Animals, Humans, Lymphangiogenesis, Lymphatic Metastasis.
Abstract
The cutaneous lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, in the afferent phase of the immune response, and in the metastatic spread of skin cancers. However, the lymphatic system has not received as much scientific attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of its development and function. The recent identification of genes that specifically control lymphatic development and the growth of lymphatic vessels (lymphangiogenesis), together with the discovery of new lymphatic endothelium-specific markers, have now provided new insights into the molecular mechanisms that control lymphatic growth and function. Moreover, studies of several genetic mouse models have set the framework for a new molecular model for embryonic lymphatic vascular development, and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. These scientific advances have also provided surprising evidence that malignant tumors can directly promote lymphangiogenesis and lymphatic metastasis, and that lymphatic vessels play a major role in cutaneous inflammation and in the cutaneous response to UVB irradiation.
DOI: 10.1038/sj.jid.5700464
PubMed: 16983326
Links to Exploration step
pubmed:16983326Le document en format XML
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Cueni</name><affiliation><nlm:affiliation>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16983326</idno><idno type="pmid">16983326</idno><idno type="doi">10.1038/sj.jid.5700464</idno><idno type="wicri:Area/PubMed/Corpus">003881</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003881</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">New insights into the molecular control of the lymphatic vascular system and its role in disease.</title><author><name sortKey="Cueni, Leah N" sort="Cueni, Leah N" uniqKey="Cueni L" first="Leah N" last="Cueni">Leah N. Cueni</name><affiliation><nlm:affiliation>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></analytic><series><title level="j">The Journal of investigative dermatology</title><idno type="ISSN">0022-202X</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chemokine CCL21</term><term>Chemokines, CC (physiology)</term><term>Endothelium, Lymphatic (physiology)</term><term>Glycoproteins (physiology)</term><term>Humans</term><term>Lymphangiogenesis</term><term>Lymphatic Metastasis</term><term>Lymphatic Vessels (anatomy & histology)</term><term>Lymphatic Vessels (embryology)</term><term>Lymphatic Vessels (physiology)</term><term>Lymphedema (genetics)</term><term>Lymphedema (therapy)</term><term>Sarcoma, Kaposi (etiology)</term><term>Vascular Endothelial Growth Factor C (physiology)</term><term>Vascular Endothelial Growth Factor D (physiology)</term><term>Vascular Endothelial Growth Factor Receptor-3 (physiology)</term><term>Vesicular Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Chemokines, CC</term><term>Glycoproteins</term><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor D</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Chemokine CCL21</term><term>Vesicular Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Sarcoma, Kaposi</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Lymphangiogenesis</term><term>Lymphatic Metastasis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cutaneous lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, in the afferent phase of the immune response, and in the metastatic spread of skin cancers. However, the lymphatic system has not received as much scientific attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of its development and function. The recent identification of genes that specifically control lymphatic development and the growth of lymphatic vessels (lymphangiogenesis), together with the discovery of new lymphatic endothelium-specific markers, have now provided new insights into the molecular mechanisms that control lymphatic growth and function. Moreover, studies of several genetic mouse models have set the framework for a new molecular model for embryonic lymphatic vascular development, and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. These scientific advances have also provided surprising evidence that malignant tumors can directly promote lymphangiogenesis and lymphatic metastasis, and that lymphatic vessels play a major role in cutaneous inflammation and in the cutaneous response to UVB irradiation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16983326</PMID><DateCreated><Year>2006</Year><Month>09</Month><Day>19</Day></DateCreated><DateCompleted><Year>2006</Year><Month>10</Month><Day>26</Day></DateCompleted><DateRevised><Year>2012</Year><Month>03</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-202X</ISSN><JournalIssue CitedMedium="Print"><Volume>126</Volume><Issue>10</Issue><PubDate><Year>2006</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The Journal of investigative dermatology</Title><ISOAbbreviation>J. Invest. Dermatol.</ISOAbbreviation></Journal><ArticleTitle>New insights into the molecular control of the lymphatic vascular system and its role in disease.</ArticleTitle><Pagination><MedlinePgn>2167-77</MedlinePgn></Pagination><Abstract><AbstractText>The cutaneous lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, in the afferent phase of the immune response, and in the metastatic spread of skin cancers. However, the lymphatic system has not received as much scientific attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of its development and function. The recent identification of genes that specifically control lymphatic development and the growth of lymphatic vessels (lymphangiogenesis), together with the discovery of new lymphatic endothelium-specific markers, have now provided new insights into the molecular mechanisms that control lymphatic growth and function. Moreover, studies of several genetic mouse models have set the framework for a new molecular model for embryonic lymphatic vascular development, and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. These scientific advances have also provided surprising evidence that malignant tumors can directly promote lymphangiogenesis and lymphatic metastasis, and that lymphatic vessels play a major role in cutaneous inflammation and in the cutaneous response to UVB irradiation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cueni</LastName><ForeName>Leah N</ForeName><Initials>LN</Initials><AffiliationInfo><Affiliation>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Detmar</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CA69184</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA92644</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Invest Dermatol</MedlineTA><NlmUniqueID>0426720</NlmUniqueID><ISSNLinking>0022-202X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C515478">CCL21 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C515479">Ccl21c protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054421">Chemokine CCL21</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042643" MajorTopicYN="N">Vascular Endothelial Growth Factor D</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D040321" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-3</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D033921" MajorTopicYN="N">Vesicular Transport Proteins</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>100</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>9</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>10</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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