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The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.

Identifieur interne : 003399 ( PubMed/Corpus ); précédent : 003398; suivant : 003400

The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.

Auteurs : L. Feller ; Jn Masipa ; Nh Wood ; Ej Raubenheimer ; J. Lemmer

Source :

AIDS research and therapy [ 1742-6405 ] ; 2008.

RBID : pubmed:18226270

Abstract

Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable.

DOI: 10.1186/1742-6405-5-2
PubMed: 18226270

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<author><name sortKey="Feller, L" sort="Feller, L" uniqKey="Feller L" first="L" last="Feller">L. Feller</name>
<affiliation><nlm:affiliation>Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria, South Africa. lfeller@medunsa.ac.za</nlm:affiliation>
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<author><name sortKey="Masipa, Jn" sort="Masipa, Jn" uniqKey="Masipa J" first="Jn" last="Masipa">Jn Masipa</name>
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<author><name sortKey="Wood, Nh" sort="Wood, Nh" uniqKey="Wood N" first="Nh" last="Wood">Nh Wood</name>
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<author><name sortKey="Raubenheimer, Ej" sort="Raubenheimer, Ej" uniqKey="Raubenheimer E" first="Ej" last="Raubenheimer">Ej Raubenheimer</name>
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<author><name sortKey="Lemmer, J" sort="Lemmer, J" uniqKey="Lemmer J" first="J" last="Lemmer">J. Lemmer</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.</title>
<author><name sortKey="Feller, L" sort="Feller, L" uniqKey="Feller L" first="L" last="Feller">L. Feller</name>
<affiliation><nlm:affiliation>Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria, South Africa. lfeller@medunsa.ac.za</nlm:affiliation>
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<author><name sortKey="Masipa, Jn" sort="Masipa, Jn" uniqKey="Masipa J" first="Jn" last="Masipa">Jn Masipa</name>
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<author><name sortKey="Wood, Nh" sort="Wood, Nh" uniqKey="Wood N" first="Nh" last="Wood">Nh Wood</name>
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<author><name sortKey="Raubenheimer, Ej" sort="Raubenheimer, Ej" uniqKey="Raubenheimer E" first="Ej" last="Raubenheimer">Ej Raubenheimer</name>
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<author><name sortKey="Lemmer, J" sort="Lemmer, J" uniqKey="Lemmer J" first="J" last="Lemmer">J. Lemmer</name>
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<front><div type="abstract" xml:lang="en">Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable.</div>
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<DateCreated><Year>2008</Year>
<Month>03</Month>
<Day>26</Day>
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<DateCompleted><Year>2008</Year>
<Month>08</Month>
<Day>21</Day>
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<Title>AIDS research and therapy</Title>
<ISOAbbreviation>AIDS Res Ther</ISOAbbreviation>
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<ArticleTitle>The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable.</AbstractText>
<AbstractText Label="RESULTS AND CONCLUSION" NlmCategory="CONCLUSIONS">Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.</AbstractText>
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The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.

The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.

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