Massive localized lymphedema with unusual presentations: report of 2 cases and review of the literature.
Identifieur interne : 003204 ( PubMed/Corpus ); précédent : 003203; suivant : 003205Massive localized lymphedema with unusual presentations: report of 2 cases and review of the literature.
Auteurs : Agata M. Bogusz ; Sean M. Hussey ; Payal Kapur ; Yan Peng ; S Tunc GokaslanSource :
- International journal of surgical pathology [ 1940-2465 ] ; 2011.
English descriptors
- KwdEn :
- MESH :
Abstract
Massive localized lymphedema is a benign soft tissue lesion that usually presents as a large mass in morbidly obese adults. The diagnosis may be challenging as it can mimic other lesions, including well-differentiated liposarcoma. We report 2 cases of massive localized lymphedema with unusual presentation. The first case is a recurrent massive localized lymphedema in the right thigh of a 40-year-old morbidly obese woman. In addition to typical massive localized lymphedema features such as prominent edema and vascular proliferation in the adipose tissue, we observed prominent and abundant multinucleated stromal floret-like giant cells, arborizing network of capillaries, and areas of hyalinized collagen. Our second case is in a rare location (scrotum extending into penile soft tissue) in an overweight 55-year-old male. This lesion exhibits striking smooth muscle hyperplasia. Lack of staining by antibodies against murine double minute 2 protein and cyclin dependent kinase 4 and absence of high mobility group AT- hook 2 transcription factor rearrangement by fluorescence in situ hybridization support our diagnosis of massive localized lymphedema in both cases.
DOI: 10.1177/1066896908320833
PubMed: 18611926
Links to Exploration step
pubmed:18611926Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Massive localized lymphedema with unusual presentations: report of 2 cases and review of the literature.</title><author><name sortKey="Bogusz, Agata M" sort="Bogusz, Agata M" uniqKey="Bogusz A" first="Agata M" last="Bogusz">Agata M. Bogusz</name><affiliation><nlm:affiliation>Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9072, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hussey, Sean M" sort="Hussey, Sean M" uniqKey="Hussey S" first="Sean M" last="Hussey">Sean M. Hussey</name></author><author><name sortKey="Kapur, Payal" sort="Kapur, Payal" uniqKey="Kapur P" first="Payal" last="Kapur">Payal Kapur</name></author><author><name sortKey="Peng, Yan" sort="Peng, Yan" uniqKey="Peng Y" first="Yan" last="Peng">Yan Peng</name></author><author><name sortKey="Gokaslan, S Tunc" sort="Gokaslan, S Tunc" uniqKey="Gokaslan S" first="S Tunc" last="Gokaslan">S Tunc Gokaslan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:18611926</idno><idno type="pmid">18611926</idno><idno type="doi">10.1177/1066896908320833</idno><idno type="wicri:Area/PubMed/Corpus">003204</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003204</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Massive localized lymphedema with unusual presentations: report of 2 cases and review of the literature.</title><author><name sortKey="Bogusz, Agata M" sort="Bogusz, Agata M" uniqKey="Bogusz A" first="Agata M" last="Bogusz">Agata M. Bogusz</name><affiliation><nlm:affiliation>Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9072, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hussey, Sean M" sort="Hussey, Sean M" uniqKey="Hussey S" first="Sean M" last="Hussey">Sean M. Hussey</name></author><author><name sortKey="Kapur, Payal" sort="Kapur, Payal" uniqKey="Kapur P" first="Payal" last="Kapur">Payal Kapur</name></author><author><name sortKey="Peng, Yan" sort="Peng, Yan" uniqKey="Peng Y" first="Yan" last="Peng">Yan Peng</name></author><author><name sortKey="Gokaslan, S Tunc" sort="Gokaslan, S Tunc" uniqKey="Gokaslan S" first="S Tunc" last="Gokaslan">S Tunc Gokaslan</name></author></analytic><series><title level="j">International journal of surgical pathology</title><idno type="eISSN">1940-2465</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Diagnosis, Differential</term><term>Humans</term><term>In Situ Hybridization, Fluorescence</term><term>Liposarcoma (diagnosis)</term><term>Lymphedema</term><term>Obesity, Morbid</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Liposarcoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Diagnosis, Differential</term><term>Humans</term><term>In Situ Hybridization, Fluorescence</term><term>Lymphedema</term><term>Obesity, Morbid</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Massive localized lymphedema is a benign soft tissue lesion that usually presents as a large mass in morbidly obese adults. The diagnosis may be challenging as it can mimic other lesions, including well-differentiated liposarcoma. We report 2 cases of massive localized lymphedema with unusual presentation. The first case is a recurrent massive localized lymphedema in the right thigh of a 40-year-old morbidly obese woman. In addition to typical massive localized lymphedema features such as prominent edema and vascular proliferation in the adipose tissue, we observed prominent and abundant multinucleated stromal floret-like giant cells, arborizing network of capillaries, and areas of hyalinized collagen. Our second case is in a rare location (scrotum extending into penile soft tissue) in an overweight 55-year-old male. This lesion exhibits striking smooth muscle hyperplasia. Lack of staining by antibodies against murine double minute 2 protein and cyclin dependent kinase 4 and absence of high mobility group AT- hook 2 transcription factor rearrangement by fluorescence in situ hybridization support our diagnosis of massive localized lymphedema in both cases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18611926</PMID><DateCreated><Year>2011</Year><Month>04</Month><Day>08</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>22</Day></DateCompleted><DateRevised><Year>2011</Year><Month>04</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1940-2465</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Apr</Month></PubDate></JournalIssue><Title>International journal of surgical pathology</Title><ISOAbbreviation>Int. J. Surg. Pathol.</ISOAbbreviation></Journal><ArticleTitle>Massive localized lymphedema with unusual presentations: report of 2 cases and review of the literature.</ArticleTitle><Pagination><MedlinePgn>212-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/1066896908320833</ELocationID><Abstract><AbstractText>Massive localized lymphedema is a benign soft tissue lesion that usually presents as a large mass in morbidly obese adults. The diagnosis may be challenging as it can mimic other lesions, including well-differentiated liposarcoma. We report 2 cases of massive localized lymphedema with unusual presentation. The first case is a recurrent massive localized lymphedema in the right thigh of a 40-year-old morbidly obese woman. In addition to typical massive localized lymphedema features such as prominent edema and vascular proliferation in the adipose tissue, we observed prominent and abundant multinucleated stromal floret-like giant cells, arborizing network of capillaries, and areas of hyalinized collagen. Our second case is in a rare location (scrotum extending into penile soft tissue) in an overweight 55-year-old male. This lesion exhibits striking smooth muscle hyperplasia. Lack of staining by antibodies against murine double minute 2 protein and cyclin dependent kinase 4 and absence of high mobility group AT- hook 2 transcription factor rearrangement by fluorescence in situ hybridization support our diagnosis of massive localized lymphedema in both cases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bogusz</LastName><ForeName>Agata M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9072, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hussey</LastName><ForeName>Sean M</ForeName><Initials>SM</Initials></Author><Author ValidYN="Y"><LastName>Kapur</LastName><ForeName>Payal</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Yan</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Gokaslan</LastName><ForeName>S Tunc</ForeName><Initials>ST</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>07</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Surg Pathol</MedlineTA><NlmUniqueID>9314927</NlmUniqueID><ISSNLinking>1066-8969</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017404" MajorTopicYN="Y">In Situ Hybridization, Fluorescence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008080" MajorTopicYN="N">Liposarcoma</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009767" MajorTopicYN="Y">Obesity, Morbid</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>7</Month><Day>10</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>7</Month><Day>10</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18611926</ArticleId><ArticleId IdType="pii">1066896908320833</ArticleId><ArticleId IdType="doi">10.1177/1066896908320833</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003204 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 003204 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:18611926
|texte= Massive localized lymphedema with unusual presentations: report of 2 cases and review of the literature.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:18611926" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |