Complex ecological dynamics and eradicability of the vector borne macroparasitic disease, lymphatic filariasis.
Identifieur interne : 003172 ( PubMed/Corpus ); précédent : 003171; suivant : 003173Complex ecological dynamics and eradicability of the vector borne macroparasitic disease, lymphatic filariasis.
Auteurs : Manoj Gambhir ; Edwin MichaelSource :
- PloS one [ 1932-6203 ] ; 2008.
English descriptors
- KwdEn :
- Animals, Bites and Stings (parasitology), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Elephantiasis, Filarial (transmission), Filaricides (therapeutic use), Humans, Larva (physiology), Microfilariae (growth & development), Microfilariae (physiology), Prevalence, Sensitivity and Specificity.
- MESH :
- chemical , therapeutic use : Filaricides.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- growth & development : Microfilariae.
- parasitology : Bites and Stings.
- physiology : Larva, Microfilariae.
- prevention & control : Elephantiasis, Filarial.
- transmission : Elephantiasis, Filarial.
- Animals, Humans, Prevalence, Sensitivity and Specificity.
Abstract
The current global efforts to control the morbidity and mortality caused by infectious diseases affecting developing countries--such as HIV/AIDS, polio, tuberculosis, malaria and the Neglected Tropical Diseases (NTDs)-have led to an increasing focus on the biological controllability or eradicability of disease transmission by management action. Here, we use an age-structured dynamical model of lymphatic filariasis transmission to show how a quantitative understanding of the dynamic processes underlying infection persistence and extinction is key to evaluating the eradicability of this macroparasitic disease.
DOI: 10.1371/journal.pone.0002874
PubMed: 18716676
Links to Exploration step
pubmed:18716676Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Complex ecological dynamics and eradicability of the vector borne macroparasitic disease, lymphatic filariasis.</title><author><name sortKey="Gambhir, Manoj" sort="Gambhir, Manoj" uniqKey="Gambhir M" first="Manoj" last="Gambhir">Manoj Gambhir</name><affiliation><nlm:affiliation>Department of Infectious Disease Epidemiology, School of Medicine, Imperial College London, London, United Kingdom. m.gambhir@imperial.ac.uk</nlm:affiliation></affiliation></author><author><name sortKey="Michael, Edwin" sort="Michael, Edwin" uniqKey="Michael E" first="Edwin" last="Michael">Edwin Michael</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18716676</idno><idno type="pmid">18716676</idno><idno type="doi">10.1371/journal.pone.0002874</idno><idno type="wicri:Area/PubMed/Corpus">003172</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003172</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Complex ecological dynamics and eradicability of the vector borne macroparasitic disease, lymphatic filariasis.</title><author><name sortKey="Gambhir, Manoj" sort="Gambhir, Manoj" uniqKey="Gambhir M" first="Manoj" last="Gambhir">Manoj Gambhir</name><affiliation><nlm:affiliation>Department of Infectious Disease Epidemiology, School of Medicine, Imperial College London, London, United Kingdom. m.gambhir@imperial.ac.uk</nlm:affiliation></affiliation></author><author><name sortKey="Michael, Edwin" sort="Michael, Edwin" uniqKey="Michael E" first="Edwin" last="Michael">Edwin Michael</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bites and Stings (parasitology)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Elephantiasis, Filarial (transmission)</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>Larva (physiology)</term><term>Microfilariae (growth & development)</term><term>Microfilariae (physiology)</term><term>Prevalence</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Bites and Stings</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Larva</term><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Prevalence</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The current global efforts to control the morbidity and mortality caused by infectious diseases affecting developing countries--such as HIV/AIDS, polio, tuberculosis, malaria and the Neglected Tropical Diseases (NTDs)-have led to an increasing focus on the biological controllability or eradicability of disease transmission by management action. Here, we use an age-structured dynamical model of lymphatic filariasis transmission to show how a quantitative understanding of the dynamic processes underlying infection persistence and extinction is key to evaluating the eradicability of this macroparasitic disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18716676</PMID><DateCreated><Year>2008</Year><Month>08</Month><Day>21</Day></DateCreated><DateCompleted><Year>2008</Year><Month>12</Month><Day>18</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>3</Volume><Issue>8</Issue><PubDate><Year>2008</Year><Month>Aug</Month><Day>06</Day></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Complex ecological dynamics and eradicability of the vector borne macroparasitic disease, lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>e2874</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0002874</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The current global efforts to control the morbidity and mortality caused by infectious diseases affecting developing countries--such as HIV/AIDS, polio, tuberculosis, malaria and the Neglected Tropical Diseases (NTDs)-have led to an increasing focus on the biological controllability or eradicability of disease transmission by management action. Here, we use an age-structured dynamical model of lymphatic filariasis transmission to show how a quantitative understanding of the dynamic processes underlying infection persistence and extinction is key to evaluating the eradicability of this macroparasitic disease.</AbstractText><AbstractText Label="METHODOLOGY/PRINCIPAL FINDINGS" NlmCategory="RESULTS">We investigated the persistence and extinction dynamics of lymphatic filariasis by undertaking a numerical equilibrium analysis of a deterministic model of parasite transmission, based on varying values of the initial L3 larval density in the system. The results highlighted the likely occurrence of complex dynamics in parasite transmission with three major outcomes for the eradicability of filariasis. First, both vector biting and worm breakpoint thresholds are shown to be complex dynamic entities with values dependent on the nature and magnitude of vector-and host specific density-dependent processes and the degree of host infection aggregation prevailing in endemic communities. Second, these thresholds as well as the potential size of the attractor domains and hence system resilience are strongly dependent on peculiarities of infection dynamics in different vector species. Finally, the existence of multiple stable states indicates the presence of hysteresis nonlinearity in the filariasis system dynamics in which infection thresholds for infection invasion are lower but occur at higher biting rates than do the corresponding thresholds for parasite elimination.</AbstractText><AbstractText Label="CONCLUSIONS/SIGNIFICANCE" NlmCategory="CONCLUSIONS">The variable dynamic nature of thresholds and parasite system resilience reflecting both initial conditions and vector species-infection specificities, and the existence of hysteresis loop phenomenon, suggests that eradication of filariasis may require taking a more flexible and locally relevant approach to designing elimination programmes compared to the current command and control approach advocated by the global programme.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gambhir</LastName><ForeName>Manoj</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease Epidemiology, School of Medicine, Imperial College London, London, United Kingdom. m.gambhir@imperial.ac.uk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michael</LastName><ForeName>Edwin</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI069387</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI069387-01A1</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>08</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005369">Filaricides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2003 Nov 1;188(9):1371-81</RefSource><PMID Version="1">14593597</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Adv Parasitol. 2007;65:191-237</RefSource><PMID Version="1">18063097</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1967;61(5):663-6</RefSource><PMID Version="1">6055558</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bull World Health Organ. 1968;38(6):935-41</RefSource><PMID Version="1">4235739</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1988;82(1):138-45</RefSource><PMID Version="1">3051543</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epidemiol Infect. 1989 Dec;103(3):693-702</RefSource><PMID Version="1">2691270</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Indian J Med Res. 1990 Jul;91:293-7</RefSource><PMID Version="1">2228061</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitology. 1992;104 Suppl:S81-90</RefSource><PMID Version="1">1589303</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epidemiol Infect. 1992 Jun;108(3):483-93</RefSource><PMID Version="1">1601082</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1996 Mar-Apr;90(2):119-21</RefSource><PMID Version="1">8761566</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitology. 1996 Apr;112 ( Pt 4):409-28</RefSource><PMID Version="1">8935952</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitology. 1998 Mar;116 ( Pt 3):243-55</RefSource><PMID Version="1">9550218</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epidemiol Infect. 2000 Jun;124(3):529-41</RefSource><PMID Version="1">10982078</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2001 Jul;23(7):363-71</RefSource><PMID Version="1">11472556</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2001 Oct 11;413(6856):591-6</RefSource><PMID Version="1">11595939</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Med Vet Entomol. 2002 Dec;16(4):409-23</RefSource><PMID Version="1">12510894</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Trop Med Parasitol. 2002 Dec;96 Suppl 2:S143-52</RefSource><PMID Version="1">12625927</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Trop. 2003 May;86(2-3):275-82</RefSource><PMID Version="1">12745144</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1992 Sep-Oct;86(5):523-30</RefSource><PMID Version="1">1475823</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Trop. 1993 Mar;53(1):1-26</RefSource><PMID Version="1">8096106</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1993 Oct 28;365(6449):797-805</RefSource><PMID Version="1">8413664</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 1994 Aug;51(2):244-9</RefSource><PMID Version="1">8074259</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epidemiol Infect. 1995 Oct;115(2):325-44</RefSource><PMID Version="1">7589272</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 1998 Oct;59(4):606-14</RefSource><PMID Version="1">9790439</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Parasitol. 2005 Feb;21(2):88-96</RefSource><PMID Version="1">15664532</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Parasitol. 2006 May;22(5):226-33</RefSource><PMID Version="1">16564745</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Parasitol. 2006 Jul;22(7):313-21</RefSource><PMID Version="1">16713738</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Parasitol. 2006 Nov;22(11):529-35</RefSource><PMID Version="1">16971182</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Med Vet Entomol. 2006 Sep;20(3):261-72</RefSource><PMID Version="1">17044876</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2006 Jan;3(5):e112</RefSource><PMID Version="1">16435910</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Ecol Evol. 2007 Apr;22(4):185-91</RefSource><PMID Version="1">17175060</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Parasitol. 2007 Nov;23(11):511-4</RefSource><PMID Version="1">17951109</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Infect Dis. 2004 Apr;4(4):223-34</RefSource><PMID Version="1">15050941</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001733" MajorTopicYN="N">Bites and Stings</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug 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