Filarial infection is resisted differentially by subjects having different blood group phenotypes.
Identifieur interne : 002E63 ( PubMed/Corpus ); précédent : 002E62; suivant : 002E64Filarial infection is resisted differentially by subjects having different blood group phenotypes.
Auteurs : Vandana Dixit ; A K Pati ; A K Gupta ; P S Bisen ; G B K S. PrasadSource :
- Journal of clinical laboratory analysis [ 1098-2825 ] ; 2009.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Blood Group Antigens (blood), Blood Group Antigens (immunology), Child, Child, Preschool, Data Interpretation, Statistical, Disease Susceptibility (blood), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (immunology), Female, Humans, India, Male, Microfilariae (isolation & purification), Middle Aged, Sex Characteristics, Wuchereria bancrofti (immunology), Young Adult.
- MESH :
- chemical , blood : Blood Group Antigens.
- chemical , immunology : Blood Group Antigens.
- blood : Disease Susceptibility, Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Wuchereria bancrofti.
- isolation & purification : Microfilariae.
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Data Interpretation, Statistical, Female, Humans, India, Male, Middle Aged, Sex Characteristics, Young Adult.
Abstract
This study was aimed to elucidate the relationship between major blood group antigens (BGAs) and susceptibility or resistance to human lymphatic filariasis. A total of 492 human subjects, living in Raipur city of Chhattisgarh, endemic for bancroftian filariasis in Central India, were screened for the presence of Wuchereria bancrofti microfilariae and disease manifestations. The frequency of BGAs was tabulated as a function of the status of filariasis, namely normal (no infection), mf carrier (presence of microfilariae in blood), and elephantiasis (confirmed clinical manifestations). The comparison of ABO phenotype distributions among all the three groups clearly indicated that disease status has a significant relationship with the blood group attributes. The result of chi2 analysis of the frequencies of ABO phenotypes observed in microfilaraemic and elephantiasis groups (observed frequency vs. expected frequency computed based on the distribution of the normal population) revealed that there has been a significant alteration in the distribution of ABO phenotypes in microfilaraemic, but not in elephantiasis, group. The susceptibility to filarial infection was computed as a function of blood group phenotypes in the population. The susceptibility and conditional susceptibility for elephantiasis were the least among the subjects with AB phenotypes. The mechanism of association between filariasis and ABO antigens needs to be further explored to understand how the distribution of BGAs affects susceptibility/resistance to infection.
DOI: 10.1002/jcla.20317
PubMed: 19455632
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Prasad</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19455632</idno><idno type="pmid">19455632</idno><idno type="doi">10.1002/jcla.20317</idno><idno type="wicri:Area/PubMed/Corpus">002E63</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Filarial infection is resisted differentially by subjects having different blood group phenotypes.</title><author><name sortKey="Dixit, Vandana" sort="Dixit, Vandana" uniqKey="Dixit V" first="Vandana" last="Dixit">Vandana Dixit</name><affiliation><nlm:affiliation>School of Studies in Biochemistry and Biotechnology, Jiwaji University, Gwalior, India.</nlm:affiliation></affiliation></author><author><name sortKey="Pati, A K" sort="Pati, A K" uniqKey="Pati A" first="A K" last="Pati">A K Pati</name></author><author><name sortKey="Gupta, A K" sort="Gupta, A K" uniqKey="Gupta A" first="A K" last="Gupta">A K Gupta</name></author><author><name sortKey="Bisen, P S" sort="Bisen, P S" uniqKey="Bisen P" first="P S" last="Bisen">P S Bisen</name></author><author><name sortKey="Prasad, G B K S" sort="Prasad, G B K S" uniqKey="Prasad G" first="G B K S" last="Prasad">G B K S. Prasad</name></author></analytic><series><title level="j">Journal of clinical laboratory analysis</title><idno type="eISSN">1098-2825</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Blood Group Antigens (blood)</term><term>Blood Group Antigens (immunology)</term><term>Child</term><term>Child, Preschool</term><term>Data Interpretation, Statistical</term><term>Disease Susceptibility (blood)</term><term>Elephantiasis, Filarial (blood)</term><term>Elephantiasis, Filarial (immunology)</term><term>Female</term><term>Humans</term><term>India</term><term>Male</term><term>Microfilariae (isolation & purification)</term><term>Middle Aged</term><term>Sex Characteristics</term><term>Wuchereria bancrofti (immunology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Blood Group Antigens</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Blood Group Antigens</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Disease Susceptibility</term><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Microfilariae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Data Interpretation, Statistical</term><term>Female</term><term>Humans</term><term>India</term><term>Male</term><term>Middle Aged</term><term>Sex Characteristics</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was aimed to elucidate the relationship between major blood group antigens (BGAs) and susceptibility or resistance to human lymphatic filariasis. A total of 492 human subjects, living in Raipur city of Chhattisgarh, endemic for bancroftian filariasis in Central India, were screened for the presence of Wuchereria bancrofti microfilariae and disease manifestations. The frequency of BGAs was tabulated as a function of the status of filariasis, namely normal (no infection), mf carrier (presence of microfilariae in blood), and elephantiasis (confirmed clinical manifestations). The comparison of ABO phenotype distributions among all the three groups clearly indicated that disease status has a significant relationship with the blood group attributes. The result of chi2 analysis of the frequencies of ABO phenotypes observed in microfilaraemic and elephantiasis groups (observed frequency vs. expected frequency computed based on the distribution of the normal population) revealed that there has been a significant alteration in the distribution of ABO phenotypes in microfilaraemic, but not in elephantiasis, group. The susceptibility to filarial infection was computed as a function of blood group phenotypes in the population. The susceptibility and conditional susceptibility for elephantiasis were the least among the subjects with AB phenotypes. The mechanism of association between filariasis and ABO antigens needs to be further explored to understand how the distribution of BGAs affects susceptibility/resistance to infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19455632</PMID><DateCreated><Year>2009</Year><Month>05</Month><Day>25</Day></DateCreated><DateCompleted><Year>2009</Year><Month>08</Month><Day>27</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1098-2825</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>3</Issue><PubDate><Year>2009</Year></PubDate></JournalIssue><Title>Journal of clinical laboratory analysis</Title><ISOAbbreviation>J. Clin. Lab. Anal.</ISOAbbreviation></Journal><ArticleTitle>Filarial infection is resisted differentially by subjects having different blood group phenotypes.</ArticleTitle><Pagination><MedlinePgn>186-91</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jcla.20317</ELocationID><Abstract><AbstractText>This study was aimed to elucidate the relationship between major blood group antigens (BGAs) and susceptibility or resistance to human lymphatic filariasis. A total of 492 human subjects, living in Raipur city of Chhattisgarh, endemic for bancroftian filariasis in Central India, were screened for the presence of Wuchereria bancrofti microfilariae and disease manifestations. The frequency of BGAs was tabulated as a function of the status of filariasis, namely normal (no infection), mf carrier (presence of microfilariae in blood), and elephantiasis (confirmed clinical manifestations). The comparison of ABO phenotype distributions among all the three groups clearly indicated that disease status has a significant relationship with the blood group attributes. The result of chi2 analysis of the frequencies of ABO phenotypes observed in microfilaraemic and elephantiasis groups (observed frequency vs. expected frequency computed based on the distribution of the normal population) revealed that there has been a significant alteration in the distribution of ABO phenotypes in microfilaraemic, but not in elephantiasis, group. The susceptibility to filarial infection was computed as a function of blood group phenotypes in the population. The susceptibility and conditional susceptibility for elephantiasis were the least among the subjects with AB phenotypes. The mechanism of association between filariasis and ABO antigens needs to be further explored to understand how the distribution of BGAs affects susceptibility/resistance to infection.</AbstractText><CopyrightInformation>Copyright 2009 Wiley-Liss, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dixit</LastName><ForeName>Vandana</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>School of Studies in Biochemistry and Biotechnology, Jiwaji University, Gwalior, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pati</LastName><ForeName>A K</ForeName><Initials>AK</Initials></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>A K</ForeName><Initials>AK</Initials></Author><Author ValidYN="Y"><LastName>Bisen</LastName><ForeName>P S</ForeName><Initials>PS</Initials></Author><Author ValidYN="Y"><LastName>Prasad</LastName><ForeName>G B K S</ForeName><Initials>GB</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Lab Anal</MedlineTA><NlmUniqueID>8801384</NlmUniqueID><ISSNLinking>0887-8013</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001789">Blood Group Antigens</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001789" MajorTopicYN="N">Blood Group Antigens</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003627" MajorTopicYN="N">Data Interpretation, Statistical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004198" MajorTopicYN="N">Disease Susceptibility</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007194" MajorTopicYN="N">India</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008842" MajorTopicYN="N">Microfilariae</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012727" MajorTopicYN="N">Sex Characteristics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="Y">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>5</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>5</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>8</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19455632</ArticleId><ArticleId IdType="doi">10.1002/jcla.20317</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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